☆ 4.4 Review

Anticoagulation and hemostasis on extracorporeal membrane oxygenation

CURRENT OPINION IN PEDIATRICS (2023)

相关参考文献

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Article Engineering, Biomedical

2021 ELSO Adult and Pediatric Anticoagulation Guidelines

Ali B. McMichael et al.

Summary: These guidelines provide educational information for adult and pediatric anticoagulation in extracorporeal membrane oxygenation, aiming to support physicians and other health professionals in assessing and managing patients undergoing ECLS / ECMO. However, they are not consensus recommendations and do not guarantee successful outcomes. Adherence to guidelines should be coupled with clinical judgment and individual patient consultation.

ASAIO JOURNAL (2022)

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Article Engineering, Biomedical

Platelet Transfusion and In-Hospital Mortality in Veno-Arterial Extracorporeal Membrane Oxygenation Patients

Michael Mazzeffi et al.

Summary: Thrombocytopenia during ECMO is associated with higher in-hospital mortality, especially in patients who receive 4 or more platelet transfusions. Randomized controlled trials are needed to determine appropriate indications for platelet transfusion in ECMO patients.

ASAIO JOURNAL (2022)

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Article Critical Care Medicine

RBC Transfusion in Venovenous Extracorporeal Membrane Oxygenation: A Multicenter Cohort Study

Senta Jorinde Raasveld et al.

Summary: This study aims to provide an overview of red blood cell transfusion in patients on venovenous extracorporeal membrane oxygenation. The study found that red blood cell transfusion has a high occurrence rate even in non-bleeding patients on extracorporeal membrane oxygenation.

CRITICAL CARE MEDICINE (2022)

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Article Critical Care Medicine

What Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding

Meghan Delaney et al.

Summary: This study provides guidance and expert consensus on laboratory testing and blood product attributes for plasma and platelet transfusions in critically ill pediatric patients.

PEDIATRIC CRITICAL CARE MEDICINE (2022)

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Article Critical Care Medicine

Plasma and Platelet Transfusions Strategies in Neonates and Children Undergoing Cardiac Surgery With Cardiopulmonary Bypass or Neonates and Children Supported by Extracorporeal Membrane Oxygenation: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding

Jill M. Cholette et al.

Summary: This study aims to present recommendations and consensus statements on plasma and platelet transfusions in critically ill neonates and children undergoing cardiac surgery. Lack of evidence hinders the establishment of clear indications for plasma and platelet transfusions in these patients.

PEDIATRIC CRITICAL CARE MEDICINE (2022)

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Review Critical Care Medicine

Role of extracorporeal membrane oxygenation in pediatric cancer patients: a systematic review and meta-analysis of observational studies

Valerie Slooff et al.

Summary: The use of ECMO in pediatric patients with underlying malignancies is controversial. This study aimed to estimate the outcome and complications of ECMO treatment in these children. The results showed higher mortality rates for children with malignancies receiving ECMO compared to general PICU patients, suggesting the need for additional data to determine the patients who may benefit or be harmed by ECMO.

ANNALS OF INTENSIVE CARE (2022)

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Review Medicine, General & Internal

The Changing Landscape of Anticoagulation in Pediatric Extracorporeal Membrane Oxygenation: Use of the Direct Thrombin Inhibitors

Cindy Neunert et al.

Summary: Bleeding and thrombosis are common complications in pediatric patients undergoing ECMO therapy. While unfractionated heparin (UFH) is commonly used as an anticoagulant, it has several disadvantages. Direct thrombin inhibitors (DTIs) may be a promising alternative. This review discusses the use of UFH and DTIs in pediatric ECMO therapy.

FRONTIERS IN MEDICINE (2022)

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Article Cardiac & Cardiovascular Systems

Impact of fresh frozen plasma transfusion on mortality in extracorporeal membrane oxygenation

Zhenglian Luo et al.

