4.4 Article

Pharmacology of pannexin channels

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cardiac & Cardiovascular Systems

Pannexin 1: a novel regulator of acute hypoxic pulmonary vasoconstriction

Benjamin Grimmer et al.

Summary: This study identifies Panx1 as a novel regulator of HPV, but its role is not necessarily linked to ATP release and downstream signaling via P2Y receptors or TRPV4 activation. Instead, Panx1 appears to modulate the Ca2+ response of PASMC to hypoxia. Furthermore, Panx1 does not affect the development of chronic hypoxic PH.

CARDIOVASCULAR RESEARCH (2022)

Review Biochemistry & Molecular Biology

The Anti-Inflammatory Properties of Licorice (Glycyrrhiza glabra)-Derived Compounds in Intestinal Disorders

Camila dos Santos Leite et al.

Summary: Intestinal diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancer (CRC), pose a significant health burden globally. Licorice, a traditional Chinese medicine, exhibits anti-inflammatory and antioxidant properties that may have therapeutic potential for intestinal disorders.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Physiology

GLIAL CONNEXINS AND PANNEXINS IN THE HEALTHY AND DISEASED BRAIN

Christian Giaume et al.

Summary: Over the past few decades, research has shown that glial cells interact dynamically with neurons, impacting their activity and survival. Connexins and pannexins play a key role in these interactions, and understanding their function can provide insights into neuronal behavior and aid in the development of therapeutic strategies for brain diseases.

PHYSIOLOGICAL REVIEWS (2021)

Review Biochemistry & Molecular Biology

Mechanisms of Connexin Regulating Peptides

D. Ryan King et al.

Summary: Gap junctions (GJ) and connexins are crucial in cellular physiology and have been investigated for their potential therapeutic applications in various diseases. Modulating GJ signaling pathways and designing peptides have shown promise as attractive targets for therapeutic intervention. However, the overall mechanisms of action of connexin targeting peptides are still not fully understood despite years of research.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biology

ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels

Adishesh K. Narahari et al.

Summary: The study demonstrated that Panx1 channels activated by caspase allow large molecule permeation, including anionic and large-molecule permeants, while also allowing large cationic molecules to permeate at a slower rate. Additionally, Panx1 channels provide a pathway for the flux of ATP and other signaling metabolites, both anionic (glutamate) and cationic (spermidine).
Article Biochemistry & Molecular Biology

Pannexin 1 binds beta-catenin to modulate melanoma cell growth and metabolism

Samar Sayedyahossein et al.

Summary: The study revealed a direct interaction between PANX1 and beta-catenin to modulate growth and metabolism in melanoma cells, providing mechanistic insight into melanoma progression. This interaction may be a new component of the Wnt signaling pathway in various contexts.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Review Biochemistry & Molecular Biology

Mechanisms of ATP release in pain: role of pannexin and connexin channels

Manuel F. Munoz et al.

Summary: Pain serves as a physiological response to bodily damage and can progress into chronic conditions with emotional and psychological aspects. Understanding the mechanisms of ATP release and the role of connexin and pannexin channels in pain processing remains an unresolved question.

PURINERGIC SIGNALLING (2021)

Article Biochemistry & Molecular Biology

A venous-specific purinergic signaling cascade initiated by Pannexin 1 regulates TNFα-induced increases in endothelial permeability

Daniela Maier-Begandt et al.

Summary: The study found that the proinflammatory cytokine TNF alpha specifically decreased barrier function in venous endothelium but not arterial endothelium, which was attributed to the differential expression of CLDN11. TNF alpha also increased the permselectivity of Cl- over Na+ in venous endothelium but not in arterial endothelium, indicating vein-specific effects.

SCIENCE SIGNALING (2021)

Review Cardiac & Cardiovascular Systems

Nonsteroidal Mineralocorticoid Receptor Antagonists: Exploring Role in Cardiovascular Disease

Kristin Watson et al.

