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Melatonin as a Harmonizing Factor of Circadian Rhythms, Neuronal Cell Cycle and Neurogenesis: Additional Arguments for Its Therapeutic Use in Alzheimer's Disease

CURRENT NEUROPHARMACOLOGY (2023)

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Review Neurosciences

Melatonin as a Chronobiotic with Sleep-promoting Properties

Francy Cruz-Sanabria et al.

Summary: In this study, the use of exogenous melatonin (exo-MEL) as a sleep-promoting drug is comprehensively reviewed. The pharmacological mechanisms, clinical outcomes, and factors such as timing of administration and doses are discussed. The effects of exo-MEL are interpreted in relation to changes in endogenous melatonin.

CURRENT NEUROPHARMACOLOGY (2023)

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Review Geriatrics & Gerontology

Aging, circadian disruption and neurodegeneration: Interesting interplay

Avnish Kumar Verma et al.

Summary: The circadian system is a complex molecular network that coordinates the internal synchronization of an organism in response to the environment. Aging affects circadian clock functioning and can lead to neurological anomalies, while environmental factors such as Artificial Light at Night (ALAN) can cause circadian disruption and result in pathological diseases. There is evidence suggesting that circadian dysregulation may be a predisposing factor for age-related neurodegenerative diseases, although more research is needed. Chrono-enhancement approaches have been proposed as intervention strategies to mitigate the impacts of circadian disruption.

EXPERIMENTAL GERONTOLOGY (2023)

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Review Cell Biology

Melatonin: a multitasking indoleamine to modulate hippocampal neurogenesis

Alejandro Romero et al.

Summary: Neurodegeneration affects various cell types and the potential of neural stem cells to generate new neuronal populations may be a relevant factor in fighting neurodegeneration and aging. Recent evidence suggests that melatonin may modulate adult hippocampal neurogenesis. Preclinical studies have shown that melatonin can enhance molecular and signaling pathways involved in neurogenesis. This article summarizes the current knowledge and highlights the therapeutic potential of melatonin in neurodegeneration.

NEURAL REGENERATION RESEARCH (2023)

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Review Behavioral Sciences

Effects of melatonin supplementation on BDNF concentrations and depression: A systematic review and meta-analysis of randomized controlled trials

Nafiseh Shokri-Mashhadi et al.

Summary: This comprehensive systematic review and meta-analysis aimed to evaluate the effects of melatonin supplementation on brain-derived neurotrophic factor (BDNF) concentration and clinical depressive disorder. The results showed that melatonin supplementation had no significant effect on BDNF concentration but improved depression. Subgroup analysis indicated that melatonin supplementation significantly decreased BDNF levels in doses <= 10 mg/day, with more than 4 weeks of duration, and in men.

BEHAVIOURAL BRAIN RESEARCH (2023)

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Article Biochemistry & Molecular Biology

REM Sleep Deprivation Alters Learning-Induced Cell Proliferation and Generation of Newborn Young Neurons in the Dentate Gyrus of the Dorsal Hippocampus

Shweta Tripathi et al.

Summary: The hippocampus-dependent trace-appetitive conditioning task can increase cell proliferation and the generation of newborn young neurons. Evidence suggests that adult hippocampal neurogenesis and rapid eye movement (REM) sleep play a crucial role in memory consolidation. However, REM sleep deprivation may have detrimental effects on cell proliferation in the hippocampus.

ACS CHEMICAL NEUROSCIENCE (2022)

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Review Clinical Neurology

A critical review of the pharmacological treatment of REM sleep behavior disorder in adults: time for more and larger randomized placebo-controlled trials

Moran Gilat et al.

Summary: RBD is a parasomnia causing patients to physically act out their dreams, with clonazepam and melatonin being the first-line pharmacological treatment options. Clinical observations show most patients have reported improvement with these drugs, although recent trials did not find them to be superior to placebo.

JOURNAL OF NEUROLOGY (2022)

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Review Biochemistry & Molecular Biology

p27, The Cell Cycle and Alzheimer′s Disease

Ana Garcia-Osta et al.

Summary: The cell cycle is regulated by factors such as p27(Kip1), which controls different functions in the nucleus and cytoplasm. In Alzheimer's disease, alterations to cell cycle events and increased neurogenesis have been observed, suggesting a role for p27(Kip1) in the disease process.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

A Growing Link between Circadian Rhythms, Type 2 Diabetes Mellitus and Alzheimer's Disease

Xuemin Peng et al.

Summary: T2DM patients are at higher risk of developing AD, and circadian rhythm disruption may contribute to both diseases. Promising therapeutic strategies for T2DM and AD include pharmacological and non-pharmacological treatments.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Neurosciences

Putative Factors Interfering Cell Cycle Re-Entry in Alzheimer's Disease: An Omics Study with Differential Expression Meta-Analytics and Co-Expression Profiling

Sze Chung Yuen et al.

Summary: This study utilized meta-analysis and co-expression analysis of omic data to identify putative factors in neuronal cell cycle re-entry (CCR) in Alzheimer's disease (AD). The results highlighted the importance of cellular dyshomeostasis and impaired ubiquitination proteasome system in CCR.

JOURNAL OF ALZHEIMERS DISEASE (2022)

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Article Neurosciences

FOXG1 as a Potential Therapeutic Target for Alzheimer's Disease with a Particular Focus on Cell Cycle Regulation

Jia Wang et al.

Summary: This study explores the role of FOXG1 in Alzheimer's disease (AD) and its involvement in cell cycle regulation. By negatively regulating the levels of p21-activated kinase (PAK3), FOXG1 inhibits cell cycle reentry and reduces neuronal apoptosis and Aβ deposition. Increasing the level of FOXG1 may present a therapeutic strategy for AD.

JOURNAL OF ALZHEIMERS DISEASE (2022)

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Review Neurosciences

Sleep and circadian rhythms in Parkinson's disease and preclinical models

Jeremy Hunt et al.

Summary: The use of animal models is crucial for understanding the mechanisms of Parkinson's disease. This review examines the extent to which different mouse models accurately reflect the sleep and circadian abnormalities observed in Parkinson's disease.

MOLECULAR NEURODEGENERATION (2022)

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Article Immunology

Aging disrupts circadian gene regulation and function in macrophages

Eran Blacher et al.

Summary: Aging is associated with the loss of diurnally rhythmic innate immune responses, particularly due to a decrease in Kruppel-like factor 4 (Klf4) expression in aged macrophages. Disruption of circadian innate immune homeostasis in aged macrophages may underlie the age-related loss of protective immune responses. These findings highlight KLF4 as a critical transcription factor regulating macrophage gene expression and phagocytosis in the context of aging.

NATURE IMMUNOLOGY (2022)

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Review Clinical Neurology

Circadian rhythms in neurodegenerative disorders

Malik Nassan et al.

Summary: The circadian system governs physiological processes like sleep, alertness, and cognition, and disruptions in circadian homeostasis can have detrimental effects on human health, especially in neurodegenerative disorders. There is a bidirectional relationship between circadian function and neurodegeneration, highlighting the importance of studying circadian disruption in these disorders. Research in this field could lead to novel circadian-based therapeutic interventions for disabling conditions like Parkinson's, Alzheimer's, and other neurodegenerative diseases.

NATURE REVIEWS NEUROLOGY (2022)

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Review Medicine, Research & Experimental

Benefits and adverse events of melatonin use in the elderly (Review)

Lucretia Anghel et al.

Summary: Melatonin is a hormone secreted by the pineal gland that plays a role in circadian rhythm regulation. Decreased melatonin secretion with age may contribute to neurodegenerative diseases and other disorders. Melatonin has sleep-inducing, cytoprotective, and anti-inflammatory properties. However, there is inconsistency in scientific data regarding the optimal dose and long-term safety of melatonin.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2022)

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Review Cell Biology

Adult Neurogenesis under Control of the Circadian System

Amira A. H. Ali et al.

