☆ 4.8 Review

Current understanding of passive and active targeting nanomedicines to enhance tumor accumulation

COORDINATION CHEMISTRY REVIEWS (2023)

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Article Pharmacology & Pharmacy

Comparison of three synthetic transferrin mimetic small peptides to promote the blood-brain barrier penetration of vincristine liposomes for improved glioma targeted therapy

Solmaz Mojarad-Jabali et al.

Summary: The development of a modified liposomal formulation has shown promising results in facilitating brain targeted delivery and selective accumulation within glioma cells. Among the studied targeting ligands, T7-modified liposomes demonstrated superior BBB penetration, brain distribution, and increased accumulation in glioma cells, leading to improved anti-glioma outcomes through targeted cytotoxicity and apoptosis. These results suggest that T7-modified liposomes could serve as a potential platform for effective brain targeted delivery and glioma therapy in clinical settings.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Review Biotechnology & Applied Microbiology

Charge reversal nano-systems for tumor therapy

Peng Zhang et al.

Summary: This review comprehensively summarizes the recent advances in charge-reversal nanocarriers, including their roles in cellular uptake, charge-conversion mechanisms in response to specific stimuli, the relationship between chemical structure and charge reversal activity, and commonly used polymeric materials.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Pharmacology & Pharmacy

Destruction of tumor vasculature by vascular disrupting agents in overcoming the limitation of EPR effect

Zhilin Liu et al.

Summary: Nanomedicine improves the efficiency of delivering antitumor drugs into tumors, but insufficient tumor penetration hampers therapeutic efficacy. Vascular disrupting agent (VDA) nanomedicines selectively destroy immature tumor vessels, block the supply of oxygen and nutrients, and increase vascular permeability, reducing the dependence on enhanced permeability and retention effect. This review discusses the recent progress and application of VDA nanomedicines in cancer therapy, including mechanisms, delivery strategies, and combination therapies.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Article Chemistry, Multidisciplinary

A Hybrid Supramolecular Polymeric Nanomedicine for Cascade-Amplified Synergetic Cancer Therapy

Kai Yang et al.

Summary: The study developed a hybrid supramolecular polymeric nanomedicine that combines chemodynamic therapy and chemotherapy by catalyzing the production of highly toxic radicals to release drugs and enhance therapeutic efficacy. The combination therapy stimulates immune response and enhances the effectiveness of immunotherapy by promoting intratumoral infiltration of cytotoxic T lymphocytes.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Review Pharmacology & Pharmacy

Antibody and Cellular-Based Therapies for Pediatric Acute Lymphoblastic Leukemia: Mechanisms and Prospects

Wei Li et al.

Summary: This review highlights the mechanisms and application status of innovative antibody and cellular-based therapies for pediatric acute lymphoblastic leukemia (ALL), and discusses the significant prospects and challenges.

PHARMACOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Engineering a HEK-293T exosome-based delivery platform for efficient tumor-targeting chemotherapy/internal irradiation combination therapy

Congcong Wang et al.

Summary: Researchers have developed a multifunctional exosome-based drug delivery platform that can target and treat tumor cells. The platform showed efficient drug delivery in vitro and excellent tumor-targeting capacity in vivo. This study provides novel insight into the treatment of certain types of cancer and has great potential for improving therapeutic efficacy.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Multidisciplinary Sciences

In vivo hitchhiking of immune cells by intracellular self-assembly of bacteria-mimetic nanomedicine for targeted therapy of melanoma

Cheng Gao et al.

Summary: This study reports an in vivo strategy to construct cell-based nanomedicine carriers using bacteria-mimetic gold nanoparticles, which are selectively phagocytosed by immune cells and self-assemble into intracellular aggregates. The optimized carriers improve drug delivery and enhance antitumor immunotherapy through photothermal treatment and immune checkpoint blockade.

SCIENCE ADVANCES (2022)

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Review Chemistry, Multidisciplinary

Glioma diagnosis and therapy: Current challenges and nanomaterial-based solutions

Tianzhong Li et al.

Summary: Glioma, one of the most dreadful central nervous system tumors, has a high incidence rate and remains a significant challenge for treatment. However, the development of nanomedicine provides new opportunities for long-term therapy. Various obstacles, such as the blood-brain barrier permeation, hypoxia, and complex tumor microenvironment, hinder the development of novel therapeutics. Efforts have been made to explore nanoformulations to improve permeation and address these challenges. The article provides an overview of glioma classification, pathogenic factors, current therapeutic approaches, and innovative strategies, concluding with suggestions for future improvement in diagnosis and therapy.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Pharmacology & Pharmacy

Cell-based drug delivery systems and their in vivo fate

Liuxin Yang et al.

