4.6 Article

Dexamethasone and doxycycline functionalized nanoparticles enhance osteogenic properties of titanium surfaces

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Polymer Science

Antibacterial Effect of Functionalized Polymeric Nanoparticles on Titanium Surfaces Using an In Vitro Subgingival Biofilm Model

Jaime Bueno et al.

Summary: This study aimed to evaluate the antibacterial effect of polymeric nanoparticles functionalized with calcium, zinc, or doxycycline on a subgingival biofilm model. The results showed that doxycycline-functionalized nanoparticles had higher antibacterial activity and reduced bacterial load on titanium discs.

POLYMERS (2022)

Review Dentistry, Oral Surgery & Medicine

The role of foreign body response in peri-implantitis: What is the evidence?

Saso Ivanovski et al.

Summary: This review discusses the process of osseointegration between titanium dental implants and surrounding tissues, as well as the etiology of crestal bone loss characteristic of peri-implantitis. It explores the possible role of foreign body reactions and implant-related material release in peri-implantitis. While further research is needed, the available evidence suggests that osseointegration is a state of homeostasis and there is no evidence to support a causative role of foreign body reactions in peri-implant bone loss.

PERIODONTOLOGY 2000 (2022)

Article Pharmacology & Pharmacy

Dexamethasone and Doxycycline Doped Nanoparticles Increase the Differentiation Potential of Human Bone Marrow Stem Cells

Manuel Toledano-Osorio et al.

Summary: This study evaluated the effect of different prototypes of bioactive nanoparticles on human bone marrow stem cells. They found that Dex-NPs and Dox-NPs exhibited excellent osteogenic potential and promoted cell differentiation.

PHARMACEUTICS (2022)

Article Nanoscience & Nanotechnology

Fabrication of Dexamethasone-Loaded Dual-Metal-Organic Frameworks on Polyetheretherketone Implants with Bacteriostasis and Angiogenesis Properties for Promoting Bone Regeneration

Tianhua Xiao et al.

Summary: A multifunctional PEEK implant with strong antibacterial ability, angiogenesis promotion, and osteogenesis properties was developed. The coating on the implant surface released various substances upon degradation, forming an alkaline microenvironment and enhancing its bioactivity. In vitro and in vivo experiments demonstrated promising clinical potential for bone graft materials.

ACS APPLIED MATERIALS & INTERFACES (2021)

Review Dentistry, Oral Surgery & Medicine

Efficacy of local antibiotic therapy in the treatment of peri-implantitis: A systematic review and meta-analysis

Manuel Toledano et al.

Summary: The study aimed to evaluate the efficacy of local antibiotics in treating peri-implantitis, showing a reduction in peri-implant probing depth and bleeding on probing. Compared to control groups without local antibiotic application, the study found that local antibiotics can effectively reduce peri-implant probing depths and bleeding without adverse effects.

JOURNAL OF DENTISTRY (2021)

Review Dentistry, Oral Surgery & Medicine

Testing active membranes for bone regeneration: A review

Manuel Toledano-Osorio et al.

Summary: GBR is used to handle maxillofacial bone defects, but current membranes do not completely fulfill requirements, driving need for ideal membrane development; New membrane features require specific evaluation techniques, while nanotechnology and osteoimmunomodulation have impacted cells-membranes interaction.

JOURNAL OF DENTISTRY (2021)

Article Polymer Science

Doxycycline-Doped Polymeric Membranes Induced Growth, Differentiation and Expression of Antigenic Phenotype Markers of Osteoblasts

Manuel Toledano-Osorio et al.

Summary: The study found that blending silica nanoparticles improved proliferation and differentiation of osteoblasts, while scaffolds doped with doxycycline achieved the best results. Doxycycline functionalized membranes showed higher immunomodulation activity in osteoblasts, indicating their potential as candidates for use in GBR procedures for challenging pathologies.

POLYMERS (2021)

Article Dentistry, Oral Surgery & Medicine

Doxycycline-doped membranes induced osteogenic gene expression on osteoblastic cells

Manuel Toledano-Osorio et al.

Summary: The study investigated the impact of novel silicon dioxide composite membranes functionalized with zinc or doxycycline on osteoblastic cell gene expression. Results showed that the use of SiO2-NPs in polymeric scaffolds improved osteogenic gene expression, with the best results achieved by doxycycline doping. Zinc and doxycycline functionalized membranes significantly influenced the expression of several osteogenic gene markers, highlighting their potential for use in GBR procedures.

JOURNAL OF DENTISTRY (2021)

Article Materials Science, Biomaterials

Substrate-independent polymer coating with stimuli-responsive dexamethasone release for on-demand fibrosis inhibition

Pingyun Yuan et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

Review Engineering, Biomedical

Nano-scale modification of titanium implant surfaces to enhance osseointegration

Julio C. M. Souza et al.

ACTA BIOMATERIALIA (2019)

Article Chemistry, Physical

Modified Polymeric Nanoparticles Exert In Vitro Antimicrobial Activity Against Oral Bacteria

Manuel Toledano-Osorio et al.

MATERIALS (2018)

Review Dentistry, Oral Surgery & Medicine

Prevalences of peri-implantitis and peri-implant mucositis: systematic review and meta-analysis

Chun-Teh Lee et al.

JOURNAL OF DENTISTRY (2017)

Article Multidisciplinary Sciences

Bioactive Polymeric Nanoparticles for Periodontal Therapy

Raquel Osorio et al.

PLOS ONE (2016)

Editorial Material Orthopedics

Wnt Signaling: An Emerging Target for Bone Regeneration

Philipp Leucht et al.

JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS (2015)

Article Biochemistry & Molecular Biology

Role of Wnt signaling in fracture healing

Huiyun Xu et al.

BMB REPORTS (2014)

Article Chemistry, Multidisciplinary

Terminology for biorelated polymers and applications (IUPAC Recommendations 2012)

Michel Vert et al.

PURE AND APPLIED CHEMISTRY (2012)

Article Dentistry, Oral Surgery & Medicine

Differential cytokine expressions affect the severity of peri-implant disease

Poliana Mendes Duarte et al.

CLINICAL ORAL IMPLANTS RESEARCH (2009)

Review Biochemistry & Molecular Biology

OPG/RANK/RANKL signaling system and its significance in nephrology

Katarzyna Klejna et al.

FOLIA HISTOCHEMICA ET CYTOBIOLOGICA (2009)

Article Endocrinology & Metabolism

Wnt signaling during fracture repair

Frank J. Secreto et al.

Current Osteoporosis Reports (2009)

Article Dentistry, Oral Surgery & Medicine

Gingival crevicular fluid levels of RANKL and OPG in periodontal diseases:: implications of their relative ratio

Nagihan Bostanci et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2007)

Review Rheumatology

Biology of RANK, RANKL, and osteoprotegerin

Brendan F. Boyce et al.

ARTHRITIS RESEARCH & THERAPY (2007)

Article Endocrinology & Metabolism

Effects of dissociated glucocorticoids on OPG and RANKL in osteoblastic cells

E. L. Humphrey et al.

Article Engineering, Biomedical

A scanning electron microscopy study of human osteoblast morphology on five orthopedic metals

C Schmidt et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH (2002)

Review Endocrinology & Metabolism

Bone morphogenetic proteins in human bone regeneration

EHJ Groeneveld et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2000)