期刊
DOKLADY BIOCHEMISTRY AND BIOPHYSICS
卷 509, 期 1, 页码 41-46出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1607672923700151
关键词
uracil derivatives; synthesis; antiviral activity; human cytomegalovirus
A new series of 1-[ω-(bromophenoxy)alkyl]-uracil derivatives containing various fragments were synthesized and tested for their antiviral activity against human cytomegalovirus. It was found that the compound with a bridge of five methylene groups exhibited high anti-cytomegalovirus activity in vitro.
The synthesis of a new series of 1-[& omega;-(bromophenoxy)alkyl]-uracil derivatives containing in position 3 naphthalen-1-yl-, naphthalen-2-yl-, 1-bromonaphthalen-2-ylmethyl, benzyl, and anthracene 9-methyl fragment was carried out. The antiviral properties of the synthesized compounds were studied against human cytomegalovirus. It was found that the compound that contained a bridge of five methylene groups has a high anti-cytomegalovirus activity in vitro.
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