Summary: Cell-based drug delivery systems have gained attention for their unique biological properties and self-powered functions. They exhibit excellent biocompatibility, low immunogenicity, long circulation time, tissue-homing characteristics, and the ability to cross biological barriers. Various cells have been explored as functional vectors for loading and delivering therapeutic payloads, showing potential for disease treatment. The fate of these cell-based drug delivery systems in vivo depends on biological properties, loaded drugs, physiological and pathological circumstances, and the body's response.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Article Multidisciplinary Sciences

Supramolecular engineering of cell membrane vesicles for cancer immunotherapy

Shaolong Qi et al.

Summary: In this study, a cell-friendly supramolecular strategy was proposed to engineer cell membranes, enabling specific accumulation of supramolecular cell membrane vesicles (SCMVs) in tumors and effective tumor ablation through photodynamic therapy and immunotherapy.

SCIENCE BULLETIN (2022)

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Review Medicine, Research & Experimental

Antibody-based drug delivery systems for cancer therapy: Mechanisms, challenges, and prospects

Zhoujiang Chen et al.

Summary: Antibody-based cancer therapy has emerged as an efficient therapeutic strategy with diverse clinical manifestations and applications. Various drug delivery platforms have been developed to enhance therapeutic efficacy. Antibody-based drug delivery systems play an important role in cancer therapy by addressing the current challenges of antibody application and utilizing advanced drug delivery technologies.

THERANOSTICS (2022)

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Review Chemistry, Multidisciplinary

Peptide-functionalized liposomes as therapeutic and diagnostic tools for cancer treatment

Jafrin Jobayer Sonju et al.

Summary: This review focuses on recent advances in peptide-functionalized liposomal formulation techniques in cancer diagnosis and treatment, highlighting the benefits and current challenges of these novel techniques.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Engineering, Biomedical

Tumor microenvironment triple-responsive nanoparticles enable enhanced tumor penetration and synergetic chemo-photodynamic therapy

Man Shu et al.

Summary: A novel combined chemo/photodynamic therapy has been developed using pH/ROS/MMP-2 triple-responsive drug nanocarriers for efficient treatment of solid tumors. The nanoparticles can effectively accumulate in tumors, release drugs in response to intracellular pH and ROS levels, and amplify ROS generation with external laser irradiation to achieve extraordinary therapeutic efficacy. The treatment showed substantial tumor shrinkage and eradication with low toxicity in major organs, indicating great potential for tumor therapy.

BIOMATERIALS (2021)

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Review Chemistry, Multidisciplinary

The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors

Mukaddes Izci et al.

Summary: Research has shown that despite efforts to utilize the EPR effect for enhanced delivery of nanomaterials to solid tumors, the results are still poor. Furthermore, some studies question the role of the EPR effect, suggesting that nanomaterials may enter tumors through active mechanisms rather than through endothelial gaps.

CHEMICAL REVIEWS (2021)

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Review Pharmacology & Pharmacy

Self-propelling micro-/nano-motors: Mechanisms, applications, and challenges in drug delivery

Jianting Zhang et al.

Summary: Self-propelling micro-/nano-motors (MNMs) show enormous potential in various applications, such as drug delivery, by overcoming the challenge of low permeation of biological barriers. Research progress and application of these innovative motor designs are expected to play a crucial role in future clinical practice.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Chemistry, Multidisciplinary

A dual-guide bioinspired drug delivery strategy of a macrophage-based carrier against postoperative triple-negative breast cancer recurrence

Yue Qiu et al.

Summary: In this study, a macrophage-based carrier was designed to enhance the efficiency of targeting recurrent tumors through a dual-guide strategy. Both in vitro and in vivo experiments demonstrated the significant effectiveness of the carrier in inhibiting tumor recurrence post-operation.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

Manipulating dynamic tumor vessel permeability to enhance polymeric micelle accumulation

Yuta Inoue et al.

Summary: Improving the efficiency of drug delivery systems by manipulating nano-eruptions is a major goal in polymeric micelle research. Compounds like a TGF-beta inhibitor and chloroquine were found to have beneficial effects on intratumoral distribution of DDSs through different mechanisms.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

Sequential Modulations of Tumor Vasculature and Stromal Barriers Augment the Active Targeting Efficacy of Antibody-Modified Nanophotosensitizer in Desmoplastic Ovarian Carcinoma

Yue Yan et al.

