Mitochondrial-targeted nanoparticles: Delivery and therapeutic agents in cancer

Article Nanoscience & Nanotechnology

Efficient Magnetic Nanocatalyst-Induced Chemo- and Ferroptosis Synergistic Cancer Therapy in Combination with T1-T2 Dual-Mode Magnetic Resonance Imaging Through Doxorubicin Delivery

Ling Zhu et al.

Summary: The nanocatalyst ipGdIO-Dox can induce cancer cells to undergo ferroptosis, exhibiting excellent anticancer efficacy and the ability for tumor diagnosis under MRI guidance.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

Photoactive Bionic Virus Robustly Elicits the Synergy Anticancer Activity of Immunophotodynamic Therapy

Kerong Chen et al.

Summary: Researchers have developed a biomimetic virus-like nanocomplex that improves cancer theranostics through mimicking the infection mechanism of coronaviruses. This nanocomplex has various potential biomedical applications.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

Transferrin Protein Corona-Modified CuGd Core-Shell Nanoplatform for Tumor-Targeting Photothermal and Chemodynamic Synergistic Therapies

Xiangyu Qi et al.

Summary: A novel protein corona-modified nanoplatform has been developed for tumor-targeting photothermal and chemodynamic synergistic therapy. The nanoplatform exhibits high photothermal conversion efficiency and excellent stability. It shows strong chemodynamic therapy ability and can induce cancer cell death. Additionally, it can accurately diagnose cancer, making it a promising candidate for photothermal and chemodynamic synergistic theranostics.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Engineering, Biomedical

Multifunctional liquid metal-based nanoparticles with glycolysis and mitochondrial metabolism inhibition for tumor photothermal therapy

Xing-Lan Ding et al.

Summary: This study designed a tumor acidity-responsive nanoparticle that combines ATP generation inhibition and photothermal therapy to enhance tumor treatment. By inhibiting glycolysis and increasing oxidative stress, the nanoparticles degrade and cause mitochondrial dysfunction, leading to reduced ATP production and heat shock protein expression, ultimately improving the therapeutic effect of photothermal therapy.

BIOMATERIALS (2022)

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Article Chemistry, Multidisciplinary

Photodecaging of a Mitochondria-Localized Iridium(III) Endoperoxide Complex for Two-Photon Photoactivated Therapy under Hypoxia

Shi Kuang et al.

Summary: A novel mitochondria-localized iridium(III) endoperoxide prodrug is reported, which releases highly cytotoxic iridium(III) complex, singlet oxygen, and alkoxy radical under two-photon irradiation in NIR. This approach shows potential for the treatment of hypoxic tumors.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Medicine, Research & Experimental

Preparation of a Self-Assembled Rhein-Doxorubicin Nanogel Targeting Mitochondria and Investigation on Its Antihepatoma Activity

Li Wu et al.

Summary: Mitochondria-regulating Rhein-DOX nanogel with improved bioavailability and increased anticancer efficacy is a promising strategy for the development of long-term antihepatoma agents with low toxicity.

MOLECULAR PHARMACEUTICS (2022)

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Article Chemistry, Multidisciplinary

Undifferentiated destruction of mitochondria by photoacoustic shockwave to overcome chemoresistance and radiation resistance in cancer therapy

Liming Liu et al.

Summary: A strategy of precise mitochondrial destruction using photoacoustic shockwave was proposed to overcome resistance in cancer therapy. By localizing in mitochondria and generating shockwave, nanoparticles can effectively induce apoptosis and combat resistant tumor cells.

NANOSCALE (2022)

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Article Biotechnology & Applied Microbiology

Mitochondria-targeting multifunctional nanoplatform for cascade phototherapy and hypoxia-activated chemotherapy

Jie Lv et al.

Summary: By combining photodynamic therapy, photothermal therapy, and hypoxia-activated chemotherapy, this study developed a mitochondrial targeted nanoplatform that can synergistically treat tumors and maximize the therapeutic window.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Homologous targeting nanoparticles for enhanced PDT against osteosarcoma HOS cells and the related molecular mechanisms

Yang Wang et al.

Summary: This study constructed a theranostic nanoplatform with homologous targeting ability and photoacoustic/fluorescence imaging ability, and demonstrated its potential application in osteosarcoma treatment through in vitro and in vivo experiments.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Nanoscience & Nanotechnology

A Platelet-Mimicking Single-Atom Nanozyme for Mitochondrial Damage-Mediated Mild-Temperature Photothermal Therapy

Pengyuan Qi et al.

