☆ 4.7 Review

Radiotherapy and radio-sensitization in H3K27M-mutated diffuse midline gliomas

CNS NEUROSCIENCE & THERAPEUTICS (2023)

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Review Oncology

Immune Microenvironment and Immunotherapies for Diffuse Intrinsic Pontine Glioma

Yujia Chen et al.

Summary: Diffuse intrinsic pontine glioma (DIPG) is a malignant primary glial tumor that mainly affects children and lacks effective treatment methods. Immunotherapy has shown promise in the treatment of DIPG, and this review summarizes the immune profile of DIPG and the results of clinical trials, aiming to clarify the development of novel immunotherapies for DIPG treatment.

CANCERS (2023)

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Article Medicine, General & Internal

Adjuvant Temozolomide Chemotherapy With or Without Interferon Alfa Among Patients With Newly Diagnosed High-grade Gliomas: A Randomized Clinical Trial

Chengcheng Guo et al.

Summary: This study compared the efficacy and toxic effects of the combination of temozolomide and interferon alfa with temozolomide alone in patients with newly diagnosed high-grade gliomas. The results showed that the combination treatment significantly prolonged overall survival compared to standard treatment, especially in patients with O6-methylguanine-DNA methyltransferase unmethylation. However, the combination treatment was associated with more common toxic effects.

JAMA NETWORK OPEN (2023)

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Article Oncology

Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and Safety

Nicholas A. Vitanza et al.

Summary: This study reports the first administration of repeatedly dosed intracranial B7-H3 CAR T cells for patients with DIPG, indicating tolerability, detection of CAR T cells in the CSF, elevation of CSF cytokines supporting locoregional immune activation, and the feasibility of serial mass spectrometry from both serum and CSF.

CANCER DISCOVERY (2023)

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Article Multidisciplinary Sciences

GD2-CART cell therapy for H3K27M-mutated diffuse midline gliomas

Robbie G. Majzner et al.

Summary: Diffuse intrinsic pontine glioma (DIPG) and other H3K27M-mutated diffuse midline gliomas (DMGs) are lethal pediatric tumors of the central nervous system. GD2-directed chimeric antigen receptor (CAR) T cells show promising preclinical efficacy. Four patients with H3K27M-mutated DIPG or spinal cord DMG were treated with GD2-CAR T cells and showed clinical and radiographic improvement.

NATURE (2022)

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Review Biochemistry & Molecular Biology

Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies

Izac J. Findlay et al.

Summary: Diffuse midline glioma (DMG) is a deadly CNS tumor in children and adolescents, characterized by global hypomethylation of H3K27me3. Studies have shown high levels of intertumoral and intratumoral heterogeneity in DMG, which makes precision-based medicine challenging to execute successfully.

ONCOGENE (2022)

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Article Multidisciplinary Sciences

PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation

Prasidda Khadka et al.

Summary: PPM1D has been identified as a key factor in the development of diffuse midline glioma, with truncating mutations in PPM1D driving the growth of certain DMGs. The study demonstrates that PPM1D mutations enhance gliomagenesis and its phosphatase activity is required for oncogenesis. Additionally, the study reveals the oncogenic effects of PPM1D truncation on cell cycle, DNA damage response, and p53 pathways, suggesting potential therapeutic vulnerabilities.

NATURE COMMUNICATIONS (2022)

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Review Oncology

Targeting Cell Cycle Checkpoint Kinases to Overcome Intrinsic Radioresistance in Brain Tumor Cells

Tijana Vlatkovic et al.

Summary: This review summarizes the knowledge in brain tumor treatment through radiosensitization and cell cycle checkpoint inhibition via targeting ATM, ATR, CHK1, CHK2, and WEE1 kinases. Radiation therapy is an important part of standard treatment for brain tumors, but tumor cells' resistance limits its efficacy. Inhibiting cell cycle checkpoint control to increase tumor sensitivity to radiation therapy is a promising approach.