Summary: The study highlights the importance of regulating the tumor microenvironment to enhance the therapeutic efficacy of active-targeted nanophotosensitizers, with normalization of tumor vasculature and photoablation of stromal cells improving tumor accumulation and cancer cell accessibility of the nanoparticles. This sequential regulation strategy significantly enhances the antitumor efficacy of active-targeted nanoparticles, providing a basis for accelerating their clinical translation.

ADVANCED SCIENCE (2021)

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Article Engineering, Biomedical

Facile fabrication of robust, hyaluronic acid-surfaced and disulfide-crosslinked PLGA nanoparticles for tumor-targeted and reduction-triggered release of docetaxel

Xiuxiu Wang et al.

Summary: High-efficacy targeted nanotherapeutics based on FDA approved polymers like PLGA, such as HA-sPLGA XNPs, show promise in achieving enhanced treatment of A549 lung tumor, with fast cellular uptake and significantly improved potency compared to other nanoparticles. These nanoparticles demonstrate prolonged elimination half-life and notable tumor accumulation, making them a unique and potentially translatable platform for chemotherapy of CD44-overexpressing tumors.

ACTA BIOMATERIALIA (2021)

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Review Pharmacology & Pharmacy

Tumor microenvironment remodeling-based penetration strategies to amplify nanodrug accessibility to tumor parenchyma q

Yanhong Liu et al.

Summary: Significant advances in nano delivery systems offer new hope for tumor prevention, diagnosis, and treatment, but challenges persist in achieving clinical therapeutic effects against solid tumors. Biological barriers, such as abnormal tumor vasculature and abundant stroma cells within the tumor microenvironment (TME), impede the penetration and distribution of nanodrugs. Advanced strategies for TME remodeling are reviewed to overcome these obstacles and facilitate intratumoral permeation of nanodrugs.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Nanoscience & Nanotechnology

Engineering of Neutrophil Membrane Camouflaging Nanoparticles Realizes Targeted Drug Delivery for Amplified Antitumor Therapy

Jingshuai Wang et al.

Summary: The addition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on neutrophil membrane (NM)-based nanoparticles enhances cellular internalization and cytotoxicity to tumor cells, leading to improved antitumor efficacy. Targeting adhesion originated from NM to immune evasion and subsequent excellent cellular internalization contributes to significant tumor inhibition and survival rates in mice.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Biotechnology & Applied Microbiology

Evaluation of the stability of cucurbit[8]uril-based ternary host-guest complexation in physiological environment and the fabrication of a supramolecular theranostic nanomedicine

Han Wu et al.

Summary: The study confirmed the stability of host-guest complexation between CB[8] and 4,4'-bipyridinium and napththyl guest in physiological environment, leading to the successful construction of a supramolecular nanomedicine based on this molecular recognition with promising potentials in anticancer therapy.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Nanoscience & Nanotechnology

Target-Specific Magnetic Resonance Imaging of Human Prostate Adenocarcinoma Using NaDyF4-NaGdF4 Core Shell Nanoparticles

Armita Dash et al.

Summary: The development of NaDyF4-NaGdF4 core-shell nanoparticles for targeting prostate cancer cells was illustrated using preclinical MRI technology. The nanoparticles demonstrated efficient proton relaxivities at both clinical and preclinical magnetic field strengths, showing potential for noninvasive diagnosis. In vivo studies on active and passive targeting revealed the superiority of active targeting, with nearly double the efficiency compared to passive targeting.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Engineering, Biomedical

The protein corona and its effects on nanoparticle-based drug delivery systems

Hanmei Li et al.

Summary: The formation of a protein corona (PC) on nanoparticles (NPs) in the blood can influence their behavior. Strategies to reduce PC formation or exploit it to enhance NP functions are discussed in this review. Studying protein-NP interactions can provide insights into their clinical activity in health and disease.

ACTA BIOMATERIALIA (2021)

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Article Engineering, Biomedical

Bacterial navigation for tumor targeting and photothermally-triggered bacterial ghost transformation for spatiotemporal drug release

Songzhi Xie et al.

Summary: The study proposed a strategy to load drugs into bacteria for self-guided delivery to tumor tissues and release drugs in tumors through in situ transformation into bacterial ghosts, integrating photothermal effects, chemotherapy, and immunotherapy in a concise manner.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Multidisciplinary

Supramolecular Polymerization-Induced Nanoassemblies for Self-Augmented Cascade Chemotherapy and Chemodynamic Therapy of Tumor

Kuikun Yang et al.