Summary: This study found a significant correlation between FFP transfusion and in-hospital mortality in ECMO patients. Higher APTT, higher levels of UA, and lower PLT counts were identified as risk factors for FFP transfusion.

PERFUSION-UK (2022)

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Review Cardiac & Cardiovascular Systems

Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis

Ariane Willems et al.

Summary: A comparative study of anticoagulation strategies in patients receiving ECMO treatment revealed that an anti-Xa-based approach was associated with fewer bleeding events and lower mortality rates compared to a time-based strategy, with no significant increase in thrombotic events.

PERFUSION-UK (2021)

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Article Hematology

Platelet transfusion is associated with 90-day and 1-year mortality for adult patients requiring veno-arterial extracorporeal membrane oxygenation

Stephen A. Esper et al.

Summary: Platelet transfusion was associated with increased 90-day and 1-year mortality for patients requiring VA-ECMO, while no individual component blood product was associated with one-year mortality for patients requiring VV-ECMO.

VOX SANGUINIS (2021)

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Article Critical Care Medicine

Comparison of Bivalirudin Versus Heparin for Maintenance Systemic Anticoagulation During Adult and Pediatric Extracorporeal Membrane Oxygenation

Troy G. Seelhammer et al.

Summary: The study compared the effects of conventional heparin and bivalirudin anticoagulants in adult and pediatric patients receiving extracorporeal membrane oxygenation support. The adult group using bivalirudin showed reduced hospital mortality, while the pediatric group had decreased transfusion requirements in the first 24 hours. No significant differences were found between the two groups in terms of age, sex, and treatment-related complications.

CRITICAL CARE MEDICINE (2021)

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Article Critical Care Medicine

Anticoagulation and Transfusion Management During Neonatal and Pediatric Extracorporeal Membrane Oxygenation: A Survey of Medical Directors in the United States*

Caroline P. Ozment et al.

Summary: Comparison of anticoagulation management and blood transfusion practices in neonatal and pediatric extracorporeal membrane oxygenation patients in the United States shows wide variations, with most centers using heparin as the primary anticoagulant and a combination of monitoring assays. Platelet transfusion thresholds vary widely, highlighting the need for future research to establish optimal management strategies.

PEDIATRIC CRITICAL CARE MEDICINE (2021)

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Article Pediatrics

Epidemiology of the Use of Hemostatic Agents in Children Supported by Extracorporeal Membrane Oxygenation: A Pediatric Health Information System Database Study

Marianne E. Nellis et al.

Summary: Children supported by ECMO receive a significant number of hemostatic blood products, with a rising trend in the use of antifibrinolytics such as TXA. Further studies are needed to evaluate the effectiveness of these hemostatic strategies.

FRONTIERS IN PEDIATRICS (2021)

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Article Engineering, Biomedical

Correlation Among Antifactor Xa, Activated Partial Thromboplastin Time, and Heparin Dose and Association with Pediatric Extracorporeal Membrane Oxygenation Complications

Ali B. V. McMichael et al.

ASAIO JOURNAL (2020)

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Article Critical Care Medicine

Platelet Transfusion Practice and Related Outcomes in Pediatric Extracorporeal Membrane Oxygenation*

Katherine Cashen et al.

PEDIATRIC CRITICAL CARE MEDICINE (2020)

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Article Critical Care Medicine

Pediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines*

Marianne E. Nellis et al.

PEDIATRIC CRITICAL CARE MEDICINE (2020)

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Article Engineering, Biomedical

Impact of Circuit Size on Coagulation and Hemolysis Complications in Pediatric Extracorporeal Membrane Oxygenation

Timothy M. Maul et al.

ASAIO JOURNAL (2020)

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Article Critical Care Medicine

Evaluation of Bivalirudin As an Alternative to Heparin for Systemic Anticoagulation in Pediatric Extracorporeal Membrane Oxygenation*

Mohammed Hamzah et al.

PEDIATRIC CRITICAL CARE MEDICINE (2020)

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Article Critical Care Medicine

Epidemiology of Hemostatic Transfusions in Children Supported by Extracorporeal Membrane Oxygenation

Oliver Karam et al.

