☆ 4.3 Review

Role of Small Molecule Ligands in IgE-Mediated Allergy

CURRENT ALLERGY AND ASTHMA REPORTS (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

Binding to Iron Quercetin Complexes Increases the Antioxidant Capacity of the Major Birch Pollen Allergen Bet v 1 and Reduces Its Allergenicity

Andreas Regner et al.

Summary: Bet v 1 is a major allergen in birch pollen, with up to 95% of birch-sensitized patients responding to it. It belongs to the pathogenesis-related PR 10 family and is involved in plant defense. This study found that Bet v 1 can bind to iron quercetin complexes (FeQ2), reducing allergenicity and contributing to anti-inflammatory stimuli in human monocytes.

ANTIOXIDANTS (2023)

添加到收藏夹

Article Chemistry, Applied

Covalent polyphenol modification of a reactive cysteine in the major apple allergen Mal d 1

Jana Unterhauser et al.

Summary: Naturally occurring polyphenols can modify the molecular properties of food allergens. In the case of the major apple allergen Mal d 1, reactions with oxidized polyphenols result in the formation of a covalent adduct, leading to a loss of conformational IgE epitopes and reduced allergenicity. The modified allergen does not affect its three-dimensional fold or ligand binding, but partially covers an IgE epitope on its surface.

FOOD CHEMISTRY (2023)

添加到收藏夹

Review Allergy

C-Type Lectin Receptor Mediated Modulation of T2 Immune Responses to Allergens

Alba Angelina et al.

Summary: This review summarizes the role of C-type lectin receptors (CLRs) in regulating type 2 immune responses to allergens. CLRs recognize carbohydrates in common allergens and trigger signaling pathways that polarize CD4(+) T cells towards specific Th2 responses. Understanding the role of CLRs may lead to the development of novel strategies for allergic diseases.

CURRENT ALLERGY AND ASTHMA REPORTS (2023)

添加到收藏夹

Article Allergy

Structural and ligand binding analysis of the pet allergens Can f 1 and Fel d 7

Jungki Min et al.

Summary: This study presents crystal structures, NMR, molecular dynamics, and fluorescence studies of dog allergen Can f 1 and its closely related cat allergen Fel d 7. It is found that Can f 1 and Fel d 7 have open and positively charged calyxes, while other dog allergens have closed and negatively charged ones. Fatty acid screening reveals that Can f 1 and Fel d 7 bind multiple ligands with preferences for palmitic acid and oleic acid. The results provide valuable insights into selectivity determinants and candidate ligands for pet allergens Can f 1 and Fel d 7.

FRONTIERS IN ALLERGY (2023)

添加到收藏夹

Article Immunology

Systematic Characterization of the Group 2 House Dust Mite Allergen in Dermatophagoides microceras

Rei-Hsing Hu et al.

Summary: This study identified and characterized the allergen-like protein Der m 2 in the indoor house dust mite Dermatophagoides microceras (Der m). Der m 2 was found to induce inflammatory responses in cell and mouse models of allergic asthma. Treatment with the fungal immunomodulatory protein FIP-fve alleviated the inflammation caused by Der m 2-induced asthma in mice.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

The diversity of lipocalin receptors

Bernhard Redl et al.

Summary: Lipocalins are crucial carriers of hydrophobic molecules and play a role in various physiological processes in different species. They interact with cell receptors to exert their biological effects. Recent research has revealed new findings on the molecules involved in cellular uptake or signaling effects of lipocalins.

BIOCHIMIE (2022)

添加到收藏夹

Review Allergy

Managing the allergy and asthma epidemic in 2020s-Lessons from the Finnish experience

Tari Haahtela et al.

Summary: Finland implemented a systematic public health programme for a decade to reduce the burden of allergic disorders by revisiting prevention strategies. The programme emphasized on allergy health and the connection with the natural environment, improving allergy management practices. The results after ten years were favorable, with changes in healthcare practices, reduced disability among patients, and significant cost savings achieved.

ALLERGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

NLRP3 priming due to skin damage precedes LTP allergic sensitization in a mouse model

Diego Pazos-Castro et al.

Summary: In this study, the two-hit hypothesis of inflammatory diseases was applied to investigate the sensitization of food allergy. It was found that long-term depilation in mice resulted in immunological changes, which were further enhanced by the addition of allergen. The encounter with allergen also led to skin remodeling and infiltration of mucosal tissues. Additionally, the study with human ILC2s demonstrated that allergen could induce a phenotype switch. These findings have important implications for understanding the development of food allergy.