Summary: Aldosterone plays a crucial role in cardiovascular diseases, but the use of traditional steroidal MRAs is often limited by the risk of hyperkalemia. Nonsteroidal MRAs have been developed to overcome this limitation and have the potential to reduce cardiac and renal outcomes in conditions like heart failure, hypertension, and type 2 diabetes with renal disease.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2021)

Article Multidisciplinary Sciences

Discovery of a natural cyan blue: A unique food-sourced anthocyanin could replace synthetic brilliant blue

Pamela R. Denish et al.

Summary: The color of food plays a critical role in the food and beverage industries, with blue being one of the rarest colors in natural food. Finding a natural blue food colorant remains a challenge for the global food industry, and a multidisciplinary approach has been demonstrated to be powerful in addressing this issue.

SCIENCE ADVANCES (2021)

Review Biochemistry & Molecular Biology

Pannexin 1 as a driver of inflammation and ischemia-reperfusion injury

Michael Koval et al.

Summary: Panx1 is a widely expressed protein forming large channels involved in inflammation and injury responses by releasing ATP and metabolites. It plays a crucial role in mediating signaling in response to pro-inflammatory stimuli, with a focus on vasculature coordination.

PURINERGIC SIGNALLING (2021)

Review Oncology

Pannexin biology and emerging linkages to cancer

Dale W. Laird et al.

Summary: Pannexins, including PANX1, PANX2, and PANX3, play a role in connecting the cytoplasm to the extracellular milieu and have been implicated in promoting tumor growth and metastasis in many tumor cells. Thus, blocking Pannexins may have utility in cancer therapeutics.

TRENDS IN CANCER (2021)

Review Biochemistry & Molecular Biology

Pannexin 1 Channels as a Therapeutic Target: Structure, Inhibition, and Outlook

Kathleen E. Navis et al.

ACS CHEMICAL NEUROSCIENCE (2020)

Article Multidisciplinary Sciences

Structures of human pannexin 1 reveal ion pathways and mechanism of gating

Zheng Ruan et al.

NATURE (2020)

Review Neurosciences

Regulation of pannexin channels in the central nervous system by Src family kinases

Alexander W. Lohman et al.

NEUROSCIENCE LETTERS (2019)

Article Biochemistry & Molecular Biology

Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane

Leon J. DeLalio et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Review Physiology

The Role of Connexin and Pannexin Channels in Perinatal Brain Injury and Inflammation

Kelly Q. Zhou et al.

FRONTIERS IN PHYSIOLOGY (2019)

Article Multidisciplinary Sciences

Role of pannexin-1 in the cellular uptake, release and hydrolysis of anandamide by T84 colon cancer cells

Mireille Alhouayek et al.

SCIENTIFIC REPORTS (2019)

Article Peripheral Vascular Disease

Probenecid Inhibits -Adrenergic Receptor-Mediated Vasoconstriction in the Human Leg Vasculature

Michael Nyberg et al.

HYPERTENSION (2018)

Review Physiology

Revisiting multimodal activation and channel properties of Pannexin 1

Yu-Hsin Chiu et al.

JOURNAL OF GENERAL PHYSIOLOGY (2018)

Article Physiology

Pannexin-1 channels on endothelial cells mediate vascular inflammation during lung ischemia-reperfusion injury

Ashish K. Sharma et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2018)

Review Biochemistry & Molecular Biology

Connexins and Pannexins in Vascular Function and Disease

Filippo Molica et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Cardiac & Cardiovascular Systems

Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone

Miranda E. Good et al.

CIRCULATION RESEARCH (2018)

Article Biochemistry & Molecular Biology

Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents

Nicole E. Burma et al.

NATURE MEDICINE (2017)

Article Multidisciplinary Sciences

A quantized mechanism for activation of pannexin channels

Yu-Hsin Chiu et al.

Nature Communications (2017)

Article Physiology

Carbenoxolone inhibits Pannexin1 channels through interactions in the first extracellular loop

Kevin Michalski et al.

JOURNAL OF GENERAL PHYSIOLOGY (2016)

Review Cell Biology

Next-Generation Connexin anc Pannexin Cell Biology

Jessica L. Esseltine et al.