Summary: This review discusses the role of the circadian system in adult neurogenesis at both the systemic and cellular levels. Better understanding of this role can help develop new treatment strategies to improve cognitive deterioration associated with chronodisruption or neurodegenerative diseases.

CELLS (2022)

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Article Biology

Melatonin exerts neuroprotection in a chronodisrupted rat model through reduction in oxidative stress and modulation of autophagy

Avnish Kumar Verma et al.

Summary: The study showed that melatonin can exert a potent neuroprotective effect by reducing oxidative stress, inflammation, and autophagy. Melatonin supplementation may be a promising neurotherapeutic approach for treating neurodegenerative disorders caused by circadian disturbances.

CHRONOBIOLOGY INTERNATIONAL (2022)

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Review Biochemistry & Molecular Biology

Melatonin in ventricular and subarachnoid cerebrospinal fluid: Its function in the neural glymphatic network and biological significance for neurocognitive health

Russel J. Reiter et al.

Summary: The central nervous system has a specialized cerebrospinal fluid/lymph network called the glymphatic system, which removes toxic molecules and metabolic by-products from the neural parenchyma. Melatonin, released directly into the cerebrospinal fluid, functions as a potent antioxidant and anti-inflammatory agent, and can remove pathogenic toxins from the brain.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

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Review Endocrinology & Metabolism

Role of melatonin in Alzheimer's disease: From preclinical studies to novel melatonin-based therapies

Jaydeep Roy et al.

Summary: In this review, the developmental trends and neuroprotective mechanisms of melatonin therapies for Alzheimer's disease (AD) are examined. Melatonin has been shown to alleviate various pathological processes in AD and beneficially affect behavior in animal models. Clinical studies demonstrate positive effects of melatonin on sleep, cognition, behavior, and psychiatric symptoms in AD patients.

FRONTIERS IN NEUROENDOCRINOLOGY (2022)

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Review Geriatrics & Gerontology

Melatonin as an Anti-Aging Therapy for Age-Related Cardiovascular and Neurodegenerative Diseases

Virna Margarita Martin Gimenez et al.

Summary: Aging is a gradual process that leads to increased vulnerability to weakness, disease, and death. It affects cellular, organ, and overall organism functions, resulting in various dysfunctions and impairments. Aging is associated with the development and progression of diseases, particularly in the cardiovascular and central nervous systems.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Review Biochemistry & Molecular Biology

Melatonin: A Neurotrophic Factor?

Armida Miranda-Riestra et al.

Summary: Melatonin, a hormone that synchronizes the internal environment with the photoperiod, has various functions such as regulating sleep-wake rhythm, body temperature, immune system, cardiovascular system, and providing neuroprotection by scavenging free radicals. Recent research supports its role as a neurotrophic factor, contributing to neuronal survival, proliferation, and differentiation.

MOLECULES (2022)

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Review Neurosciences

The Role of DNA Damage in Neural Plasticity in Physiology and Neurodegeneration

Anna Konopka et al.

Summary: DNA damage and repair play important roles in neural plasticity and may contribute to neurodegenerative diseases.

FRONTIERS IN CELLULAR NEUROSCIENCE (2022)

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Review Medicine, Research & Experimental

Cdk5-p25 as a key element linking amyloid and tau pathologies in Alzheimer's disease: Mechanisms and possible therapeutic interventions

Subhamita Maitra et al.

Summary: Despite being expressed in various tissues, the activity of Cdk5 is limited to the central nervous system. Cdk5 plays a crucial role in the pathogenesis of Alzheimer's disease by being abnormally overactivated, leading to the hyper-phosphorylation of ll-amyloid precursor protein and tau and contributing to the development of the disease. Inhibiting the activity of Cdk5-p25 could be a promising strategy for anti-AD therapeutics.

LIFE SCIENCES (2022)

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Article Psychology, Biological

Melatonin treatment improves cognitive deficits by altering inflammatory and neurotrophic factors in the hippocampus of obese mice

Soraya Mansouri et al.

Summary: Overweight and obesity increase the risk of developing dementia and cognitive deficits. Neuroinflammation is a key mechanism behind cognitive impairment in obese patients. Melatonin treatment has shown potential therapeutic effects for memory decline in various conditions. This study found that melatonin treatment improved cognitive impairment in obese mice, reducing inflammation and increasing neurotrophic factors.

PHYSIOLOGY & BEHAVIOR (2022)

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Article Clinical Neurology

Melatonin (MEL) and its use in neurological diseases and insomnia: Recommendations of the French Medical and Research Sleep Society (SFRMS)

M. F. Vecchierini et al.

Summary: This article summarizes the main results of MEL therapy in some neurological diseases and insomnia approved by the consensus group. Studies show beneficial effects of MEL in mild cognitive impairment and Alzheimer patients with sleep disorders, but not in moderate to severe Alzheimer's disease.

REVUE NEUROLOGIQUE (2021)

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Review Cell Biology

Role of Human Mesenchymal Stem Cells in Regenerative Therapy

Jayavardini Vasanthan et al.

Summary: Mesenchymal stem cells (MSCs) are multipotent cells with the potential for tissue regeneration, can be easily isolated and cultured in vitro, and have been proven to be valuable for therapy. Quality control parameters, mechanisms of action, and applications in regenerative medicine and tissue engineering are important aspects to consider when utilizing MSCs.

CELLS (2021)

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Article Biochemistry & Molecular Biology

Obesity-linked circular RNA circTshz2-2 regulates the neuronal cell cycle and spatial memory in the brain

Gwangho Yoon et al.

Summary: Metabolic syndromes, including obesity, result in neuropathophysiological changes in the brain leading to cognitive deficits. A recently identified obesity-linked circRNA, circTshz2-2, was found to affect neuronal cell cycle and spatial memory. Dysregulation of circTshz2-2 alters gene expression related to cell division, impacts cell cycle progression, and influences memory function, highlighting a potential link between metabolic syndromes and cognitive impairments.

MOLECULAR PSYCHIATRY (2021)

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Article Neurosciences

Dysregulated clock gene expression and abnormal diurnal regulation of hippocampal inhibitory transmission and spatial memory in amyloid precursor protein transgenic mice

Allison R. Fusilier et al.

Summary: Research has shown disrupted circadian gene regulation, hippocampal physiology, and memory in AD mouse models, providing insights into possible chronotherapeutic strategies to ameliorate Alzheimer's disease symptoms or delay pathological onset.

NEUROBIOLOGY OF DISEASE (2021)

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Review Clinical Neurology

Melatonin levels in the Alzheimer's disease continuum: a systematic review

Amber Nous et al.

Summary: The systematic review found disruptions in (night-time) melatonin levels in AD patients compared to age-matched controls, indicating the potential use of melatonin as a blood biomarker for disease progression in AD. Further research is needed to understand the role of the melatonergic system in the pathophysiology of AD and to explore the potential anti-AD effects of melatonin as a future treatment option.

ALZHEIMERS RESEARCH & THERAPY (2021)

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Review Cell Biology

Exploring the multifunctional role of melatonin in regulating autophagy and sleep to mitigate Alzheimer's disease neuropathology

Md Farhad Hossain et al.

Summary: Melatonin plays crucial roles in Alzheimer's disease by promoting autophagy, improving sleep quality, and counteracting oxidative stress. The therapeutic potential of melatonin in AD may involve its multifunctional properties.

AGEING RESEARCH REVIEWS (2021)

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Review Biochemistry & Molecular Biology

Deciphering the Interacting Mechanisms of Circadian Disruption and Alzheimer's Disease

Md. Sahab Uddin et al.

Summary: Alzheimer's disease is a crucial factor in progressive dementia, characterized by the accumulation of amyloid beta plaques in the brain. The dysfunction of the circadian system in AD may lead to irregular sleep patterns, which in turn can exacerbate the progression of the disease. Understanding the interaction between circadian disruption and AD pathogenesis is important for earlier detection and potential therapies for dementia.

