☆ 4.4 Review

Insight of Engineered Nano-based Biologics Approaches used to Combat Autoimmune Disease using TNF-a & amp; IL Inhibitors

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2023)

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Review Immunology

Secukinumab in the treatment of psoriatic arthritis or ankylosing spondyloarthritis with multiple sclerosis: a case series with literature review

Mehmet Akif Eksin et al.

Summary: This study evaluated the effectiveness of secukinumab in the treatment of multiple sclerosis (MS) and its accompanying ankylosing spondylitis or psoriatic arthritis. The results showed that secukinumab can effectively alleviate symptoms and does not lead to progression of MS.

IMMUNOTHERAPY (2022)

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Review Food Science & Technology

Exploring the role of polyphenols in rheumatoid arthritis

Tapan Behl et al.

Summary: Rheumatoid arthritis is a chronic, inflammatory autoimmune disorder that causes joint inflammation, bone erosions, and cartilaginous destruction. Current treatments have severe adverse effects, prompting the search for new therapeutic options. Research suggests that dietary polyphenols may have potential efficacy in treating rheumatoid arthritis.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

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Article Gastroenterology & Hepatology

Patients With Inflammatory Bowel Disease on Treatment Have Lower Rates of Celiac Disease

Motasem Alkhayyat et al.

Summary: In this study, a large database was used to explore the association between celiac disease and inflammatory bowel disease (IBD) and the impact of IBD treatment. The results showed a bidirectional association between celiac disease and IBD, with a stronger association observed in Crohn's disease (CD). Patients with IBD who received corticosteroids, 5-aminosalicylates, immunomodulators, or anti-tumor necrosis factor drugs had a lower association with celiac disease. Additional research is needed to understand the underlying mechanisms for the modification of celiac disease incidence by IBD therapy.

INFLAMMATORY BOWEL DISEASES (2022)

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Review Pharmacology & Pharmacy

TNF-α: The shape of small molecules to come?

Alexander Domling et al.

Summary: In 2020, the anti-TNF monoclonal antibody Humira generated a huge cumulative sales, surpassing Lipitor as the most successful drug in the industry. However, due to limitations in CNS applications, small-molecule drugs are being developed to benefit a wider range of diseases.

DRUG DISCOVERY TODAY (2022)

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Article Fisheries

Expression of Interleukin-2 receptor subunit gamma (IL-2R?) and its binding with IL-2 induced activation of CD4 T lymphocytes in flounder (Paralichthys olivaceus)

Mengmeng Zhao et al.

Summary: By cloning interleukin-2 receptor subunit gamma (IL-2R gamma) in flounder and producing specific antibodies, this study characterized the expression of flounder IL-2R gamma (fIL-2R gamma) at transcriptional and cellular levels and investigated its interaction with flounder IL-2 (fIL-2). The results demonstrated that fIL-2R gamma was expressed on both T and B lymphocytes and the binding of fIL-2R gamma and fIL-2 activated CD4 T lymphocytes.

FISH & SHELLFISH IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Structural and functional insights into a novel pre-clinical-stage antibody targeting IL-17A for treatment of autoimmune diseases

Jin-gen Xu et al.

Summary: This study developed a novel monoclonal antibody, HB0017, that specifically targets the pro-inflammatory cytokine IL-17A. The antibody effectively antagonized the functions of IL-17A in human and monkey cells and showed therapeutic efficacy in treating inflammatory disorders and psoriasis in a mouse model. It could potentially serve as an alternative biological therapy for patients with inflammation and autoimmune diseases.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Review Biochemistry & Molecular Biology

Therapeutic potential of interleukin-2 in autoimmune diseases

Yeshuang Yuan et al.

Summary: Autoimmune diseases can be treated by restoring immune balance, and low-dose interleukin-2 (IL-2) has immunoregulatory effects on regulatory T cells (T-reg cells). Recent advances have explored the therapeutic potential of IL-2 or IL-2-derived molecules in the treatment of autoimmune diseases.

TRENDS IN MOLECULAR MEDICINE (2022)

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Article Pharmacology & Pharmacy

Model-Informed Approach Supporting Approval of Adalimumab (HUMIRA) in Pediatric Patients with Ulcerative Colitis from a Regulatory Perspective

Ruo-Jing Li et al.