CANCERS (2022)

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Article Biology

The H3K27M mutation alters stem cell growth, epigenetic regulation, and differentiation potential

N. Kfoury-Beaumont et al.

Summary: This study used human embryonic stem cell models to investigate how H3K27M mutation affects cellular proliferation and differentiation. The researchers found that H3K27M mutation increased stem cell properties and interfered with normal differentiation, leading to abnormal gene expression and reduced fidelity of gene regulation. These findings suggest that H3K27M mutation plays a role in gliomagenesis through persistent clonogenicity and aberrant differentiation, accompanied by alterations in histone and DNA methylation.

BMC BIOLOGY (2022)

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Article Oncology

Venetoclax Cooperates with Ionizing Radiation to Attenuate Diffuse Midline Glioma Tumor Growth

Krishna Madhavan et al.

Summary: This study demonstrates that venetoclax inhibits the anti-apoptotic function of radiation-induced BCL2 in pediatric DMG, leading to increased apoptosis. The results from these preclinical studies suggest the potential use of the BCL2 inhibitor venetoclax combined with radiotherapy for pediatric DMG.

CLINICAL CANCER RESEARCH (2022)

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Review Oncology

The prognostic significance of HIST1H3B/C and H3F3A K27M mutations in diffuse midline gliomas is influenced by patient age

Huy Gia Vuong et al.

Summary: This study found that H3.3 mutation is associated with shorter survival in pediatric patients and longer survival in adult patients with DMGs. Patient age is a factor modulating the prognosis of H3.1 and H3.3 K27M mutations in DMG patients.

JOURNAL OF NEURO-ONCOLOGY (2022)

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Review Cell Biology

Cell cycle control in cancer

Helen K. Matthews et al.

Summary: This review highlights the importance of cell cycle regulation in preventing genetic errors and cell proliferation, and how disruption of these mechanisms is associated with cancer development. Cancer arises from continuous cell division and evasion of cell cycle control mechanisms.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

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Review Genetics & Heredity

Histone post-translational modifications - cause and consequence of genome function

Gonzalo Millan-Zambrano et al.

Summary: This Review discusses the impact of histone post-translational modifications (PTMs) on DNA processes and emphasizes their role in genome regulation. It explores the different ways in which PTMs can influence DNA-templated processes, such as transcription, recombination, replication, DNA repair, and genomic architecture. The review also highlights important advances in understanding how histone PTMs can exert direct or indirect effects on genome function.

NATURE REVIEWS GENETICS (2022)

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Article Oncology

The intrinsic and microenvironmental features of diffuse midline glioma: Implications for the development of effective immunotherapeutic treatment strategies

Mika L. Persson et al.

Summary: Diffuse midline glioma (DMG) is a pediatric tumor with a cold tumor microenvironment, which limits the efficacy of traditional immunotherapies. Cell-based therapies and oncolytic viruses are being evaluated to overcome this limitation. Improving our understanding of DMG's features is crucial for the development of effective immunotherapies.

NEURO-ONCOLOGY (2022)

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Article Oncology

STAT3 is a biologically relevant therapeutic target in H3K27M-mutant diffuse midline glioma

Liang Zhang et al.

Summary: The study identified STAT3 as a biologically relevant therapeutic target in H3K27M-mutant DMG. STAT3 inhibitors demonstrated robust cytotoxic activity in vitro, and inhibition of STAT3 partially restored expression of the lost polycomb repressive mark H3K27me3 in H3K27M-mutant DMG.

NEURO-ONCOLOGY (2022)

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Article Cell Biology

BMI-1 regulates DNA end resection and homologous recombination repair

Amira Fitieh et al.

Summary: BMI-1 is a crucial regulator of gene transcriptional silencing during development. Its role in the DNA damage response has recently gained attention, but the exact mechanism remains unclear. This study establishes that BMI-1 plays an important role in the repair of DNA double-strand breaks through homologous recombination by promoting DNA end resection. Mechanistically, BMI-1 facilitates the recruitment of CtIP, allowing accumulation of RPA and RAD51 at DNA damage sites. Additionally, H2A ubiquitylation at K119 has been found to promote end resection.