SCIENTIFIC REPORTS (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Role of Lipids in Allergic Sensitization: A Systematic Review

Georgina V. Hopkins et al.

Summary: This systematic review examines the role of lipids in allergic sensitization. The results provide strong evidence that intrinsic lipids from allergen sources can enhance or inhibit allergic sensitization through various mechanisms. Further research using human relevant in vitro models and clinical studies is needed to fully understand the role of lipids in allergic sensitization.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Structural Flexibility of PR-10 Food Allergens

Sebastian Fuehrer et al.

Summary: PR-10 proteins are a major cause of food allergic reactions. This study analyzes the structural flexibility of thirteen PR-10 proteins from prevalent plant food sources and reveals that they have inherently flexible protein backbones in solution, with protein-specific extent of flexibility.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Article Allergy

Mammalian derived lipocalin and secretoglobin respiratory allergens strongly bind ligands with potentially immune modulating properties

Bente Janssen-Weets et al.

Summary: Allergens from furry animals, such as lipocalins and secretoglobins, play a role in chemical communication and have the ability to bind small volatile compounds. This study aims to understand the physiological function of these allergens and their role in sensitization. By analyzing their ligand-binding characteristics, the researchers found that these allergens have high thermal stability and bind certain ligands associated with semiochemical and immune-modulating functions. The findings contribute to the understanding of major mammalian respiratory allergens as carriers of semiochemicals.

FRONTIERS IN ALLERGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Human IgE monoclonal antibody recognition of mite allergen Der p 2 defines structural basis of an epitope for IgE cross-linking and anaphylaxis in vivo

Kriti Khatri et al.

Summary: Immunoglobulin E (IgE) antibody plays a critical role in adaptive allergen-induced immune responses, affecting up to 40% of the global population. This study reports the crystal structure of a house dust mite allergen, Der p 2, in complex with a human IgE monoclonal antibody, providing insights into the IgE antibody repertoire to a major mite allergen.

PNAS NEXUS (2022)

添加到收藏夹

Review Allergy

Lipid Ligands and Allergenic LTPs: Redefining the Paradigm of the Protein-Centered Vision in Allergy

Zulema Gonzalez-Klein et al.

Summary: Lipid Transfer Proteins (LTPs) are a widely distributed allergen family that can cause various allergic reactions. Recent studies have shown that the ligands carried by LTPs play a significant role in their allergenic capacity. Research on the role of lipids in allergic sensitization can enhance our understanding of the molecular events leading to allergy.

FRONTIERS IN ALLERGY (2022)

添加到收藏夹

Review Allergy

Inhalant Mammal-Derived Lipocalin Allergens and the Innate Immunity

Tuomas Virtanen

Summary: A major part of important mammalian respiratory allergens belongs to the lipocalin family of proteins. The allergenicity of lipocalin allergens cannot be easily explained by their physicochemical properties. Allergic sensitization involves the innate and adaptive immunities, with IL-4 playing a crucial role in the type 2 immune response. Lipocalin allergens can enter the immune system through lipocalin and innate immunity-associated cell-surface receptors.

FRONTIERS IN ALLERGY (2022)

添加到收藏夹

Article Allergy

Cow's milk protein β-lactoglobulin confers resilience against allergy by targeting complexed iron into immune cells

Franziska Roth-Walter et al.

Summary: Research has shown that holoBLG plays a key role in preventing allergies by reducing IgE binding and affecting mast cell degranulation. Consistently, only treatment with holoBLG in mice prevented allergic sensitization and anaphylaxis, while maintaining regulatory T cells. Additionally, holoBLG facilitates AhR activation, contributing to allergy prevention.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structural Characterization of Act c 10.0101 and Pun g 1.0101-Allergens from the Non-Specific Lipid Transfer Protein Family

Andrea O'Malley et al.

Summary: The study found that allergens from the nsLTP family have structural similarities and may trigger cross-reactive reactions with other nsLTP family proteins. These allergens may affect the surface regions where immunoglobulin E binds by binding ligands.

MOLECULES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens

Alexander C. Y. Foo et al.