Summary: In this study, a novel platelet membrane-coated mesoporous Fe single-atom nanozyme (PMS) was developed for efficient tumor therapy. The PMS showed satisfactory NIR-II photothermal performance, high peroxidase activity, good tumor-targeting ability, and the ability to serve as a carrier for protein drugs. In vitro and in vivo experiments demonstrated the PMS's ability to inhibit HSP expression and effectively accumulate in tumor sites without causing significant toxicity in major organs. This study provides a new promising approach for cancer treatment using biomimetic mesoporous Fe single-atom nanozymes.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

VB12-Sericin-PBLG-IR780 Nanomicelles for Programming Cell Pyroptosis via Photothermal (PTT)/Photodynamic (PDT) Effect-Induced Mitochondrial DNA (mitoDNA) Oxidative Damage

Weihong Guo et al.

Summary: In this study, VB12-sericin-PBLG-IR780 nanomicelles were successfully synthesized, which can induce pyroptosis through photothermal effect and promote DC maturation and activate antitumor immunity.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Engineering, Biomedical

Lipase-triggered drug release from BCL2 inhibitor ABT-199-loaded nanoparticles to elevate anti-leukemic activity through enhanced drug targeting on the mitochondrial membrane

Bin Liang et al.

Summary: PEG-ABT-199, a novel drug carrier, can effectively encapsulate and release ABT-199, enhancing its anti-leukemic ability and significantly reducing side effects. This nanoparticle has low toxicity to normal cells and shows potential for clinical application.

ACTA BIOMATERIALIA (2022)

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Article Chemistry, Analytical

pH-Sensitive Bioprobe for Multichannel Mitochondrial Imaging and Photodynamic Therapy

Lu Zhang et al.

Summary: Tumor targeting therapy and photodynamic therapy are effective anti-cancer therapies. The design and synthesis of multifunctional organic phototheranostic agents play an increasingly positive role in cancer diagnosis and treatment.

ANALYTICAL CHEMISTRY (2022)

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Article Chemistry, Applied

Chitosan derivatives functionalized dual ROS-responsive nanocarriers to enhance synergistic oxidation-chemotherapy

Jia-Xin Liao et al.

Summary: In this study, a dual ROS-responsive nanocarriers were developed for specific and controlled drug release in cancer cells by gradually responding to the endogenous ROS level, thereby enhancing the synergistic therapy effect.

CARBOHYDRATE POLYMERS (2022)

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Review Biochemistry & Molecular Biology

Emerging trends in nano-bioactive-mediated mitochondria-targeted therapeutic stratagems using polysaccharides, proteins and lipidic carriers

Kayalvizhi Rajendran et al.

Summary: The encapsulation of bioactives in nanodimensional particles can overcome their limitations in clinical applicability and improve their bioavailability and therapeutic efficacy. Nanocarriers derived from biopolymers have shown promise in encapsulating bioactives, but incorporating cell-specific and mitochondria-specific elements requires further research.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Medicine, Research & Experimental

Gold Nanoparticle-Decorated Drug Nanocrystals for Enhancing Anticancer Efficacy and Reversing Drug Resistance Through Chemo-/Photothermal Therapy

Jihui Wang et al.

Summary: The article introduces a promising multifunctional nanocarrier that integrates chemotherapy and photothermal therapy to enhance anticancer efficacy, sensitize drug-resistant cancer cells, and diminish cancer stem cells.

MOLECULAR PHARMACEUTICS (2022)

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Article Biochemistry & Molecular Biology

Doxorubicin-Conjugated Zinc Oxide Nanoparticles, Biogenically Synthesised Using a Fungus Aspergillus niger, Exhibit High Therapeutic Efficacy against Lung Cancer Cells

Prakriti Mishra et al.

Summary: This study investigated the therapeutic effectiveness of doxorubicin-conjugated zinc oxide nanoparticles against a lung cancer cell line. The nanoparticles were synthesized using a fungus with a high tolerance for zinc, and their cytotoxic effects were compared to doxorubicin alone. The results showed that the doxorubicin-conjugated zinc oxide nanoparticles strongly inhibited the proliferation of lung cancer cells and induced apoptosis. The study suggests that these biogenically synthesized nanoparticles have potential as a drug delivery system.