CELL REPORTS (2022)

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Article Neurosciences

A tumor suppressor role for EZH2 in diffuse midline glioma pathogenesis

Swati Dhar et al.

Summary: This study demonstrates the tumor suppressor function of EZH2 in pediatric high-grade gliomas, specifically diffuse midline gliomas, and highlights the caution needed when translating EZH2 inhibitors for clinical treatment.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2022)

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Review Oncology

Glioma Stem Cells in Pediatric High-Grade Gliomas: From Current Knowledge to Future Perspectives

Marc-Antoine Da-Veiga et al.

Summary: Pediatric high-grade glioma (pHGG) has a poor prognosis, especially in younger patients. The highly malignant glioma stem cells (GSCs) remain poorly investigated in pediatric cases, despite being well described in adult brain tumors. Understanding the role of GSCs in pediatric tumors could lead to targeted treatments for better outcomes.

CANCERS (2022)

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Article Multidisciplinary Sciences

AURKA and PLK1 inhibition selectively and synergistically block cell cycle progression in diffuse midline glioma

Dennis S. Metselaar et al.

Summary: This study demonstrates the overexpression of AURKA and PLK1 in DMG and suggests that targeting these proteins simultaneously could be a potential therapeutic strategy for these pediatric brain tumors.

ISCIENCE (2022)

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Review Health Care Sciences & Services

Diffuse Intrinsic Pontine Glioma: Molecular Landscape, Evolving Treatment Strategies and Emerging Clinical Trials

Sudarshawn Damodharan et al.

Summary: Diffuse intrinsic pontine glioma (DIPG) is a type of brainstem tumor that occurs primarily in children and is characterized by high infiltrative capacity and multiple genetic mutations. Advances in molecular understanding, including the categorization of tumors with the H3 K27M mutation and the development of treatment options, have improved our knowledge of this disease.

JOURNAL OF PERSONALIZED MEDICINE (2022)

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Article Biology

Mre11 exonuclease activity promotes irreversible mitotic progression under replication stress

Yoshitami Hashimoto et al.

Summary: The study reveals a novel role of Mre11 exonuclease activity in promoting the initial progression of mitotic entry under replication stress and suggests that it facilitates the processing of stalled replication forks, leading to irreversible mitotic progression and replisome disassembly.

LIFE SCIENCE ALLIANCE (2022)

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Review Immunology

Current perspectives on diffuse midline glioma and a different role for the immune microenvironment compared to glioblastoma

Casper J. Pachocki et al.

Summary: DMG is a highly malignant pediatric brain tumor with a near-zero survival rate. Recent advances in research have revealed that DMG and GBM are distinct disease entities, with separate tissue characteristics and genetic profiles. DMG has a unique immune microenvironment, characterized by low levels of immune cell infiltration, inflammation, and immunosuppression that may impact disease development and outcome.

JOURNAL OF NEUROINFLAMMATION (2022)

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Article Medicine, General & Internal

Oncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma

Jaime Gallego Perez-Larraya et al.

Summary: This study investigated the use of oncolytic virus DNX-2401 in pediatric patients with diffuse intrinsic pontine glioma (DIPG). The results showed that treatment with DNX-2401 led to changes in T-cell activity and reduction or stabilization of tumor size in some patients, but also caused adverse events.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Cell Biology

GANT-61 Induces Autophagy and Apoptosis in Glioblastoma Cells despite their heterogeneity

Gabriela Basile Carballo et al.

Summary: Glioblastoma is a common adult primary tumor of the CNS characterized by rapid growth and invasiveness. Resistance to chemotherapy in GBM may be due to cancer stem cells activating molecular pathways. Inhibiting the SHH signaling pathway induces apoptosis and autophagy in GBM cells, suggesting it as a potential therapeutic approach for refractory patients.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2021)

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Article Clinical Neurology

Clinico-pathological and molecular characterization of diffuse midline gliomas: is there a prognostic significance?

