☆ 4.1 Review

Optimizing liver transplant prioritization for hepatocellular carcinoma through risk stratification

CURRENT OPINION IN ORGAN TRANSPLANTATION (2023)

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Editorial Material Gastroenterology & Hepatology

Decreased Urgency Among Liver Transplantation Candidates With Hepatocellular Carcinoma in the United States

Allison J. Kwong et al.

LIVER TRANSPLANTATION (2022)

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Article Gastroenterology & Hepatology

The Impact of Median Model for End-Stage Liver Disease at Transplant Minus 3 National Policy on Waitlist Outcomes in Patients With and Without Hepatocellular Carcinoma

Sarah Bernards et al.

Summary: The UNOS policy to limit exception points for liver cancer patients on the waitlist has successfully reduced the dropout probability and equalized waitlist dropout rates between patients with and without HCC. However, it has also disadvantaged certain HCC patients.

LIVER TRANSPLANTATION (2022)

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Article Gastroenterology & Hepatology

National Trends and Waitlist Outcomes of Locoregional Therapy Among Liver Transplant Candidates With Hepatocellular Carcinoma in the United States

Allison J. Kwong et al.

Summary: The utilization of locoregional therapy, especially radioembolization, is increasing among liver transplant candidates in the United States. Patients with greater tumor burden and more compensated liver disease receive more treatments while waiting for transplantation. Bridging therapy is associated with a lower risk of waitlist dropout.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Article Surgery

OPTN/SRTR 2020 Annual Data Report: Liver

A. J. Kwong et al.

Summary: The COVID-19 pandemic had a significant impact on transplant programs and outcomes, but the number of liver transplants performed in the United States reached a record high. Living donation activity decreased, but the survival rates for patients with liver transplants continued to improve. The liver transplant waitlists for both adults and children decreased in size, and a new liver distribution policy based on acuity circles was implemented. The predominant indication for liver transplants among adults in 2020 was alcohol-associated liver disease.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

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Article Gastroenterology & Hepatology

Impact of major hepatocellular carcinoma policy changes on liver transplantation for hepatocellular carcinoma in the United States

Rahil H. Shah et al.

Summary: Changes in hepatocellular carcinoma (HCC) exception policies based on the Model for End-Stage Liver Disease (MELD) have had an impact on transplant rates and waitlist mortality. However, the impact varies across geographic areas.

LIVER TRANSPLANTATION (2022)

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Article Gastroenterology & Hepatology

Favorable Survival with Non-curative Treatments for Patients with Early-Stage Hepatocellular Carcinoma After Liver Transplant Denial

Andreas Zori et al.

Summary: In this study, patients with early-stage HCC who were denied liver transplant listing due to non-tumor reasons and instead underwent locoregional therapy (LRT) had favorable overall survival, with those with Child-Pugh A cirrhosis showing significantly longer survival compared to those with Child-Pugh B/C cirrhosis. Patients with Child-Pugh A cirrhosis had survival rates approaching the national average for liver transplant recipients, while those with Child-Pugh B/C cirrhosis had significantly worse outcomes.

DIGESTIVE DISEASES AND SCIENCES (2021)

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Review Transplantation

Evaluation and selection of the liver transplant candidate: updates on a dynamic and evolving process

Michael Kriss et al.

Summary: Advancements in liver transplant evaluation, including dynamic frailty indices, expanded criteria for transplant candidacy and improved diagnostics, have transformed candidate selection. Donor selection, with the introduction of hypothermic organ preservation and expansion of donor sources, has become integral to the evaluation process. Refinements in evaluating critically ill patients, such as those with acute alcohol-related hepatitis, aid in balancing futility versus utility in liver transplant selection.

CURRENT OPINION IN ORGAN TRANSPLANTATION (2021)

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Article Gastroenterology & Hepatology

A novel waitlist dropout score for hepatocellular carcinoma - identifying a threshold that predicts worse post-transplant survival

Neil Mehta et al.

Summary: The study analyzed the risk of wait-list dropout among patients with hepatocellular carcinoma in different regions and found that patients with higher dropout risk scores may have poorer post-transplant survival.

JOURNAL OF HEPATOLOGY (2021)

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Review Gastroenterology & Hepatology

Epidemiology and surveillance for hepatocellular carcinoma: New trends

Amit G. Singal et al.

JOURNAL OF HEPATOLOGY (2020)

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Article Surgery

Development and validation of an optimized prediction of mortality for candidates awaiting liver transplantation

Dimitris Bertsimas et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2019)

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Article Surgery

Predictors of low risk for dropout from the liver transplant waiting list for hepatocellular carcinoma in long wait time regions: Implications for organ allocation

Neil Mehta et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2019)

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Article Gastroenterology & Hepatology

Increasing Liver Transplantation Wait-List Dropout for Hepatocellular Carcinoma With Widening Geographical Disparities: Implications for Organ Allocation

Neil Mehta et al.

LIVER TRANSPLANTATION (2018)

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Article Gastroenterology & Hepatology

Intention-to-Treat Survival Benefit of Liver Transplantation in Patients With Hepatocellular Cancer

Quirino Lai et al.

HEPATOLOGY (2017)

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Article Surgery

Comparison of two equivalent model for end-stage liver disease scores for hepatocellular carcinoma patients using data from the United Network for Organ Sharing liver transplant waiting list registry

Sarah K. Alver et al.

TRANSPLANT INTERNATIONAL (2017)

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Article Gastroenterology & Hepatology

Comparison of Liver Transplant-Related Survival Benefit in Patients With Versus Without Hepatocellular Carcinoma in the United States

Kristin Berry et al.

GASTROENTEROLOGY (2015)

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Article Gastroenterology & Hepatology

MELDEQ: An Alternative Model for End-Stage Liver Disease Score for Patients With Hepatocellular Carcinoma

Michael R. Marvin et al.

LIVER TRANSPLANTATION (2015)

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Article Gastroenterology & Hepatology

A method for establishing allocation equity among patients with and without hepatocellular carcinoma on a common liver transplant waiting list

Alessandro Vitale et al.

JOURNAL OF HEPATOLOGY (2014)

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Article Gastroenterology & Hepatology

Identification of Liver Transplant Candidates With Hepatocellular Carcinoma and a Very Low Dropout Risk: Implications for the Current Organ Allocation Policy

Neil Mehta et al.

LIVER TRANSPLANTATION (2013)

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Article Surgery

Risk factors for liver transplant waitlist dropout in patients with hepatocellular carcinoma

Sang-Jae Park et al.

CLINICAL TRANSPLANTATION (2012)

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Article Gastroenterology & Hepatology

A model for dropout assessment of candidates with or without hepatocellular carcinoma on a common liver transplant waiting list

Christian Toso et al.

HEPATOLOGY (2012)

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