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Review
Pharmacology & Pharmacy
Christian Bailly et al.
Summary: TIM-3 is an immune checkpoint that is actively investigated as a potential target for cancer treatment. sTIM-3 is an active circulating protein found in the plasma of patients with various diseases, and its production is associated with the cleavage of a membrane receptor by metalloproteases. sTIM-3 has been reported to be elevated in multiple diseases and has the potential to serve as a biomarker.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Parasitology
Christian Bailly
Summary: Neglected tropical parasitic diseases (NTD) are prevalent and require cost-effective treatments. The TIM-3/galectin-9 checkpoint has been shown to play a key role in antiparasitic immunity. This review discusses the role of this checkpoint in seven major NTD and evaluates the potential use of anti-TIM-3 antibodies as a therapeutic approach. The use of anti-TIM-3 antibodies has shown promising results in cases of leishmaniasis, malaria, and schistosomiasis, but has been less effective in echinococcosis and Chagas disease.
Article
Biology
Charlotte Toustou et al.
Summary: N-glycosylation is an important post-translational modification that is highly conserved in eukaryotes, bacteria, and archaea. The processing of N-glycans in eukaryotes is sequential and involves specific steps in the secretory pathway. Recent research has also highlighted the regulation of N-glycosylation, including the biosynthesis of complex-type N-glycans and the role of TMEM165 in different eukaryotic clades.
BIOLOGICAL REVIEWS
(2022)
Article
Oncology
Atsushi Saitou et al.
Summary: The MET receptor is associated with resistance to tyrosine kinase inhibitors in non-small cell lung cancer. This study explores the roles of N-glycans in the proteolytic processing of MET and HGF-induced MET signaling. The findings suggest that N-glycans of MET affect the status and function of the receptor in a site-specific manner.
Article
Immunology
Aleksei Parshenkov et al.
Summary: Altered surface glycosylation is a major characteristic of tumor cells and can be recognized by lectins, which can distinguish tumor cells from healthy cells based on the expression of glycosylation-dependent markers. Lectins induce cell death through various pathways, and their broad cytotoxic response makes them potential candidates for therapies targeting tumor cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Francisca Diniz et al.
Summary: Alterations in glycosylation are commonly observed in cancer cells. Strategies targeting cancer-associated glycans, such as monoclonal antibodies, antibody-drug conjugates, and nanoparticles, have the potential to improve drug delivery to tumor cells and enhance therapeutic efficacy. Nanoparticles can also be used for drug delivery in cancer therapy, including encapsulating vaccines and targeting glycoproteins or glycan-binding proteins. These strategies have significant potential for personalized treatment approaches in the pharmaceutical and clinical sectors.
Review
Chemistry, Analytical
Anuj Shrivastava et al.
Summary: This review provides a comprehensive overview of N-glycosylation diversity and its functional importance for monoclonal antibody therapeutic products. Various strategies and techniques for oligosaccharide characterization are described, including analysis of intact glycoproteins, subunits, glycopeptides, and released glycans. Unique challenges associated with the analysis of this important post-translational modification are discussed.
ANALYTICA CHIMICA ACTA
(2022)
Review
Biochemistry & Molecular Biology
Jin-Taek Hwang et al.
Summary: Post-translational modification (PTM) is an essential mechanism for enhancing the functional diversity of proteins and adjusting their signaling networks. The reversible conjugation of ubiquitin (Ub) and ubiquitin-like proteins (Ubls) to cellular proteins is among the most prevalent PTM, which modulates various cellular and physiological processes by altering the activity, stability, localization, trafficking, or interaction networks of its target molecules. The dysregulation of Ub/Ubl modifications is associated with various diseases, providing new targets for drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Ana Luiza Gomes de Morais et al.
Summary: TIM-3 has been associated with advanced stages and shorter survival in several tumor types. Early clinical trials with anti-TIM-3 monoclonal antibodies have shown safety, but further investigations are needed to determine their antitumor activity. The TIM-3 pathway is complex, requiring the development of different inhibitors to overcome resistance.
