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Sex differences in type 2 diabetes

DIABETOLOGIA (2023)

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Article Endocrinology & Metabolism

Investigating the causal relationships between excess adiposity and cardiometabolic health in men and women

Pascal M. M. Mutie et al.

Summary: This study explores the causal relationships between BMI and cardiometabolic diseases and risk factors using two-stage least-squares Mendelian randomisation and non-linear MR fractional polynomial method. The results show that there is a non-linear causal relationship between BMI and type 2 diabetes, hypertension, and coronary artery disease. There are also non-linear relationships between BMI and cardiometabolic risk factors. The causal effect of BMI on LDL-cholesterol is influenced by sex and menopause status.

DIABETOLOGIA (2023)

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Article Endocrinology & Metabolism

Serum sex hormone-binding globulin is a mediator of the association between intrahepatic lipid content and type 2 diabetes: the Maastricht Study

Pomme I. H. G. Simons et al.

Summary: Serum SHBG mediates the association between IHL content and type 2 diabetes, with a higher contribution in women.

DIABETOLOGIA (2023)

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Article Endocrinology & Metabolism

Gender Differences in the Risk of Adverse Outcomes After Incident Diabetic Foot Hospitalization: A Population Cohort Study

Giuseppe Seghieri et al.

Summary: Males have a higher incidence of DFD compared to females. After DFD, males have a higher risk of coronary artery disease, while females have a higher risk of stroke. Amputations and LEAD-no proc are significantly associated with cardiovascular events and mortality in females, while LLR reduces the risk in both genders.

CURRENT DIABETES REVIEWS (2022)

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Article Endocrinology & Metabolism

4. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Medical Care in Diabetes-2022

Summary: The American Diabetes Association's Standards of Medical Care in Diabetes provide clinical practice recommendations, treatment goals, and tools for evaluating quality of care for diabetes patients. The standards are regularly updated by a multidisciplinary expert committee and feedback from readers is welcome.

DIABETES CARE (2022)

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Article Endocrinology & Metabolism

Pregnancy Outcomes in Young Women With Youth-Onset Type 2 Diabetes Followed in the TODAY Study

Jeanie B. Tryggestad et al.

Summary: This study assessed pregnancy outcomes in young women with youth-onset type 2 diabetes and found a high rate of maternal complications related to significant socioeconomic disadvantage. Improving contraception rates and reproductive planning could potentially prevent these serious complications in young mothers and infants.

DIABETES CARE (2022)

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Article Endocrinology & Metabolism

Sex differences in intraorgan fat levels and hepatic lipid metabolism: implications for cardiovascular health and remission of type 2 diabetes after dietary weight loss

Aaron Jesuthasan et al.

Summary: This study found that in patients with type 2 diabetes, women have similar levels of liver and pancreas fat as men, along with higher hepatic VLDL1-TG production rates. There are differences in the dynamics of triglyceride turnover between sexes in type 2 diabetes and following weight loss, which may contribute to the disproportionately elevated cardiovascular risk in women with diabetes.

DIABETOLOGIA (2022)

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Review Endocrinology & Metabolism

Causes and Consequences of Polycystic Ovary Syndrome: Insights From Mendelian Randomization

Tiantian Zhu et al.

Summary: PCOS is a common endocrine disorder affecting women, and its risk factors are not well understood. Mendelian randomization studies have found that obesity, testosterone levels, insulin levels, and other factors may have a causal role in PCOS. PCOS may increase the risk of breast cancer and decrease the risk of endometrioid ovarian cancer, but it has no direct causal effect on type 2 diabetes, coronary heart disease, or stroke.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2022)

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Review Gastroenterology & Hepatology

Intra-pancreatic fat deposition: bringing hidden fat to the fore

Maxim S. Petrov et al.

Summary: Fatty pancreas disease is a common condition that not only affects physical health, but is also associated with the development of multiple diseases. Research has shown that weight loss can alleviate symptoms of type 2 diabetes, and reversing fatty pancreas disease may prevent or intercept the progression of major pancreatic diseases in the future.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

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Article Medicine, General & Internal

Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring: A Nationwide Cohort Study

Maarten J. Wensink et al.

Summary: The study found that paternal metformin treatment before conception is associated with an increased risk of major birth defects, particularly genital birth defects in boys. Further research is needed to confirm these findings and determine causation.

