4.2 Article

Clinical benefits of vortioxetine 20 mg/day in patients with major depressive disorder

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Vortioxetine 20 mg/day in patients with major depressive disorder: updated analysis of efficacy, safety, and optimal timing of dose adjustment

Michael Cronquist Christensen et al.

Summary: This study analyzed the efficacy and tolerability of vortioxetine in patients with major depressive disorder. The results showed that vortioxetine 20 mg/day was more effective than 10 mg/day, with similar tolerability. In flexible-dose studies, nearly half of the patients received 20 mg/day after 1 week and two-thirds received 20 mg/day as their final dosage.

CNS SPECTRUMS (2023)

Article Clinical Neurology

Vortioxetine in patients with major depressive disorder and high levels of anxiety symptoms: An updated analysis of efficacy and tolerability

Michael Adair et al.

Summary: This study assessed the efficacy and tolerability of Vortioxetine in treating anxiety symptoms in patients with major depressive disorder. The results showed a clear dose-response relationship for Vortioxetine in improving depressive, anxiety, and functioning symptoms. Additionally, Vortioxetine was found to be superior to agomelatine in patients with an inadequate response to prior therapy.

JOURNAL OF AFFECTIVE DISORDERS (2023)

Review Pharmacology & Pharmacy

Vortioxetine in major depressive disorder: from mechanisms of action to clinical studies. An updated review

Javier De Diego-Adelino et al.

Summary: Vortioxetine is a multimodal-acting antidepressant that shows improvements in cognitive function, making it a promising therapeutic option for patients with MDD and concomitant conditions.

EXPERT OPINION ON DRUG SAFETY (2022)

Review Biochemistry & Molecular Biology

The relationship between dose and serotonin transporter occupancy of antidepressants-a systematic review

Anders Sorensen et al.

Summary: Brain imaging techniques allow visualization of SERT occupancy with antidepressant dose. Studies show a hyperbolic relationship between dose and occupancy, plateauing around 80% at minimum recommended dose. Limitations include fragmented data, small sample sizes, and short study durations. Future research should standardize methods and investigate lower dose occupancy.

MOLECULAR PSYCHIATRY (2022)

Article Psychiatry

Real-world effectiveness of vortioxetine in outpatients with major depressive disorder: functioning and dose effects

Eugenia Papalexi et al.

Summary: This study assessed the real-world effectiveness of vortioxetine in patients with major depressive disorder (MDD) and found statistically significant and clinically relevant improvements in functioning. Higher doses of vortioxetine were associated with significantly greater improvements in functioning.

BMC PSYCHIATRY (2022)

Article Clinical Neurology

Early Improvement with Vortioxetine Predicts Response and Remission: A Post Hoc Analysis of Data from a Clinical Trial Conducted in Japan

Takeshi Inoue et al.

Summary: This study investigated the predictive value of early partial improvement with vortioxetine for treatment response and remission, finding that early improvers were more likely to achieve response and remission at week 8. Positive predictive values for response and remission with vortioxetine were around 70% and 50%, respectively, while negative predictive values were around 70% and 80%, respectively.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2021)

Article Psychology, Clinical

Vortioxetine Versus Placebo for Major Depressive Disorder: A Comprehensive Analysis of the Clinical Trial Dataset

Nadia Iovieno et al.

Summary: A meta-analysis of studies on Vortioxetine in adults with major depressive disorder showed that the drug is more effective than placebo in improving depression, anxiety, and cognition. Studies with a low placebo response rate demonstrated a greater difference in efficacy between the drug and placebo.

JOURNAL OF CLINICAL PSYCHIATRY (2021)

Article Clinical Neurology

Efficacy of Vortioxetine on Anhedonia: Results from a Pooled Analysis of Short-Term Studies in Patients with Major Depressive Disorder

Roger S. McIntyre et al.

Summary: The study found that there were significant improvements in depressive symptoms and functioning in patients with MDD treated with vortioxetine, with treatment effects mainly driven by the impact on MADRS anhedonia factors.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2021)

Article Clinical Neurology

Effectiveness, tolerability, and dropout rates of vortioxetine in comorbid depression: A naturalistic study

Vera De Carlo et al.

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL (2020)

Review Pharmacology & Pharmacy

Vortioxetine: a novel antidepressant for the treatment of major depressive disorder

Xenia Gonda et al.

EXPERT OPINION ON DRUG DISCOVERY (2019)

Article Urology & Nephrology

Antidepressants and Sexual Dysfunctions: a Translational Perspective

Jocelien D. A. Olivier et al.

CURRENT SEXUAL HEALTH REPORTS (2019)

Review Clinical Neurology

Functional Recovery in Major Depressive Disorder: Providing Early Optimal Treatment for the Individual Patient

Oloruntoba J. Oluboka et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2018)

Article Clinical Neurology

Efficacy of vortioxetine on the physical symptoms of major depressive disorder

Michael Cronquist Christensen et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2018)

Review Psychiatry

Pharmacological treatment of unipolar depressive disorders: summary of WFSBP guidelines

Michael Bauer et al.

INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE (2017)

Article Psychology, Clinical

New Empirical Definition of Major Depressive Episode Recovery and Its Positive Impact on Future Course of Illness

Lewis L. Judd et al.

JOURNAL OF CLINICAL PSYCHIATRY (2016)

Review Pharmacology & Pharmacy

Vortioxetine, a novel antidepressant with multimodal activity: Review of preclinical and clinical data

Connie Sanchez et al.

PHARMACOLOGY & THERAPEUTICS (2015)

Article Clinical Neurology

A randomized, double-blind, placebo-controlled study of vortioxetine on cognitive function in depressed adults

Roger S. McIntyre et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2014)

Article Clinical Neurology

The effect of prolonged duration of untreated depression on antidepressant treatment outcome

Jens Drachmann Bukh et al.

JOURNAL OF AFFECTIVE DISORDERS (2013)

Article Pharmacology & Pharmacy

Occupancy of the Serotonin Transporter after Administration of Lu AA21004 and its Relation to Plasma Concentration in Healthy Subjects

Johan Areberg et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2012)

Article Clinical Neurology

Onset, time course and trajectories of Improvement with antidepressants

Raymond W. Lam

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2012)

Article Pharmacology & Pharmacy

Pharmacological Effects of Lu AA21004: A Novel Multimodal Compound for the Treatment of Major Depressive Disorder

A. Mork et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)

Article Clinical Neurology

Duration of untreated illness and antidepressant fluvoxamine response in major depressive disorder

Akiko Okuda et al.

PSYCHIATRY AND CLINICAL NEUROSCIENCES (2010)

Review Pharmacology & Pharmacy

Is the significant superiority of escitalopram compared with other antidepressants clinically relevant?

Stuart A. Montgomery et al.

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY (2009)

Review Pharmacology & Pharmacy

Assessing treatment effects in clinical trials with the Discan metric of the Sheehan Disability Scale

Kathy Harnett Sheehan et al.

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY (2008)

Article Psychology, Clinical

Is there a common resilience mechanism underlying antidepressant drug response? Evidence from 2848 patients

Hans H. Stassen et al.

JOURNAL OF CLINICAL PSYCHIATRY (2007)