Summary: A supramolecular nanoparticle has been developed for chemodynamic therapy, which can release radicals and platinum (IV) prodrug in tumors to enhance H2O2 generation. The nanoparticles can be readily excreted via renal clearance to avoid systemic toxicity, providing potential for novel cascade chemo/chemodynamic therapy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Physical

Cell membrane camouflaged bismuth nanoparticles for targeted photothermal therapy of homotypic tumors

Xiaoling Ren et al.

Summary: The research demonstrated the camouflage of Bi nanoparticles (NPs) with mouse colon cancer CT26 cells membrane (CT26 CCM), which resulted in improved biocompatibility and targeting ability. The camouflage process efficiently coated Bi NPs cores with CCM shell, enhancing their therapeutic potential for imaging-guided photothermal therapy.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Selective transferrin coating as a facile strategy to fabricate BBB-permeable and targeted vesicles for potent RNAi therapy of brain metastatic breast cancer in vivo

Yaohua Wei et al.

Summary: Transferrinfunctionalized chimeric polymersomes carrying siRNA against polo-like kinase 1 (Tf@TBP-CPs-siPLK1) showed significant efficacy in treating brain metastatic breast cancer by promoting blood-brain barrier penetration and high tumor cell specificity.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

Use of Oppositely Polarized External Magnets To Improve the Accumulation and Penetration of Magnetic Nanocarriers into Solid Tumors

Jessica F. Liu et al.

ACS NANO (2020)

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Peptide-enhanced tumor accumulation of upconversion nanoparticles for sensitive upconversion luminescence/magnetic resonance dual-mode bioimaging of colorectal tumors

Xinxin Li et al.

ACTA BIOMATERIALIA (2020)

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Improving Tumor Accumulation of Aptamers by Prolonged Blood Circulation

Ding Ding et al.

ANALYTICAL CHEMISTRY (2020)

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Ultrasmall platinum nanoparticles enable deep tumor penetration and synergistic therapeutic abilities through free radical species-assisted catalysis to combat cancer multidrug resistance

Ranjith Kumar Kankala et al.

CHEMICAL ENGINEERING JOURNAL (2020)

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The Use of Lactose as an Alternative Coating for Nanoparticles

Jamie L. Betker et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

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Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

Min Li et al.

NATURE COMMUNICATIONS (2020)

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Enzyme-Triggered Transcytosis of Dendrimer-Drug Conjugate for Deep Penetration into Pancreatic Tumors

Guowei Wang et al.

ACS NANO (2020)

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Fabrication of Glyco-Metal-Organic Frameworks for Targeted Interventional Photodynamic/Chemotherapy for Hepatocellular Carcinoma through Percutaneous Transperitoneal Puncture

Jun Hu et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

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Review Chemistry, Multidisciplinary

Nanoarchitectured Structure and Surface Biofunctionality of Mesoporous Silica Nanoparticles

Ranjith Kumar Kankala et al.

ADVANCED MATERIALS (2020)

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Hyaluronic acid-modified liposomal honokiol nanocarrier: Enhance anti-metastasis and antitumor efficacy against breast cancer

Jing Wang et al.

CARBOHYDRATE POLYMERS (2020)

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Galactosylated TPGS Micelles for Docetaxel Targeting to Hepatic Carcinoma: Development, Characterization, and Biodistribution Study

Pawan Tekchandani et al.

AAPS PHARMSCITECH (2020)

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Small Morph Nanoparticles for Deep Tumor Penetration via Caveolae-Mediated Transcytosis

Zipeng Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Self-Reporting and Splitting Nanopomegranates Potentiate Deep Tissue Cancer Radiotherapy via Elevated Diffusion and Transcytosis

Li Wang et al.

ACS NANO (2020)

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Review Engineering, Biomedical

Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand

Ahmed O. Elzoghby et al.

BIOMATERIALS (2020)

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Systemic delivery of aptamer-drug conjugates for cancer therapy using enzymatically generated self-assembled DNA nanoparticles

Binh Thanh Tran et al.

NANOSCALE (2020)

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NANO TODAY (2019)

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ACTA BIOMATERIALIA (2019)

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Tumor Targeting by Peptide-Decorated Gold Nanoparticles

Barbara Albertini et al.

MOLECULAR PHARMACEUTICS (2019)

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Cell Membrane-Camouflaged NIR II Fluorescent Ag2Te Quantum Dots-Based Nanobioprobes for Enhanced In Vivo Homotypic Tumor Imaging

Jing-Jing Zhang et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Magnetic targeting combined with active targeting of dual-ligand iron oxide nanoprobes to promote the penetration depth in tumors for effective magnetic resonance imaging and hyperthermia

Ling Chen et al.