Summary: Many major allergens bind to hydrophobic lipid-like molecules, and removing these lipids can significantly alter the stability and resistance properties of the allergenic protein, impacting T-cell epitope generation and allergenicity. Techniques like reverse-phase HPLC and thermal annealing can be used to remove endogenous lipids from allergens like Bla g 1, providing valuable insights into the role of lipids in the allergic response.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2021)

添加到收藏夹

Review Allergy

Allergens and their associated small molecule ligands-their dual role in sensitization

Maksymilian Chruszcz et al.

Summary: Many allergens have hydrophobic cavities that can bind hydrophobic small-molecule ligands, with different specificities. Some allergens can bind a variety of small molecules in vitro, but not all of these are their natural ligands.

ALLERGY (2021)

添加到收藏夹

Article Food Science & Technology

Microscale Thermophoresis Reveals Oxidized Glutathione as High-Affinity Ligand of Mal d 1

Soraya Chebib et al.

Summary: PR-10 proteins can bind various ligands due to their unique secondary structure, which may influence the biological function and allergenicity of the protein. Natural products found in apples, such as flavonoids, glutathione, and glutathione disulfide, were identified as potential ligands of Mal d 1. Molecular docking analysis revealed the binding mechanism between the ligands and Mal d 1, providing further insights into the physiological role of the protein.

FOODS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

The key to the allergenicity of lipid transfer protein (LTP) ligands: A structural characterization

Zulema Gonzalez-Klein et al.

Summary: This study analyzed the natural ligands carried by allergenic LTPs and found that they shared a chemical identity with a polar head essential for protein-ligand binding. These ligands could be transported through a skin cellular model, leading to the detection of phosphorylated phytosphingosine. Overexpression of sphingosine kinase 1 in keratinocytes incubated with the LTP-ligand complex suggests a potential role in mediating allergic responses.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2021)

添加到收藏夹

Article Allergy

Cat-NPC2, a Newly Identified Allergen, With High Cross-Reactivity to Can f 7

Dan-Xuan Zhu et al.

Summary: This study identified and characterized a novel cat allergen, NPC2 protein, which was recognized by at least 14.5% of cat-allergic patients with high specific IgE levels. Cross-reactivity between Cat-NPC2 and Can f7/Der f2 was demonstrated, providing insights for improved component-resolved diagnosis in pet allergy.

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Biophysical and biological impact on the structure and IgE-binding of the interaction of the olive pollen allergen Ole e 7 with lipids

Carmen Oeo-Santos et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Major Cat Allergen Fel d 1 Binds Steroid and Fatty Acid Semiochemicals: A Combined In Silico and In Vitro Study

Cecile Bienboire-Frosini et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Plant Sciences

Structural insights into the lipid transfer mechanism of a non-specific lipid transfer protein

Zaid Kamal Madni et al.

PLANT JOURNAL (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

A role of heparan sulphate proteoglycan in the cellular uptake of lipocalins ß-lactoglobulin and allergen Fel d 4

Matthias Habeler et al.

BIOLOGICAL CHEMISTRY (2020)

添加到收藏夹

Article Immunology

Identification of a Heme Activation Site on the MD-2/TLR4 Complex

John D. Belcher et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Impact of Different Lipid Ligands on the Stability and IgE-Binding Capacity of the Lentil Allergen Len c 3

Ekaterina I. Finkina et al.

BIOMOLECULES (2020)

添加到收藏夹

Article Multidisciplinary Sciences

The major allergen Der p 2 is a cholesterol binding protein

Kavita Reginald et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Impact of lipid binding on the tertiary structure and allergenic potential of Jug r 3, the non-specific lipid transfer protein from walnut

Pawel Dubiela et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Review Immunology

Allergy to Mus m 1: Allergy to Mus m 1: A review of structural, and immunological features

Marlon Munera et al.

IMMUNOLOGY LETTERS (2019)

添加到收藏夹

Article Allergy

Multiple roles of Bet v 1 ligands in allergen stabilization and modulation of endosomal protease activity

Wai Tuck Soh et al.

ALLERGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Identification of a natural ligand of the hazel allergen Cor a 1

Thessa Jacob et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Article Immunology

A Human IgE Antibody Binding Site on Der p 2 for the Design of a Recombinant Allergen for Immunotherapy

Jill Glesner et al.

