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Acinar cells and the development of pancreatic fibrosis

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CYTOKINE & GROWTH FACTOR REVIEWS
卷 71-72, 期 -, 页码 40-53

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ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2023.05.003

关键词

Pancreas; Fibrosis; Inflammation; Oncogenesis; Acinar cells

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Pancreatic fibrosis is caused by excessive deposition of collagen and fibronectin extracellular matrix in the pancreatic tissue due to repeated injury in chronic pancreatic diseases. The pathophysiology involves acinar cell injury, duct dysfunction, stellate cell activation, and persistent inflammatory response. The role of acinar cells in pancreatic fibrosis and potential clinical significance are discussed.
Pancreatic fibrosis is caused by excessive deposition of extracellular matrixes of collagen and fibronectin in the pancreatic tissue as a result of repeated injury often seen in patients with chronic pancreatic diseases. The most common causative conditions include inborn errors of metabolism, chemical toxicity and autoimmune disorders. Its pathophysiology is highly complex, including acinar cell injury, acinar stress response, duct dysfunction, pancreatic stellate cell activation, and persistent inflammatory response. However, the specific mechanism remains to be fully clarified. Although the current therapeutic strategies targeting pancreatic stellate cells show good efficacy in cell culture and animal models, they are not satisfactory in the clinic. Without effective intervention, pancreatic fibrosis can promote the transformation from pancreatitis to pancreatic cancer, one of the most lethal malignancies. In the normal pancreas, the acinar component accounts for 82% of the exocrine tissue. Abnormal acinar cells may activate pancreatic stellate cells directly as cellular source of fibrosis or indirectly via releasing various substances and initiate pancreatic fibrosis. A comprehensive understanding of the role of acinar cells in pancreatic fibrosis is critical for designing effective intervention strategies. In this review, we focus on the role of and mechanisms underlying pancreatic acinar injury in pancreatic fibrosis and their potential clinical significance.

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