MOLECULES (2022)

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Article Oncology

Tumor acidity and near-infrared light responsive drug delivery MoS2-based nanoparticles for chemo-photothermal therapy

Wen Zhang et al.

Summary: This study introduces a novel MoS2/PDA-TPP nanocomposite loaded with chemotherapy drug DOX for dual-response tumor microenvironment therapy, utilizing tumor-specific mitochondria accumulation and photothermal therapy to enhance anti-tumor effects. The nanoplatform demonstrates pH-responsive drug release under acidic TME conditions and triggers mitochondrial-dependent apoptosis through ROS production and MMP reduction. Additionally, hyperthermia induced by PTT effectively causes tumor cell death without severe inflammation to adjacent tissues, providing a promising strategy to overcome multidrug resistance in cancer treatment.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2022)

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Article Chemistry, Multidisciplinary

Recent Advancements in Mitochondria-Targeted Nanoparticle Drug Delivery for Cancer Therapy

Jiangsheng Xu et al.

Summary: Mitochondria are critical organelles for producing energy in cells and can be targeted for cancer therapy. Mitochondria-targeting nanotechnologies have shown high efficacy for cancer treatment both in vitro and in vivo, and can be intelligently designed based on the characteristics of the tumor microenvironment.

NANOMATERIALS (2022)

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Article Biotechnology & Applied Microbiology

Bioengineered miR-34a modulates mitochondrial inner membrane protein 17 like 2 (MPV17L2) expression toward the control of cancer cell mitochondrial functions

Wan-Rong Yi et al.

Summary: This study aims to investigate the role of miR-34a-5p in the regulation of mitochondrial functions in human carcinoma cells using a new bioengineered miRNA molecule. The results show that the bioengineered miR-34a-5p effectively reduces the levels of mitochondrial inner membrane protein MPV17L2, leading to lower respiratory chain activities and intracellular ATP levels. Additionally, the study demonstrates that biologic miR-34a-5p significantly reduces cancer cell mitochondrial respiration capacity and increases oxidative stress and apoptotic cell death.

BIOENGINEERED (2022)

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Article Biochemistry & Molecular Biology

In Vitro Effects of Mitochondria-Targeted Antioxidants in a Small-Cell Carcinoma of the Ovary of Hypercalcemic Type and in Type 1 and Type 2 Endometrial Cancer

Mariana Casteloa et al.

Summary: This study evaluated the anticancer activity of three new compounds on ovarian and endometrial cancer cells. The results showed a time- and concentration-dependent decrease in cell viability and led to apoptosis and changes in mitochondrial function. These compounds also exhibited antioxidant activity, which might be related to cell death.

BIOMEDICINES (2022)

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Article Pharmacology & Pharmacy

A biotin-modified and H2O2-activatable theranostic nanoplatform for enhanced photothermal and chemical combination cancer therapy

Chuanjiang Jian et al.

Summary: In this study, a biotin-modified and activatable nanotheranostic system is developed for the synergistic photothermal therapy and chemotherapy of melanoma. The system can efficiently deliver H2O2-triggered photosensitizer and cytotoxic drugs to tumor site, leading to mitochondrial damage and ROS increase for tumor cell apoptosis. The system shows high uptake efficiency and therapeutic efficacy in in vitro and in vivo experiments.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2022)

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Article Chemistry, Multidisciplinary

Synergistic Reinforcing of Immunogenic Cell Death and Transforming Tumor-Associated Macrophages Via a Multifunctional Cascade Bioreactor for Optimizing Cancer Immunotherapy

Cong Huang et al.

Summary: This study proposes a two-way enhancement of immunogenic cell death (ICD) using a CaO2@CuS-MnO2@HA (CCMH) nanocomposite. The study found that CCMH with NIR irradiation can generate sufficient damage-associated molecular patterns (DAMPs), reprogram the immunosuppressive tumor microenvironment, and activate antitumor immunity.

ADVANCED MATERIALS (2022)

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Article Chemistry, Multidisciplinary

Green Synthesis of Gold Nanoparticles and Study of Their Inhibitory Effect on Bulk Cancer Cells and Cancer Stem Cells in Breast Carcinoma

Jihui Wang et al.

