Developmental genetics: The structural basis of malleable teeth

Article Biochemistry & Molecular Biology

Chitin contributes to the formation of a feeding structure in a predatory nematode

Shuai Sun et al.

Summary: This study reveals the key role of chitin in the formation of teeth-like denticles in Pristionchus pacificus, which is important for understanding the predation and feeding structure plasticity of nematodes.

CURRENT BIOLOGY (2023)

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Article Genetics & Heredity

The oscillating Mucin-type protein DPY-6 has a conserved role in nematode mouth and cuticle formation

Shuai Sun et al.

Summary: This study identified a gene involved in nematode mouth formation and revealed its role in mouth morphology and external cuticle deposition. Additionally, previously unrecognized defects in the mouth structure were discovered through geometric morphometric analysis. The findings of this study open up new avenues for researching the molecular composition of nematode mouths, which is crucial for understanding their extreme ecological diversification.

GENETICS (2022)

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Article Genetics & Heredity

An expanded auxin-inducible degron toolkit for Caenorhabditis elegans

Guinevere E. Ashley et al.

Summary: This study presents a toolkit for enhancing the application of the AID system in Caenorhabditis elegans, including tissue-specific and pan-somatic TIR1-expressing strains, as well as plasmids for constructing repair templates for generating fluorescent protein::AID fusions. These reagents will complement existing TIR1 strains and facilitate rapid and high-throughput tagging of genes with fluorescent protein::AID.

GENETICS (2021)

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Review Biochemistry & Molecular Biology

Spatiotemporal control of CRISPR/Cas9 gene editing

Chenya Zhuo et al.

Summary: The CRISPR/Cas9 gene editing technology shows promise in treating genetic and infectious diseases but faces challenges in precise editing. Emerging strategies to regulate CRISPR/Cas9 activity have shown potential in improving spatiotemporal control, but obstacles and limitations remain for clinical translation. Further exploration is needed to enhance the spatiotemporal operability of CRISPR/Cas9.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Multidisciplinary Sciences