期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 223, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2023.113173
关键词
Genistein; Carbon dots; Isoflavone; Phytochemicals; Antioxidants; Anti-inflammation
Genistein-C-dots, synthesized from genistein, exhibit antioxidant and anti-inflammatory properties. They inhibit pro-inflammatory cytokine levels and enhance anti-inflammatory cytokine expression. These C-dots also feature biocompatibility and low cytotoxicity, making them a potential therapeutic vehicle against inflammatory conditions.
Genistein, an isoflavone from soybean, has attracted attention due to its health benefits, particularly antioxidant and anti-inflammatory activities. Clinical applications of genistein, however, have been limited due to the considerable hydrophobicity and lower bioavailability of the molecule. In this study, carbon dots (C-dots) synthesized from genistein as the carbonaceous precursor exhibit antioxidant properties in test-tube and cell experiments. Anti-inflammatory activity of the genistein-C-dots was also recorded in LPS stimulated macrophages, manifested in inhibition of pro-inflammatory cytokine levels and enhancement anti-inflammatory cytokine expression. The antioxidant and anti-inflammatory effects of the genistein-C-dots, particularly in comparison to the parent genistein molecules, likely account to the display of functional genistein residues on the C-dots' surfaces, and low band gap energy facilitating electron scavenging. Importantly, the genistein-C-dots featured biocompatibility and low cytotoxicity, underlining their potential as a therapeutic vehicle against inflammatory conditions.
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