Summary: This article discusses the FDA approval of HUMIRA (adalimumab) injection for the treatment of moderately to severely active ulcerative colitis (UC) in pediatric patients aged 5 and older. The study showed that adalimumab has a well-established safety profile and efficacy in pediatric populations. The dosing regimen for pediatric patients with UC was determined based on a model-informed exposure bridging strategy, incorporating both efficacy and safety considerations.

AAPS JOURNAL (2022)

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Article Immunology

Treatment of EAE mice with Treg, G-MDSC and IL-2: a new insight into cell therapy for multiple sclerosis

Mohammad Mehdi Ghorbani et al.

Summary: This study investigates the therapeutic and protective effects of suppressive immune cells and pivotal cytokines on a multiple sclerosis disease model. Pre- and post-treatment of the model mice resulted in no weight change, reduced pro-inflammatory cells, and suppression of undesired pathological properties.

IMMUNOTHERAPY (2022)

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Review Immunology

Systematic Review of Safety and Efficacy of IL-1-Targeted Biologics in Treating Immune-Mediated Disorders

Dennis D. Arnold et al.

Summary: This systematic review evaluates the safety and efficacy of anakinra, canakinumab, rilonacept, gevokizumab, and bermekimab compared to placebo, standard-of-care treatment or other biologics for the treatment of immune-mediated disorders. The review finds that these biologics have varying safety and efficacy profiles in treating specific diseases.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Materials Science, Biomaterials

Immunotherapeutic nanoparticles: From autoimmune disease control to the development of vaccines

Romina Mitarotonda et al.

Summary: The development of nanoparticles for therapeutic purposes, especially vaccines, has shown significant progress in recent years. Targeted delivery of vaccines through nanotechnology is expected to increase the immune response potential in the future. Ultimately, nanotechnology will be the foundation for future immunotherapy.

BIOMATERIALS ADVANCES (2022)

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Article Rheumatology

Risk factors associated with initiation of a biologic disease modifying anti-rheumatic drug in patients with rheumatoid arthritis: A nested case-control study on 34,925 patients

Eun Hye Park et al.

Summary: This study identified specific risk factors for the initiation of biological disease-modifying anti-rheumatic drugs (bDMARDs) in patients with rheumatoid arthritis (RA) in Korea. The results showed that aggressive treatment strategies early on may lead to less use of bDMARDs later on, while intensive therapy observed before bDMARD initiation may reflect the refractory nature of RA during that period.

JOINT BONE SPINE (2021)

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Article Rheumatology

Golimumab effectiveness in biologic inadequate responding patients with rheumatoid arthritis, psoriatic arthritis and spondyloarthritis in real-life from the Italian registry GISEA

Florenzo Iannone et al.

Summary: The study evaluated the clinical effectiveness of golimumab in biologic inadequate responder patients with RA, SpA, and PsA. Golimumab showed similar effectiveness in SpA and PsA patients, but was less effective in multi-failure RA patients, especially as monotherapy. Male patients had better outcomes.

JOINT BONE SPINE (2021)

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Review Pharmacology & Pharmacy

Preclinical discovery and development of adalimumab for the treatment of rheumatoid arthritis

Eleftherios Pelechas et al.

Summary: Adalimumab is a fully human TNF alpha inhibitor with a rapid onset of action. It has a generally good safety and efficacy profile. Due to its success, numerous biosimilars have emerged, but not for all indications of the bio-originator.

EXPERT OPINION ON DRUG DISCOVERY (2021)

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Review Immunology

Ixekizumab in the treatment of psoriatic arthritis

Eric Lespessailles et al.

Summary: Psoriatic arthritis (PsA) is a chronic rheumatic disorder with various phenotypic features. IL-17 plays a critical role in the onset of PsA, and the monoclonal antibody Ixekizumab, targeting IL-17A, has shown promising efficacy and safety in PsA treatment.

IMMUNOTHERAPY (2021)

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Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Review Immunology

The revisited role of interleukin-1 alpha and beta in autoimmune and inflammatory disorders and in comorbidities

Paola Galozzi et al.

Summary: The interleukin (IL) 1 family of cytokines plays a significant role in inflammation and immunity, with imbalance in IL-1 alpha and IL-1 beta signaling leading to severe inflammatory diseases. Inhibiting IL-1 signaling has been identified as an effective strategy to prevent and treat various inflammatory disorders.