Niveditha Manjunath et al.

Summary: The study found differences in frequency and location of pediatric and adult DMGs, mutually exclusive H3K27M mutation with IDH mutation, and excellent concordance between immunohistochemistry (H-scoring) and sequencing for H3K27M mutation evaluation. However, prognosis remains poor regardless of age, location, and H3K27M status. Adjuvant therapy significantly impacts survival in adults but not in pediatric cases.

NEUROLOGICAL SCIENCES (2021)

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Article Oncology

Transcriptomic Analysis of Diffuse Intrinsic Pontine Glioma (DIPG) Identifies a Targetable ALDH-Positive Subset of Highly Tumorigenic Cancer Stem-like Cells

Rachel K. Surowiec et al.

Summary: ALDH(+) DIPG cells exhibit stem-like properties with increased proliferation and neurosphere formation, as well as higher metabolic activity. Pharmacologic targeting of MAPKJPI3K/mTOR can reduce the stem-like characteristics of DIPGs, inhibiting tumor growth.

MOLECULAR CANCER RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Relationships between DNA repair and RTK-mediated signaling pathways

Thomas Chabot et al.

Summary: Receptor Tyrosine Kinases (RTKs) play a crucial role in cancer cell survival and are relevant targets in cancer research. Recent studies have shown a close relationship between RTK signaling and DNA repair regulation, providing new research directions for the development of therapeutic strategies targeting both pathways.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

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Article Cell Biology

An extending ATR-CHK1 circuitry: the replication stress response and beyond

Antoine Simoneau et al.

Summary: ATR is recognized as the master regulator of genomic integrity and replication stress. Recent studies have shown that ATR also plays a crucial role in controlling replication fork speed and stability, replication origin firing, completion of genome duplication, and chromosome segregation during the unperturbed cell cycle.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2021)

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Article Medicine, Research & Experimental

Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models

Katherine Deland et al.

Summary: The study suggests that deleting Atm in DIPG models can enhance tumor radiosensitivity, especially in the absence of p53. Mice with p53 wild-type tumors also showed improved survival after radiotherapy, regardless of Atm deletion. Tumor genotype may determine whether inhibiting ATM during radiotherapy is an effective approach.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Review Biochemistry & Molecular Biology

Regulation of DNA double-strand break repair pathway choice: a new focus on 53BP1

Fan Zhang et al.

Summary: This review highlights the critical role of 53BP1 in coordinating DSB repair pathways and promoting NHEJ-mediated DSB repair. It also discusses how 53BP1 enhances the sensitivity of BRCA1-deficient cancers to PARPi, offering a new avenue for improving cancer therapy strategies.

JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B (2021)

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Review Biochemistry & Molecular Biology

Chromatin Regulation throuch Ubiquitin and Ubiquitin-like Histone Modifications

Robert M. Vaughan et al.

Summary: Chromatin functions are influenced by histone post-translational modifications, particularly ubiquitin and ubiquitin-like modifications which act as signaling molecules. Recent discoveries have shown the importance of histone ubiquitination in DNA methylation control, PTM crosstalk, nucleosome structure, and phase separation, while the diversity and functions associated with histone UBL modifications continue to expand. The future holds key questions that will further drive discovery at the intersection of epigenetics and ubiquitin signaling.

TRENDS IN BIOCHEMICAL SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Wee1 Kinase: A Potential Target to Overcome Tumor Resistance to Therapy

Francesca Esposito et al.

Summary: During the cell cycle, DNA lesions are repaired by the DNA damage response (DDR) machinery, with CSCs showing higher resistance to therapy. Wee1 inhibition may enhance the effectiveness of DNA-damaging treatments by forcing tumor cells and CSCs to enter mitosis with damaged DNA, leading to cell death.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Oncology

H3K27M-mutant diffuse midline gliomas should be further molecularly stratified: an integrated analysis of 669 patients

Huy Gia Vuong et al.

