期刊
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
卷 111, 期 516, 页码 1509-1521出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/01621459.2016.1148611
关键词
DC algorithm; Dose finding; Individualized dose rule; Risk bound; Weighted support vector regression
资金
- NCI [P01 CA142538]
- [U01-N5082062]
In dose-finding clinical trials, it is becoming increasingly important to account for individual-level heterogeneity while searching for optimal doses to ensure an optimal individualized dose rule (IDR) maximizes the expected beneficial clinical outcome for each individual. In this article, we advocate a randomized trial design where candidate dose levels assigned to study subjects are randomly chosen from a continuous distribution within a safe range. To estimate the optimal IDR using such data, we propose an outcome weighted learning method based on a nonconvex loss function, which can be solved efficiently using a difference of convex functions algorithm. The consistency and convergence rate for the estimated IDR are derived, and its small-sample performance is evaluated via simulation studies. We demonstrate that the proposed method outperforms competing approaches. Finally, we illustrate this method using data from a cohort study for warfarin (an anti-thrombotic drug) dosing. Supplementary materials for this article are available online.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据