4.7 Article

Smooth muscle contributes to the development and function of a layered intestinal stem cell niche

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Spatiotemporal analysis of human intestinal development at single-cell resolution

David Fawkner-Corbett et al.

Summary: This study uses single-cell RNA sequencing and spatial transcriptomics to investigate human intestinal development, identifying various cell states, developmental programs, and differentiation hierarchies. It provides insights into the formation of different cell types in the gut and offers valuable resources for further research in this field.
Article Cell & Tissue Engineering

Mapping Development of the Human Intestinal Niche at Single-Cell Resolution

Emily M. Holloway et al.

Summary: Through studying human intestinal development, it was found that smooth muscle cells of the muscularis mucosa release WNT and RSPONDIN ligands near proliferative crypts, while a mesenchymal population with high expression of PDGFRA(HI)/F3(HI)/DLL1(HI) serves as a source of NEUREGULIN1 (NRG1). NRG1 promotes increased cellular diversity through differentiation of secretory lineages.

CELL STEM CELL (2021)

Article Multidisciplinary Sciences

Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage

Mara Martin-Alonso et al.

Summary: Smooth muscle cells in the intestine may play a crucial role in supplying BMP antagonists, maintaining reparative and fetal-like features, and influencing intestinal epithelial regeneration through MMP17. This discovery establishes smooth muscle cells as modulators of intestinal epithelial regeneration and the stem cell niche.

NATURE COMMUNICATIONS (2021)

Article Gastroenterology & Hepatology

Bone Morphogenetic Protein Pathway Antagonism by Grem1 Regulates Epithelial Cell Fate in Intestinal Regeneration

Martijn A. J. Koppens et al.

Summary: The study reveals that BMP signaling inhibits dedifferentiation of intestinal epithelial cells, and attenuation of the BMP pathway through stromal upregulation of Grem1 is essential for adaptive reprogramming in intestinal regeneration. However, the functional impact of this intervention is submaximal, suggesting potential therapeutic pathway manipulation in inflammatory bowel disease.

GASTROENTEROLOGY (2021)

Article Multidisciplinary Sciences

Cells of the human intestinal tract mapped across space and time

Rasa Elmentaite et al.

Summary: The study analyzes cells from various stages of human development along the intestinal tract, revealing transcriptionally distinct BEST4 epithelial cells and implicating IgG sensing as a function of tuft cells. It also describes neural cell populations in the developing enteric nervous system and identifies key players in the formation of lymphoid tissue in early human development and inflammatory bowel disease.

NATURE (2021)

Article Cell & Tissue Engineering

Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient

Neil McCarthy et al.

CELL STEM CELL (2020)

Review Cell Biology

Cellular and molecular architecture of the intestinal stem cell niche

Neil McCarthy et al.

NATURE CELL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Distinct populations of crypt-associated fibroblasts act as signaling hubs to control colon homeostasis

Michael David Bruegger et al.

PLOS BIOLOGY (2020)

Article Genetics & Heredity

A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity

Lei Chen et al.

NATURE GENETICS (2019)

Article Biochemistry & Molecular Biology

Comprehensive Integration of Single-Cell Data

Tim Stuart et al.

Article Biochemistry & Molecular Biology

Genetic and Mechanical Regulation of Intestinal Smooth Muscle Development

Tyler R. Huycke et al.

Article Cell Biology

Morphogenesis and Compartmentalization of the Intestinal Crypt

Kaelyn D. Sumigray et al.

DEVELOPMENTAL CELL (2018)

Article Biotechnology & Applied Microbiology

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Andrew Butler et al.

NATURE BIOTECHNOLOGY (2018)

Article Multidisciplinary Sciences

PDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo

Gediminas Greicius et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biochemistry & Molecular Biology

Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease

James Kinchen et al.

Article Cell Biology

Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche

Yuemin Celina Chee et al.

DEVELOPMENTAL CELL (2018)

Article Multidisciplinary Sciences

Subepithelial telocytes are an important source of Wnts that supports intestinal crypts

Michal Shoshkes-Carmel et al.

NATURE (2018)

Article Multidisciplinary Sciences

BMP signaling controls buckling forces to modulate looping morphogenesis of the gut

Nandan L. Nerurkar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

CD34+ mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury

Igor Stzepourginski et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes

Zhen Qi et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1

Hanna M. Eilken et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

Transcriptome of interstitial cells of Cajal reveals unique and selective gene signatures

Moon Young Lee et al.

PLOS ONE (2017)

Article Biochemical Research Methods

High-resolution 3D analysis of mouse small-intestinal stroma

Jeremiah Bernier-Latmani et al.

NATURE PROTOCOLS (2016)

Article Biochemistry & Molecular Biology

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

Hayley Davis et al.

NATURE MEDICINE (2015)

Article Developmental Biology

Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts

Zahra Kabiri et al.

DEVELOPMENT (2014)

Review Biochemistry & Molecular Biology

The Intestinal Crypt, A Prototype Stem Cell Compartment

Hans Clevers

Article Cell & Tissue Engineering

Transplantation of Expanded Fetal Intestinal Progenitors Contributes to Colon Regeneration after Injury

Robert P. Fordham et al.

CELL STEM CELL (2013)

Article Multidisciplinary Sciences

Villification: How the Gut Gets Its Villi

Amy E. Shyer et al.

SCIENCE (2013)

Article Biochemistry & Molecular Biology

Optimality in the Development of Intestinal Crypts

Shalev Itzkovitz et al.

Article Gastroenterology & Hepatology

Redundant Sources of Wnt Regulate Intestinal Stem Cells and Promote Formation of Paneth Cells

Henner F. Farin et al.

GASTROENTEROLOGY (2012)

Article Cell Biology

Platelet-derived growth factor receptor α-positive cells in the tunica muscularis of human colon

Masaaki Kurahashi et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2012)

Article Pathology

RNAscope A Novel in Situ RNA Analysis Platform for Formalin-Fixed, Paraffin-Embedded Tissues

Fay Wang et al.

JOURNAL OF MOLECULAR DIAGNOSTICS (2012)

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Article Multidisciplinary Sciences

Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells

Tae-Hee Kim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Physiology

Mesenchymal Cells of the Intestinal Lamina Propria

D. W. Powell et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 73 (2011)

Review Anatomy & Morphology

Vertebrate Intestinal Endoderm Development

Jason R. Spence et al.

DEVELOPMENTAL DYNAMICS (2011)

Article Biochemical Research Methods

Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt

Steffen Durinck et al.

NATURE PROTOCOLS (2009)

Article Developmental Biology

An in vivo reporter of BMP signaling in organogenesis reveals targets in the developing kidney

Ulrika Blank et al.

BMC DEVELOPMENTAL BIOLOGY (2008)

Article Multidisciplinary Sciences

Identification of stem cells in small intestine and colon by marker gene Lgr5

Nick Barker et al.

NATURE (2007)

Article Multidisciplinary Sciences

Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors

Cynthia Kosinski et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Anatomy & Morphology

Bmp signaling is required for intestinal growth and morphogenesis

Lorene E. Batts et al.

DEVELOPMENTAL DYNAMICS (2006)

Article Gastroenterology & Hepatology

Epithelial cells and their neighbors I. Role of intestinal myofibroblasts in development, repair, and cancer

DW Powell et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2005)

Article Multidisciplinary Sciences

De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine

APG Haramis et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms

TG Hamilton et al.

MOLECULAR AND CELLULAR BIOLOGY (2003)