Summary: The study found that TP53 mutations in H3-DMGs were associated with shorter survival, while ACVR1 and FGFR1 mutations were linked to prolonged survival. Additionally, ATRX loss was correlated with better overall survival. Adjusted for age, gender, and tumor location, TP53 mutations, absence of ACVR1 or FGFR1 mutations remained significant poor prognostic factors.

JOURNAL OF NEURO-ONCOLOGY (2021)

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Article Genetics & Heredity

Chinese Glioma Genome Atlas (CGGA) : A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients

Zheng Zhao et al.

Summary: The Chinese Glioma Genome Atlas (CGGA) is a user-friendly data portal for the storage and interactive exploration of cross-omics data related to gliomas. It provides researchers with rapid and convenient access to high-quality functional genomic data resources for biological studies and clinical applications.

GENOMICS PROTEOMICS & BIOINFORMATICS (2021)

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Article Oncology

A phase I/II study of bevacizumab, irinotecan and erlotinib in children with progressive diffuse intrinsic pontine glioma

Fatma E. El-Khouly et al.

Summary: This study found that daily erlotinib is safe and well tolerated in doses up to 85 mg/m(2) when combined with biweekly bevacizumab and irinotecan in children with progressive DIPG. The median overall survival of the study patients was longer than known from literature.

JOURNAL OF NEURO-ONCOLOGY (2021)

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Article Biochemistry & Molecular Biology

Histone sumoylation and chromatin dynamics

Hong-Yeoul Ryu et al.

Summary: Histone sumoylation plays diverse roles in regulating chromatin structure, transcription processes, DNA repair, and chromosome segregation, and is involved in complex signaling codes with other histone modifications and RNAPII-CTD.

NUCLEIC ACIDS RESEARCH (2021)

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Review Clinical Neurology

Challenges in diagnosis and management of adult spinal cord gliomas

C. Campello et al.

Summary: Intramedullary spinal cord gliomas have low incidence rates and pose challenges in diagnosis and treatment. Clinical presentation and imaging are non-specific, with surgery being the primary treatment option.

REVUE NEUROLOGIQUE (2021)

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Clinical and Genomic Characteristics of Adult Diffuse Midline Glioma

Changhee Park et al.

Summary: PFS6 after radiotherapy was associated with prolonged survival in adult patients with DMG. Genome-based matched therapy may be an encouraging approach for progressive adult patients with DMG.

CANCER RESEARCH AND TREATMENT (2021)

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A DNA Repair and Cell Cycle Gene Expression Signature in Pediatric High-Grade Gliomas: Prognostic and Therapeutic Value

Natacha Entz-Werle et al.

Summary: Pediatric high-grade gliomas (pHGGs) are incurable brain tumors that exhibit resistance to standard therapies. This study investigated the expression of DNA repair and cell cycle genes in pHGGs to propose a novel classification based on therapeutic vulnerabilities. Several potential new diagnostic markers were identified among the DNA repair factors studied.

CANCERS (2021)

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Chemosensitization of Temozolomide-Resistant Pediatric Diffuse Midline Glioma Using Potent Nanoencapsulated Forms of a N(3)-Propargyl Analogue

Vahid Heravi Shargh et al.

Summary: The study introduces N3P nanoparticles as a promising approach for treating TMZ-resistant DIPG, showing strong anticancer efficacy and overcoming drug resistance. Additionally, dynamic PET scans demonstrate localized distribution and retention of the nanoparticles in the rat brain following administration through CED.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Biochemistry & Molecular Biology

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Tatsuya Suwa et al.

Summary: Metastasis of cancer cells relies on the suitable microenvironment. The complex cellular society and diverse oxygen and nutrient supply in tumor tissue affect the characteristics of cancer cells and their resistance to radiation. Understanding tumor microenvironments and their influence on cancer behavior is crucial for developing novel therapeutic strategies.

