Incidental finding of anti-mitochondrial antibody: A neglected entity needing reappraisal

Article Allergy

Antimitochondrial Antibodies: from Bench to Bedside

Francesca Colapietro et al.

Summary: Anti-mitochondrial antibodies (AMA) are typical biomarkers of primary biliary cholangitis (PBC) and are highly specific for diagnosis, although they can also be detected in healthy individuals. Managing patients without liver disease symptoms remains a challenge.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2022)

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Article Gastroenterology & Hepatology

Low incidence of primary biliary cholangitis in 139 anti-mitochondrial antibodies-positive patients with other liver or non-liver diseases

Weijia Duan et al.

Summary: This study evaluated the incidence and predictors of PBC development in AMA-positive patients at baseline. The results showed a low risk of developing PBC over time in AMA-positive patients.

HEPATOLOGY COMMUNICATIONS (2022)

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Article Immunology

Primary biliary cholangitis with normal alkaline phosphatase: A neglected clinical entity challenging current guidelines

Benedetta Terziroli Beretta-Piccoli et al.

Summary: The study found a high proportion of patients with PBC among those with normal ALP levels and positive AMA. Histological diagnosis of PBC was shown in AMA-negative/PBC-specific ANA-positive individuals for the first time, and GGT was identified as a potential biomarker in PBC patients with normal baseline ALP levels. The current guidelines for diagnosing PBC may not cover the full extent of PBC presentation, highlighting the clinical implications for timely treatment initiation.

JOURNAL OF AUTOIMMUNITY (2021)

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Article Immunology