Summary: This study selected hyaluronic acid to synthesize gold nanoparticles with potent anti-cancer activity, which showed improved physico-chemical properties and enhanced biological effects against bulk cancer cells as well as cancer stem cells. The nano-scaled structure of the gold nanoparticles and the combined effect from NIR-induced hyperthermia contributed to the intensified bioactivity. The biocompatible nature of these nanoparticles supported their potential as a candidate for the development of novel chemotherapeutic drugs.

NANOMATERIALS (2022)

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Article Nanoscience & Nanotechnology

Nontoxic Metal-Free Visible Light-Responsive Carbon Nitride Quantum Dots Cause Oxidative Stress and Cancer-Specific Membrane Damage

Pranjali Yadav et al.

Summary: Graphitic carbon nitride quantum dots (g-CNQDs) can generate reactive oxygen species under visible light illumination, causing oxidative stress and cell death in glioma cells. This treatment method is biocompatible with normal cells and can induce necrosis in cancer cells in an acidic tumor environment.

ACS APPLIED BIO MATERIALS (2022)

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Article Nanoscience & Nanotechnology

Efficient Magnetic Nanocatalyst-Induced Chemo- and Ferroptosis Synergistic Cancer Therapy in Combination with T-1-T-2 Dual-Mode Magnetic Resonance Imaging Through Doxorubicin Delivery

Ling Zhu et al.

Summary: A novel magnetic nanocatalyst was developed for MRI-guided chemo- and ferroptosis synergistic cancer therapies, releasing abundant Fe(II) ions to induce oxidative stress and promote ferroptosis.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Nanoscience & Nanotechnology

Mitochondria-Targeting MoS2-Based Nanoagents for Enhanced NIR-II Photothermal-Chemodynamic Synergistic Oncotherapy

Xiao Li et al.

Summary: MPFPT nanosheets demonstrate enhanced therapeutic efficacy by targeting mitochondria, good photothermal performance, and acceleration of the Fenton reaction, making them promising nanoagents for oncotherapy.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Pharmacology & Pharmacy

Dequalinium-derived Nanoconstructs: A Promising Vehicle for Mitochon-drial Targeting

Abhishek Pawar et al.

Summary: Mitochondria, as the power house of the cell, plays a crucial role in drug targeting for the treatment of diseases. By modifying drug carriers such as DQAsomes, drugs can be efficiently targeted to mitochondria, leading to enhanced therapeutic outcomes.

CURRENT DRUG DELIVERY (2021)

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Article Multidisciplinary Sciences

Induction of mitochondria mediated apoptosis in human ovarian cancer cells by folic acid coated tin oxide nanoparticles

Demiana H. Hanna et al.

Summary: The study aimed to prepare folic acid coated tin oxide nanoparticles (FA-SnO2 NPs) for targeted therapy against human ovarian cancer cells with minimal side effects on normal cells. The results showed that FA-SnO2 NPs effectively inhibited SKOV3 cancer cell growth through reactive oxygen species generation, induced apoptosis, and altered expression of related proteins. Overall, the findings suggest that FA-SnO2 NPs could be a promising therapeutic candidate for human ovarian cancer with a specific targeting moiety.

PLOS ONE (2021)

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Article Chemistry, Physical

Mitochondria-Targeted Bovine Serum Albumin@Copper Sulfide Nanocomposites Conjugated with Rhodamine-110 Dye for an Enhanced Efficacy of Cancer Photothermal Therapy

Haibei Tong et al.

Summary: In this study, mitochondria-targeted and highly efficient photothermal R-BSA@CuS nanocomposites were successfully prepared, showing significant anticancer effects on breast cancer cells and the ability to penetrate 3D multicellular tumor spheroids. These nanocomposites have important potential applications in cancer photothermal therapy.

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION (2021)

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Article Cell Biology

Dynamic Control of Mitochondrial Ca2+ Levels as a Survival Strategy of Cancer Cells

Corina T. Madreiter-Sokolowski et al.

Summary: Cancer cells have increased energy demands and maintaining mitochondrial Ca2+ homeostasis is crucial for their survival. The ER-mitochondrial linkage and UCP2 play key roles in the mitochondrial Ca2+ uptake route in cancer cells. Disrupting the balance of these factors can lead to cancer cell death.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Chemistry, Multidisciplinary

Smart Design of Mitochondria-Targeted and ROS-Responsive CPI-613 Delivery Nanoplatform for Bioenergetic Pancreatic Cancer Therapy

Yi-Mei Zhang et al.

