期刊
CURRENT ORGANIC CHEMISTRY
卷 27, 期 4, 页码 297-307出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272827666230417104739
关键词
Photoclick reaction; bioorthogonal reaction; protein labeling; dipolar cycloaddition; tetrazole; SPAAC
Click reactions have become popular among chemists due to their ambient reaction parameters and wide application in various research fields. Photoinitiated click reactions provide additional spatial and temporal control, ensuring productive bioorthogonal reactions. This review discusses various types of 1,3-dipolar cycloaddition reactions and their applications in protein bioconjugation.
Click reactions have gained enormous popularity among chemists for their ambient reaction parameters and wide application in various frontier research fields. Photo-initiated click reactions add another dimension of spatiotemporal control which ensures fruitful bioorthogonal reaction. Several cycloaddition reactions, enlisted in the category of 'photo click' reactions due to the fast kinetics and ambient reaction conditions, are widely utilized by scientists for bioorthogonal conjugation. In this review, various types of 1,3-dipolar cycloaddition reactions and their applications in the field of protein bioconjugation are discussed.
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