AUTOIMMUNITY REVIEWS (2021)

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Review Chemistry, Medicinal

The Role of Chronic Inflammation in Various Diseases and Anti-inflammatory Therapies Containing Natural Products

Ren-Xiao Wang et al.

Summary: Chronic inflammation is a long-term immune response to harmful stimuli, implicated in the development of various diseases. Targeting inflammation presents new opportunities for treatment, and natural products show therapeutic potential for diseases associated with chronic inflammation.

CHEMMEDCHEM (2021)

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Review Medicine, General & Internal

An updated guide in the management of psoriasis for every practitioner

Teodora-Larisat Timis et al.

Summary: Psoriasis is a common chronic skin disorder with genetic and immunological components. Current treatments include topical drugs, phototherapy, systemic drugs, and biological agents, with topical and phototherapy typically used for mild to moderate cases, and systemic drugs and biologics for moderate to severe cases. It is important for physicians to understand the pathophysiological mechanisms of psoriasis and to recommend appropriate therapies for adult, pediatric, and pregnant patients based on individual characteristics and treatment guidelines.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2021)

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Review Biochemistry & Molecular Biology

The Role of TNF-α and Anti-TNF-α Agents during Preconception, Pregnancy, and Breastfeeding

Katarzyna Romanowska-Prochnicka et al.

Summary: TNF-alpha plays a crucial role in influencing hormone synthesis, placental architecture, and embryonic development during pregnancy. Increased levels of TNF-alpha are associated with pregnancy loss and preeclampsia, and may also impact trophoblast biology and maternal immune cells. Additionally, the release of cytokines and chemokines in syncytiotrophoblasts may be affected by chronic inflammatory diseases in pregnancy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Mast Cell Cytokines IL-1, IL-33, and IL-36 Mediate Skin Inflammation in Psoriasis: A Novel Therapeutic Approach with the Anti-Inflammatory Cytokines IL-37, IL-38, and IL-1Ra

Pio Conti et al.

Summary: Psoriasis is a skin disease characterized by autoimmune features and inflammatory symptoms, often accompanied by various comorbidities. Immune cells like MCs and cytokines such as IL-36 play significant roles in the inflammation process of psoriasis, while IL-38 and IL-37 may serve as potential therapeutic tools for inhibiting inflammation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Chemistry, Multidisciplinary

Toward a Better Regeneration through Implant-Mediated Immunomodulation: Harnessing the Immune Responses

Ben Zhang et al.

Summary: This review provides an in-depth analysis of immune response in tissue repair/regeneration and discusses various implant-mediated immunomodulation strategies. It focuses on major immune cells such as neutrophils, macrophages, and T cells, as well as methods to regulate immune response through physical, chemical, and biological cues. Finally, scaffold-facilitated regenerations of different tissue types are presented, highlighting the importance of immunomodulation in tissue regeneration.

ADVANCED SCIENCE (2021)

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Review Biochemistry & Molecular Biology

Gold Nanoparticles: Multifaceted Roles in the Management of Autoimmune Disorders

Khadijeh Koushki et al.

Summary: Gold nanoparticles have unique properties that make them ideal for research in bio-nanotechnology, with their ease of synthesis, stability, high drug-loading capacity, and biocompatibility. They have the potential to manage various autoimmune disorders by modulating toxicity, biodistribution, biocompatibility, and effects.

BIOMOLECULES (2021)

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Article Immunology

Regulatory T cell function in autoimmune disease

Anandi Rajendeeran et al.

Summary: Regulatory T cells play a crucial role in maintaining immune system balance in autoimmune diseases. Understanding and enhancing Treg function may be a significant direction for future treatment of autoimmune diseases.

JOURNAL OF TRANSLATIONAL AUTOIMMUNITY (2021)

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Article Immunology

Distinct roles of interleukin-17 and T helper 17 cells among autoimmune diseases

Shintaro Akiyama et al.

Summary: IL-17 and TH17 cells may have protective roles rather than pro-inflammatory roles in the intestine. IL-17 inhibition may induce inflammation in the intestine by favoring TH1 pathways, which explains the lack of response to IL-17 inhibitors in IBD.