Summary: This study developed a novel mitochondria-targeted and ROS-triggered drug delivery nanoplatform for effective pancreatic cancer therapy, showing effective mitochondrial targeting, ROS-cleaving capability, and robust therapeutic performances.

NANOMATERIALS (2021)

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Review Biotechnology & Applied Microbiology

Polymeric Nanoparticles for Mitochondria Targeting Mediated Robust Cancer Therapy

Yajing Sun et al.

Summary: Researchers are focusing on developing polymeric nanoparticles targeted at mitochondria to enhance the efficiency of cancer therapy.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Review Biotechnology & Applied Microbiology

Multifunctional Mitochondria-Targeting Nanosystems for Enhanced Anticancer Efficacy

Tingting Hu et al.

Summary: Mitochondria play crucial roles in cancer cells, and precise delivery of anticancer agents to mitochondria can be a novel strategy for enhanced cancer treatment. Overcoming the challenge of mitochondrial negative potential preventing molecules from reaching them, advancements in nanosystems such as liposomes, nanoparticles, and nanomicelles provide hope for targeted drug delivery.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Chemistry, Physical

An Efficient Carbon-Based Drug Delivery System for Cancer Therapy through the Nucleus Targeting and Mitochondria Mediated Apoptotic Pathway

Junfeng Zhang et al.

Summary: The study developed a new nanodrug delivery system using carbon-based nanomaterials as a carrier for doxorubicin, effectively increasing the accumulation of DOX in tumor cell nuclei and tissues, leading to tumor growth inhibition.

SMALL METHODS (2021)

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Article Biochemistry & Molecular Biology

Arginine and lysine methylation of MRPS23 promotes breast cancer metastasis through regulating OXPHOS

Lingxia Liu et al.

Summary: This study uncovered a unique mechanism of controlling OXPHOS through arginine and lysine methylation, and highlighted the impact of the PRMT7-SETD6-MRPS23 axis during breast cancer metastasis.

ONCOGENE (2021)

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Article Biotechnology & Applied Microbiology

Graphene oxide (GO)-based nanosheets with combined chemo/photothermal/photodynamic therapy to overcome gastric cancer (GC) paclitaxel resistance by reducing mitochondria-derived adenosine-triphosphate (ATP)

Weihong Guo et al.

Summary: The study developed a drug delivery system with potential to reverse drug resistance, enhancing anti-tumor effects on gastric cancer through photothermal therapy, effectively inhibiting P-gp's efflux pump function.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Nanoscience & Nanotechnology

Mitochondrial Voltage-Dependent Anion Channel 1-Hexokinase-II Complex-Targeted Strategy for Melanoma Inhibition Using Designed Multiblock Peptide Amphiphiles

Fan Zhang et al.

Summary: The amphiphilic peptides derived from VDAC1-HK-II complex show potential as a novel anticancer therapy for melanoma, targeting mitochondria-mediated apoptosis and demonstrating comparable efficacy to sorafenib in melanoma cell inhibition.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Mitochondria-Targeting Enhanced Phototherapy by Intrinsic Characteristics Engineered One-for-All Nanoparticles

Zhen Sun et al.

Summary: This work introduces a well-designed Fe-doped Bi2S3 nanoneedle that localizes to mitochondria, producing extra ROS with inherent photothermal effect, and demonstrates enhanced therapeutic effect by combining photodynamic therapy (PDT) and photothermal therapy (PTT) targeting mitochondria.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

Cancer Cytomembrane-Cloaked Prussian Blue Nanoparticles Enhance the Efficacy of Mild-Temperature Photothermal Therapy by Disrupting Mitochondrial Functions of Cancer Cells

Pei Wang et al.

Summary: Researchers have developed a nanosystem for mild-temperature photothermal therapy by using modified nanoparticles, achieving efficient treatment of cancer cells by disrupting ATP production. This innovative approach shows significant potential for various biomedical applications.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Medicine, Research & Experimental

Nanotherapeutic approaches to target mitochondria in cancer

Shalini Mani et al.

Summary: Nanotechnology-based approaches offer incredible potential in cancer therapeutics due to their higher target specificity, demonstrating a potential and efficient way to target mitochondria of cancer cells for improved survival rates of cancer patients.

LIFE SCIENCES (2021)

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Review Biotechnology & Applied Microbiology

Mitochondria-Targeted Nanomedicine for Enhanced Efficacy of Cancer Therapy

Yan Gao et al.

