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Article
Pharmacology & Pharmacy
Min Dong et al.
Summary: A series of dihydroartemisinin-isatin hybrids were designed and synthesized, and their antiproliferative activity against lung cancer cell lines was evaluated. The hybrids showed significant activity, surpassing the activity of dihydroartemisinin and artemisinin. In particular, hybrid 6a demonstrated comparable activity to common chemotherapeutic drugs and showed higher potency against multidrug-resistant lung cancer cell lines. Furthermore, hybrid 6a exhibited good selectivity and stability, making it a promising candidate for further development as an anti-lung cancer chemotherapeutic agent.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Shu Zhang et al.
Summary: Cancer is a major burden on global healthcare systems, and artemisinin derivatives show promise as anticancer agents. These derivatives can promote cancer cell apoptosis, inhibit cancer cell invasion and migration, and demonstrate good safety and tolerability.
ARCHIV DER PHARMAZIE
(2022)
Article
Chemistry, Multidisciplinary
Yanhua Wang et al.
Summary: This study designed and synthesized a series of artemisinin-isatin hybrids and evaluated their antiproliferative activity against breast cancer cells. The preliminary results showed that some of the hybrids exhibited activity against both drug-sensitive and doxorubicin-resistant breast cancer cell lines. Structure-activity relationship analysis revealed the significant influence of linker and substituents on the activity. Certain hybrids displayed the most active anti-cancer activity, comparable to doxorubicin. Therefore, these hybrids could serve as important templates for developing novel anti-breast cancer agents.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Zhe Zhang et al.
Summary: A series of propylene tethered compounds were designed and synthesized, and their antiproliferative activity against lung cancer cell lines was evaluated. Among them, hybrid 6f showed promising activity against drug-resistant lung cancer cells and low cytotoxicity towards normal lung cells. It also exhibited acceptable stability in vitro and in vivo.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Oncology
Melina Arnold et al.
Summary: Breast cancer is the most commonly diagnosed cancer worldwide, with over 2.3 million new cases and 685,000 deaths in 2020. There is significant geographic variation in incidence rates, with lower rates in some Asian and African countries and higher rates in countries like Australia, New Zealand, Northern America, and parts of Europe. Mortality rates show less variation, but transitioning countries still bear a disproportionate burden of breast cancer deaths. By 2040, the burden of breast cancer is predicted to increase further due to population growth and ageing. Global efforts are needed to address this growing burden, especially in transitioning countries where incidence rates are rising rapidly and mortality rates remain high.
Editorial Material
Multidisciplinary Sciences
Mischa Bonn et al.
Article
Oncology
Hyuna Sung et al.
Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Review
Biochemistry & Molecular Biology
Sijongesonke Peter et al.
Summary: Artemisinin and its derivatives have shown promising efficacy as anticancer and antimalarial agents, and combination therapy is an effective approach to overcome the limitations associated with current drugs.
Article
Pharmacology & Pharmacy
Haodong Hou et al.
Summary: The designed and synthesized hybrids showed higher antiproliferative activity against lung cancer cell lines compared to the parent drug, while exhibiting no cytotoxicity towards normal cells. The structure-activity relationships revealed the significant influence of substituents on the isatin moiety on the activity of the hybrids.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Jacques Ferlay et al.
Summary: The study briefly reviews the methods and data sources used in compiling the IARC GLOBOCAN cancer statistics for 2020 and summarizes the main results. It estimated that there were nearly 19.3 million new cancer cases and almost 10 million cancer deaths worldwide in 2020, with the most commonly diagnosed cancers being female breast cancer and lung cancer, and the most common causes of cancer death being lung cancer and liver cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Oncology
Ran Yu et al.
Summary: Dihydroartemisinin (DHA) has shown efficacy not just in treating malaria, but also in inhibiting tumor growth and modulating immune system function. Through inducing oxidative stress and programmed cell death, DHA has the potential to become an alternative therapy for malignant tumors and inflammatory diseases.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Sibylle Loibl et al.
Summary: Breast cancer diagnosis and treatment have become increasingly complex, incorporating various biomarkers and neoadjuvant therapies, with de-escalation schemes for radiotherapy now becoming standard practice.
Article
Oncology
Shaoyuan Lei et al.
Summary: Breast cancer is the most commonly diagnosed cancer and leading cause of cancer death among women worldwide, with significant variations in incidence and mortality rates among different countries. Global burden of breast cancer is rapidly increasing, with a need for increased health awareness, effective prevention strategies, and improved access to medical treatment.
CANCER COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Xiaoshuo Dai et al.
Summary: This article comprehensively summarizes the latest progress and research findings on the anticancer activities of dihydroartemisinin (DHA), focusing on its molecular mechanisms and pharmacological effects. It also discusses new methods to improve DHA's bioavailability and its synergistic anti-tumor effects with other clinical drugs. Additionally, it highlights the need for further research on the anticancer effects of DHA to provide strong theoretical support for its use as an anticancer drug.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Chemistry, Medicinal
Feng Gao et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Review
Multidisciplinary Sciences
Jose A. Fernandez
JOURNAL OF THE INDIAN INSTITUTE OF SCIENCE
(2020)
Review
Biochemistry & Molecular Biology
Bushra Hafeez Kiani et al.
MOLECULAR BIOLOGY REPORTS
(2020)
Review
Chemistry, Multidisciplinary
Marcos Juanes et al.
CHEMISTRY-A EUROPEAN JOURNAL
(2019)
Article
Pharmacology & Pharmacy
Shanshan Li et al.
CURRENT PHARMACEUTICAL DESIGN
(2013)
