Morphological and biomechanical analyses of the human healthy and glaucomatous aqueous outflow pathway: Imaging-to-modeling

Review Ophthalmology

Pathogenesis of glaucoma: Extracellular matrix dysfunction in the trabecular meshwork-A review

Kate E. Keller et al.

Summary: The trabecular meshwork regulates the outflow of aqueous humour and changes in the extracellular matrix can lead to increased outflow resistance and glaucoma development.

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2022)

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Article Critical Care Medicine

Ocular biomechanics during improvised explosive device blast: A computational study using eye-specific models

Alireza Karimi et al.

Summary: Eye injuries caused by explosive devices are significant, and the blast wave can result in elevated intraocular pressure. This study utilized eye-specific models to calculate the biomechanical stresses and strains in the eye caused by IED explosions.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2022)

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Article Chemistry, Multidisciplinary

Trabecular Meshwork Motion Profile from Pulsatile Pressure Transients: A New Platform to Simulate Transitory Responses in Humans and Nonhuman Primates

Chen Xin et al.

Summary: This study introduces a new laboratory platform to investigate the motion responses of trabecular meshwork (TM) to ocular transients. The findings suggest that abnormal TM motion is a leading cause of glaucoma and that the platform permits quantitation of TM motion responses to designed pulse transients. The study's implications include improved interpretation of new TM motion measurements in clinic and a better understanding of glaucoma mechanisms and management.

APPLIED SCIENCES-BASEL (2022)

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Article Computer Science, Interdisciplinary Applications

Modeling the biomechanics of the conventional aqueous outflow pathway microstructure in the human eye

Alireza Karimi et al.

Summary: Intraocular pressure is determined by the resistance of aqueous humor outflow, which is influenced by the mechanical properties of trabecular meshwork, Schlemm's canal inner wall, and juxtacanalicular connective tissue. Understanding the biomechanical interactions of aqueous humor with outflow tissues is crucial for regulating outflow resistance and fluid dynamics in the eye.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2022)

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Article Computer Science, Interdisciplinary Applications

Biomechanics of human trabecular meshwork in healthy and glaucoma eyes via dynamic Schlemm's canal pressurization

Alireza Karimi et al.

Summary: The stiffness of the trabecular meshwork is significantly higher in glaucoma eyes compared to healthy eyes, indicating differences in viscoelastic mechanical behavior. These findings shed light on the mechanical property distinctions in the outflow pathway of healthy and glaucomatous eyes under dynamic loading, potentially serving as a new biomarker for early diagnosis of glaucoma.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2022)

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Article Medicine, General & Internal

Pulsatile Trabecular Meshwork Motion: An Indicator of Intraocular Pressure Control in Primary Open-Angle Glaucoma

Rong Du et al.

Summary: The study revealed that pulsatile trabecular meshwork motion decreased in POAG patients with higher diurnal IOP fluctuation. Measurement of pulsatile TM motion with PhS-OCT may have clinical potential for evaluating diurnal IOP fluctuation.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Engineering, Biomedical

The Effect of Intraocular Pressure Load Boundary on the Biomechanics of the Human Conventional Aqueous Outflow Pathway

Alireza Karimi et al.

Bioengineering (2022)

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Article Medicine, General & Internal

Viscoelastic Biomechanical Properties of the Conventional Aqueous Outflow Pathway Tissues in Healthy and Glaucoma Human Eyes

Alireza Karimi et al.

Summary: This study revealed the differences in viscoelastic mechanical properties among different regions of the ocular conventional outflow pathway and between healthy and glaucomatous tissues using OCT imaging technology.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Ophthalmology

Relative Contributions of Intraocular and Cerebrospinal Fluid Pressures to the Biomechanics of the Lamina Cribrosa and Laminar Neural Tissues

Alireza Karimi et al.

Summary: This study investigated the effects of intraocular pressure and cerebrospinal fluid pressure on the optic nerve head. The results showed that the effects of intraocular pressure were more significant in terms of stress, strain, and deformation compared to cerebrospinal fluid pressure.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2022)

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Article Biotechnology & Applied Microbiology

An Optimized Method to Decellularize Human Trabecular Meshwork

Devon J. Crouch et al.

Summary: This study provides an optimized protocol for decellularization of the trabecular meshwork (TM), a structure important in regulating intraocular pressure. The use of ammonium hydroxide (NH4OH) effectively removes cells while preserving tissue structure, offering potential applications in glaucoma research and tissue regeneration.