TRENDS IN CELL BIOLOGY (2016)

Article Biochemistry & Molecular Biology

Emerging concepts regarding pannexin 1 in the vasculature

Miranda E. Good et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2015)

Article Multidisciplinary Sciences

Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation

Alexander W. Lohman et al.

NATURE COMMUNICATIONS (2015)

Review Biochemistry & Molecular Biology

Pannexin channels and their links to human disease

Silvia Penuela et al.

BIOCHEMICAL JOURNAL (2014)

Review Biochemistry & Molecular Biology

Pannexin-1 as a potentiator of ligand-gated receptor signaling

Brant E. Isakson et al.

CHANNELS (2014)

Article Biochemistry & Molecular Biology

Pannexin1 channels act downstream of P2X7 receptors in ATP-induced murine T-cell death

Kenji F. Shoji et al.

CHANNELS (2014)

Article Biochemistry & Molecular Biology

Activation, Permeability, and Inhibition of Astrocytic and Neuronal Large Pore (Hemi)channels

Daniel Bloch Hansen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Multidisciplinary Sciences

Unexpected link between an antibiotic, pannexin channels and apoptosis

Ivan K. H. Poon et al.

NATURE (2014)

Review Physiology

The pannexins: past and present

Stephen R. Bond et al.

FRONTIERS IN PHYSIOLOGY (2014)

Article Physiology

The food dye FD&C Blue No. 1 is a selective inhibitor of the ATP release channel Panx1

Junjie Wang et al.

JOURNAL OF GENERAL PHYSIOLOGY (2013)

Review Neurosciences

The bizarre pharmacology of the ATP release channel pannexin1

Gerhard Dahl et al.

NEUROPHARMACOLOGY (2013)

Article Multidisciplinary Sciences

Pannexin 1 involvement in bladder dysfunction in a multiple sclerosis model

Hiromitsu Negoro et al.

SCIENTIFIC REPORTS (2013)

Article Cell Biology

Thrombin-induced ATP release from human umbilical vein endothelial cells

Stefanie Goedecke et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2012)

Article Biochemistry & Molecular Biology

Pannexin1 Drives Multicellular Aggregate Compaction via a Signaling Cascade That Remodels the Actin Cytoskeleton

Brian A. Bao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Homeostasis of Extracellular ATP in Human Erythrocytes

Nicolas Montalbetti et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Multidisciplinary Sciences

Targeting Pannexin1 Improves Seizure Outcome

Marcelo F. Santiago et al.

PLOS ONE (2011)

Article Biochemistry & Molecular Biology

A New Mode of Mineralocorticoid Receptor Antagonism by a Potent and Selective Nonsteroidal Molecule

Jerome Fagart et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Cell Biology

A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP

Feng Qiu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2009)

Article Biochemistry & Molecular Biology

Mefloquine Blockade of Pannexin1 Currents: Resolution of a Conflict

Rodolfo Iglesias et al.

CELL COMMUNICATION AND ADHESION (2009)

Article Pharmacology & Pharmacy

Pharmacological Characterization of Pannexin-1 Currents Expressed in Mammalian Cells

Weihong Ma et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)

Article Cell Biology

P2X7 receptor-Pannexin1 complex:: pharmacology and signaling

R. Iglesias et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2008)

Article Cell Biology

Probenecid, a gout remedy, inhibits pannexin 1 channels

William Silverman et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2008)

Article Multidisciplinary Sciences

Activation of Pannexin-1 Hemichannels Augments Aberrant Bursting in the Hippocampus

Roger J. Thompson et al.

SCIENCE (2008)

Article Cell Biology

Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters

Junjie Wang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)

Article Multidisciplinary Sciences

The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds

Yi-Jen Huang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Biochemistry & Molecular Biology

Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor

Pablo Pelegrin et al.

EMBO JOURNAL (2006)

Article Biochemistry & Molecular Biology

Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes

R Bruzzone et al.

JOURNAL OF NEUROCHEMISTRY (2005)

Article Multidisciplinary Sciences

Potent block of Cx36 and Cx50 gap junction channels by mefloquine

SJ Cruikshank et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

Connexin mimetic peptides: specific inhibitors of gap-junctional intercellular communication

WH Evans et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2001)