ANNALS OF INTERNAL MEDICINE (2022)

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Article Endocrinology & Metabolism

Pregnancy Outcomes of Young Women With Type 2 Diabetes: Poor Care and Inadequate Attention to Glycemia

Helen R. Murphy et al.

DIABETES CARE (2022)

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Article Gastroenterology & Hepatology

NAFLD improves risk prediction of type 2 diabetes: with effect modification by sex and menopausal status

Yejin Kim et al.

Summary: NAFLD is associated with an increased risk of T2D, especially in premenopausal women. Adding NAFLD to conventional risk factors improves the prediction of T2D risk.

HEPATOLOGY (2022)

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Article Endocrinology & Metabolism

Women with type 2 diabetes and coronary artery disease have a higher risk of heart failure than men, with a significant gender interaction between heart failure risk and risk factor management: a retrospective registry study

Yuko Fujita et al.

Summary: Women with type 2 diabetes and coronary artery disease have a higher risk of heart failure compared to men. There are gender differences in the relationship between heart failure risk and risk factor management, particularly regarding low-density lipoprotein cholesterol and systolic blood pressure.

BMJ OPEN DIABETES RESEARCH & CARE (2022)

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Article Endocrinology & Metabolism

Sex-specific differences in prevalence of nonalcoholic fatty liver disease in subjects with prediabetes and type 2 diabetes

Elena Succurro et al.

Summary: This study aimed to investigate the prevalence of NAFLD in adults with one or more cardio-metabolic risk factors and analyze the impact of sex on NAFLD prevalence. The results showed that women with prediabetes and type 2 diabetes have a higher risk of NAFLD compared to men, and the deterioration of metabolic risk factors is more severe in women.

DIABETES RESEARCH AND CLINICAL PRACTICE (2022)

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Article Cardiac & Cardiovascular Systems

Effects of Empagliflozin in Women and Men With Heart Failure and Preserved Ejection Fraction

Javed Butler et al.

Summary: This study evaluated the influence of sex on the effects of empagliflozin in patients with HF and preserved ejection fraction. The results showed that empagliflozin reduced the risk of cardiovascular death or hospitalization for HF to a similar degree in both men and women. Sex did not modify the relationship between empagliflozin and outcomes across ejection fraction groups.

CIRCULATION (2022)

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Article Medicine, General & Internal

Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction

S. D. Solomon et al.

Summary: The study shows that SGLT2 inhibitors are effective in reducing the risk of hospitalization for heart failure and cardiovascular death among patients with chronic heart failure and a left ventricular ejection fraction of 40% or less. However, whether they are effective in patients with a higher left ventricular ejection fraction remains uncertain.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Endocrinology & Metabolism

Lifetime risk, life expectancy, and years of life lost to type 2 diabetes in 23 high-income jurisdictions: a multinational, population-based study

Dunya Tomic et al.

Summary: This study aimed to estimate the lifetime risk, life expectancy, and years of life lost to type 2 diabetes in high-income settings. The findings showed that despite a decline in lifetime risk and improvements in life expectancy, the burden of type 2 diabetes remains substantial. Tailored public health strategies are needed to improve health outcomes for people with diabetes.

LANCET DIABETES & ENDOCRINOLOGY (2022)

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Article Medicine, General & Internal

Sex differences in the association of fasting glucose with HbA1c, and their consequences for mortality: A Mendelian randomization study

Guoyi Yang et al.

Summary: This study investigated the relationship between hemoglobin A1c (HbA1c) and glucose levels, and found that hemoglobin and iron were inversely associated with HbA1c. Fasting glucose showed a stronger association with HbA1c and diabetes in women compared to men. HbA1c in men underestimated fasting glucose, possibly due to erythrocyte properties.

EBIOMEDICINE (2022)

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Article Cardiac & Cardiovascular Systems

Gender disparities in time-to-initiation of cardioprotective glucose-lowering drugs in patients with type 2 diabetes and cardiovascular disease: a Danish nationwide cohort study

Kristian Lokke Funck et al.

Summary: This study aims to examine the impact of gender and specific type of cardiovascular disease diagnosis on the time-to-initiation of cardioprotective GLDs after a dual diagnosis of T2DM and CVD.