Summary: Nanomedicines have been developed to deliver anticancer drugs selectively to tumor sites, with a focus on targeting mitochondria for cancer treatment. Various strategies are used to damage mitochondria and enhance cancer therapeutic modalities.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Nanoscience & Nanotechnology

Nanoparticle-Mediated Routing of Antibiotics into Mitochondria in Cancer Cells

Aman Bajpai et al.

Summary: Researchers have developed mitochondria-targeted antibiotic-loaded nanoparticles that can enhance the effectiveness of antibiotics in cancer therapy and reduce toxicity to noncancerous cells. These nanoparticles improve cancer cell killing ability and show less toxicity towards noncancerous cells, potentially opening up a new avenue for anticancer therapy.

ACS APPLIED BIO MATERIALS (2021)

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Article Chemistry, Multidisciplinary

An effective in vivo mitochondria-targeting nanocarrier combined with a π-extended porphyrin-type photosensitizer

Satrialdi et al.

Summary: In photodynamic therapy, mitochondria are an important target for cancer therapy, but most clinically used photosensitizers have poor tumor accumulation and lack of mitochondria targeting ability. Using a nanocarrier platform, specific delivery of photosensitizers to mitochondria can be achieved, leading to significant in vivo antitumor activity. This study highlights the importance of a mitochondria-targeted nanocarrier system for enhancing the in vivo PDT efficacy in cancer therapy across different tumor types.

NANOSCALE ADVANCES (2021)

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Article Chemistry, Multidisciplinary

Gold nanoclusters as a GSH activated mitochondrial targeting photosensitizer for efficient treatment of malignant tumors

Chen Fan et al.

Summary: In this study, a strategy using Mito-Au-25@MnO2 nanocomposites to achieve enhanced PDT was proposed. The nanocomposite dis-integrated in the presence of GSH, allowing accurate mitochondrial targeting and highly efficient PDT in cancer cells through oxidation pressure elevation and mitochondrial targeting under the irradiation of 808 nm light.

RSC ADVANCES (2021)

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Review Chemistry, Multidisciplinary

Inorganic-inorganic nanohybrids for drug delivery, imaging and photo-therapy: recent developments and future scope

Goeun Choi et al.

Summary: Advanced nanotechnology is rapidly advancing in the field of novel hybrid nanomaterials, with materials like gold, iron, and silica showing great potential in biomedical applications. Recent research also indicates the promising use of up-conversion nanomaterials in treating deep-seated tumor tissues.

CHEMICAL SCIENCE (2021)

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Article Multidisciplinary Sciences

Induction of mitochondria mediated apoptosis in human ovarian cancer cells by folic acid coated tin oxide nanoparticles

Demiana H. Hanna et al.

Summary: The folic acid coated tin oxide nanoparticles (FA-SnO2 NPs) showed superior inhibition effects against SKOV3 cancer cells by generating higher reactive oxygen species that led to cell apoptosis. Additionally, FA-SnO2 NPs significantly increased the percentage of apoptotic cells and altered the expression levels of key proteins involved in apoptosis. The results suggest that FA-SnO2 NPs could be a promising therapeutic candidate for human ovarian cancer with potential for targeted therapy.

PLOS ONE (2021)

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Review Cell Biology

Mitochondria as playmakers of apoptosis, autophagy and senescence

Marianna Abate et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2020)

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Article Chemistry, Physical

Mitochondria-targeting supra-carbon dots: Enhanced photothermal therapy selective to cancer cells and their hyperthermia molecular actions

Yanting Shen et al.

CARBON (2020)

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Article Chemistry, Multidisciplinary

Self-Mineralized Photothermal Bacteria Hybridizing with Mitochondria-Targeted Metal-Organic Frameworks for Augmenting Photothermal Tumor Therapy

Qi-Wen Chen et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Article Engineering, Biomedical

Defeating relapsed and refractory malignancies through a nano-enabled mitochondria-mediated respiratory inhibition and damage pathway

Zhengyang Yang et al.

BIOMATERIALS (2020)

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Article Engineering, Biomedical

ROS-augmented and tumor-microenvironment responsive biodegradable nanoplatform for enhancing chemo-sonodynamic therapy

Jie An et al.