NEUROCHEMICAL RESEARCH (2021)

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Article Cell & Tissue Engineering

Melatonin induces the rejuvenation of long-term ex vivo expanded periodontal ligament stem cells by modulating the autophagic process

Yi-Zhou Tan et al.

Summary: The study showed that long-term ex vivo expansion can lead to cellular senescence and impaired autophagy, and melatonin can induce cellular rejuvenation by restoring autophagy, potentially through the PI3K/AKT/mTOR signaling pathway.

STEM CELL RESEARCH & THERAPY (2021)

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Review Pharmacology & Pharmacy

Melatonin as a Chronobiotic and Cytoprotective Agent in Parkinson's Disease

Santiago Perez-Lloret et al.

Summary: Melatonin may play a role in the prevention and treatment of Parkinson's disease, particularly in addressing sleep disorders. Disrupted melatonin receptor density in PD patients may contribute to alterations in the sleep/wake cycle.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Melatonin Protects against the Side-Effects of 5-Fluorouracil on Hippocampal Neurogenesis and Ameliorates Antioxidant Activity in an Adult Rat Hippocampus and Prefrontal Cortex

Kornrawee Suwannakot et al.

Summary: Melatonin has neuroprotective effects against 5-FU-induced oxidative stress by restoring antioxidant enzyme levels and protein expression in the rat hippocampus and PFC.

ANTIOXIDANTS (2021)

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Article Neurosciences

Neuronal Cell Cycle Re-Entry Enhances Neuropathological Features in AppNLF Knock-In Mice

Tomas Barrett et al.

Summary: The study reveals that forced neuronal cell cycle re-entry in mice expressing humanized A beta leads to the development of additional AD-related pathologies, including tau pathology, neuroinflammation, brain leukocyte infiltration, DNA damage response, and neurodegeneration. This highlights the significant role of aberrant cell cycle re-entry in AD pathogenesis and provides a unique mouse model for studying the disease.

JOURNAL OF ALZHEIMERS DISEASE (2021)

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Article Endocrinology & Metabolism

Treatment of isolated REM sleep behavior disorder using melatonin as a chronobiotic

Dieter Kunz et al.

Summary: The study found that clock-timed, low-dose, long-term melatonin treatment in patients with isolated REM sleep behavior disorder (iRBD) seems to be associated with symptom improvement, which can last for years, challenging the view of melatonin having purely symptomatic effects.

JOURNAL OF PINEAL RESEARCH (2021)

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Review Behavioral Sciences

Neurocognitive effects of melatonin treatment in healthy adults and individuals with Alzheimer's disease and insomnia: A systematic review and meta-analysis of randomized controlled trials

Dewan Md. Sumsuzzman et al.

Summary: Endogenous melatonin levels are inversely associated with age and cognitive deficits. Clinical trials show that melatonin may improve psychopathological behavior disturbances, but its effect on cognitive function is still unclear. The study found that melatonin treatment improved cognitive outcomes in Alzheimer's disease patients, especially in the mild stage. In healthy subjects, daytime melatonin treatment decreased accuracy but did not significantly affect reaction time or memory function.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

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Article Cell Biology

Integrative Functional Genomic Analysis of Molecular Signatures and Mechanistic Pathways in the Cell Cycle Underlying Alzheimer's Disease

Zhike Zhou et al.

Summary: This study identified differentially expressed cell cycle genes and trophic factor receptors in AD patients compared to nondementia controls, and constructed coexpression modules with the strongest correlation with AD. Through PCC analysis, key trophic receptors interacting with cell cycle genes were filtered, revealing important signaling pathways such as glutamatergic synapse and PI3K-Akt pathway, offering potential new targets for therapeutic intervention in AD.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Immunology

Circadian Clock Regulates Inflammation and the Development of Neurodegeneration

Xiao-Lan Wang et al.

Summary: The circadian clock plays a crucial role in regulating key physiological processes and maintaining homeostasis, with disruptions affecting immune response, brain function, and neurodegeneration. By controlling the clock mechanisms in immune and brain cells, as well as systemic inflammation, the circadian system may offer potential targets for preventing and treating inflammation and neurodegenerative diseases.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Review Neurosciences

Melatonin: From Neurobiology to Treatment

Giovanni Biggio et al.

Summary: Melatonin, as the major regulator of the sleep/wake cycle, has important physiological and pharmacological roles in controlling neuronal plasticity and neuroprotection. Its secretion peaks during brain development and decreases during aging, impacting sleep patterns and neuronal plasticity. Exogenous melatonin has shown effective chronobiotic and sleep promoting effects, leading to its recent recommendation for treating insomnia in individuals over 55 years old.

BRAIN SCIENCES (2021)

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Article Medicine, General & Internal

Association of Sleep and β-Amyloid Pathology Among Older Cognitively Unimpaired Adults

Philip S. Insel et al.

Summary: In older cognitively unimpaired adults, there is an association between nighttime sleep duration and regional Aβ pathology, with increased nighttime sleep duration linked to reduced Aβ standardized uptake value ratio. Daytime sleep may be associated with an increased risk for early Aβ accumulation, but does not compensate for the loss of nighttime sleep, demonstrating a circadian rhythm dependence of sleep in preventing Aβ accumulation.

JAMA NETWORK OPEN (2021)

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Review Clinical Neurology

Altered Biological Rhythm and Alzheimer's Disease: A Bidirectional Rela-tionship

Manli Wang et al.

Summary: Biological rhythm disruption has become a research focus in recent years, particularly in relation to Alzheimer's disease. Studies have shown that this disruption may occur before the onset of clinical symptoms of AD. Understanding the relationship between AD and biological rhythm disruption can help in early diagnosis and treatment of the disease.

CURRENT ALZHEIMER RESEARCH (2021)

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Review Medicine, Research & Experimental

Defining circadian disruption in neurodegenerative disorders

Christopher S. Colwell

Summary: Neurodegenerative diseases are complex disorders with diverse symptoms such as ataxias and dementias. One common symptom among these diseases is disruption of the sleep/wake cycle, potentially linked to dysfunction in the circadian timing system.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Review Neurosciences

Interacting influences of aging and Alzheimer's disease on circadian rhythms

Marilyn J. Duncan

EUROPEAN JOURNAL OF NEUROSCIENCE (2020)

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Article Biochemistry & Molecular Biology

Melatonin interacts with repeat domain of Tau to mediate disaggregation of paired helical filaments

Abhishek Ankur Balmik et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2020)

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Article Endocrinology & Metabolism

Circadian learning and memory changes in Aβ1-42 induced Alzheimer's mice

Xuepei Li et al.

METABOLIC BRAIN DISEASE (2020)

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Article Cell Biology

Inhibition of REV-ERBs stimulates microglial amyloid-beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer's disease

Jiyeon Lee et al.

AGING CELL (2020)

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Article Neurosciences

Circadian rhythm of redox state regulates membrane excitability in hippocampal CA1 neurons

Ghazal Naseri Kouzehgarani et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2020)

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Review Neurosciences

Therapeutic implications of circadian clocks in neurodegenerative diseases

Yu Chen Chang et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2020)

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Article Endocrinology & Metabolism

Decreased circadian fluctuation in cognitive behaviors and synaptic plasticity in APP/PS1 transgenic mice

Yexin He et al.

METABOLIC BRAIN DISEASE (2020)

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Article Endocrinology & Metabolism

Melatonin restores the pluripotency of long-term-cultured embryonic stem cells through melatonin receptor-dependent m6A RNA regulation

Lei Yang et al.

JOURNAL OF PINEAL RESEARCH (2020)

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Article Clinical Neurology

Melatonin Prevents Neddylation Dysfunction in Aβ42-Exposed SH-SY5Y Neuroblastoma Cells by Regulating the Amyloid Precursor Protein-Binding Protein 1 Pathway

Mayuri Shukla et al.

CURRENT ALZHEIMER RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Sleep Loss Can Cause Death through Accumulation of Reactive Oxygen Species in the Gut

Alexandra Vaccaro et al.