CARDIOVASCULAR DIABETOLOGY (2022)

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Article Endocrinology & Metabolism

Predictors of type 2 diabetes remission in the Diabetes Remission Clinical Trial (DiRECT)

G. Thom et al.

Summary: The study aimed to identify predictors of type 2 diabetes remission, and found that weight loss was the strongest predictor of remission at both 12 and 24 months. Other predictors included being prescribed fewer medications, lower triglyceride and gamma-glutamyl transferase levels, and reporting better quality of life.

DIABETIC MEDICINE (2021)

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Article Endocrinology & Metabolism

Sex Differences in the Risk of Coronary Heart Disease Associated With Type 2 Diabetes: A Mendelian Randomization Analysis

Tricia M. Peters et al.

Summary: The study found that genetic risk of type 2 diabetes affects the odds of coronary heart disease (CHD) similarly in both women and men, indicating no sex differential in the causal effect of diabetes on CHD risk. This suggests that prevention and management of type 2 diabetes for CHD risk reduction should be prioritized equally in both sexes.

DIABETES CARE (2021)

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Review Endocrinology & Metabolism

The absolute and relative risk of type 2 diabetes after gestational diabetes: A systematic review and meta-analysis of 129 studies

Rebecca A. Dennison et al.

Summary: The percentage of women developing T2DM after GDM is variable, with around a third developing diabetes within 15 years of pregnancy. The risk of developing T2DM increases with each additional year after pregnancy and higher BMI at follow-up.

DIABETES RESEARCH AND CLINICAL PRACTICE (2021)

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Article Biochemistry & Molecular Biology

Brown adipose tissue is associated with cardiometabolic health

Tobias Becher et al.

Summary: A retrospective analysis of over 50,000 patients' F-18-FDG PET/CT scans revealed that individuals with brown adipose tissue had lower odds of cardiometabolic conditions. The presence of brown adipose tissue was independently correlated with lower odds of type 2 diabetes, dyslipidemia, coronary artery disease, cerebrovascular disease, congestive heart failure, and hypertension. The beneficial effects of brown adipose tissue were more pronounced in individuals with overweight or obesity, suggesting a potential role in mitigating the deleterious effects of obesity.

NATURE MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Gender differences in screening for glucose perturbations, cardiovascular risk factor management and prognosis in patients with dysglycaemia and coronary artery disease: results from the ESC-EORP EUROASPIRE surveys

Giulia Ferrannini et al.

Summary: This study found that known diabetes was more common among women with CAD, but men were more likely to have dysglycaemia. Women showed poorer control of cardiovascular risk factors compared to men. Women with CAD had a higher risk of cardiovascular events.

CARDIOVASCULAR DIABETOLOGY (2021)

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Review Multidisciplinary Sciences

Sex difference for the risk of amputation in diabetic patients: A systematic review and meta-analysis

Lei Fan et al.

Summary: This study found that male diabetic patients have a higher risk of amputation compared to female diabetic patients, and the predictive value of sex difference in amputation risk among diabetic patients was mild.

PLOS ONE (2021)

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Article Endocrinology & Metabolism

Gender-related variables for health research

Mathias W. Nielsen et al.

Summary: This study proposes the concept of gender as a sociocultural variable and develops a gender assessment tool for clinical and population research. Through factor analysis, 11 variables were reduced to 7 gender-related variables, which were found to be associated with self-rated general health, physical and mental health, and health-risk behaviors through regression analysis.

BIOLOGY OF SEX DIFFERENCES (2021)

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Article Medicine, General & Internal

Major Depressive Disorder (MDD) and Antidepressant Medication Are Overrepresented in High-Dose Statin Treatment

Leutner Michael et al.

Summary: This study found that there was a higher proportion of MDD among patients treated with statins compared to non-treated patients, with a dose-dependent relationship between statins and the diagnosis of MDD. Low-dose statin treatment was associated with a lower risk of MDD, while high-dose statin treatment was associated with a higher risk of MDD.

FRONTIERS IN MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Sex differences in the association of prediabetes and type 2 diabetes with microvascular complications and function: The Maastricht Study

Rianneke de Ritter et al.

Summary: The study investigated the associations between diabetes and microvascular complications in a population-based cohort, finding that men with type 2 diabetes had higher risks of certain microvascular complications compared to men with normal glucose metabolism, while women did not show significant sex differences.

CARDIOVASCULAR DIABETOLOGY (2021)

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Article Medicine, General & Internal

Association of Race/Ethnicity, Gender, and Socioeconomic Status With Sodium-Glucose Cotransporter 2 Inhibitor Use Among Patients With Diabetes in the US

Lauren A. Eberly et al.

