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COVID-19 associated ketosis and diabetic ketoacidosis: A rapid review

DIABETES OBESITY & METABOLISM (2023)

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Impacts of COVID-19 on Glycemia and Risk of Diabetic Ketoacidosis

Anukriti Sharma et al.

Summary: Reports indicate that COVID-19 may impact pancreatic function and increase T2D risk. A study comparing COVID-19(+) patients and matched control subjects found a statistically significant increase in HbA(1c) and T2D risk among COVID-19(+) patients. The study also suggests that COVID-19-attributed T2D risk may be due to increased recognition during COVID-19 management.

DIABETES (2023)

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Article Endocrinology & Metabolism

The impact of COVID-19 on Diabetic Ketoacidosis patients

Faraz Khan et al.

Summary: This study compared the prevalence and outcomes of Diabetic Ketoacidosis (DKA) patients before and during the pandemic, revealing that the prevalence of DKA increased significantly during the COVID-19 pandemic period, with higher mortality rates among DKA/COVID-19+ patients. It is recommended to screen all COVID-19+ patients for DKA and prioritize ICU treatment for DKA/COVID-19+ patients with certain risk factors.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2022)

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Article Endocrinology & Metabolism

Association Between SGLT2 Inhibitor Treatment and Diabetic Ketoacidosis and Mortality in People With Type 2 Diabetes Admitted to Hospital With COVID-19

Kamlesh Khunti et al.

Summary: This study aimed to investigate the association between prescription of SGLT2 inhibitors and the incidence of diabetic ketoacidosis (DKA) or mortality in people with type 2 diabetes hospitalized with COVID-19. The study found that there was no significant difference in the occurrence of DKA or in-hospital mortality between patients prescribed SGLT2 inhibitors and those who were not.

DIABETES CARE (2022)

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Article Medicine, Research & Experimental

Metabolic alkalosis in type 2 diabetic patients with severe COVID-19

Xiaomin Xie et al.

Summary: This study retrospectively reviewed data of 24 patients with severe COVID-19 and compared 11 patients with type 2 diabetes (T2D) and 13 patients with normal glucose tolerance (NGT). The results showed that the blood indicators of T2D patients were significantly higher than those of the NGT group, and treatment with traditional Chinese medicine and beraprost sodium improved breathing difficulties and metabolic alkalosis.

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE (2022)

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Article Virology

Newly diagnosed diabetes mellitus, DKA, and COVID-19: Causality or coincidence? A report of three cases

Kulachanya Suwanwongse et al.

Summary: COVID-19's impact on the endocrine system has not been extensively studied, with only a few case reports indicating a potential risk for diabetes mellitus. Case studies suggest that COVID-19 may exacerbate metabolic complications of existing diabetes mellitus in patients.

JOURNAL OF MEDICAL VIROLOGY (2021)

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Article Emergency Medicine

SARS-CoV-2 Infection and Associated Rates of Diabetic Ketoacidosis in a New York City Emergency Department

Jared Ditkowsky et al.

Summary: The study found that despite a 26.9% decrease in emergency department (ED) volumes during the peak of the COVID-19 pandemic in New York City, diagnoses of diabetic ketoacidosis (DKA) increased drastically by 70.1% compared to the previous year.

WESTERN JOURNAL OF EMERGENCY MEDICINE (2021)

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Article

New-onset diabetes mellitus with COVID-19: Coincidence or cause

J. Muthukrishnan et al.

Medical Journal Armed Forces India (2021)

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Letter Endocrinology & Metabolism

Proportion of newly diagnosed diabetes in COVID-19 patients: A systematic review and meta-analysis

Thirunavukkarasu Sathish et al.

DIABETES OBESITY & METABOLISM (2021)

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Article Endocrinology & Metabolism

Diabetic ketoacidosis and mortality in COVID-19 infection

J. S. Stevens et al.

Summary: Patients with diabetes have increased morbidity and mortality from COVID-19. The combination of DKA and COVID-19 is associated with greater mortality, driven by older age and COVID-19 severity. Factors such as higher HbA1c levels, older age, and need for pressors are related to increased risk of mortality in patients with DKA and COVID-19.

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Article Endocrinology & Metabolism

Marked hyperglycemia and ketosis in a non-obese patient with new onset diabetes and very mild COVID-19 symptoms: A case report

Amerta Ghosh et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2021)

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Article Medicine, General & Internal

COVID-19 and Combined Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar Nonketotic Coma: Report of 11 Cases

Balraj Singh et al.

Summary: This case series presents 11 cases of combined diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar nonketotic coma (HHNK) in COVID-19 patients, with a wide age range and a higher proportion of male patients. Patients mainly present with neurological symptoms, respiratory symptoms, and metabolic disorders, with a severe condition and high mortality rate.

JOURNAL OF INVESTIGATIVE MEDICINE HIGH IMPACT CASE REPORTS (2021)

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Article Endocrinology & Metabolism

COVID-19 infection may cause ketosis and ketoacidosis

Juyi Li et al.

DIABETES OBESITY & METABOLISM (2020)

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Letter Endocrinology & Metabolism

Why is hyperglycaemia worseningCOVID-19 and its prognosis?

Antonio Ceriello et al.

DIABETES OBESITY & METABOLISM (2020)

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Article Endocrinology & Metabolism

Newly diagnosed diabetes is associated with a higher risk of mortality than known diabetes in hospitalized patients withCOVID-19

Huiqing Li et al.

DIABETES OBESITY & METABOLISM (2020)

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Article Emergency Medicine

Newly diagnosed diabetes and diabetic ketoacidosis precipitated by COVID-19 infection

Ashley Heaney et al.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2020)

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Letter Endocrinology & Metabolism

COVID-19, ketoacidosis and new-onset diabetes: Are there possible cause and effect relationships among them?

Sandro Gentile et al.

DIABETES OBESITY & METABOLISM (2020)

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Letter Endocrinology & Metabolism

Protracted ketonaemia in hyperglycaemic emergencies in COVID-19: a retrospective case series

Eleni Armeni et al.

LANCET DIABETES & ENDOCRINOLOGY (2020)

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Article Emergency Medicine

FIRST-TIME DIABETIC KETOACIDOSIS IN TYPE 2 DIABETICS WITH COVID-19 INFECTION: A NOVEL CASE SERIES

Alexander Croft et al.

JOURNAL OF EMERGENCY MEDICINE (2020)

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Article Endocrinology & Metabolism

Short term follow-up of patients presenting with acute onset diabetes and diabetic ketoacidosis during an episode of COVID-19

Mohammad Shafi Kuchay et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

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Article Infectious Diseases

Clinical dilemma of DKA and Covid-19 infection: A case report

Margarita Gianniosis et al.

IDCASES (2020)

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Letter Medicine, Research & Experimental

Ketonuria with or without ketoacidosis as the presenting manifestation of SARS-CoV-2 (COVID-19) among uncontrolled type 2 diabetic patients

Mohamed H. Emara et al.

MEDICAL HYPOTHESES (2020)

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Review Endocrinology & Metabolism

Diabetic ketoacidosis precipitated by COVID-19: A report of two cases and review of literature

Pavan Kumar Reddy et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

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Article Endocrinology & Metabolism

Acute Hyperglycemic Crises with Coronavirus Disease-19: Case Reports

Na-young Kim et al.

DIABETES & METABOLISM JOURNAL (2020)

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Article Endocrinology & Metabolism

Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection: a case report

Tim Hollstein et al.

NATURE METABOLISM (2020)

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