CELL (2020)

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Review Biochemistry & Molecular Biology

Protective Effects of Melatonin on Neurogenesis Impairment in Neurological Disorders and Its Relevant Molecular Mechanisms

Joseph Wai-Hin Leung et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Cellular Mechanisms of Melatonin: Insight from Neurodegenerative Diseases

Dongmei Chen et al.

BIOMOLECULES (2020)

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Article Biochemistry & Molecular Biology

Sleep Disturbance Forecasts β-Amyloid Accumulation across Subsequent Years

Joseph R. Winer et al.

CURRENT BIOLOGY (2020)

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Review Immunology

The effect of insomnia on development of Alzheimer's disease

Shaghayegh Sadeghmousavi et al.

JOURNAL OF NEUROINFLAMMATION (2020)

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Article Neurosciences

Effects of physical activity and melatonin on brain-derived neurotrophic factor and cytokine expression in the cerebellum of high-fat diet-fed rats

Ai Sugiyama et al.

NEUROPSYCHOPHARMACOLOGY REPORTS (2020)

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Review Multidisciplinary Sciences

The role of melatonin in targeting cell signaling pathways in neurodegeneration

Mayuri Shukla et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2019)

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Review Clinical Neurology

Association between circadian rhythms and neurodegenerative diseases

Yue Leng et al.

LANCET NEUROLOGY (2019)

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Article Biochemistry & Molecular Biology

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer's disease

Elena P. Moreno-Jimenez et al.

NATURE MEDICINE (2019)

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Article Multidisciplinary Sciences

Circadian clock protein Rev-erba regulates neuroinflammation

Percy Griffin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Multidisciplinary Sciences

Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons

D. Zada et al.

NATURE COMMUNICATIONS (2019)

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Differential Function of Melatonin MT1 and MT2 Receptors in REM and NREM Sleep

Gabriella Gobbi et al.

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Article Endocrinology & Metabolism

Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux

Enrique Luengo et al.

JOURNAL OF PINEAL RESEARCH (2019)

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Melatonin: Clinical Perspectives in Neurodegeneration

Daniel P. Cardinali

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Article Endocrinology & Metabolism

Melatonin protects mouse oocytes from DNA damage by enhancing nonhomologous end-joining repair

Jiyeon Leem et al.

JOURNAL OF PINEAL RESEARCH (2019)

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Effects of a Tailored Lighting Intervention on Sleep Quality, Rest-Activity, Mood, and Behavior in Older Adults With Alzheimer Disease and Related Dementias: A Randomized Clinical Trial

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Comparison of the Effects of Melatonin and Oxazepam on Anxiety Levels and Sleep Quality in Patients With ST-Segment-Elevation Myocardial Infarction Following Primary Percutaneous Coronary Intervention: A Randomized Clinical Trial

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New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

Nava Zisapel

BRITISH JOURNAL OF PHARMACOLOGY (2018)

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Review Clinical Neurology

A Systematic Review and Meta-Analysis of the Risk of Dementia Associated with Benzodiazepine Use, After Controlling for Protopathic Bias

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CNS DRUGS (2018)

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Neural Correlates of Sleep Disturbance in Alzheimer's Disease: Role of the Precuneus in Sleep Disturbance

Teruyuki Matsuoka et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

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Review Neurosciences

REM Sleep Behavior Disorder and Alzheimer's Disease: Definitely No Relationship?

Andrea Galbiati et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

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Review Neurosciences

Multi-Faceted Role of Melatonin in Neuroprotection and Amelioration of Tau Aggregates in Alzheimer's Disease

Abhishek Ankur Balmik et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

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Melatonin disturbs SUMOylation-mediated crosstalk between c-Myc and nestin via MT1 activation and promotes the sensitivity of paclitaxel in brain cancer stem cells

Hyemin Lee et al.

JOURNAL OF PINEAL RESEARCH (2018)

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Melatonin ameliorates Aβ42-induced alteration of βAPP-processing secretases via the melatonin receptor through the Pin1/GSK3β/NF-κB pathway in SH-SY5Y cells

Vorapin Chinchalongporn et al.

JOURNAL OF PINEAL RESEARCH (2018)

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Review Biochemistry & Molecular Biology

Melatonin: A Versatile Protector against Oxidative DNA Damage

Annia Galano et al.

MOLECULES (2018)

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Review Pharmacology & Pharmacy

Protective roles of melatonin against the amyloid-dependent development of Alzheimer's disease: A critical review

Bruno Vincent

PHARMACOLOGICAL RESEARCH (2018)

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Article Neurosciences

Foxg1 deletion impairs the development of the epithalamus

Bin Liu et al.

MOLECULAR BRAIN (2018)

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Review Neurosciences

Sleep Disorders Associated With Alzheimer's Disease: A Perspective

Anna Brzecka et al.

FRONTIERS IN NEUROSCIENCE (2018)

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Article Pharmacology & Pharmacy

Melatonin Attenuates Dysregulation of the Circadian Clock Pathway in Mice With CCl4-Induced Fibrosis and Human Hepatic Stellate Cells

Barbara Gonzalez-Fernandez et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Neurosciences

The Circadian Oscillator of the Cerebral Cortex: Molecular, Biochemical and Behavioral Effects of Deleting the Arntl Clock Gene in Cortical Neurons

Tenna Bering et al.

CEREBRAL CORTEX (2018)

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Review Geriatrics & Gerontology

Meta-analysis of randomized, double-blind, placebo-controlled trials of melatonin in Alzheimer's disease

Yuan-Yuan Wang et al.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2017)

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Article Neurosciences

Impact of Melatonin Receptor-Signaling on Zeitgeber Time-Dependent Changes in Cell Proliferation and Apoptosis in the Adult Murine Hippocampus

Michaela Fredrich et al.

HIPPOCAMPUS (2017)

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Article Neurosciences

Alterations of Clock Gene RNA Expression in Brain Regions of a Triple Transgenic Model of Alzheimer's Disease

Francesco Bellanti et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

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Article Neurosciences

Circadian Kinetics of Cell Cycle Progression in Adult Neurogenic Niches of a Diurnal Vertebrate

Veronica Akle et al.

JOURNAL OF NEUROSCIENCE (2017)

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Article Endocrinology & Metabolism

Melatonin promotes circadian rhythm-induced proliferation through Clock/histone deacetylase 3/c-Myc interaction in mouse adipose tissue

Zhenjiang Liu et al.

JOURNAL OF PINEAL RESEARCH (2017)

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Review Endocrinology & Metabolism

Melatonin: A pleiotropic molecule that modulates DNA damage response and repair pathways

Maryam Majidinia et al.

JOURNAL OF PINEAL RESEARCH (2017)

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Review Geriatrics & Gerontology

Neurodegeneration and the Circadian Clock

Suzanne Hood et al.

FRONTIERS IN AGING NEUROSCIENCE (2017)

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Review Developmental Biology

Melatonin, adolescence, and the brain: An insight into the period-specific influences of a multifunctional signaling molecule

O. J. Onaolapo et al.

BIRTH DEFECTS RESEARCH (2017)

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Review Neurosciences

Mechanisms of Melatonin in Alleviating Alzheimer's Disease

Mayuri Shukla et al.

CURRENT NEUROPHARMACOLOGY (2017)

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Review Clinical Neurology

Circadian Disruption Associated with Alzheimer's Disease

Yumna Saeed et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2017)

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Review Neurosciences

Melatonin: Pharmacology, Functions and Therapeutic Benefits

Sylvie Tordjman et al.

CURRENT NEUROPHARMACOLOGY (2017)

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Article Physiology

Protective Effects of Melatonin on the Activity of SOD, CAT, GSH-Px and GSH Content in Organs of Mice after Administration of SNP

Zofia Goc et al.

CHINESE JOURNAL OF PHYSIOLOGY (2017)

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Article Otorhinolaryngology

Protective effects of melatonin and selenium against apoptosis of olfactory sensory neurons: A rat model study

Sema Koc et al.