Summary: This study showed that Black and female patients as well as those with low socioeconomic status were less likely to receive SGLT2 inhibitor treatment among patients with type 2 diabetes in the US.

JAMA NETWORK OPEN (2021)

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Editorial Material Endocrinology & Metabolism

Does diabetes mellitus mitigate the gender gap in COVID-19 mortality?

Alexandra Kautzky-Willer

Summary: During the COVID-19 pandemic, diabetes emerged as a prominent risk factor for severe outcomes and increased mortality, with men at higher risk regardless of age or region. Gender differences in infection rates and outcomes among diabetic patients are still unclear, potentially influenced by biological, behavioral, and psychosocial factors.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2021)

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Article Cell Biology

Sex differences in brown adipose tissue activity and cold-induced thermogenesis

Carsten T. Herz et al.

Summary: This study found that the prevalence of cold-activated BAT is slightly but non-significantly higher in pre-menopausal women than men. CIT is increased in females and independently associated with estradiol, suggesting that sex hormones may play a role in different thermogenic responses between men and women.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2021)

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Review Endocrinology & Metabolism

Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver

Gijs H. Goossens et al.

Summary: This review discusses the impact of sexual dimorphism on adipose tissue distribution, substrate metabolism, and tissue-specific insulin sensitivity, as well as its potential implications for cardiometabolic health. It also highlights the influence of lifestyle factors and genetic mechanisms in a sex-specific manner, which may affect metabolic complications and disease risk.

NATURE REVIEWS ENDOCRINOLOGY (2021)

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Article Endocrinology & Metabolism

Effects of sodium-glucose co-transporter-2 inhibitors in type 2 diabetes in women versus men

Karin Radholm et al.

DIABETES OBESITY & METABOLISM (2020)

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Review Biology

Association between shift work and risk of type 2 diabetes mellitus: a systematic review and dose-response meta-analysis of observational studies

Yinyan Gao et al.

CHRONOBIOLOGY INTERNATIONAL (2020)

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Review Endocrinology & Metabolism

Sex differences in metabolic regulation and diabetes susceptibility

Blandine Tramunt et al.

DIABETOLOGIA (2020)

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Article Cardiac & Cardiovascular Systems

Does type 2 diabetes confer higher relative rates of cardiovascular events in women compared with men?

Morten Malmborg et al.

EUROPEAN HEART JOURNAL (2020)

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Article Cardiac & Cardiovascular Systems

Sex Differences in Blood Pressure Trajectories Over the Life Course

Hongwei Ji et al.

JAMA CARDIOLOGY (2020)

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Article Endocrinology & Metabolism

Sex Disparities in Cardiovascular Outcome Trials of Populations With Diabetes: A Systematic Review and Meta-analysis

Kristin K. Clemens et al.

DIABETES CARE (2020)

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Article Endocrinology & Metabolism

Age-, sex- and ethnicity-related differences in body weight, blood pressure, HbA1c and lipid levels at the diagnosis of type 2 diabetes relative to people without diabetes

Alison K. Wright et al.

DIABETOLOGIA (2020)

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Article Cardiac & Cardiovascular Systems

Sex Differences in Cardiovascular Effectiveness of Newer Glucose-Lowering Drugs Added to Metformin in Type 2 Diabetes Mellitus

Valeria Raparelli et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

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Review Cardiac & Cardiovascular Systems

Heterogeneity of antidiabetic treatment effect on the risk of major adverse cardiovascular events in type 2 diabetes: a systematic review and meta-analysis

Elvira D'Andrea et al.

CARDIOVASCULAR DIABETOLOGY (2020)

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Article Biology

Lifetime night work exposure and the risk of type 2 diabetes: results from the longitudinal study of adult health (ELSA-Brasil)

Aline Silva-Costa et al.

CHRONOBIOLOGY INTERNATIONAL (2020)

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Review Endocrinology & Metabolism

Do Women with Diabetes Need More Intensive Action for Cardiovascular Reduction than Men with Diabetes?

Juergen Harreiter et al.

CURRENT DIABETES REPORTS (2020)

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Article Endocrinology & Metabolism

Sex Differences in Rates of Change and Burden of Metabolic Risk Factors Among Adults Who Did and Did Not Go On to Develop Diabetes: Two Decades of Follow-up From the Tehran Lipid and Glucose Study

Azra Ramezankhani et al.

