BODIPY-based probes for hypoxic environments

Hypoxic environment is an important feature of solid tumors, which comes from the imbalance of oxygen supply and consumption. Over the past few years, substantial progress has focused on the design of hypoxia probes derived from BODIPY scaffolds. Such probes are of particular interest and are closely related to tumor resistance to various therapies. This review highlights the construction strategies, recog- nition mechanisms as well as biological imaging applications of various BODIPY-based hypoxia probes. The aim is to inspire novel approaches and innovations for designing fluorescent probes to image hypoxic environments, and promote the development of diagnostics for tumors and hypoxia-responsive anti- cancer nanomedicines.(c) 2023 Elsevier B.V. All rights reserved.

Automated summary

The hypoxic environment is a significant characteristic of solid tumors, resulting from an imbalance between oxygen supply and consumption. Recent progress has been made in designing hypoxia probes derived from BODIPY scaffolds. These probes have attracted particular attention and are closely related to tumor resistance to various therapies. This review focuses on the construction strategies, recognition mechanisms, and biological imaging applications of various BODIPY-based hypoxia probes, aiming to inspire novel approaches and innovations for designing fluorescent probes for imaging hypoxic environments and promoting the development of tumor diagnostics and hypoxia-responsive anti-cancer nanomedicines.