AMERICAN JOURNAL OF RHINOLOGY & ALLERGY (2016)

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Article Cell Biology

Inhibition of ERK1/2 Signaling Pathway is in Melatonin's Antiproliferative Effect on Human MG-63 Osteosarcoma Cells

Lifeng Liu et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2016)

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Neuroprotective Mechanisms Mediated by CDK5 Inhibition

Gohar Mushtaq et al.

CURRENT PHARMACEUTICAL DESIGN (2016)

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Review Chemistry, Medicinal

DYRK1A inhibition as potential treatment for Alzheimer's disease

Silvia Stotani et al.

FUTURE MEDICINAL CHEMISTRY (2016)

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Article Endocrinology & Metabolism

Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling

Yushu Dong et al.

JOURNAL OF PINEAL RESEARCH (2016)

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Review Endocrinology & Metabolism

Melatonin as an antioxidant: under promises but over delivers

Russel J. Reiter et al.

JOURNAL OF PINEAL RESEARCH (2016)

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Article Biochemistry & Molecular Biology

Embryonic stem-like cells from rabbit blastocysts cultured with melatonin could differentiate into three germ layers in vitro and in vivo

Ruxue Wei et al.

MOLECULAR REPRODUCTION AND DEVELOPMENT (2016)

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Article Biochemistry & Molecular Biology

Melatonin attenuates the high-fat diet and streptozotocin-induced reduction in rat hippocampal neurogenesis

Prapimpun Wongchitrat et al.

NEUROCHEMISTRY INTERNATIONAL (2016)

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Article Cell Biology

Prophylactic Role of Oral Melatonin Administration on Neurogenesis in Adult Balb/C Mice during REM Sleep Deprivation

Gabriela Lopez-Armas et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

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Article Multidisciplinary Sciences

Moderate Changes in the Circadian System of Alzheimer's Disease Patients Detected in Their Home Environment

Kamila Weissova et al.

PLOS ONE (2016)

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Review Geriatrics & Gerontology

Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases

Qiuyang Zheng et al.

FRONTIERS IN AGING NEUROSCIENCE (2016)

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Article Genetics & Heredity

Genetically Blocking the Zebrafish Pineal Clock Affects Circadian Behavior

Zohar Ben-Moshe Livne et al.

PLOS GENETICS (2016)

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Article Cell Biology

Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/-synuclein aggregation

Ling-Yan Su et al.

AUTOPHAGY (2015)

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Review Cell Biology

Neuronal cell cycle: the neuron itself and its circumstances

Jose M. Frade et al.

CELL CYCLE (2015)

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Article Biochemistry & Molecular Biology

A novel DYRK1A (Dual specificity tyrosine phosphorylation-regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitro

Severine Coutadeur et al.

JOURNAL OF NEUROCHEMISTRY (2015)

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Article Endocrinology & Metabolism

Melatonin reverses H2O2-induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway

Long Zhou et al.

JOURNAL OF PINEAL RESEARCH (2015)

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Article Endocrinology & Metabolism

Melatonin regulates the transcription of βAPP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells

Jiraporn Panmanee et al.

JOURNAL OF PINEAL RESEARCH (2015)

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Review Endocrinology & Metabolism

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

Lucien C. Manchester et al.

JOURNAL OF PINEAL RESEARCH (2015)

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Article Biochemistry & Molecular Biology

p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer's disease

X-Q Yao et al.

MOLECULAR PSYCHIATRY (2015)

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Review Cell Biology

The p75 neurotrophin receptor: at the crossroad of neural repair and death

Rick B. Meeker et al.

NEURAL REGENERATION RESEARCH (2015)

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Review Neurosciences

SLEEP DEPRIVATION AND HIPPOCAMPAL VULNERABILITY: CHANGES IN NEURONAL PLASTICITY, NEUROGENESIS AND COGNITIVE FUNCTION

J. C. Kreutzmann et al.

NEUROSCIENCE (2015)

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Article Neurosciences

Melatonin attenuates methamphetamine-induced inhibition of neurogenesis in the adult mouse hippocampus: An in vivo study

Rachen Singhakumar et al.

NEUROSCIENCE LETTERS (2015)

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Article Multidisciplinary Sciences

The Effects of Two Polymorphisms on p21cip1 Function and Their Association with Alzheimer's Disease in a Population of European Descent

Sharon C. Yates et al.

PLOS ONE (2015)

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Article Multidisciplinary Sciences

Circadian Clock Genes Are Essential for Normal Adult Neurogenesis, Differentiation, and Fate Determination

Astha Malik et al.

PLOS ONE (2015)

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Article Multidisciplinary Sciences

The Molecular Mechanism of Amyloid β42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins

Magdalena Cieslik et al.

PLOS ONE (2015)

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Article Oncology

Epigenetic alterations in the suprachiasmatic nucleus and hippocampus contribute to age-related cognitive decline

Scott H. Deibel et al.

ONCOTARGET (2015)

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Article Biotechnology & Applied Microbiology

The Protective Effect of Melatonin on Neural Stem Cell against LPS-Induced Inflammation

Juhyun Song et al.

BIOMED RESEARCH INTERNATIONAL (2015)

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Review Pharmacology & Pharmacy

Circadian clock disruption in neurodegenerative diseases: cause and effect?

Erik S. Musiek

FRONTIERS IN PHARMACOLOGY (2015)

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Article Endocrinology & Metabolism

Melatonin stimulates the nonamyloidogenic processing of βAPP through the positive transcriptional regulation of ADAM10 and ADAM17

Mayuri Shukla et al.

JOURNAL OF PINEAL RESEARCH (2015)

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Review Endocrinology & Metabolism

Melatonin feedback on clock genes: a theory involving the proteasome

Jerry Vriend et al.

JOURNAL OF PINEAL RESEARCH (2015)

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Article Multidisciplinary Sciences

Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer's Disease

Woo-Joo Song et al.

PLOS ONE (2015)

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Review Clinical Neurology

Aging and Circadian Rhythms

Jeanne F. Duffy et al.

SLEEP MEDICINE CLINICS (2015)

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Article Chemistry, Multidisciplinary

Melatonin attenuates phenytoin sodium-induced DNA damage

Ufuk Erenberk et al.

DRUG AND CHEMICAL TOXICOLOGY (2014)

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Article Biochemistry & Molecular Biology

Melatonin stimulates antioxidant enzymes and reduces oxidative stress in experimental traumatic brain injury: the Nrf2-ARE signaling pathway as a potential mechanism

Ke Ding et al.

FREE RADICAL BIOLOGY AND MEDICINE (2014)

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Article Cell Biology

Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock

Rui Ye et al.

GENES & DEVELOPMENT (2014)

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Review Biochemistry & Molecular Biology

Melatonin Regulates Aging and Neurodegeneration through Energy Metabolism, Epigenetics, Autophagy and Circadian Rhythm Pathways

Anorut Jenwitheesuk et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

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Article Clinical Neurology

Benzodiazepines and the potential trophic effect of antidepressants on dentate gyrus cells in mood disorders

Maura Boldrini et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2014)

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Article Endocrinology & Metabolism

Melatonin-mediated β-catenin activation protects neuron cells against prion protein-induced neurotoxicity

Jae-Kyo Jeong et al.

JOURNAL OF PINEAL RESEARCH (2014)

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Article Clinical Neurology

Melatonin ameliorates oxidative stress, modulates death receptor pathway proteins, and protects the rat cerebrum against bisphenol-A-induced apoptosis

Mohamed A. El-Missiry et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2014)

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Review Clinical Neurology

'The clocks that time us'-circadian rhythms in neurodegenerative disorders

Aleksandar Videnovic et al.

NATURE REVIEWS NEUROLOGY (2014)

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Article Neurosciences

Neuroprotective and cognitive enhancing effects of a multi-targeted food intervention in an animal model of neurodegeneration and depression

Yuliya E. Borre et al.