EXPERIMENTAL AND MOLECULAR MEDICINE (2021)

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The PI3K/AKT/mTOR signaling pathway inhibitors enhance radiosensitivity in cancer cell lines

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Integrative cBioPortal Analysis Revealed Molecular Mechanisms That Regulate EGFR-PI3K-AKT-mTOR Pathway in Diffuse Gliomas of the Brain

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Summary: The study investigates the molecular changes in the EGFR-PI3K-AKT-mTOR signaling pathway in diffuse gliomas and reveals the potential for new treatment targets based on pathohistological types. A comprehensive analysis of genomic and epigenomic data suggests different behaviors of key genes across various grades of gliomas, highlighting potential new therapeutic approaches.

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DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy

Ruixue Huang et al.

Summary: Genomic instability is a characteristic of various cancers, with radiotherapy and chemotherapy in cancer treatment based on this property but also accompanied by adverse effects. Targeted cancer therapy has the potential to suppress cancer cells' DNA damage response by tailoring therapy to individual patients lacking specific DNA damage response functions, which is crucial for the emergence of promising druggable targets in the future.

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Hypofractionated radiotherapy with temozolomide in diffuse intrinsic pontine gliomas: a randomized controlled trial

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Combined Targeting of Mutant p53 and Jumonji Family Histone Demethylase Augments Therapeutic Efficacy of Radiation in H3K27M DIPG

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A phase I/II study of veliparib (ABT-888) with radiation and temozolomide in newly diagnosed diffuse pontine glioma: a Pediatric Brain Tumor Consortium study

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MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas

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Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib

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MOLECULAR CANCER RESEARCH (2020)

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A combined approach of convection-enhanced delivery of peptide nanofiber reservoir to prolong local DM1 retention for diffuse intrinsic pontine glioma treatment

Vanessa Bellat et al.

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A phase 2 study of valproic acid and radiation, followed by maintenance valproic acid and bevacizumab in children with newly diagnosed diffuse intrinsic pontine glioma or high-grade glioma

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Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance

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Global activation of oncogenic pathways underlies therapy resistance in diffuse midline glioma

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Inhibition of Sonic Hedgehog Signaling Suppresses Glioma Stem-Like Cells Likely Through Inducing Autophagic Cell Death

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EZH2: a novel target for cancer treatment

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Children with DIPG and high-grade glioma treated with temozolomide, irinotecan, and bevacizumab: the Seattle Children's Hospital experience

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Anti-tumor Effect of Hedgehog Signaling Inhibitor, Vismodegib, on Castration-resistant Prostate Cancer

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STAT3 is a key molecule in the oncogenic behavior of diffuse intrinsic pontine glioma

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Inhibition of mutant PPM1D enhances DNA damage response and growth suppressive effects of ionizing radiation in diffuse intrinsic pontine glioma

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TP53 Pathway Alterations Drive Radioresistance in Diffuse Intrinsic Pontine Gliomas (DIPG)

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Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma

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Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression

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K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

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The Brain Microenvironment Preferentially Enhances the Radioresistance of CD133+ Glioblastoma Stem-like Cells

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Genome-Wide Analyses Identify Recurrent Amplifications of Receptor Tyrosine Kinases and Cell-Cycle Regulatory Genes in Diffuse Intrinsic Pontine Glioma

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Interaction of Hypoxia-Inducible Factor-1α and Notch Signaling Regulates Medulloblastoma Precursor Proliferation and Fate

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Intratumoral Hypoxic Gradient Drives Stem Cells Distribution and MGMT Expression in Glioblastoma

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STEM CELLS (2010)

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RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins

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CELL (2009)

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Review Clinical Neurology

Treatment of diffuse intrinsic brainstem gliomas: failed approaches and future strategies

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JOURNAL OF NEUROSURGERY-PEDIATRICS (2009)

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Article Oncology

Comparative Analysis of DNA Repair in Stem and Nonstem Glioma Cell Cultures

Monica Ropolo et al.