ACTA BIOMATERIALIA (2019)

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Enzyme-activatable polymer-drug conjugate augments tumour penetration and treatment efficacy

Quan Zhou et al.

NATURE NANOTECHNOLOGY (2019)

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Dopamine Delivery via pH-Sensitive Nanoparticles for Tumor Blood Vessel Normalization and an Improved Effect of Cancer Chemotherapeutic Drugs

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Co-delivery of cisplatin and doxorubicin by covalently conjugating with polyamidoamine dendrimer for enhanced synergistic cancer therapy

Xue-Ling Guo et al.

ACTA BIOMATERIALIA (2019)

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Assemblies of Peptide-Cytotoxin Conjugates for Tumor-Homing Chemotherapy

Jinqiang Wang et al.

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Xueman Chen et al.

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Neutrophil-mimicking therapeutic nanoparticles for targeted chemotherapy of pancreatic carcinoma

Xi Cao et al.

ACTA PHARMACEUTICA SINICA B (2019)

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Tumor acidity activated triphenylphosphonium-based mitochondrial targeting nanocarriers for overcoming drug resistance of cancer therapy

Hui Yu et al.

THERANOSTICS (2019)

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A nano-immunotraining strategy to enhance the tumor targeting of neutrophils via in vivo pathogen-mimicking stimulation

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BIOMATERIALS SCIENCE (2019)

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Bacterial microbots for acid-labile release of hybrid micelles to promote the synergistic antitumor efficacy

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ACTA BIOMATERIALIA (2018)

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Steric shielding protected and acidity-activated pop-up of ligand for tumor enhanced photodynamic therapy

Kai Han et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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PEGylation of Carbonate Apatite Nanoparticles Prevents Opsonin Binding and Enhances Tumor Accumulation of Gemcitabine

Fitya Syarifa Mozar et al.

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Biotinylated Bilirubin Nanoparticles as a Tumor Microenvironment-Responsive Drug Delivery System for Targeted Cancer Therapy

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ADVANCED SCIENCE (2018)

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Enhancing the Accumulation of Polymer Micelles by Selectively Dilating Tumor Blood Vessels with NO for Highly Effective Cancer Treatment

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ADVANCED HEALTHCARE MATERIALS (2018)

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Actively Targeted Deep Tissue Imaging and Photothermal-Chemo Therapy of Breast Cancer by Antibody-Functionalized Drug-Loaded X-Ray-Responsive Bismuth Sulfide@Mesoporous Silica Core-Shell Nanoparticles

Lihua Li et al.

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Green Synthesis of Sub-10 nm Gadolinium-Based Nanoparticles for Sparkling Kidneys, Tumor, and Angiogenesis of Tumor-Bearing Mice in Magnetic Resonance Imaging

Bingbo Zhang et al.

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Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy

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JOURNAL OF CONTROLLED RELEASE (2017)

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Combination Cancer Therapy Using Chimeric Antigen Receptor-Engineered Natural Killer Cells as Drug Carriers

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ONCOLOGY REPORTS (2017)

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Enhancing Nanoparticle Accumulation and Retention in Desmoplastic Tumors via Vascular Disruption for Internal Radiation Therapy

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THERANOSTICS (2017)

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Hyaluronic Acid Conjugated Magnetic Prussian Blue@Quantum Dot Nanoparticles for Cancer Theranostics

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THERANOSTICS (2017)

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Panitumumab-Conjugated Pt-Drug Nanomedicine for Enhanced Efficacy of Combination Targeted Chemotherapy against Colorectal Cancer

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Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours

Suping Li et al.

NATURE BIOMEDICAL ENGINEERING (2017)

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Tumor vasculature normalization by orally fed erlotinib to modulate the tumor microenvironment for enhanced cancer nanomedicine and immunotherapy

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BIOMATERIALS (2017)

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Red blood cell membrane-camouflaged melanin nanoparticles for enhanced photothermal therapy

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BIOMATERIALS (2017)

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Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor Therapy

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NANO LETTERS (2016)

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Article Chemistry, Multidisciplinary

Hyaluronidase Embedded in Nanocarrier PEG Shell for Enhanced Tumor Penetration and Highly Efficient Antitumor Efficacy

Hao Zhou et al.

NANO LETTERS (2016)

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Article Nanoscience & Nanotechnology

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PEGylation of HPMA-based block copolymers enhances tumor accumulation in vivo: A quantitative study using radiolabeling and positron emission tomography

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Whole-cell SELEX aptamer-functionalised poly(ethyleneglycol)-poly(ε-caprolactone) nanoparticles for enhanced targeted glioblastoma therapy

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Redox-sensitive micelles self-assembled from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxel

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