COVID-19 associated ketosis and diabetic ketoacidosis: A rapid review

SARS-CoV-2 infection could disrupt the endocrine system directly or indirectly, which could result in endocrine dysfunction and glycaemic dysregulation, triggering transient or persistent diabetes mellitus. The literature on the complex relationship between COVID-19 and endocrine dysfunctions is still evolving and remains incompletely understood. Thus, we conducted a review on all literature to date involving COVID-19 associated ketosis or diabetic ketoacidosis (DKA). In total, 27 publications were included and analysed quantitatively and qualitatively. Studies included patients with DKA with existing or new onset diabetes. While the number of case and cohort studies was limited, DKA in the setting of COVID-19 seemed to increase risk of death, particularly in patients with new onset diabetes. Future studies with more specific variables and larger sample sizes are needed to draw better conclusions.

Automated summary

SARS-CoV-2 infection may lead to endocrine dysfunction and dysregulation of blood sugar levels, causing diabetes mellitus. The relationship between COVID-19 and endocrine dysfunctions is still not completely understood. This review analyzed 27 publications on COVID-19 associated ketosis or diabetic ketoacidosis, suggesting that DKA in the setting of COVID-19 could increase the risk of death, especially in patients with new-onset diabetes. Larger studies with more specific variables are needed for better conclusions.