JOURNAL OF IMMUNOLOGY (2019)

添加到收藏夹

Review Biotechnology & Applied Microbiology

The characteristics and biological significance of NPC2: Mutation and disease

Yanan Xu et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2019)

添加到收藏夹

Letter Allergy

Distinct Lipid Transfer Proteins display different IgE-binding activities that are affected by fatty acid binding

Roberta Aina et al.

ALLERGY (2019)

添加到收藏夹

Article Food Science & Technology

Purification and Characterization of Pathogenesis Related Class 10 Panallergens

Jane K. McBride et al.

FOODS (2019)

添加到收藏夹

Article Medicine, Research & Experimental

Canis familiaris allergen Can f 7: Expression, purification and analysis of B cell epitopes in Chinese children with dog allergies

Rui-Qi Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019)

添加到收藏夹

Review Allergy

Innate immunity in allergy

Kazuhiko Maeda et al.

ALLERGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Hydrophobic ligands influence the structure, stability, and processing of the major cockroach allergen Bla g 1

Alexander C. Y. Foo et al.

SCIENTIFIC REPORTS (2019)

添加到收藏夹

Review Immunology

Lipophilic Allergens, Different Modes of Allergen-Lipid Interaction and Their Impact on Asthma and Allergy

Uta Jappe et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Parsing the functional specificity of Siderocalin/Lipocalin 2/NGAL for siderophores and related small-molecule ligands

Matthew C. Clifton et al.

JOURNAL OF STRUCTURAL BIOLOGY-X (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

PR-10 proteins as potential mediators of melatonin-cytokinin cross-talk in plants: crystallographic studies of LlPR-10.2B isoform from yellow lupine

Joanna Sliwiak et al.

FEBS JOURNAL (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Initiation of Th2 Immunity Towards Food Allergens

Yosef Ellenbogen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

添加到收藏夹

Article Food Science & Technology

Isolation and Characterization of Wheat Derived Nonspecific Lipid Transfer Protein 2 (nsLTP2)

Sara Bosi et al.

JOURNAL OF FOOD SCIENCE (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

WHO/IUIS Allergen Nomenclature: Providing a common language

Anna Pomes et al.

MOLECULAR IMMUNOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Retinoic acid prevents immunogenicity of milk lipocalin Bos d 5 through binding to its immunodominant T-cell epitope

Karin Hufnagl et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Physiology

Niemann-Pick C2 Proteins: A New Function for an Old Family

Jiao Zhu et al.

FRONTIERS IN PHYSIOLOGY (2018)

添加到收藏夹

Review Immunology

Interaction of Non-Specific Lipid-Transfer Proteins With Plant-Deerived Lipids and Its Impact on Allergic Sensitization

Stephan Scheurer et al.

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Structural basis for cross-reactivity and conformation fluctuation of the major beech pollen allergen Fag s 1

Adolfo H. Moraes et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

A robust method for the estimation and visualization of IgE cross-reactivity likelihood between allergens belonging to the same protein family

Maksymilian Chruszcz et al.

PLOS ONE (2018)

添加到收藏夹

Letter Allergy

Enhanced Pru p 3 IgE-binding activity by selective free fatty acid-interaction

Pawel Dubiela et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Identification of the ligand of Pru p 3, a peach LTP

Nuria Cubells-Baeza et al.

PLANT MOLECULAR BIOLOGY (2017)

添加到收藏夹

Article Allergy

Mechanisms underlying induction of allergic sensitization by Pru p 3

L. Tordesillas et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ligand Binding Properties of the Lentil Lipid Transfer Protein: Molecular Insight into the Possible Mechanism of Lipid Uptake

Zakhar O. Shenkarev et al.

BIOCHEMISTRY (2017)

添加到收藏夹

Review Allergy

Structural similarities of human and mammalian lipocalins, and their function in innate immunity and allergy

E. Jensen-Jarolim et al.

ALLERGY (2016)

添加到收藏夹

Article Allergy

The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1

D. Apostolovic et al.

ALLERGY (2016)

添加到收藏夹

Article Agriculture, Multidisciplinary

Fra a 1.02 Is the Most Potent Isoform of the Bet v 1-like Allergen in Strawberry Fruit

Katrin Franz-Oberdorf et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2016)

添加到收藏夹

Meeting Abstract Allergy

Ligand Binding Preferences of Pathogenesis-Related Class 10 (PR-10) Allergens

Barry K. Hurlburt et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

添加到收藏夹

Review Plant Sciences

Lipid transfer proteins: classification, nomenclature, structure, and function

Tiina A. Salminen et al.

