An S2-responsive nanocontainer for inhibiting microbial corrosion caused by sulfate-reducing bacteria

Controlled-release materials were ideal for improving drug utilization and reducing environmental pollution. In this study, Metronidazole @ Zeolite imidazole backbone -8 nanocontainers (MNZ@ZIF-8) with high drug loading (59.8 mg/g) and S2 -specific response were prepared by co-precipitation method. Material character-ization showed that MNZ was successfully loaded into ZIF-8 and that MNZ@ZIF-8 showed excellent S2 -responsiveness in drug release experiments. The MNZ release rate increased significantly when the S2- concen-tration was greater than 0.5 mM, and the cumulative release of MNZ was even as high as 90.8% at the S2 -concentration of 5 mM. The release kinetics of MNZ@ZIF-8 was consistent with the non-Fickian diffusion mechanism of the Korsmeyer-Peppas model. The bactericidal effect of MNZ@ZIF-8 was evaluated in sulfate -reducing bacteria (SRB) medium. The nanocontainer showed 100% antibacterial effect of SRB at a concentra-tion of 300 mu g mL-1. With the increase of nanocontainer concentration, the depth of corrosion pits on the surface of Q235 test pieces gradually decreased until disappeared (300 mu g mL-1). This novel drug release system had various functions such as the simple synthesis process, antibacterial, and S2-specific response, which provided an idea for the development of drug release system with S2-as the response condition.

Automated summary

Controlled-release materials with high drug loading and S2-specific response were prepared in this study. The drug release rate increased significantly with the increase in S2 concentration. The generated nanocontainer exhibited excellent antibacterial effect and showed potential as a drug release system with S2 as the response condition.