DIABETES CARE (2020)

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Article Medicine, General & Internal

Association between prediabetes and risk of all cause mortality and cardiovascular disease: updated meta-analysis

Xiaoyan Cai et al.

BMJ-British Medical Journal (2020)

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Article Medicine, Research & Experimental

X chromosome dosage of histone demethylase KDWISC determines sex differences in adiposity

Jenny C. Link et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Sex and gender: modifiers of health, disease, and medicine

Franck Mauvais-Jarvis et al.

LANCET (2020)

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Gender differences in adverse event reports associated with antidiabetic drugs

Kyung-In Joung et al.

SCIENTIFIC REPORTS (2020)

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Article Endocrinology & Metabolism

Diabetes mellitus is associated with a higher risk for major depressive disorder in women than in men

Carola Deischinger et al.

BMJ OPEN DIABETES RESEARCH & CARE (2020)

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Article Endocrinology & Metabolism

Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial

Gary Wittert et al.

Lancet Diabetes & Endocrinology (2020)

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Article Endocrinology & Metabolism

Age- and sex-specific incidence of non-traumatic lower limb amputation in patients with type 2 diabetes mellitus in a US claims database

Sampada K. Gandhi et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2020)

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Review Endocrinology & Metabolism

Gender difference in cardiovascular outcomes with SGLT-2 inhibitors and GLP-1 receptor agonist in type 2 diabetes: A systematic review and meta-analysis of cardio-vascular outcome trials

Awadhesh Kumar Singh et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

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Does type 2 diabetes confer higher relative rates of cardiovascular events in women compared with men?

Morten Malmborg et al.

EUROPEAN HEART JOURNAL (2020)

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Article Endocrinology & Metabolism

Sex Differences in Cardiovascular Risk Profile From Childhood to Midlife Between Individuals Who Did and Did Not Develop Diabetes at Follow-up: The Bogalusa Heart Study

Tingting Du et al.

DIABETES CARE (2019)

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Emerging role of testosterone in pancreatic β cell function and insulin secretion

Weiwei Xu et al.

JOURNAL OF ENDOCRINOLOGY (2019)

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Sex-specific clinical outcomes of impaired glucose status: A long follow-up from the Tehran Lipid and Glucose Study

Donna Parizadeh et al.

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2019)

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Fournier Gangrene Associated With Sodium-Glucose Cotransporter-2 Inhibitors A Review of Spontaneous Postmarketing Cases

Susan J. Bersoff-Matcha et al.

ANNALS OF INTERNAL MEDICINE (2019)

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Review Medicine, General & Internal

Sex differences in the association between diabetes and risk of cardiovascular disease, cancer, and all-cause and cause-specific mortality: a systematic review and meta-analysis of 5,162,654 participants

Yafeng Wang et al.

BMC MEDICINE (2019)

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Article Cardiac & Cardiovascular Systems

Cardiovascular Risk and Risk Factor Management in Type 2 Diabetes Mellitus A Population-Based Cohort Study Assessing Sex Disparities

Alison K. Wright et al.

CIRCULATION (2019)

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Review Endocrinology & Metabolism

Diabetes as a risk factor for heart failure in women and men: a systematic review and meta-analysis of 47 cohorts including 12 million individuals

Toshiaki Ohkuma et al.

DIABETOLOGIA (2019)

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Article Endocrinology & Metabolism

Sex differences in the association between socioeconomic status and diabetes prevalence and incidence in China: cross-sectional and prospective studies of 0.5 million adults

Hongjiang Wu et al.

DIABETOLOGIA (2019)

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Gestational diabetes mellitus

H. David McIntyre et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

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Article Rheumatology

Diagnosis of osteoporosis in statin-treated patients is dose-dependent

Michael Leutner et al.

ANNALS OF THE RHEUMATIC DISEASES (2019)

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Article Endocrinology & Metabolism

Canagliflozin and fracture risk in individuals with type 2 diabetes: results from the CANVAS Program

Zien Zhou et al.

DIABETOLOGIA (2019)

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Article Biochemistry & Molecular Biology

Contribution of genetics to visceral adiposity and its relation to cardiovascular and metabolic disease

Torgny Karlsson et al.