PLANTA (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Ligand binding to an Allergenic Lipid Transfer Protein Enhances Conformational Flexibility resulting in an Increase in Susceptibility to Gastroduodenal Proteolysis

Syed Umer Abdullah et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Characterisation of a flavonoid ligand of the fungal protein Alt a 1

Maria Garrido-Arandia et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Agriculture, Multidisciplinary

Structural and Functional Characterization of the Hazelnut Allergen Cor a 8

Lesa R. Offermann et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Dimerization of lipocalin allergens

Merja H. Niemi et al.

SCIENTIFIC REPORTS (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Ligand Recognition of the Major Birch Pollen Allergen Bet v 1 is Isoform Dependent

Christian Seutter von Loetzen et al.

PLOS ONE (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Structure-Based Phylogenetic Analysis of the Lipocalin Superfamily

Balasubramanian Lakshmi et al.

PLOS ONE (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Secret of the major birch pollen allergen Bet v 1: identification of the physiological ligand

Christian Seutter von Loetzen et al.

BIOCHEMICAL JOURNAL (2014)

添加到收藏夹

Article Allergy

Bet v 1-a Trojan horse for small ligands boosting allergic sensitization?

C. Asam et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2014)

添加到收藏夹

Review Allergy

Allergen Ligands in the Initiation of Allergic Sensitization

Wayne R. Thomas

CURRENT ALLERGY AND ASTHMA REPORTS (2014)

添加到收藏夹

Article Allergy

Do lipids influence the allergic sensitization process?

Merima Bublin et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

添加到收藏夹

Article Biochemical Research Methods

Nitration of the Birch Pollen Allergen Bet v 1.0101: Efficiency and Site-Selectivity of Liquid and Gaseous Nitrating Agents

Kathrin Reinmuth-Selzle et al.

JOURNAL OF PROTEOME RESEARCH (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structural aspects of dog allergies: The crystal structure of a dog dander allergen Can f 4

Merja H. Niemi et al.

MOLECULAR IMMUNOLOGY (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

The major cockroach allergen Bla g 4 binds tyramine and octopamine

Lesa R. Offermann et al.

MOLECULAR IMMUNOLOGY (2014)

添加到收藏夹

Article Multidisciplinary Sciences

The Major Cow Milk Allergen Bos d 5 Manipulates T-Helper Cells Depending on Its Load with Siderophore-Bound Iron

Franziska Roth-Walter et al.

PLOS ONE (2014)

添加到收藏夹

Article Allergy

The major allergen of the Parietaria pollen contains an LPS-binding region with immuno-modulatory activity

A. Bonura et al.

ALLERGY (2013)

添加到收藏夹

Review Biochemistry & Molecular Biology

Structural and functional aspects of PR-10 proteins

Humberto Fernandes et al.

FEBS JOURNAL (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structure and Function of the Peanut Panallergen Ara h 8

Barry K. Hurlburt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Strawberry Pathogenesis-related 10 (PR-10) Fra a Proteins Control Flavonoid Biosynthesis by Binding to Metabolic Intermediates

Ana Casanal et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

添加到收藏夹

Article Immunology

Allergens as Immunomodulatory Proteins: The Cat Dander Protein Fel d 1 Enhances TLR Activation by Lipid Ligands

Jurgen Herre et al.

JOURNAL OF IMMUNOLOGY (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structural and bioinformatic analysis of the kiwifruit allergen Act d 11, a member of the family of ripening-related proteins

Maksymilian Chruszcz et al.

MOLECULAR IMMUNOLOGY (2013)

添加到收藏夹

Review Allergy

Animal Lipocalin Allergens

Christiane Hilger et al.

CURRENT ALLERGY AND ASTHMA REPORTS (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Crystallographically Mapped Ligand Binding Differs in High and Low IgE Binding Isoforms of Birch Pollen Allergen Bet v 1

Stefan Kofler et al.

JOURNAL OF MOLECULAR BIOLOGY (2012)

添加到收藏夹

Article Multidisciplinary Sciences

Nitration of the Pollen Allergen Bet v 1.0101 Enhances the Presentation of Bet v 1-Derived Peptides by HLA-DR on Human Dendritic Cells

Anette C. Karle et al.