JOURNAL OF TRANSLATIONAL AUTOIMMUNITY (2021)

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Review Biochemistry & Molecular Biology

Pattern recognition receptors in health and diseases

Danyang Li et al.

Summary: Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize specific molecular structures on pathogens, apoptotic host cells, and damaged senescent cells, bridging nonspecific immunity and specific immunity. Through the recognition and binding of ligands, PRRs can produce immunoprotective effects against infections and tumors. Research on PRRs and their ligands has greatly enhanced understanding of the signaling pathways involved, providing insights for the treatment of immune-related diseases and tumors.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Immunology

Th1, Th2, and Th17 cytokines in systemic lupus erythematosus

Farhana Muhammad Yusoff et al.

AUTOIMMUNITY (2020)

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Review Immunology

Understanding the immunopathogenesis of autoimmune diseases by animal studies using gene modulation: A comprehensive review

Keum Hwa Lee et al.

AUTOIMMUNITY REVIEWS (2020)

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Article Chemistry, Multidisciplinary

Biodegradable Nanocarriers Resembling Extracellular Vesicles Deliver Genetic Material with the Highest Efficiency to Various Cell Types

Yana Tarakanchikova et al.

SMALL (2020)

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Article Cell Biology

Gold Nanoparticles Modulate BCG-Induced Innate Immune Memory in Human Monocytes by Shifting the Memory Response towards Tolerance

Benjamin J. Swartzwelter et al.

CELLS (2020)

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Article Pharmacology & Pharmacy

Safety update of etanercept treatment for moderate to severe plaque psoriasis

Anna Campanati et al.

EXPERT OPINION ON DRUG SAFETY (2020)

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Review Immunology

Interleukin-2 as immunotherapeutic in the autoimmune diseases

Alexy Orozco Valencia et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis

Yen-Ju Lin et al.

CELLS (2020)

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Translating IL-6 biology into effective treatments

Ernest H. Choy et al.

NATURE REVIEWS RHEUMATOLOGY (2020)

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Review Engineering, Biomedical

Recent progress of graphene oxide as a potential vaccine carrier and adjuvant

Wanjun Cao et al.

ACTA BIOMATERIALIA (2020)

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Promising Nanotechnology Approaches in Treatment of Autoimmune Diseases of Central Nervous System

Maria Chountoulesi et al.

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Yijiao Qu et al.

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Risk of malignancy with non-TNFi biologic or tofacitinib therapy in rheumatoid arthritis: A meta-analysis of observational studies

Wenhui Xie et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2020)

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Immunomodulatory Dual-Sized Microparticle System Conditions Human Antigen Presenting Cells Into a Tolerogenic Phenotype In Vitro and Inhibits Type 1 Diabetes-Specific Autoreactive T Cell Responses

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FRONTIERS IN IMMUNOLOGY (2020)

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Jie Dong

FRONTIERS IN IMMUNOLOGY (2020)

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Parthopratim Dutta Majumder et al.

INDIAN JOURNAL OF OPHTHALMOLOGY (2020)

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Graphene quantum dots inhibit T cell-mediated neuroinflammation in rats

Jelena Tosic et al.

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Romina Mitarotonda et al.

CURRENT PHARMACEUTICAL DESIGN (2019)

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Jacek Hawiger et al.

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Sara Salvador-Martin et al.

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JOURNAL OF CROHNS & COLITIS (2019)

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Xiaoqian Niu et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

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Tolerogenic Ag-PLG nanoparticles induce tregs to suppress activated diabetogenic CD4 and CD8 T cells

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Abbas Shapouri-Moghaddam et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

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Marlene Seegraeber et al.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2018)

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Graphene oxide polarizes iNKT cells for production of TGFβ and attenuates inflammation in an iNKT cell-mediated sepsis model

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Quillaja brasiliensis saponin-based nanoparticulate adjuvants are capable of triggering early immune responses

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Rachel M. Wolfe et al.

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Review Medicine, General & Internal

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JOURNAL OF INTERNAL MEDICINE (2015)

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interleukin-2: Biology, Design and Application

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TRENDS IN IMMUNOLOGY (2015)

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Review Biochemistry & Molecular Biology

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Florian M. P. Meier et al.

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