The role of adiponectin for immune cell function in metabolic diseases

Adiponectin, as an indispensable regulator of the immune system, is the most abundant adipokine and is mainly produced by white adipose tissue. Adiponectin mediates the positive effects on systemic metabolism by regulating associated downstream signalling pathways; however, accumulating evidence shows that adiponectin plays an important role in regulating the function of innate and adaptive immune cells in the development of obesity and its related diseases. In this review, we focus on the biological function of adiponectin in regulating innate and adaptive immunity and outline the key role of adiponectin in various metabolic diseases, which will highlight a potential direction for adiponectin-based therapeutic interventions for metabolic diseases.

Automated summary

As an essential regulator of the immune system, adiponectin plays a crucial role in regulating the function of innate and adaptive immune cells in the development of obesity and its related diseases. It also has positive effects on systemic metabolism by regulating associated downstream signalling pathways. This review highlights the biological function of adiponectin in regulating innate and adaptive immunity and its key role in various metabolic diseases, providing a potential direction for adiponectin-based therapeutic interventions.