期刊
CURRENT GENE THERAPY
卷 23, 期 5, 页码 343-355出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1566523223666230519124519
关键词
miRNA; phytochemicals; curcumin; non-coding genes; miR-21; cancer
Studies have shown that dietary phytochemicals play an important role in cancer prevention and treatment by regulating miRNA expression.
MicroRNAs (miRNAs - similar to 22 nucleotides) are a type of non-coding RNAs that are involved in post-transcriptional gene silencing. They are known to regulate gene expression in diverse biological processes, such as apoptosis, development, and differentiation. Several studies have demonstrated that cancer initiation and progression are highly regulated by miRNA expression. The nutrients present in the diet may regulate the different stages of carcinogenesis. Interestingly, plant-based foods, like fruits and vegetables, have been shown to play a significant role in cancer prevention. Phytochemicals are bioactive compounds derived from plant sources, and they have been shown to have anti-inflammatory, antioxidant, and anticancer properties. Recent findings suggest that dietary phytochemicals, such as genistein, resveratrol, and curcumin, exert significant anticancer effects by regulating various miRNAs. In this review, we focus on the role of dietary phytochemicals in cancer prevention and treatment through the modulation of miRNA expression.
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