CURRENT ONCOLOGY REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Jiena Liu et al.
Summary: Breast cancer is the most common malignant tumor in women worldwide, and post-translational modifications (PTMs) of proteins play important roles in tumorigenesis and progression. However, the study of non-histone modifications, particularly those other than phosphorylation, has been relatively limited. This review aims to explore the functions and impact of these PTMs in breast cancer, and emphasizes the importance of developing novel therapeutic drugs targeting PTMs and biological markers for breast cancer detection.
CELL AND BIOSCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Kris Dammen-Brower et al.
Summary: This article discusses the important role of glycosylation in therapeutic proteins and provides examples of drugs that have been improved through glycoengineering. As glycoengineering strategies develop, deliberate modification of therapeutic protein glycosylation will become more prevalent.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Marta Pozniak et al.
Summary: Precise anticancer therapies using cytotoxic conjugates offer a highly attractive alternative to conventional treatment modalities. This study evaluates the significance of N-glycosylation for the internalization and toxicity of conjugates targeting HER2 and FGFR1, and demonstrates that alteration of N-glycosylation can affect the cytotoxic potential of the conjugates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xiaomin Xi et al.
Summary: MUC1 is highly expressed in breast cancer and its role in drug sensitivity is unclear. Knocking out MUC1 or inhibiting it enhances the sensitivity of breast cancer cells to drugs. Further investigation revealed that the extracellular glycosylation of MUC1 is crucial for membrane-dependent drug resistance. Targeting the glycosylation of MUC1 may promote drug sensitivity and efficacy.
CELL DEATH & DISEASE
(2022)
Review
Cell Biology
Yasmin Abaza et al.
Summary: Immune checkpoint inhibitors have had a significant impact on the treatment of solid tumors, but there has been limited progress in myeloid malignancies. The low mutational burden of acute myeloid leukemia is a potential reason for the lack of response to T-cell harnessing ICIs. Targeting agents, such as magrolimab and sabatolimab, in combination with other drugs, have shown promising activity in early clinical trials.
Article
Biochemistry & Molecular Biology
Daniel Sobral et al.
Summary: This study provides insight into the complex role of glycosylation in humans by combining genome and transcriptome profiles. It reveals that glycosylation factors are tightly regulated in healthy tissues, but impaired in aging and tumorigenesis. They may serve as potential prognostic biomarkers or therapeutic targets.
Review
Biochemistry & Molecular Biology
Jennifer S. Brodbelt
Summary: Post-translational modifications (PTMs) create diversity in proteins and affect their function and regulation. Mass spectrometry analysis allows identification and analysis of PTMs, providing a comprehensive catalog of protein forms. The top-down approach enables in-depth exploration of the impact of combinatorial PTMs on proteins.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2022)
Article
Cell Biology
David Bradley
Summary: Post-translational modifications (PTMs) are chemical modifications that regulate protein activity and function, and represent a fast mechanism for generating phenotypic diversity and divergence. Despite advances in mass spectrometry for identifying PTM classes, little is known about the selective constraints governing PTM evolution.
CURRENT OPINION IN GENETICS & DEVELOPMENT
(2022)
Article
Biochemical Research Methods
Julius Benicky et al.
Summary: Immune checkpoint inhibitors, such as PD-L1/PD-1, play crucial roles in regulating immune responses and are promising targets for cancer immunotherapy. The glycosylation of PD-L1, particularly at the N219 sequon, influences its interaction with PD-1, with complex glycans and polyLacNAc structures being predominant. Different forms of PD-L1 exhibit varying N219 occupancy and polyLacNAc contributions, potentially impacting their interactions with PD-1.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Immunology
Lizhen Zhao et al.
Summary: TIM-3, originally found on Th1 cells, has been discovered to be expressed on various immune cells with different ligands and effects. It plays a significant role in autoimmune diseases, chronic viral infections and tumors. Targeting TIM-3 is a promising approach in current immunotherapy, especially in combination with other immune checkpoint blockers.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Tyson A. Rietz et al.