BIOENGINEERING-BASEL (2022)

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Article Ophthalmology

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Colleen M. McDowell et al.

Summary: This article highlights the importance of using mice as a valuable model system for studying conventional outflow resistance and intraocular pressure. It also outlines the minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. These standards are expected to enhance scientific rigor and replicability of research findings.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2022)

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Review Ophthalmology

Normal and glaucomatous outflow regulation

Ted S. Acott et al.

Summary: Glaucoma, a complex eye disease, involves the key structures of trabecular meshwork and Schlemm's canal inner wall endothelium in regulating intraocular pressure. Glaucomatous eyes demonstrate distinctive molecular differences in aqueous outflow regions, with a loss of IOP homeostatic response leading to pathological changes. The ongoing research into outflow resistance and its regulation mechanisms has the potential to enhance our understanding of IOP regulation and glaucoma pathophysiology.

PROGRESS IN RETINAL AND EYE RESEARCH (2021)

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Article Computer Science, Interdisciplinary Applications

Analysis of the effects of finite element type within a 3D biomechanical model of a human optic nerve head and posterior pole

Alireza Karimi et al.

Summary: This study investigated the effects of different element types on the resulting ONH stresses and strains. Results showed that 10-noded tetrahedral elements yielded similar results to 20-noded hexahedral elements with significantly lower computational time, while linear element types did not yield acceptable results.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2021)

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Article Ophthalmology

Morphological factors associated with giant vacuoles with I-pores in Schlemm?s canal endothelial cells of human eyes: A serial block-face scanning electron microscopy study

David L. Swain et al.

Summary: This study utilized serial block-face scanning electron microscopy to investigate morphological factors associated with GVs with I-pores, revealing a higher presence of GVs with both basal openings and I-pores in high-flow areas, suggesting a potential strategy for glaucoma treatment.

EXPERIMENTAL EYE RESEARCH (2021)

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Article Engineering, Biomedical

Modeling the biomechanics of the lamina cribrosa microstructure in the human eye

Alireza Karimi et al.

Summary: Glaucoma is a leading cause of blindness worldwide, characterized by irreversible damage to the retinal ganglion cell axons. Limited knowledge exists on the biomechanics of the lamina cribrosa (LC) microstructure. Finite element modeling of the LC microstructure and neural tissues in human eyes showed that the microstructural models provided better estimates of stress and strain distribution compared to continuum models.

ACTA BIOMATERIALIA (2021)

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Article Computer Science, Interdisciplinary Applications

Ocular biomechanics due to ground blast reinforcement

Alireza Karimi et al.

Summary: This study aimed to estimate the IOP due to frontal IED explosion at different heights from the ground using a fluid-structure interaction model with and without GBR effects. Results revealed that considering GBR led to higher IOP, stresses, and strains in the eye.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2021)

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Review Ophthalmology

The vital role for nitric oxide in intraocular pressure homeostasis

Ester Reina-Torres et al.

Summary: Nitric oxide, catalyzed by endothelial nitric oxide synthase (eNOS) activity, plays a crucial role in maintaining endothelial and cardiovascular homeostasis. In the conventional outflow pathway of the eye, NO is a key player in regulating aqueous humor outflow resistance.

PROGRESS IN RETINAL AND EYE RESEARCH (2021)

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Article Multidisciplinary Sciences

Morphological changes in the trabecular meshwork and Schlemm's canal after treatment with topical intraocular pressure-lowering agents

Ji-Hye Park et al.

Summary: This study investigated the effects of glaucoma treatment medications on the microstructures of the aqueous outflow pathway, finding that prostaglandin analog usage significantly increased trabecular meshwork thickness and decreased Schlemm's canal area.

SCIENTIFIC REPORTS (2021)

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Article Ophthalmology

Reduced Pulsatile Trabecular Meshwork Motion in Eyes With Primary Open Angle Glaucoma Using Phase-Sensitive Optical Coherence Tomography

Kai Gao et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2020)

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Article Multidisciplinary Sciences

A model of the oscillatory mechanical forces in the conventional outflow pathway

Joseph M. Sherwood et al.