MOLECULAR CANCER RESEARCH (2009)

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Association of reactive oxygen species levels and radioresistance in cancer stem cells

Maximilian Diehn et al.

NATURE (2009)

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Article Cell & Tissue Engineering

Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells

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STEM CELLS (2009)

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Review Oncology

p21 in cancer: intricate networks and multiple activities

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NATURE REVIEWS CANCER (2009)

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Cell Cycle Control by the CDC25 Phosphatases

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ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2008)

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Review Oncology

The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways

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CANCER AND METASTASIS REVIEWS (2008)

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Article Oncology

Preradiation chemotherapy may improve survival in pediatric diffuse intrinsic brainstem gliomas: Final results of BSG 98 prospective trial

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NEURO-ONCOLOGY (2008)

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Article Biochemistry & Molecular Biology

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

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CELL (2007)

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Irradiation-induced G2/M checkpoint response requires ERK1/2 activation

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ONCOGENE (2007)

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Review Cell Biology

ATM activation and DNA damage response

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CELL CYCLE (2007)

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DNA damage checkpoints: from initiation to recovery or adaptation

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CURRENT OPINION IN CELL BIOLOGY (2007)

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Review Biochemistry & Molecular Biology

Chromatin modifications and their function

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Article Oncology

Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: A Pediatric Brain Tumor Consortium report

Ian F. Pollack et al.

NEURO-ONCOLOGY (2007)

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Review Genetics & Heredity

Mammalian single-strand break repair: Mechanisms and links with chromatin

Keith W. Caldecott

DNA REPAIR (2007)

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Article Oncology

The response of CD24-/low/CD44+ breast cancer-initiating cells to radiation

Tiffany M. Phillips et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2006)

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Article Multidisciplinary Sciences

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

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NATURE (2006)

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Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: Correlation with EGFR status, tumor grade, and survival

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Wip1 phosphatase modulates ATM-dependent signaling pathways

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MOLECULAR CELL (2006)

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Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

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CELL DEATH AND DIFFERENTIATION (2006)

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Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

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Diffuse brainstem glioma in children: critical review of clinical trials

D Hargrove et al.

LANCET ONCOLOGY (2006)

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ERK activity facilitates activation of the S-phase DNA damage checkpoint by modulating ATR function

D Wu et al.

ONCOGENE (2006)

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DNA polymerase η, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation

G Liu et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

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P53 modulates homologous recombination by transcriptional regulation of the RAD51 gene

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EMBO REPORTS (2006)

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Review Oncology

Regulation of the p53-MDM2 pathway by 14-3-3 sigma and other proteins

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SEMINARS IN CANCER BIOLOGY (2006)

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MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

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CELL (2005)

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Dual roles for DNA polymerase η in homologous DNA recombination and translesion DNA synthesis

T Kawamoto et al.

MOLECULAR CELL (2005)

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Article Biochemistry & Molecular Biology

Human DNA polymerase η promotes DNA synthesis from strand invasion intermediates of homologous recombination

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MOLECULAR CELL (2005)

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Poly(ADP-ribosylation) and genomic stability

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BIOCHEMISTRY AND CELL BIOLOGY (2005)

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PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

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GENES & DEVELOPMENT (2005)

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P53C-terminal phosphorylation by CHM and CHK2 participates in the regulation of DNA-Damage-induced C-terminal acetylation

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MOLECULAR BIOLOGY OF THE CELL (2005)

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Tumor suppressor p53 represses transcription of RECQ4 helicase

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ONCOGENE (2005)

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Review Oncology

Role of cell cycle in mediating sensitivity to radiotherapy

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INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2004)

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Cell-cycle checkpoints and cancer

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The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas

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Radiosensitization by inhibition of IκB-α phosphorylation in human glioma cells

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Surgical approach to thalamic tumors

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Signaling to chromatin through histone modifications

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CELL (2000)

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Cyclin-dependent kinase inhibitors: novel anticancer agents

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EXPERT OPINION ON INVESTIGATIONAL DRUGS (2000)

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