Quality of life benefit and clinical predictors of complete skin clearance in psoriasis: a multicenter, prospective, real-world study

Letter Dermatology

The impact of achieving and maintaining near-complete or complete skin clearance on patient quality of life in moderate-to-severe psoriasis

Caitriona Ryan et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2023)

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Letter Dermatology

Heterologous versus homologous primary and booster COVID-19 vaccination do not increase flare rate in patients with psoriasis and/or psoriatic arthritis: Insights from a real-life, multicenter, case-control study

Santo Raffaele Mercuri et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2023)

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Review Dermatology

PASI 100 response rates in moderate to severe psoriasis: a systematic literature review and analysis of clinical practice guidelines

Isabel Belinchon Romero et al.

Summary: PASI 100 response rate is primarily used in research, and the achievement rate varies for different pharmacological treatments. Clinical practice guidelines provide limited comments on PASI 100.

JOURNAL OF DERMATOLOGICAL TREATMENT (2022)

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Article Dermatology

T Helper 2 IL-4/IL-13 Dual Blockade with Dupilumab Is Linked to Some Emergent T Helper 17-Type Diseases, Including Seronegative Arthritis and Enthesitis/Enthesopathy, but Not to Humoral Autoimmune Diseases

Charlie Bridgewood et al.

Summary: The use of Dupilumab is associated with seronegative inflammatory arthritis and psoriasis, but not with classic polygenic humoral autoimmune diseases. Pathway analysis suggests that Dupilumab may affect certain cytokine pathways and contribute to immune disorders and other pathological processes.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2022)

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Article Dermatology

Super-response to guselkumab treatment in patients with moderate-to-severe psoriasis: age, body weight, baseline Psoriasis Area and Severity Index, and baseline Investigator's Global Assessment scores predict complete skin clearance

K. Reich et al.

Summary: This study described the baseline characteristics of patients with moderate-to-severe psoriasis who achieved super-response after starting treatment with Guselkumab. It found that younger patients, less obese patients, and patients with less severe psoriasis were more likely to achieve early clinical responses.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2022)

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Article Biology

Super-Responders in Moderate-Severe Psoriasis under Guselkumab Treatment: Myths, Realities and Future Perspectives

Ricardo Ruiz-Villaverde et al.

Summary: Achieving fast skin clearance is the main goal in psoriasis treatment. This retrospective analysis of psoriasis patients receiving Guselkumab treatment revealed significant correlations between depression, VAS_pruritus, DLQI, and the occurrence of super-response.

LIFE-BASEL (2022)

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Article Dermatology

Association of sex and systemic therapy treatment outcomes in psoriasis: a two-country, multicentre, prospective, noninterventional registry study

J. -T. Maul et al.

Summary: The study found that women have better treatment outcomes with systemic antipsoriatic therapy compared to men, showing higher response rates in PASI and DLQI improvements.

BRITISH JOURNAL OF DERMATOLOGY (2021)

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Article Medicine, General & Internal

The Global, Regional, and National Burden of Psoriasis: Results and Insights From the Global Burden of Disease 2019 Study

Giovanni Damiani et al.

Summary: The Global Burden of Disease study in 2019 showed that there were 4,622,594 incident cases of psoriasis worldwide in 2019, with the highest age-standardized incidence rate in high-income countries of North America and Europe. This highlights the need for objective evaluation of the disease burden to track progress at a population level.

FRONTIERS IN MEDICINE (2021)

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Article Immunology

SARS-CoV-2 Infection Induces Psoriatic Arthritis Flares and Enthesis Resident Plasmacytoid Dendritic Cell Type-1 Interferon Inhibition by JAK Antagonism Offer Novel Spondyloarthritis Pathogenesis Insights

Qiao Zhou et al.

Summary: The study found a connection between spinal entheseal plasmacytoid dendritic cells and TNF/IFN alpha production in response to microbes, with SARS-CoV-2 infection associated with PsA flares. JAK inhibition can suppress activated entheseal plasmacytoid dendritic Type-1 interferon responses, indicating a novel mechanism of PsA and SpA-related arthropathy.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Pharmacology & Pharmacy

Impact of previous biologic use and body weight on the effectiveness of guselkumab in moderate-to-severe plaque psoriasis: a real-world practice

Yi-Teng Hung et al.

Summary: The real-world effectiveness of guselkumab was found to be compromised, with delayed therapeutic response in heavier patients. Factors such as biologic exposure and previous treatments were identified as clinical predictors of reduced response to guselkumab.

THERAPEUTIC ADVANCES IN CHRONIC DISEASE (2021)

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Article Biotechnology & Applied Microbiology