4.5 Article

Association between obesity, inflammation and insulin resistance: Insights into signaling pathways and therapeutic interventions

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Obstetrics & Gynecology

The importance of nutrition in pregnancy and lactation: lifelong consequences

Nicole E. Marshall et al.

Summary: Healthy nutrition and diet play a crucial role in preconception and pregnancy, emphasizing nutrient-dense whole foods while avoiding excessive processed foods and saturated fats. Extreme restriction of any macronutrient class should be avoided, and early interventions are necessary to prevent adverse outcomes. Breastfeeding provides personalized nutrition for infants and is associated with short- and long-term health benefits for both mother and child.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2022)

Review Immunology

Resident and migratory adipose immune cells control systemic metabolism and thermogenesis

Kevin Man et al.

Summary: Glucose is a crucial energy source for mammals, and the maintenance of organismal glucose metabolism involves multiple tissues, including adipose tissue with its diverse cell types. Immune cells in adipose tissue play a critical role in regulating insulin sensitivity and thermogenesis by modulating the inflammatory tone, ultimately affecting systemic metabolism.

CELLULAR & MOLECULAR IMMUNOLOGY (2022)

Review Endocrinology & Metabolism

The dietary inflammatory index, obesity, type 2 diabetes, and cardiovascular risk factors and diseases

Rohit Hariharan et al.

Summary: Research suggests that an unhealthy diet is associated with an increased risk of obesity, T2DM, and CVD, but there is limited research on the association between dietary inflammation and T2DM and its risk factors, as well as a lack of interventional studies designed to change the inflammatory potential of diets and study its effect on cardiometabolic risk factors and diseases. Interventions studies are recommended to assess whether changes in DII can independently modulate cardiometabolic risk factors and diseases.

OBESITY REVIEWS (2022)

Article Respiratory System

CC-90001, a c-Jun N-terminal kinase (JNK) inhibitor, in patients with pulmonary fibrosis: design of a phase 2, randomised, placebo-controlled trial

Zoran Popmihajlov et al.

Summary: This study evaluates the efficacy and safety of CC-90001, an orally administered JNK inhibitor, in patients with IPF and PF-ILD. The results will contribute to the understanding of the therapeutic effect of this drug on fibrotic lung diseases.

BMJ OPEN RESPIRATORY RESEARCH (2022)

Review Pharmacology & Pharmacy

Biomaterial-Based Therapeutic Strategies for Obesity and Its Comorbidities

Jing Li et al.

Summary: Obesity is a global public health issue, and there is an urgent need for alternative treatment strategies. Only a handful of drugs are currently approved for clinical obesity treatment. Biomaterials have promising applications in obesity treatment.

PHARMACEUTICS (2022)

Review Biochemistry & Molecular Biology

Role of Micronutrients and Gut Microbiota-Derived Metabolites in COVID-19 Recovery

Teresita de Jesus Hernandez-Flores et al.

Summary: A balanced and varied diet, along with a healthy gut microbiome, have beneficial effects on health by providing adequate micronutrients and regulating the immune response.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Immunology

The Role of T Cells in Obesity-Associated Inflammation and Metabolic Disease

Chan-Su Park et al.

Summary: Obesity-induced changes in the microenvironment of adipose tissue and intestines promote chronic inflammation and insulin resistance. Different T cell subsets play varying roles in maintaining metabolic homeostasis in healthy states and contributing to metabolic syndromes in obesity.

IMMUNE NETWORK (2022)

Review Endocrinology & Metabolism

The role of Wnt pathway in obesity induced inflammation and diabetes: a review

Bhabajyoti Das et al.

Summary: Diabetes has become a major killer worldwide, with obesity and inflammation playing a significant role. The loss of insulin-producing capacity is the main reason for the development of the disease, leading to insulin resistance.

JOURNAL OF DIABETES AND METABOLIC DISORDERS (2021)

Review Nutrition & Dietetics

Berries as a Treatment for Obesity-Induced Inflammation: Evidence from Preclinical Models

Hannah Land Lail et al.

Summary: Obesity-related inflammation is associated with chronic low-grade inflammation and increased risk of chronic diseases. Berries and their bioactive components have been shown to have beneficial effects on inflammation. Berries may offer a treatment possibility for obesity-induced inflammation and associated comorbidities.

NUTRIENTS (2021)

Article Endocrinology & Metabolism

Long-Term Efficacy and Safety of Anti-Obesity Treatment: Where Do We Stand?

Young Jin Tak et al.

