期刊
DIGESTIVE AND LIVER DISEASE
卷 55, 期 10, 页码 1382-1390出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.dld.2023.04.012
关键词
Portal hypertension; Collaterals; Liver function; Decompensated event; Prognosis
Spontaneous portosystemic shunt (SPSS) is common in patients with hepatitis B-related cirrhosis and is associated with severe liver damage and a higher prevalence of decompensated events such as esophageal and gastric variceal bleeding, portal vein thrombosis, and hepatic encephalopathy.
Background: The impact of spontaneous portosystemic shunt (SPSS) on decompensated events and mortality for patients with hepatitis B-related cirrhosis remains poorly investigated.Aims: To evaluate the prevalence, clinical characteristics, and outcomes of SPSS among patients with hepatitis B-related cirrhosis.Methods: Patients who were diagnosed with hepatitis B-related cirrhosis were retrospectively recruited. All eligible patients were classified into SPSS and non-SPSS groups and their clinical characteristics and outcomes were compared and analyzed.Results: Of the 1282 patients included in this study, SPSS was identified in 488 patients (38.1%). SPSS group had more severe liver function impairment, higher prevalence and severity of esophageal and gastric varices (EGV), and a higher prevalence of EGV bleeding (EGVB), portal vein thrombosis (PVT), hepatic encephalopathy (HE), ascites, and hepatocellular carcinoma (HCC, all P < 0.05). During the follow-up period, SPSS group experienced a significantly higher incidence of EGVB, PVT, and HE (all P < 0.05); however, there was no significant difference in the incidence of ascites, HCC, and mortality between the two groups (all P > 0.05).Conclusion: With hepatitis B-related cirrhosis, SPSS was common and characterized by severe liver damage and a high prevalence of decompensated events. Moreover, patients with SPSS had higher risks of EGVB, PVT, and HE. (c) 2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
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