4.5 Editorial Material

Efficacy of PuraStat hemostatic gel for pulsating arterial bleeding during colorectal endoscopic submucosal dissection

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Summary: This study compared the effectiveness of the novel hemostatic peptide TDM-621 with conventional hemostatic methods for treating intraoperative blood oozing during endoscopic submucosal dissection (ESD). The results showed that the TDM-621 group had significantly reduced coagulations with hemostatic forceps, a higher rate of hemostasis achievement with only TDM-621, and no serious safety concerns.

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Summary: The use of Purastat significantly reduced the need for heat therapy during ESD, potentially improving post-resection wound healing. However, there were no significant differences between the groups in terms of procedure length, time for hemostasis, and delayed bleeding rate.

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