NATURE MEDICINE (2019)

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Article Medicine, General & Internal

Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction

S. D. Solomon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Article Medicine, General & Internal

Aspirin for primary prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups

Georg Gelbenegger et al.

BMC MEDICINE (2019)

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Review Biochemistry & Molecular Biology

Sex differences in cardiometabolic disorders

Eva Gerdts et al.

NATURE MEDICINE (2019)

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Article Genetics & Heredity

Causal relationships between obesity and the leading causes of death in women and men

Jenny C. Censin et al.

PLOS GENETICS (2019)

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Article Endocrinology & Metabolism

Commencing insulin glargine 100 U/mL therapy in individuals with type 2 diabetes: Determinants of achievement of HbA1c goal less than 7.0%

David R. Owens et al.

DIABETES OBESITY & METABOLISM (2019)

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Review Endocrinology & Metabolism

Risk of all-cause and CHD mortality in women versus men with type 2 diabetes: a systematic review and meta-analysis

Guodong Xu et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2019)

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Review Urology & Nephrology

Sex Hormone Binding Globulin: A Review of its Interactions With Testosterone and Age, and its Impact on Mortality in Men With Type 2 Diabetes

Sudarshan Ramachandran et al.

SEXUAL MEDICINE REVIEWS (2019)

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Article Endocrinology & Metabolism

Sex differences in the association of psychological status with measures of physical activity and sedentary behaviour in adults with type 2 diabetes

Liliana Indelicato et al.

ACTA DIABETOLOGICA (2018)

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Article Cardiac & Cardiovascular Systems

Sex Differences in Cardiovascular Pathophysiology: Why Women Are Overrepresented in Heart Failure With Preserved Ejection Fraction

Anna L. Beale et al.

CIRCULATION (2018)

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Review Cardiac & Cardiovascular Systems

Sex differences in heart failure

Evann Eisenberg et al.

CLINICAL CARDIOLOGY (2018)

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News Item Medicine, General & Internal

Postmenopausal Women With a Normal BMI Might Be Overweight or Even Obese

Rita Rubin

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

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Meeting Abstract Cardiac & Cardiovascular Systems

SEX-RELATED DIFFERENCE IN THE REGRESSION OF CORONARY ATHEROSCLEROSIS WITH THE PCSK9 INHIBITOR, EVOLOCUMAB: INSIGHTS FROM GLAGOV

Peta King et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

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Article Clinical Neurology

Sex differences in neuropathic pain intensity in diabetes

Alon Abraham et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2018)

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Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment

Hector F. Escobar-Morreale

NATURE REVIEWS ENDOCRINOLOGY (2018)

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Article Endocrinology & Metabolism

Sex-specific relevance of diabetes to occlusive vascular and other mortality: a collaborative meta-analysis of individual data from 980793 adults from 68 prospective studies

Louisa Gnatiuc et al.

LANCET DIABETES & ENDOCRINOLOGY (2018)

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Article Endocrinology & Metabolism

Characteristics of Dapagliflozin Responders: A Longitudinal, Prospective, Nationwide Dapagliflozin Surveillance Study in Korea

Eugene Han et al.

DIABETES THERAPY (2018)

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Review Endocrinology & Metabolism

Sex and Gender Differences in Prevention of Type 2 Diabetes

Juergen Harreiter et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

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Article Endocrinology & Metabolism

Characteristics of Dapagliflozin Responders: A Longitudinal, Prospective, Nationwide Dapagliflozin Surveillance Study in Korea

Eugene Han et al.

DIABETES THERAPY (2018)

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Review Endocrinology & Metabolism

Ethnic Disparities in Gestational Diabetes

Lili Yuen et al.

CURRENT DIABETES REPORTS (2018)

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Article Endocrinology & Metabolism

Sex and BMI Alter the Benefits and Risks of Sulfonylureas and Thiazolidinediones in Type 2 Diabetes: A Framework for Evaluating Stratification Using Routine Clinical and Individual Trial Data

John M. Dennis et al.