JOURNAL OF THE ROYAL SOCIETY INTERFACE (2019)

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Article Computer Science, Interdisciplinary Applications

Risk of rupture of the cerebral aneurysm in relation to traumatic brain injury using a patient-specific fluid-structure interaction model

Reza Razaghi et al.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2019)

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Article Ophthalmology

Transient Intraocular Pressure Fluctuations: Source, Magnitude, Frequency, and Associated Mechanical Energy

Daniel C. Turner et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2019)

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Article Cell Biology

Pharmacological regulation of outflow resistance distal to Schlemm's canal

Fiona McDonnell et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2018)

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Article Ophthalmology

Anatomy of the Eye and Orbit—The Clinical Essentials

Patricia C. Sanchez-Diaz

OPTOMETRY AND VISION SCIENCE (2018)

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Article Ophthalmology

Biomechanical Rigidity and Quantitative Proteomics Analysis of Segmental Regions of the Trabecular Meshwork at Physiologic and Elevated Pressures

Janice A. Vranka et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2018)

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Article Ophthalmology

Quantification of Pulse-Dependent Trabecular Meshwork Motion in Normal Humans Using Phase-Sensitive OCT

Chen Xin et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2018)

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Review Ophthalmology

Genetics and genetic testing for glaucoma

Matthew A. Miller et al.

CURRENT OPINION IN OPHTHALMOLOGY (2017)

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Review Ophthalmology

Trabecular meshwork stiffness in glaucoma

Ke Wang et al.

EXPERIMENTAL EYE RESEARCH (2017)

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Article Ophthalmology

Pressure-induced expression changes in segmental flow regions of the human trabecular meshwork

Janice A. Vranka et al.

EXPERIMENTAL EYE RESEARCH (2017)

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Article Ophthalmology

Aqueous outflow - A continuum from trabecular meshwork to episcleral veins

Teresia Carreon et al.

PROGRESS IN RETINAL AND EYE RESEARCH (2017)

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Review Cell Biology

The Outflow Pathway: A Tissue With Morphological and Functional Unity

Sergio Claudio Sacca et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2016)

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Article Ophthalmology

Mathematical Modeling of Outflow Facility Increase With Trabecular Meshwork Bypass and Schlemm Canal Dilation

Fan Yuan et al.

JOURNAL OF GLAUCOMA (2016)

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Article Multidisciplinary Sciences

Measurement of Outflow Facility Using iPerfusion

Joseph M. Sherwood et al.

PLOS ONE (2016)

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Review Pharmacology & Pharmacy

The aqueous humor outflow pathways in glaucoma: A unifying concept of disease mechanisms and causative treatment

Barbara M. Braunger et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2015)

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Article Ophthalmology

IOP telemetry in the nonhuman primate

J. Crawford Downs

EXPERIMENTAL EYE RESEARCH (2015)

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Review Ophthalmology

Extracellular matrix in the trabecular meshwork: Intraocular pressure regulation and dysregulation in glaucoma

Janice A. Vranka et al.

EXPERIMENTAL EYE RESEARCH (2015)

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Article Ophthalmology

Colocalization of outflow segmentation and pores along the inner wall of Schlemm's canal

Sietse T. Braakman et al.

EXPERIMENTAL EYE RESEARCH (2015)

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Article Cell & Tissue Engineering

Induced Pluripotent Stem Cells Restore Function in a Human Cell Loss Model of Open-Angle Glaucoma

Diala W. Abu-Hassan et al.

STEM CELLS (2015)

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Article Oncology

The intrinsic stiffness of human trabecular meshwork cells increases with senescence

Joshua T. Morgan et al.

ONCOTARGET (2015)

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Article Ophthalmology

Aqueous Humor Outflow: Dynamics and Disease

Uttio Roy Chowdhury et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2015)

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Review Ophthalmology

Intraocular Pressure Homeostasis: Maintaining Balance in a High-Pressure Environment

Ted S. Acott et al.

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2014)

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Article Biochemical Research Methods

Pulsatile motion of the trabecular meshwork in healthy human subjects quantified by phase-sensitive optical coherence tomography

Peng Li et al.

BIOMEDICAL OPTICS EXPRESS (2013)

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Review Ophthalmology

Current understanding of conventional outflow dysfunction in glaucoma

W. Daniel Stamer et al.

CURRENT OPINION IN OPHTHALMOLOGY (2012)

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Article Biochemical Research Methods

Phase-sensitive optical coherence tomography characterization of pulse-induced trabecular meshwork displacement in ex vivo nonhuman primate eyes

Peng Li et al.