NEUROPHARMACOLOGY (2014)

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Article Multidisciplinary Sciences

A Small Molecule p75NTR Ligand, LM11A-31, Reverses Cholinergic Neurite Dystrophy in Alzheimer's Disease Mouse Models with Mid- to Late-Stage Disease Progression

Danielle A. Simmons et al.

PLOS ONE (2014)

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Article Multidisciplinary Sciences

Melatonin Signaling Modulates Clock Genes Expression in the Mouse Retina

Susumu Hiragaki et al.

PLOS ONE (2014)

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Article Multidisciplinary Sciences

Melatonin Reverses Fas, E2F-1 and Endoplasmic Reticulum Stress Mediated Apoptosis and Dysregulation of Autophagy Induced by the Herbicide Atrazine in Murine Splenocytes

Shweta Sharma et al.

PLOS ONE (2014)

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Article Psychiatry

Plasma DYRK1A as a novel risk factor for Alzheimer's disease

N. Janel et al.

TRANSLATIONAL PSYCHIATRY (2014)

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Review Neurosciences

Cell cycle activity of neural precursors in the diseased mammalian brain

Sara Bragado Alonso et al.

FRONTIERS IN NEUROSCIENCE (2014)

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Article Neurosciences

Restricted nature of adult neural stem cells: re-evaluation of their potential for brain repair

Kirsten Obernier et al.

FRONTIERS IN NEUROSCIENCE (2014)

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Article Neurosciences

Notching up neural stem cell homogeneity in homeostasis and disease

Claudio Giachino et al.

FRONTIERS IN NEUROSCIENCE (2014)

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Article Oncology

RNA interference-mediated knockdown of brain-derived neurotrophic factor (BDNF) promotes cell cycle arrest and apoptosis in B-cell lymphoma cells

D. Xia et al.

NEOPLASMA (2014)

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Review Biochemistry & Molecular Biology

Melatonin Therapy in Patients with Alzheimer's Disease

Daniel P. Cardinali et al.

ANTIOXIDANTS (2014)

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Article Geriatrics & Gerontology

Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice (SAMP8)

Sara Cuesta et al.

AGE (2013)

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Article Cell Biology

Melatonin enhances DNA repair capacity possibly by affecting genes involved in DNA damage responsive pathways

Ran Liu et al.

BMC CELL BIOLOGY (2013)

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Article Endocrinology & Metabolism

Melatonin inhibits the proliferation of human osteosarcoma cell line MG-63

Lifeng Liu et al.

BONE (2013)

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Article Cell Biology

The circadian clock and cell cycle: interconnected biological circuits

Selma Masri et al.

CURRENT OPINION IN CELL BIOLOGY (2013)

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Review Neurosciences

Circadian clocks and neurodegenerative diseases: time to aggregate?

Michael H. Hastings et al.

CURRENT OPINION IN NEUROBIOLOGY (2013)

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Review Developmental Biology

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

Shuhui Lim et al.

DEVELOPMENT (2013)

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Article Pharmacology & Pharmacy

Contribution of prolonged-release melatonin and anti-benzodiazepine campaigns to the reduction of benzodiazepine and z-drugs consumption in nine European countries

Emilie Clay et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2013)

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Article Medicine, General & Internal

Effect of Melatonin on the Proliferation and Differentiation of Chondrocytes from Rat Vertebral Body Growth Plate In Vitro

Zhao-Ming Zhong et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2013)

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Review Biochemistry & Molecular Biology

Melatonin in Alzheimer's Disease

Li Lin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

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Article Neurosciences

MiR-26b, Upregulated in Alzheimer's Disease, Activates Cell Cycle Entry, Tau-Phosphorylation, and Apoptosis in Postmitotic Neurons

Sabrina Absalon et al.

JOURNAL OF NEUROSCIENCE (2013)

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Article Endocrinology & Metabolism

Melatonin potentiates running wheel-induced neurogenesis in the dentate gyrus of adult C3H/HeN mice hippocampus

Jiabei Liu et al.

JOURNAL OF PINEAL RESEARCH (2013)

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Article Endocrinology & Metabolism

Melatonin MT1 receptor-induced transcriptional up-regulation of p27Kip1 in prostate cancer antiproliferation is mediated via inhibition of constitutively active nuclear factor kappa B (NF-κB): potential implications on prostate cancer chemoprevention and therapy

Stephen Y. W. Shiu et al.

JOURNAL OF PINEAL RESEARCH (2013)

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Review Endocrinology & Metabolism

Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms

Ruediger Hardeland

JOURNAL OF PINEAL RESEARCH (2013)

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Article Biochemistry & Molecular Biology

Melatonin attenuates dexamethasone toxicity-induced oxidative stress, calpain and caspase activation in human neuroblastoma SH-SY5Y cells

Wilasinee Suwanjang et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2013)

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Article Biochemistry & Molecular Biology

Dosage of Dyrk1a Shifts Cells within a p21-Cyclin D1 Signaling Map to Control the Decision to Enter the Cell Cycle

Jia-Yun Chen et al.

MOLECULAR CELL (2013)

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Review Neurosciences

Re-cycling Paradigms: Cell Cycle Regulation in Adult Hippocampal Neurogenesis and Implications for Depression

Patricia Patricio et al.

MOLECULAR NEUROBIOLOGY (2013)

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Article Geriatrics & Gerontology

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

Bing Gong et al.

NEUROBIOLOGY OF AGING (2013)

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Article Multidisciplinary Sciences

Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer's Disease Amyloid Precursor Protein

Jiang-Li Tan et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders

Eduardo Ferracioli-Oda et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

Cycle Checkpoint Abnormalities during Dementia: A Plausible Association with the Loss of Protection against Oxidative Stress in Alzheimer's Disease

Pavel Katsel et al.

PLOS ONE (2013)

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Article Cell & Tissue Engineering

Cell Cycle Regulation During Neurogenesis in the Embryonic and Adult Brain

Arquimedes Cheffer et al.

STEM CELL REVIEWS AND REPORTS (2013)

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Article Oncology

Melatonin treatment increases the transcription of cell proliferation-related genes prior to inducing cell death in C6 glioma cells in vitro

Jiagui Qu et al.

ONCOLOGY LETTERS (2013)

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Article Cell Biology

The Circadian Molecular Clock Regulates Adult Hippocampal Neurogenesis by Controlling the Timing of Cell-Cycle Entry and Exit

Pascale Bouchard-Cannon et al.

CELL REPORTS (2013)

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Article Behavioral Sciences

Beneficial effects of benzodiazepine diazepam on chronic stress-induced impairment of hippocampal structural plasticity and depression-like behavior in mice

Yunan Zhao et al.

BEHAVIOURAL BRAIN RESEARCH (2012)

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Review Biochemistry & Molecular Biology

Co-ordination of cell cycle and differentiation in the developing nervous system

Christopher Hindley et al.

BIOCHEMICAL JOURNAL (2012)

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Article Biochemistry & Molecular Biology

Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway

Francois Mouton-Liger et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)

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Review Biochemistry & Molecular Biology

Cycling or not cycling: cell cycle regulatory molecules and adult neurogenesis

Pierre Beukelaers et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

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Article Biology

Effects of Aging on the Molecular Circadian Oscillations in Drosophila

Kuntol Rakshit et al.

CHRONOBIOLOGY INTERNATIONAL (2012)

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Article Neurosciences

Highly Pathogenic Alzheimer's Disease Presenilin 1 P117R Mutation Causes a Specific Increase in p53 and p21 Protein Levels and Cell Cycle Dysregulation in Human Lymphocytes

Emilia Bialopiotrowicz et al.

JOURNAL OF ALZHEIMERS DISEASE (2012)

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Review Cell Biology

Neddylation dysfunction in Alzheimer's disease

Yuzhi Chen et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2012)

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Article Endocrinology & Metabolism

Melatonin improves d-galactose-induced aging effects on behavior, neurogenesis, and lipid peroxidation in the mouse dentate gyrus via increasing pCREB expression

Dae Young Yoo et al.