DIABETES CARE (2018)

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Article Public, Environmental & Occupational Health

Comparison of the association of predicted fat mass, body mass index, and other obesity indicators with type 2 diabetes risk: two large prospective studies in US men and women

Dong Hoon Lee et al.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2018)

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Article Endocrinology & Metabolism

Pericardial Fat Relates to Disturbances of Glucose Metabolism in Women with the Polycystic Ovary Syndrome, but Not in Healthy Control Subjects

Michael Leutner et al.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2018)

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Male Patients with Longstanding Type 2 Diabetes Have a Higher Incidence of Hypoglycemia Compared with Female Patients

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Effect of once-weekly dulaglutide on glycated haemoglobin (HbA1c) and fasting blood glucose in patient subpopulations by gender, duration of diabetes and baseline HbA1c

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Nonlinear association of BMI with all-cause and cardiovascular mortality in type 2 diabetes mellitus: a systematic review and meta-analysis of 414,587 participants in prospective studies

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Use of statins offsets insulin-related cancer risk

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Sex-gender-related therapeutic approaches for cardiovascular complications associated with diabetes

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Diabetes mellitus as a risk factor for incident chronic kidney disease and end-stage renal disease in women compared with men: a systematic review and meta-analysis

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Sex and gender differences in therapy of type 2 diabetes

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Analysis of efficacy and safety of dulaglutide 0.75 mg stratified by sex in patients with type 2 diabetes in 2 randomized, controlled phase 3 studies in Japan

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Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus

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Gender-related different effects of a combined therapy of Exenatide and Metformin on overweight or obesity patients with type 2 diabetes mellitus

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Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes

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GLP-1 Response to Oral Glucose Is Reduced in Prediabetes, Screen-Detected Type 2 Diabetes, and Obesity and Influenced by Sex: The ADDITION-PRO Study

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Gender-based differences in glycaemic control and hypoglycaemia prevalence in patients with type 2 diabetes: results from patient-level pooled data of six randomized controlled trials

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Add-On Treatment with Liraglutide Improves Glycemic Control in Patients with Type 2 Diabetes on Metformin Therapy

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Gender-specific Effects of Treatment with Lifestyle, Metformin or Sulfonylurea on Glycemic Control and Body Weight: A German Multicenter Analysis on 9 108 Patients

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A nomogram to estimate the HbA1c response to different DPP-4 inhibitors in type 2 diabetes: a systematic review and meta-analysis of 98 trials with 24 163 patients

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The influence of socioeconomic status on future risk for developing Type 2 diabetes in the Canadian population between 2011 and 2022: differential associations by sex

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Sulfonylurea Use and Incident Cardiovascular Disease Among Patients With Type 2 Diabetes: Prospective Cohort Study Among Women

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Gender differences in the incidence and progression of diabetic retinopathy among Japanese patients with type 2 diabetes mellitus: A clinic-based retrospective longitudinal study

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The influence of sex on renal function decline in people with Type 2 diabetes

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Favourable effects of fenofibrate on lipids and cardiovascular disease in women with type 2 diabetes: results from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study

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Sex-Related Differences of Coronary Atherosclerosis Regression Following Maximally Intensive Statin Therapy Insights From SATURN

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Constant Stress increases Risk of Type-2-Diabetes Mainly affected are Women

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The Importance of Waist Circumference and BMI for Mortality Risk in Diabetic Adults

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The Role of Estrogens in Control of Energy Balance and Glucose Homeostasis

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Vulvovaginitis and balanitis in patients with diabetes treated with dapagliflozin

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Work Stress, Sense of Coherence, and Risk of Type 2 Diabetes in a Prospective Study of Middle-Aged Swedish Men and Women

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Women show a closer association between educational level and hypertension or diabetes mellitus than males: a secondary analysis from the Austrian HIS

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Mechanism and Effects of Glucose Absorption during an Oral Glucose Tolerance Test Among Females and Males

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Prescribing metformin in type 2 diabetes with a contraindication: prevalence and outcome

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Sex and the renin-angiotensin system: inequality between the sexes in response to RAS stimulation and inhibition

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Prevention of Diabetes in Women with a History of Gestational Diabetes: Effects of Metformin and Lifestyle Interventions

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Gender differences in the onset of diabetic neuropathy

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Adherence to preventive medications - Predictors and outcomes in the diabetes prevention program

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Different mechanisms for impaired fasting glucose and impaired postprandial glucose tolerance in humans

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Risk factors for renal dysfunction in type 2 diabetes - UK prospective diabetes study 74

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Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies

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A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women

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Gender difference in all-cause and cardiovascular mortality related to hyperglycaemia and newly-diagnosed diabetes

G Hu

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Increased intramyocellular lipid concentration identifies impaired glucose metabolism in women with previous gestational diabetes

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