4.7 Article

Megf10-related engulfment of excitatory postsynapses by astrocytes following severe brain injury

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Genome-wide interrogation of transfer RNA-derived small RNAs in a mouse model of traumatic brain injury

Xiao-Jian Xu et al.

Summary: This study used tsRNA and mRNA transcriptome sequencing to investigate the expression changes in tsRNAs after traumatic brain injury in a mouse model. The results identified 103 differentially expressed tsRNAs, including 56 upregulated and 47 downregulated. Interaction pairs between differentially expressed tsRNAs and mRNAs were also identified. Gene Ontology analysis revealed enrichment in terms associated with inflammation and synaptic function.

NEURAL REGENERATION RESEARCH (2022)

Article Multidisciplinary Sciences

Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice

Ting Wan et al.

Summary: Ischemic stroke can cause secondary demyelination. In this study, the authors found that expression of lipocalin-2 (LCN-2) increased in astrocytes upon injury. LCN-2 expressing astrocytes acquire a phagocytic phenotype and contribute to secondary demyelination in a mouse model of ischemic stroke.

NATURE COMMUNICATIONS (2022)

Article Neurosciences

Contralateral synaptic changes following severe unilateral brain injury

Yuan Zhuang et al.

Summary: This study found that after unilateral brain injury, spine morphology and synaptic protein expression in the contralateral hemisphere change dynamically. Over time, the behavior of rats that underwent right motor cortex resection recovered. These findings suggest that motor function recovery after unilateral brain injury is closely related to synaptic changes in the contralateral hemisphere.

BRAIN RESEARCH BULLETIN (2022)

Article Multidisciplinary Sciences

Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis

Joon-Hyuk Lee et al.

Summary: This study demonstrates that astrocytes in the adult hippocampus carry out phagocytosis through MEGF10 to maintain proper synaptic connectivity and plasticity. The findings reveal the crucial role of astrocytes in the activity-dependent elimination of excitatory synapses, highlighting the importance of this astrocytic function in supporting cognitive function.

NATURE (2021)

Article Biochemistry & Molecular Biology

Mice deficient in the NAAG synthetase II gene Rimkla are impaired in a novel object recognition task

Ivonne Becker et al.

Summary: NAAG is an abundant neuropeptide in the mammalian nervous system, playing a role in cognition and memory. Rimkla(-/-) mice, lacking NAAG, showed significantly reduced NAAG levels in all brain regions in adulthood and performed poorly in a novel object recognition test. These results suggest a direct involvement of NAAG synthesized by NAAGS-II in memory consolidation.

JOURNAL OF NEUROCHEMISTRY (2021)

Article Multidisciplinary Sciences

Stroke subtype-dependent synapse elimination by reactive gliosis in mice

Xiaojing Shi et al.

Summary: This study showed that inhibiting phagocytosis of microglia and astrocytes in ischemic stroke improved neurobehavioral outcomes, attenuated brain damage, and prevented synapse loss. In hemorrhagic stroke, inhibiting phagocytosis of microglia/macrophages but not astrocytes improved neurobehavioral outcomes. Single-cell RNA sequencing revealed downregulation of phagocytosis-related processes in astrocytes of the hemorrhagic brain compared to the ischemic brain.

NATURE COMMUNICATIONS (2021)

Article Neurosciences

Lacidipine Prevents Scopolamine-Induced Memory Impairment by Reducing Brain Oxido-nitrosative Stress in Mice

Kunal Khurana et al.

Summary: The study found that lacidipine can prevent memory impairment in a mouse model of Alzheimer's disease, reduce oxidative stress, and acetylcholinesterase activity. However, the improvement of memory and redox balance by lacidipine was attenuated in the presence of Bay-K8644.

NEUROTOXICITY RESEARCH (2021)

Article Medicine, General & Internal

Cognitive Dysfunction in a Mouse Model of Cerebral Ischemia Influences Salivary Metabolomics

Masahiro To et al.

Summary: This study evaluated salivary metabolic profiles associated with altered hippocampal BDNF expression levels in a cerebral ischemia mouse model. The results showed that tacrine administration improved impaired spatial working memory in the model. Salivary metabolite patterns may be associated with cognitive function.