JOURNAL OF BIOMEDICAL OPTICS (2012)

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Review Engineering, Biomedical

An overview of tissue and whole organ decellularization processes

Peter M. Crapo et al.

BIOMATERIALS (2011)

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Article Biophysics

Viscoelastic Properties of Isolated Collagen Fibrils

Zhilei Liu Shen et al.

BIOPHYSICAL JOURNAL (2011)

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Article Ophthalmology

Elastic Modulus Determination of Normal and Glaucomatous Human Trabecular Meshwork

Julie A. Last et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2011)

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Article Ophthalmology

eNOS, a Pressure-Dependent Regulator of Intraocular Pressure

W. Daniel Stamer et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2011)

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Article Ophthalmology

SCANNING ELECTRON MICROSCOPIC STUDIES OF THE TRABECULAR MESHWORK AND THE CANAL OF SCHLEMM - AN ATTEMPT TO LOCALIZE THE MAIN RESISTANCE TO OUTFLOW OF AQUEOUS HUMOR IN MAN

ANDERS BILL et al.

ACTA OPHTHALMOLOGICA (2009)

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Review Ophthalmology

Extracellular matrix turnover and outflow resistance

Kate E. Keller et al.

EXPERIMENTAL EYE RESEARCH (2009)

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Review Ophthalmology

The changing paradigm of outflow resistance generation: Towards synergistic models of the JCT and inner wall endothelium

Darryl R. Overby et al.

EXPERIMENTAL EYE RESEARCH (2009)

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Review Ophthalmology

The trabecular meshwork outflow pathways: Structural and functional aspects

Ernst R. Tamm

EXPERIMENTAL EYE RESEARCH (2009)

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Review Medicine, General & Internal

Mechanisms of Disease: Primary Open-Angle Glaucoma.

Young H. Kwon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

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Article Ophthalmology

Cyclic Mechanical Stress and Trabecular Meshwork Cell Contractility

Renata F. Ramos et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2009)

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Review Ophthalmology

Extracellular matrix in the trabecular meshwork

Ted S. Acott et al.

EXPERIMENTAL EYE RESEARCH (2008)

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Review Ophthalmology

Stress response of the trabecular meshwork

Paloma B. Liton et al.

JOURNAL OF GLAUCOMA (2008)

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Article Ophthalmology

Effects of cyclic intraocular pressure on conventional outflow

Renata F. Ramos et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2008)

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Review Ophthalmology

What increases outflow resistance in primary open-angle glaucoma?

Ernst R. Tamm et al.

SURVEY OF OPHTHALMOLOGY (2007)

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Article Ophthalmology

Aqueous humor outflow: What do we know? Where will it lead us?

Michael P. Fautsch et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2006)

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Review Ophthalmology

'What controls aqueous humour outflow resistance?'

M Johnson

EXPERIMENTAL EYE RESEARCH (2006)

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Review Ophthalmology

The aqueous outflow system as a mechanical pump - Evidence from examination of tissue and aqueous movement in human and non-human primates

MA Johnstone

JOURNAL OF GLAUCOMA (2004)

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Article Biophysics

Biomechanics of Schlemm's canal endothelial cells: Influence on F-actin architecture

CR Ethier et al.

BIOPHYSICAL JOURNAL (2004)

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Article Ophthalmology

A new view of the human trabecular meshwork using quick-freeze, deep-etch electron microscopy

HY Gong et al.

EXPERIMENTAL EYE RESEARCH (2002)

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Article Ophthalmology

Ultrastructural localization of collagen IV, fibronectin, and laminin in the trabecular meshwork of normal and glaucomatous eyes

CR Hann et al.

OPHTHALMIC RESEARCH (2001)

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Article Biochemistry & Molecular Biology

Expression of the glaucoma gene myocilin (MYOC) in the human optic nerve head

AF Clark et al.

FASEB JOURNAL (2001)

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Review Ophthalmology

How does nonpenetrating glaucoma surgery work? Aqueous outflow resistance and glaucoma surgery

DH Johnson et al.

JOURNAL OF GLAUCOMA (2001)

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Article Engineering, Multidisciplinary

Multi-Material ALE methods in unstructured grids

JS Peery et al.

COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING (2000)

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Morphological and biomechanical analyses of the human healthy and glaucomatous aqueous outflow pathway: Imaging-to-modeling

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