JOURNAL OF PINEAL RESEARCH (2012)

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Article Cell Biology

Interplay between MEK-ERK signaling, cyclin D1, and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons

Prashant Kumar Modi et al.

MOLECULAR BIOLOGY OF THE CELL (2012)

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Article Cell Biology

Inhibition of Polo-like kinase 1 reduces beta-amyloid-induced neuronal cell death in Alzheimer's disease

Bing Song et al.

AGING-US (2011)

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Review Pharmacology & Pharmacy

Roles of p75NTR in the pathogenesis of Alzheimer's disease: A novel therapeutic target

Fan Zeng et al.

BIOCHEMICAL PHARMACOLOGY (2011)

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Article Cell Biology

Nucleocytoplasmic Cdk5 is involved in neuronal cell cycle and death in post-mitotic neurons

Jie Zhang et al.

CELL CYCLE (2011)

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Article Developmental Biology

Light and melatonin schedule neuronal differentiation in the habenular nuclei

Nancy Hernandez de Borsetti et al.

DEVELOPMENTAL BIOLOGY (2011)

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Article Biology

Circadian Clock Gene Expression in Brain Regions of Alzheimer's Disease Patients and Control Subjects

Nicolas Cermakian et al.

JOURNAL OF BIOLOGICAL RHYTHMS (2011)

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Article Endocrinology & Metabolism

Melatonin synergistically increases resveratrol-induced heme oxygenase-1 expression through the inhibition of ubiquitin-dependent proteasome pathway: a possible role in neuroprotection

Kyoung Ja Kwon et al.

JOURNAL OF PINEAL RESEARCH (2011)

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Article Neurosciences

Early induction of c-Myc is associated with neuronal cell death

Hyun-Pil Lee et al.

NEUROSCIENCE LETTERS (2011)

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Article Cell & Tissue Engineering

Increased Re-Entry into Cell Cycle Mitigates Age-Related Neurogenic Decline in the Murine Subventricular Zone

Elizabeth A. Stoll et al.

STEM CELLS (2011)

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Article Pathology

Selective Cell Death of Hyperploid Neurons in Alzheimer's Disease

Thomas Arendt et al.

AMERICAN JOURNAL OF PATHOLOGY (2010)

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Review Medicine, Research & Experimental

Biomarkers in Alzheimer's disease: past, present and future

Katarzyna Gustaw-Rothenburg et al.

BIOMARKERS IN MEDICINE (2010)

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Review Cell Biology

A novel hypothesis for Alzheimer's disease based on neuronal tetraploidy induced by p75NTR

Jose M. Frade et al.

CELL CYCLE (2010)

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Article Clinical Neurology

Investigation of maternal melatonin effect on the hippocampal formation of newborn rat model of intrauterine cortical dysplasia

Meral Baka et al.

CHILDS NERVOUS SYSTEM (2010)

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Review Biochemistry & Molecular Biology

Pathological implications of cell cycle re-entry in Alzheimer disease

David J. Bonda et al.

EXPERT REVIEWS IN MOLECULAR MEDICINE (2010)

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Article Immunology

Melatonin Protects CD4+ T Cells from Activation-Induced Cell Death by Blocking NFAT-Mediated CD95 Ligand Upregulation

Alziana Moreno da Cunha Pedrosa et al.

JOURNAL OF IMMUNOLOGY (2010)

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Article Neurosciences

Cdk5 Suppresses the Neuronal Cell Cycle by Disrupting the E2F1-DP1 Complex

Jie Zhang et al.

JOURNAL OF NEUROSCIENCE (2010)

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Editorial Material Clinical Neurology

The involvement of cell cycle events in the pathogenesis of Alzheimer's disease

Karl Herrup

ALZHEIMERS RESEARCH & THERAPY (2010)

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Article Cell Biology

Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease

David J. Bonda et al.

AGING-US (2009)

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Review Cell Biology

The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease

Antonio Currais et al.

AGING-US (2009)

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Article Anatomy & Morphology

From Birth till Death: Neurogenesis, Cell Cycle, and Neurodegeneration

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ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2009)

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Article Endocrinology & Metabolism

Developmental and Diurnal Dynamics of Pax4 Expression in the Mammalian Pineal Gland: Nocturnal Down-Regulation Is Mediated by Adrenergic-Cyclic Adenosine 3′,5′-Monophosphate Signaling

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ENDOCRINOLOGY (2009)

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Article Biochemistry & Molecular Biology

Negative Feedback Inhibition of NFATc1 by DYRK1A Regulates Bone Homeostasis

Youngkyun Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

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Article Neurosciences

Interruption of β-Catenin Signaling Reduces Neurogenesis in Alzheimer's Disease

Ping He et al.

JOURNAL OF NEUROSCIENCE (2009)

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Long-Term Antiepileptic Drug Administration During Early Life Inhibits Hippocampal Neurogenesis in the Developing Brain

Jin Chen et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2009)

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Article Endocrinology & Metabolism

An evaluation of the neuroprotective effects of melatonin in an in vitro experimental model of age-induced neuronal apoptosis

Marta Tajes Orduna et al.

JOURNAL OF PINEAL RESEARCH (2009)

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The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events

Kiran Bhaskar et al.

MOLECULAR NEURODEGENERATION (2009)

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Article Geriatrics & Gerontology

Regenerative capacity of neural precursors in the adult mammalian brain is under the control of p53

Silvia Medrano et al.

NEUROBIOLOGY OF AGING (2009)

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Review Neurosciences

Alternative Functions of Core Cell Cycle Regulators in Neuronal Migration, Neuronal Maturation, and Synaptic Plasticity

Christopher L. Frank et al.

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Melatonin Modulates Cell Survival of New Neurons in the Hippocampus of Adult Mice

Gerardo Ramirez-Rodriguez et al.

NEUROPSYCHOPHARMACOLOGY (2009)

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Brain Clocks: From the Suprachiasmatic Nuclei to a Cerebral Network

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NEUROSCIENTIST (2009)

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Neural cell cycle dysregulation and central nervous system diseases

Wei Wang et al.

PROGRESS IN NEUROBIOLOGY (2009)

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Review Clinical Neurology

New neurons in the adult brain: The role of sleep and consequences of sleep loss

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SLEEP MEDICINE REVIEWS (2009)

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Regulation of Forkhead Transcription Factor FoxO3a Contributes to Calorie Restriction-induced Prevention of Alzheimer's Disease-type Amyloid Neuropathology and Spatial Memory Deterioration

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MITOCHONDRIA AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISORDERS (2008)

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Characterization of the human DYRK1A promoter and its regulation by the transcription factor E2F1

Barbara Maenz et al.

BMC MOLECULAR BIOLOGY (2008)

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Different fibrillar Aβ 1-42 concentrations induce adult hippocampal neurons to reenter various phases of the cell cycle

Shohreh Majd et al.

BRAIN RESEARCH (2008)

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HDAC4 inhibits cell-cycle progression and protects neurons from cell death

Nazanin Majdzadeh et al.

DEVELOPMENTAL NEUROBIOLOGY (2008)

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Neurogenesis and cell cycle-reactivated neuronal death during pathogenic tau aggregation

K. Schindowski et al.

GENES BRAIN AND BEHAVIOR (2008)

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Melatonin inhibitory effect on cAMP accumulation in the chick retina development

Lucia de Fatima Sobral Sampaio

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2008)

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Melatonin represses oxidative stress-induced activation of the MAP kinase and mTOR signaling pathways in H4IIE hepatoma cells through inhibition of Ras

Scot R. Kimball et al.

JOURNAL OF PINEAL RESEARCH (2008)

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Melatonin prevents glucocorticoid inhibition of cell proliferation and toxicity in hippocampal cells by reducing glucocorticoid receptor nuclear translocation

Isabel Quiros et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2008)

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Time-of-Day-Dependent Enhancement of Adult Neurogenesis in the Hippocampus

So-ichi Tamai et al.

