Finnish children carrying the high-risk HLA genotype have a 45-fold increased risk of type 1 diabetes compared to peers with neutral or protective genotypes

The association between HLA genotypes and type 1 diabetes is well known. We set out to examine incidence rates and ratios of type 1 diabetes depending on the risk afflicted by HLA genotype. Children with the high-risk ge-notype have a 45-fold disease risk compared to peers with neutral or protective genotypes.

Automated summary

This study examines the association between HLA genotypes and the incidence rates and risk of type 1 diabetes. The results show that children with high-risk genotype have a 45-fold increased risk of developing type 1 diabetes compared to those with neutral or protective genotypes.