PLOS ONE (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Recognition of the Major Cat Allergen Fel d 1 through the Cysteine-rich Domain of the Mannose Receptor Determines Its Allergenicity

Mohamed Emara et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

添加到收藏夹

Review Immunology

Orchestrating house dust mite-associated allergy in the lung

Lisa G. Gregory et al.

TRENDS IN IMMUNOLOGY (2011)

添加到收藏夹

Article Immunology

Differential T-cell responses and allergen uptake after exposure of dendritic cells to the birch pollen allergens Bet v 1.0101, Bet v 1.0401 and Bet v 1.1001

Ursula Smole et al.

IMMUNOBIOLOGY (2010)

添加到收藏夹

Article Immunology

The Mannose Receptor Mediates the Uptake of Diverse Native Allergens by Dendritic Cells and Determines Allergen-Induced T Cell Polarization through Modulation of IDO Activity

Pierre-Joseph Royer et al.

JOURNAL OF IMMUNOLOGY (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cytokinin-induced structural adaptability of a Lupinus luteus PR-10 protein

Humberto Fernandes et al.

FEBS JOURNAL (2009)

添加到收藏夹

Article Cell Biology

Lipopolysaccharide binding of the mite allergen Der f 2

Saori Ichikawa et al.

GENES TO CELLS (2009)

添加到收藏夹

Article Evolutionary Biology

The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands

Christian Radauer et al.

BMC EVOLUTIONARY BIOLOGY (2008)

添加到收藏夹

Article Allergy

Allergens are distributed into few protein families and possess a restricted number of biochemical functions

Christian Radauer et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2008)

添加到收藏夹

Article Biochemistry & Molecular Biology

Lupinus luteus pathogenesis-related protein as a reservoir for cytokinin

Humberto Fernandes et al.

JOURNAL OF MOLECULAR BIOLOGY (2008)

添加到收藏夹

Article Allergy

Evolutionary biology of plant food allergens

Christian Radauer et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structural basis of sterol binding by NPC2, a lysosomal protein deficient in Niemann-Pick type C2 disease

Sujuan Xu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

Crystal structure of Vigna radiata cytokinin-specific binding protein in complex with zeatin

Oliwia Pasternak et al.

PLANT CELL (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Crystal structure of peach Pru p 3, the prototypic member of the family of plant non-specific lipid transfer protein pan-allergens

N Pasquato et al.

JOURNAL OF MOLECULAR BIOLOGY (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Comparative ligand-binding analysis of ten human lipocalins

DA Breustedt et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2006)

添加到收藏夹

Article Allergy

Pollen allergens are restricted to few protein families and show distinct patterns of species distribution

C Radauer et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2006)

添加到收藏夹

Review Plant Sciences

Lipocalins - a family portrait

Joanna Grzyb et al.

JOURNAL OF PLANT PHYSIOLOGY (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein

MA Olayioye et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

添加到收藏夹

Review Biotechnology & Applied Microbiology

Plant food allergens - structural and functional aspects of allergenicity

H Breiteneder et al.

BIOTECHNOLOGY ADVANCES (2005)

添加到收藏夹

Article Biochemistry & Molecular Biology

MD-2 and Der p 2 - a tale of two cousins or distant relatives?

MM Keber et al.

JOURNAL OF ENDOTOXIN RESEARCH (2005)

添加到收藏夹

Article Biochemical Research Methods

Structure of a yellow lupin pathogenesis-related PR-10 protein belonging to a novel subclass

O Pasternak et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2005)

添加到收藏夹

Article Multidisciplinary Sciences

Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations

TL Gioannini et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

添加到收藏夹

Article Microbiology

Human tear lipocalin exhibits antimicrobial activity by scavenging microbial siderophores

M Fluckinger et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular lipopolysaccharide recognition

A Gruber et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

添加到收藏夹

Review Food Science & Technology

Structural, biological, and evolutionary relationships of plant food allergens sensitizing via the gastrointestinal tract

ENC Mills et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2004)

添加到收藏夹

Article Immunology

Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen

SC Eisenbarth et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2002)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structural basis of non-specific lipid binding in maize lipid-transfer protein complexes revealed by high-resolution X-ray crystallography

GW Han et al.

JOURNAL OF MOLECULAR BIOLOGY (2001)

添加到收藏夹

Article Biochemistry & Molecular Biology

Crystal structure of the allergen Equ c 1 -: A dimeric lipocalin with restricted IgE-reactive epitopes

MB Lascombe et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.