期刊
DNA AND CELL BIOLOGY
卷 42, 期 7, 页码 372-389出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/dna.2022.0644
关键词
gastric cancer; immune infiltration; prognosis; bioinformatics
Using weighted gene co-expression network analysis, we identify Aldo-Keto Reductase Family 1 Member B (AKR1B1) as a key gene for immune regulation in gastric cancer. AKR1B1 is associated with immune infiltration level and histologic grade of gastric cancer. In vitro experiments show that AKR1B1-overexpressed THP-1-derived macrophages promote the proliferation and migration of gastric cancer cells.
Infiltrated immune cells are an important constitute of tumor microenvironment, which exert complex effects on gastric cancer (GC) pathogenesis and progression. By using weighted gene co-expression network analysis, integrating the data from The Cancer Genome Atlas-stomach adenocarcinoma and GSE62254, we identify Aldo-Keto Reductase Family 1 Member B (AKR1B1) as a hub gene for immune regulation in GC. Notably, AKR1B1 is associated with higher immune infiltration and worse histologic grade of GC. In addition, AKR1B1 is an independent factor for predicting the survival rate of GC patients. In vitro experiments further demonstrated that AKR1B1-overexpressed THP-1-derived macrophages promoted the proliferation and migration of GC cells. Taken together, AKR1B1 plays an important role in GC progression by regulating immune microenvironment, which could be a biomarker for predicting GC prognosis as well as a potential therapeutic target for GC treatment.
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