BIOMATERIALS (2020)

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Article Environmental Sciences

Silver nanoparticles modulate mitochondrial dynamics and biogenesis in HepG2 cells

Jiangyan Li et al.

ENVIRONMENTAL POLLUTION (2020)

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Article Engineering, Biomedical

Core-shell structured upconversion nanocrystal-dendrimer composite as a carrier for mitochondria targeting and catalase enhanced anti-cancer photodynamic therapy

Shuang Liang et al.

BIOMATERIALS (2020)

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Article Biotechnology & Applied Microbiology

Tumor- and mitochondria-targeted nanoparticles eradicate drug resistant lung cancer through mitochondrial pathway of apoptosis

He Wang et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Review Pharmacology & Pharmacy

Cell-Penetrating Peptides in Diagnosis and Treatment of Human Diseases: From Preclinical Research to Clinical Application

Jing Xie et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Nanoscience & Nanotechnology

Mitochondria-Targeting Organic Nanoparticles for Enhanced Photodynamic/Photothermal Therapy

Chaonan Li et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Nanoscience & Nanotechnology

Ultrasmall Peptide-Coated Platinum Nanoparticles for Precise NIR-II Photothermal Therapy by Mitochondrial Targeting

Zhaoyu Ma et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Engineering, Biomedical

A mitochondria-targeting magnetothermogenic nanozyme for magnet-induced synergistic cancer therapy

Jinchao Shen et al.

BIOMATERIALS (2020)

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Article Biotechnology & Applied Microbiology

Biodegradable hollow mesoporous organosilica nanotheranostics (HMON) for multi-mode imaging and mild photo-therapeutic-induced mitochondrial damage on gastric cancer

Weihong Guo et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

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Article Engineering, Biomedical

Chlorin e6 and CRISPR-Cas9 dual-loading system with deep penetration for a synergistic tumoral photodynamic-immunotherapy

Chengli Yang et al.

BIOMATERIALS (2020)

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Article Chemistry, Multidisciplinary

Near-infrared triggered Ti3C2/g-C3N4 heterostructure for mitochondria-targeting multimode photodynamic therapy combined photothermal therapy

Yiyi Zhang et al.

NANO TODAY (2020)

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Article Polymer Science

Cationic Water-Soluble Pillar[5]arene-Modified Cu2-xSe Nanoparticles: Supramolecular Trap for ATP and Application in Targeted Photothermal Therapy in the NIR-II Window

Moupan Cen et al.

ACS MACRO LETTERS (2020)

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Review Biochemistry & Molecular Biology

Mitochondria at Work: New Insights into Regulation and Dysregulation of Cellular Energy Supply and Metabolism

Volker Schirrmacher

BIOMEDICINES (2020)

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Article Chemistry, Multidisciplinary

Mitochondria-targeting NO gas nanogenerator for augmenting mild photothermal therapy in the NIR-II biowindow

Canchen Wu et al.

CHEMICAL COMMUNICATIONS (2020)

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Review Cell Biology

Mitochondria in cancer

Debora Grasso et al.

CELL STRESS (2020)

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Article Engineering, Biomedical

A pH-Activatable nanoparticle for dual-stage precisely mitochondria-targeted photodynamic anticancer therapy

Tong Qi et al.

BIOMATERIALS (2019)

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Article Spectroscopy

Phloroglucinol-conjugated gold nanoparticles targeting mitochondrial membrane potential of human cervical (HeLa) cancer cell lines

Mahalingam Mahalakshmi et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2019)

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Article Chemistry, Physical

TiO2 Nanosheets with the Au Nanocrystal-Decorated Edge for Mitochondria-Targeting Enhanced Sonodynamic Therapy

Yu Cao et al.

CHEMISTRY OF MATERIALS (2019)

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Article Nanoscience & Nanotechnology

Polyethylenimine Coated Graphene Oxide Nanoparticles for Targeting Mitochondria in Cancer Cells

Abhik Mallick et al.

ACS APPLIED BIO MATERIALS (2019)

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Article Medicine, Research & Experimental

Self-generating oxygen enhanced mitochondrion-targeted photodynamic therapy for tumor treatment with hypoxia scavenging

Zhengyang Yang et al.

THERANOSTICS (2019)

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Article Chemistry, Multidisciplinary

Glycyrrhetinic Acid Functionalized Graphene Oxide for Mitochondria Targeting and Cancer Treatment In Vivo

Chao Zhang et al.

SMALL (2018)

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