Summary: TIM-3 has emerged as an attractive immune checkpoint target for cancer immunotherapy, with its upregulation associated with tumor progression and decreased survival rates. Despite the potential advantages of small-molecule inhibitors, their discovery has lagged behind that of antibody therapeutics.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Endocrinology & Metabolism
Lindsey R. Conroy et al.
Summary: N-linked glycosylation is a complex process that connects metabolism to signaling in almost all cells, playing important roles in the brain. Aberrant N-linked glycosylation may potentially drive neurological disorders.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Wenjuan Zeng et al.
Summary: Chemoresistance to cisplatin is closely related to aberrant changes in protein glycosylation. This study utilized proteomic and N-glycoproteomic methods to comprehensively characterize cisplatin resistance-related membrane proteins in non-small cell lung cancer cells. The findings indicate that alterations in protein abundance and glycosylation levels are associated with the development of cisplatin resistance, impacting cell migration and invasion ability, as well as intracellular drug accumulation.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Christian Bailly et al.
Summary: Lactose is a common excipient in pharmaceutical products with immuno-modulatory effects, especially in targeting the TIM-3/Gal-9 and PD-1/PD-L1 immune checkpoints. The potential use of lactose and Gal-9 in cancer treatment and immunoregulation is highlighted in this review.
Review
Biochemistry & Molecular Biology
Ana Magalhaes et al.
Summary: O-glycosylation is a frequent post-translational modification of proteins with functional implications in both physiological and disease contexts. The biosynthesis depends on regulation of cellular glycosylation machinery, affecting organ-, tissue-, and cell-specific functions. Diseases triggered or modulated by aberrant O-glycosylation include genetic disorders, infectious diseases, and cancer, with potential therapeutic strategies focusing on O-glycans and their pathways.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Review
Cell Biology
Chiara De Vellis et al.
Summary: Malignant melanoma, originating from the malignant transformation of melanocytes, is the most aggressive form of skin cancer. Aberrant glycosylation, including sialylation, fucosylation, and N- and I-glycan branching, is considered a hallmark of cancer and plays a role in promoting melanoma progression through activation of invasion and metastasis, immune evasion, and cell proliferation.
Article
Cell & Tissue Engineering
Vivien Strauch et al.
Article
Biology
Gerard Vergoten et al.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2020)
Article
Biology
Christian Bailly et al.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2020)
Review
Cell Biology
Sheng-Hung Wang et al.
JOURNAL OF BIOMEDICAL SCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Kevin Brown Chandler et al.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Review
Biochemistry & Molecular Biology
Shinya Hanashima et al.
CARBOHYDRATE RESEARCH
(2018)
Article
Multidisciplinary Sciences
Amit K. Gandhi et al.
SCIENTIFIC REPORTS
(2018)
Review
Biochemistry & Molecular Biology
Lucas Veillon et al.
ACS CHEMICAL NEUROSCIENCE
(2018)
Article
Multidisciplinary Sciences
Chia-Wei Li et al.
NATURE COMMUNICATIONS
(2016)
Article
Chemistry, Multidisciplinary
Yuya Asahina et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2013)
Article
Immunology
Mi Jin Lee et al.
Article
Immunology
Erhu Cao et al.
Article
Immunology
Peter R. Wilker et al.
INTERNATIONAL IMMUNOLOGY
(2007)
Article
Chemistry, Physical
M. Meziane-Tani et al.
JOURNAL OF PHYSICAL CHEMISTRY A
(2006)
Article
Chemistry, Multidisciplinary
WL Jorgensen et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY
(2005)
Article
Chemistry, Physical
WL Jorgensen et al.
JOURNAL OF PHYSICAL CHEMISTRY B
(2004)
Article
Chemistry, Physical
P Lagant et al.
JOURNAL OF PHYSICAL CHEMISTRY A
(2004)
Article
Biochemistry & Molecular Biology
G Vergoten et al.