CRITICAL CARE MEDICINE (2020)

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Article Critical Care Medicine

Prospective Exploratory Experience With Bivalirudin Anticoagulation in Pediatric Extracorporeal Membrane Oxygenation

Lindsay M. Ryerson et al.

PEDIATRIC CRITICAL CARE MEDICINE (2020)

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Article Critical Care Medicine

Quantifiable Bleeding in Children Supported by Extracorporeal Membrane Oxygenation and Outcome

Marianne E. Nellis et al.

CRITICAL CARE MEDICINE (2019)

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Article Cardiac & Cardiovascular Systems

Extracorporeal membrane oxygenation support in pediatrics

Tugba Erdil et al.

ANNALS OF CARDIOTHORACIC SURGERY (2019)

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Article Critical Care Medicine

RBC Transfusion Practice in Pediatric Extracorporeal Membrane Oxygenation Support

Jennifer A. Muszynski et al.

CRITICAL CARE MEDICINE (2018)

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Article Critical Care Medicine

RBC Exposure in Pediatric Extracorporeal Membrane Oxygenation: Epidemiology and Factors Associated With Large Blood Transfusion Volume*

Conor P. O'Halloran et al.

PEDIATRIC CRITICAL CARE MEDICINE (2018)

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Article Critical Care Medicine

Recommendations on the Indications for RBC Transfusion for the Critically III Child Receiving Support From Extracorporeal Membrane Oxygenation, Ventricular Assist, and Renal Replacement Therapy Devices From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative

Melania M. Bembea et al.

PEDIATRIC CRITICAL CARE MEDICINE (2018)

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Article Critical Care Medicine

Factors Associated with Bleeding and Thrombosis in Children Receiving Extracorporeal Membrane Oxygenation

Heidi J. Dalton et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

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Article Medical Laboratory Technology

Management of Anticoagulation and Hemostasis for Pediatric Extracorporeal Membrane Oxygenation

Arun Saini et al.

CLINICS IN LABORATORY MEDICINE (2014)

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Article Critical Care Medicine

RBC Transfusion in Pediatric Patients Supported With Extracorporeal Membrane Oxygenation: Is There an Impact on Tissue Oxygenation?

Richard T. Fiser et al.

PEDIATRIC CRITICAL CARE MEDICINE (2014)

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Article Critical Care Medicine

Anti-Factor Xa Assay Is a Superior Correlate of Heparin Dose Than Activated Partial Thromboplastin Time or Activated Clotting Time in Pediatric Extracorporeal Membrane Oxygenation

Anna Liveris et al.

PEDIATRIC CRITICAL CARE MEDICINE (2014)

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Article Engineering, Biomedical

Anticoagulation Monitoring during Pediatric Extracorporeal Membrane Oxygenation

Melania M. Bembea et al.

ASAIO JOURNAL (2013)

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Article Critical Care Medicine

Variability in Anticoagulation Management of Patients on Extracorporeal Membrane Oxygenation: An International Survey

Melania M. Bembea et al.

PEDIATRIC CRITICAL CARE MEDICINE (2013)

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Article Pathology

Evaluation of Heparin Assay for Coagulation Management in Newborns Undergoing ECMO

Wassia A. Khaja et al.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2010)

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Article Anesthesiology

Anticoagulation and Coagulation Management for ECMO

William C. Oliver

SEMINARS IN CARDIOTHORACIC AND VASCULAR ANESTHESIA (2009)

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Article Cardiac & Cardiovascular Systems

Anticoagulation and pediatric extracorporeal membrane oxygenation: Impact of activated clotting time and heparin dose on survival

Christopher W. Baird et al.

ANNALS OF THORACIC SURGERY (2007)

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Article Critical Care Medicine

The use of the activated clotting time for monitoring heparin therapy in critically ill patients

JJ Waele et al.

INTENSIVE CARE MEDICINE (2003)

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