Summary: The guidelines for obesity control recommend lifestyle interventions along with medical treatment for overweight patients to achieve significant weight loss and improved cardiometabolism. Recent studies have shown that a combination of pharmacotherapy and behavior-based interventions can lead to effective weight reduction, although careful consideration of benefits and risks is necessary when initiating drug therapy in obese individuals.

CURRENT OBESITY REPORTS (2021)

Article Medicine, Research & Experimental

Docking protein 1 and free fatty acids are associated with insulin resistance in patients with type 2 diabetes mellitus

Xiaoqin Ha et al.

Summary: IR in T2DM patients without obesity or pre-DM is associated with high serum FFA concentration and low expression of DOK1. Lower expression of DOK1 may inhibit lipid synthesis and worsen IR.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2021)

Article Multidisciplinary Sciences

Distinct mechanisms involving diacylglycerol, ceramides, and inflammation underlie insulin resistance in oxidative and glycolytic muscles from high fat-fed rats

Shailee Jani et al.

Summary: The study found that a high-fat diet led to accumulation of DAG and ceramides, activation of PKC, and induction of inflammatory pathways in a fiber type-specific manner.

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

β-Sitosterol Circumvents Obesity Induced Inflammation and Insulin Resistance by down-Regulating IKKβ/NF-κB and JNK Signaling Pathway in Adipocytes of Type 2 Diabetic Rats

Selvaraj Jayaraman et al.

Summary: Beta-sitosterol is a highly potent antidiabetic drug that can ameliorate inflammatory responses and reduce insulin resistance in type 2 diabetic rats by modulating intracellular signaling pathways.

MOLECULES (2021)

Review Cell Biology

The complex role of Wnt ligands in type 2 diabetes mellitus and related complications

Xiaobo Nie et al.

Summary: Type 2 diabetes mellitus is a major chronic disease with increasing global prevalence, and the Wnt signalling pathways play crucial roles in its occurrence and progression. However, our understanding of the exact roles of Wnts in these diseases is still rudimentary due to the complexity of the pathways and the conflicting effects of different family members.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Review Biochemistry & Molecular Biology

Selective inhibitors for JNK signalling: a potential targeted therapy in cancer

Qinghua Wu et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Endothelial Dysfunction in Obesity-Induced Inflammation: Molecular Mechanisms and Clinical Implications

Ibrahim Kalle Kwaifa et al.

BIOMOLECULES (2020)

Article Cardiac & Cardiovascular Systems

Metabolic Inflammation and Insulin Resistance in Obesity

Huaizhu Wu et al.

CIRCULATION RESEARCH (2020)

Review Cell Biology

Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes

Justin Hou Ming Yung et al.

Review Endocrinology & Metabolism

Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective

Zhaoping Wang et al.

DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2020)

Article Endocrinology & Metabolism

Role of TLR4 in the induction of inflammatory changes in adipocytes and macrophages

K. McKernan et al.

ADIPOCYTE (2020)

Review Cell Biology

What Is Nuclear Factor Kappa B (NF-κB) Doing in and to the Mitochondrion?

Benedict C. Albensi

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Review Endocrinology & Metabolism

Polymeric Carriers for Controlled Drug Delivery in Obesity Treatment

Di Huang et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2019)

Review Endocrinology & Metabolism

Current pharmacotherapy for obesity

Gitanjali Srivastava et al.

NATURE REVIEWS ENDOCRINOLOGY (2018)

Article Multidisciplinary Sciences

The molecular basis of JAK/STAT inhibition by SOCS1

Nicholas P. D. Liau et al.

NATURE COMMUNICATIONS (2018)

Review Endocrinology & Metabolism

Progress and challenges in anti-obesity pharmacotherapy

Daniel H. Bessesen et al.

LANCET DIABETES & ENDOCRINOLOGY (2018)

Review Endocrinology & Metabolism

Interrelationship of canonical and non-canonical Wnt signalling pathways in chronic metabolic diseases

Ian Ackers et al.

DIABETES & VASCULAR DISEASE RESEARCH (2018)

Review Endocrinology & Metabolism

JNK at the crossroad of obesity, insulin resistance, and cell stress response

Giovanni Solinas et al.

MOLECULAR METABOLISM (2017)

Article Integrative & Complementary Medicine

Agrimonia pilosa Ledeb. aqueous extract improves impaired glucose tolerance in high-fat diet-fed rats by decreasing the inflammatory response

Hwan Hee Jang et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2017)

Review Cell Biology

The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells

Farhad Seif et al.