JOURNAL OF CLINICAL MEDICINE (2021)

Article Biochemistry & Molecular Biology

Pinoresinol diglucoside alleviates ischemia/reperfusion-induced brain injury by modulating neuroinflammation and oxidative stress

Yi Zhang et al.

Summary: The study found that PDG can significantly alleviate MCAO-induced neurological dysfunction in mice and reduce infarct volume, brain water content, and neuron injury. PDG treatment decreased levels of inflammatory and oxidative stress markers in brain tissue while increasing antioxidant enzyme activities. Additionally, PDG could regulate pathways related to inflammation and oxidative stress to reduce I/R-induced brain injury.

CHEMICAL BIOLOGY & DRUG DESIGN (2021)

Article Immunology

AXL kinase-mediated astrocytic phagocytosis modulates outcomes of traumatic brain injury

Hang Zhou et al.

Summary: The study demonstrates the role of AXL in transforming astrocytes into a phagocytic phenotype after TBI through the AXL/STAT1/ABCA1 pathway, which helps limit neuroinflammation and improve neurological impairments. The findings provide a potential therapeutic target for TBI.

JOURNAL OF NEUROINFLAMMATION (2021)

Article Nutrition & Dietetics

Probiotic Supplementation and High-Intensity Interval Training Modify Anxiety-Like Behaviors and Corticosterone in High-Fat Diet-Induced Obesity Mice

Parisa Foroozan et al.

Summary: In high-fat diet-induced obesity mice, probiotic supplementation and high-intensity interval training (HIIT) can reduce obesity, anxiety-like behaviors, and corticosterone levels. The combination of HIIT and probiotics may have a greater effect on anxiety indices compared to using them separately.

NUTRIENTS (2021)

Article Biochemistry & Molecular Biology

Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction

Hiroyuki Konishi et al.

EMBO JOURNAL (2020)

Review Immunology

Phagocytosis in the Brain: Homeostasis and Disease

Dylan A. Galloway et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Developmental Biology

Astrocytes, neurons, synapses: a tripartite view on cortical circuit development

Isabella Farhy-Tselnicker et al.

NEURAL DEVELOPMENT (2018)

Review Neurosciences

Recent Advances in Pathophysiology of Traumatic Brain Injury

Parmeet Kaur et al.

CURRENT NEUROPHARMACOLOGY (2018)

Article Biochemistry & Molecular Biology

Traumatic Brain Injury in Aged Mice Induces Chronic Microglia Activation, Synapse Loss, and Complement-Dependent Memory Deficits

Karen Krukowski et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Behavioral Sciences

Time-of-Day and Age Impact on Memory in Elevated Plus-Maze Test in Rats

Nicanor Morales-Delgado et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2018)

Review Neurosciences

Cell Biology of Astrocyte-Synapse Interactions

Nicola J. Allen et al.

NEURON (2017)

Article Neurosciences

Expression of MEGF10 in cholinergic and glutamatergic neurons

Yu Fujita et al.

NEUROSCIENCE LETTERS (2017)

Article Multidisciplinary Sciences

Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway

Yosuke M. Morizawa et al.

NATURE COMMUNICATIONS (2017)

Article Neurosciences

Disruption of Network Synchrony and Cognitive Dysfunction After Traumatic Brain Injury

John A. Wolf et al.

FRONTIERS IN SYSTEMS NEUROSCIENCE (2016)

Article Critical Care Medicine

Septohippocampal Neuromodulation Improves Cognition after Traumatic Brain Injury

Darrin J. Lee et al.

JOURNAL OF NEUROTRAUMA (2015)

Article Psychiatry

Cognitive Sequelae of Traumatic Brain Injury

Amanda R. Rabinowitz et al.

PSYCHIATRIC CLINICS OF NORTH AMERICA (2014)

Article Multidisciplinary Sciences

Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

Won-Suk Chung et al.

NATURE (2013)

Review Neurosciences

Postsynaptic signaling during plasticity of dendritic spines

Hideji Murakoshi et al.

TRENDS IN NEUROSCIENCES (2012)

Article Cell Biology

The Postsynaptic Organization of Synapses

Morgan Sheng et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Review Clinical Neurology

Astrocytes: biology and pathology

Michael V. Sofroniew et al.

ACTA NEUROPATHOLOGICA (2010)