PLOS ONE (2008)

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Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons

Zengqiang Yuan et al.

SCIENCE (2008)

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Rapid eye movement sleep deprivation contributes to reduction of neurogenesis in the hippocampal dentate gyrus of the adult rat

Ruben Guzman-Marin et al.

SLEEP (2008)

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Role of cell cycle proteins in CNS injury

Kimberly R. Byrnes et al.

NEUROCHEMICAL RESEARCH (2007)

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Inhibition of melatonin biosynthesis induces neurofilament hyperphosphorylation with activation of cyclin-dependent kinase 5

Shaohui Wang et al.

NEUROCHEMICAL RESEARCH (2007)

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Cell-cycle control and cortical development

Colette Dehay et al.

NATURE REVIEWS NEUROSCIENCE (2007)

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p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells

Claudie Hooper et al.

NEUROSCIENCE LETTERS (2007)

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Riding tandem: Circadian clocks and the cell cycle

Tim Hunt et al.

CELL (2007)

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Review Neurosciences

Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?

Karl Herrup et al.

NATURE REVIEWS NEUROSCIENCE (2007)

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Chronic administration of melatonin reduces cerebral injury biomarkers in SAMP8

Javier Gutierrez-Cuesta et al.

JOURNAL OF PINEAL RESEARCH (2007)

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ERK activity and G1 phase progression: Identifying dispensable versus essential activities and primary versus secondary targets

Jessie Villanueva et al.

MOLECULAR BIOLOGY OF THE CELL (2007)

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Neuronal cell cycle re-entry mediates Alzheimer disease-type changes

Andrew McShea et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2007)

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Review Cell Biology

Post-translational modifications regulate the ticking of the circadian clock

Monica Gallego et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

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The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease

Ryo Kimura et al.

HUMAN MOLECULAR GENETICS (2007)

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Review Biochemistry & Molecular Biology

Connecting cell-cycle activation to neurodegeneration in Drosophila

Vikram Khurana et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2007)

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Review Biochemistry & Molecular Biology

Distinct destructive signal pathways of neuronal death in Alzheimer's disease

Yong Shen et al.

TRENDS IN MOLECULAR MEDICINE (2006)

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Maternal melatonin effects on clock gene expression in a nonhuman primate fetus

C. Torres-Farfan et al.

ENDOCRINOLOGY (2006)

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Article Geriatrics & Gerontology

Gene expression correlates of neurofibrillary tangles in Alzheimer's disease

Travis Dunckley et al.

NEUROBIOLOGY OF AGING (2006)

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NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21

Joseph R. Arron et al.

NATURE (2006)

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Inhibition of the cdk5/p25 fragment formation may explain the antiapoptotic effects of melatonin in an experimental model of Parkinson's disease

D Alvira et al.

JOURNAL OF PINEAL RESEARCH (2006)

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Article Pathology

Cell-cycle markers in a transgenic mouse model of human tauopathy - Increased levels of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1

P Delobel et al.

AMERICAN JOURNAL OF PATHOLOGY (2006)

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TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model

V Khurana et al.

CURRENT BIOLOGY (2006)

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The cell cycle in Alzheimer disease: A unique target for neuropharmacology

KM Webber et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2005)

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Sleep deprivation suppresses neurogenesis in the adult hippocampus of rats

R Guzman-Marin et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2005)

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Antiproliferative activity of melatonin by transcriptional inhibition of cyclin D1 expression: a molecular basis for melatonin-induced oncostatic effects

G Cini et al.

JOURNAL OF PINEAL RESEARCH (2005)

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Expression of Ki67, PCNA and the chromosome replication licensing protein Mcm2 in glial cells of the ageing human hippocampus increases with the burden of Alzheimer-type pathology

SB Wharton et al.

NEUROSCIENCE LETTERS (2005)

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Review Endocrinology & Metabolism

Functional MT1 and MT2 melatonin receptors in mammals

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ENDOCRINE (2005)

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Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury

S Di Giovanni et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Oxidative imbalance in Alzheimer's disease

XW Zhu et al.

MOLECULAR NEUROBIOLOGY (2005)

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A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons

YL Zheng et al.

EMBO JOURNAL (2005)

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Interactions between melatonin and nicotinamide nucleotide: NADH preservation in cells and in cell-free systems by melatonin

DX Tan et al.

JOURNAL OF PINEAL RESEARCH (2005)

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Review Cell Biology

MCM proteins: DNA damage, mutagenesis and repair

JM Bailis et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2004)

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Effect of inhibiting melatonin biosynthesis on spatial memory retention and tau phosphorylation in rat

LQ Zhu et al.

JOURNAL OF PINEAL RESEARCH (2004)

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Melatonin, human aging, and age-related diseases

M Karasek

EXPERIMENTAL GERONTOLOGY (2004)

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Review Neurosciences

Cell cycle regulation of neuronal apoptosis in development and disease

EBE Becker et al.

PROGRESS IN NEUROBIOLOGY (2004)

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Light regulates the cell cycle in zebrafish

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CURRENT BIOLOGY (2003)

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APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain

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JOURNAL OF CELL BIOLOGY (2003)

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Neurogenesis and the cell cycle

S Ohnuma et al.

NEURON (2003)

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Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels

JN Zhou et al.

JOURNAL OF PINEAL RESEARCH (2003)

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Neurobehavioural performance effects of daytime melatonin and temazepam administration

NL Rogers et al.

JOURNAL OF SLEEP RESEARCH (2003)

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β-catenin regulation during the cell cycle:: Implications in G2/M and apoptosis

D Olmeda et al.

MOLECULAR BIOLOGY OF THE CELL (2003)

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Cyclin C expression is involved in the pathogenesis of Alzheimer's disease

U Ueberham et al.

NEUROBIOLOGY OF AGING (2003)

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Oxidative stress, cell cycle, and neurodegeneration

JA Klein et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

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Cell cycle and cell fate interactions in neural development

F Cremisi et al.

CURRENT OPINION IN NEUROBIOLOGY (2003)

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beta-Amyloid modulates tyrosine kinase B receptor expression in SHSY5Y neuroblastoma cells: Influence of the antioxidant melatonin

G Olivieri et al.

NEUROSCIENCE (2003)

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Genetic and environmental factors in cancer and neurodegenerative diseases

L Migliore et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2002)

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Circadian control of Neurogenesis

EM Goergen et al.

JOURNAL OF NEUROBIOLOGY (2002)

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Cyclin D1 and cyclin E are co-localized with cyclo-oxygenase 2 (COX-2) in pyramidal neurons in Alzheimer disease temporal cortex

JJM Hoozemans et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2002)

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Altered distribution of cell cycle transcriptional regulators during Alzheimer disease

KL Jordan-Sciutto et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2002)

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Posttranslational mechanisms regulate the mammalian circadian clock

C Lee et al.

CELL (2001)

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The transcription factor Pax6 is required for development of the diencephalic dorsal midline secretory radial glia that form the subcommissural organ

G Estivill-Torrús et al.

MECHANISMS OF DEVELOPMENT (2001)

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The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice

K Tateishi et al.

JOURNAL OF CELL BIOLOGY (2001)

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Review Neurosciences

Cell cycle and cell fate in the nervous system

S Ohnuma et al.

CURRENT OPINION IN NEUROBIOLOGY (2001)

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Neuronal polo-like kinase in Alzheimer disease indicates cell cycle changes

PLR Harris et al.

NEUROBIOLOGY OF AGING (2000)

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Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability

R Sears et al.

GENES & DEVELOPMENT (2000)

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Neurotoxicity induces cleavage of p35 to p25 by calpain

MS Lee et al.

NATURE (2000)

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Article Biochemistry & Molecular Biology

The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons

YZ Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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Article Endocrinology & Metabolism

Neuroprotection by melatonin from glutamate-induced excitotoxicity during development of the cerebellum in the chick embryo

A Espinar et al.

JOURNAL OF PINEAL RESEARCH (2000)

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