CELL COMMUNICATION AND SIGNALING (2017)

Review Endocrinology & Metabolism

Liraglutide for weight management: a critical review of the evidence

A. Mehta et al.

OBESITY SCIENCE & PRACTICE (2017)

Review Endocrinology & Metabolism

Evolution of pharmacological obesity treatments: focus on adverse side-effect profiles

A. J. Krentz et al.

DIABETES OBESITY & METABOLISM (2016)

Article Cell Biology

Cell Signaling and Stress Responses

Gokhan S. Hotamisligil et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)

Review Immunology

Resolution of inflammation: what Controls its Onset?

Michelle A. Sugimoto et al.

FRONTIERS IN IMMUNOLOGY (2016)

Article Medicine, General & Internal

A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management

Xavier Pi-Sunyer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Multidisciplinary Sciences

Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance

Lin Jia et al.

NATURE COMMUNICATIONS (2014)

Review Immunology

From monocytes to M1/M2 macrophages: phenotypical vs. functional differentiation

Paola Italiani et al.

FRONTIERS IN IMMUNOLOGY (2014)

Article Integrative & Complementary Medicine

Artemisia iwayomogi Extract Attenuates High-Fat Diet-Induced Obesity by Decreasing the Expression of Genes Associated with Adipogenesis in Mice

Yeji Choi et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)

Review Biochemistry & Molecular Biology

PPARγ signaling and metabolism: the good, the bad and the future

Maryam Ahmadian et al.

NATURE MEDICINE (2013)

Review Pharmacology & Pharmacy

Anti-obesity drugs: a review about their effects and their safety

Giuseppe Derosa et al.

EXPERT OPINION ON DRUG SAFETY (2012)

Review Endocrinology & Metabolism

What causes the insulin resistance underlying obesity?

Olga T. Hardy et al.

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2012)

Review Cell Biology

NF-κB, Inflammation, and Metabolic Disease

Rebecca G. Baker et al.

CELL METABOLISM (2011)

Article Medicine, General & Internal

The Effects of Salsalate on Glycemic Control in Patients With Type 2 Diabetes A Randomized Trial

Allison B. Goldfine et al.

ANNALS OF INTERNAL MEDICINE (2010)

Article Pharmacology & Pharmacy

Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice

Young-Sil Lee et al.

BIOCHEMICAL PHARMACOLOGY (2010)

Article Urology & Nephrology

IL-10/TGF-β-Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis

Qi Cao et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)

Review Gastroenterology & Hepatology

TLR4 and Insulin Resistance

Jane J. Kim et al.

GASTROENTEROLOGY RESEARCH AND PRACTICE (2010)

Article Biochemistry & Molecular Biology

Wnt5b stimulates adipogenesis by activating PPARγ, and inhibiting the β-catenin dependent Wnt signaling pathway together with Wnt5a

F. H. J. van Tienen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

Article Biochemistry & Molecular Biology

Regulation of PPARγ function by TNF-α

Jianping Ye

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

Article Multidisciplinary Sciences

HSP72 protects against obesity-induced insulin resistance

Jason Chung et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Biochemistry & Molecular Biology

TNF-α and adipocyte biology

William P. Cawthorn et al.

FEBS LETTERS (2008)

Article Physiology

SOCS proteins causing trouble in insulin action

P. Lebrun et al.

ACTA PHYSIOLOGICA (2008)

Article Cardiac & Cardiovascular Systems

Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity

Francis Kim et al.

CIRCULATION RESEARCH (2007)

Review Pharmacology & Pharmacy

Pharmacological treatment of the overweight patient

George A. Bray et al.

PHARMACOLOGICAL REVIEWS (2007)

Article Medicine, Research & Experimental

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Carey N. Lumeng et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Review Pathology

Chronic inflammation: a failure of resolution?

Toby Lawrence et al.

INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY (2007)

Letter Cardiac & Cardiovascular Systems

Limitations in the clinical assessment of obesity: Comments on the American Heart Association's 2006 statement

Alberto Morales et al.

REVISTA ESPANOLA DE CARDIOLOGIA (2007)

Article Biochemistry & Molecular Biology

JNK and tumor necrosis factor-α mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes

MTA Nguyen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Immunology

CD14 is required for MyD88-independent LPS signaling

ZF Jiang et al.

NATURE IMMUNOLOGY (2005)

Article Biochemistry & Molecular Biology

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

DS Cai et al.

NATURE MEDICINE (2005)

Article Multidisciplinary Sciences

A central role for JNK in obesity and insulin resistance

J Hirosumi et al.

NATURE (2002)

Article Medicine, General & Internal

An alternative to body mass index for standardizing body weight for stature

A Bagust et al.

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2000)