相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Immune Microenvironment and Immunotherapies for Diffuse Intrinsic Pontine Glioma
Yujia Chen et al.
CANCERS (2023)
Adjuvant Temozolomide Chemotherapy With or Without Interferon Alfa Among Patients With Newly Diagnosed High-grade Gliomas: A Randomized Clinical Trial
Chengcheng Guo et al.
JAMA NETWORK OPEN (2023)
Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and Safety
Nicholas A. Vitanza et al.
CANCER DISCOVERY (2023)
GD2-CART cell therapy for H3K27M-mutated diffuse midline gliomas
Robbie G. Majzner et al.
NATURE (2022)
Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies
Izac J. Findlay et al.
ONCOGENE (2022)
PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation
Prasidda Khadka et al.
NATURE COMMUNICATIONS (2022)
Targeting Cell Cycle Checkpoint Kinases to Overcome Intrinsic Radioresistance in Brain Tumor Cells
Tijana Vlatkovic et al.
CANCERS (2022)
The H3K27M mutation alters stem cell growth, epigenetic regulation, and differentiation potential
N. Kfoury-Beaumont et al.
BMC BIOLOGY (2022)
Venetoclax Cooperates with Ionizing Radiation to Attenuate Diffuse Midline Glioma Tumor Growth
Krishna Madhavan et al.
CLINICAL CANCER RESEARCH (2022)
The prognostic significance of HIST1H3B/C and H3F3A K27M mutations in diffuse midline gliomas is influenced by patient age
Huy Gia Vuong et al.
JOURNAL OF NEURO-ONCOLOGY (2022)
Cell cycle control in cancer
Helen K. Matthews et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)
Histone post-translational modifications - cause and consequence of genome function
Gonzalo Millan-Zambrano et al.
NATURE REVIEWS GENETICS (2022)
The intrinsic and microenvironmental features of diffuse midline glioma: Implications for the development of effective immunotherapeutic treatment strategies
Mika L. Persson et al.
NEURO-ONCOLOGY (2022)
STAT3 is a biologically relevant therapeutic target in H3K27M-mutant diffuse midline glioma
Liang Zhang et al.
NEURO-ONCOLOGY (2022)
BMI-1 regulates DNA end resection and homologous recombination repair
Amira Fitieh et al.
CELL REPORTS (2022)
A tumor suppressor role for EZH2 in diffuse midline glioma pathogenesis
Swati Dhar et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2022)
Glioma Stem Cells in Pediatric High-Grade Gliomas: From Current Knowledge to Future Perspectives
Marc-Antoine Da-Veiga et al.
CANCERS (2022)
AURKA and PLK1 inhibition selectively and synergistically block cell cycle progression in diffuse midline glioma
Dennis S. Metselaar et al.
ISCIENCE (2022)
Diffuse Intrinsic Pontine Glioma: Molecular Landscape, Evolving Treatment Strategies and Emerging Clinical Trials
Sudarshawn Damodharan et al.
JOURNAL OF PERSONALIZED MEDICINE (2022)
Mre11 exonuclease activity promotes irreversible mitotic progression under replication stress
Yoshitami Hashimoto et al.
LIFE SCIENCE ALLIANCE (2022)
Current perspectives on diffuse midline glioma and a different role for the immune microenvironment compared to glioblastoma
Casper J. Pachocki et al.
JOURNAL OF NEUROINFLAMMATION (2022)
Oncolytic DNX-2401 Virus for Pediatric Diffuse Intrinsic Pontine Glioma
Jaime Gallego Perez-Larraya et al.
NEW ENGLAND JOURNAL OF MEDICINE (2022)
GANT-61 Induces Autophagy and Apoptosis in Glioblastoma Cells despite their heterogeneity
Gabriela Basile Carballo et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2021)
Clinico-pathological and molecular characterization of diffuse midline gliomas: is there a prognostic significance?
Niveditha Manjunath et al.
NEUROLOGICAL SCIENCES (2021)
Transcriptomic Analysis of Diffuse Intrinsic Pontine Glioma (DIPG) Identifies a Targetable ALDH-Positive Subset of Highly Tumorigenic Cancer Stem-like Cells
Rachel K. Surowiec et al.
MOLECULAR CANCER RESEARCH (2021)
Relationships between DNA repair and RTK-mediated signaling pathways
Thomas Chabot et al.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)
An extending ATR-CHK1 circuitry: the replication stress response and beyond
Antoine Simoneau et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2021)
Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models
Katherine Deland et al.
JOURNAL OF CLINICAL INVESTIGATION (2021)
Regulation of DNA double-strand break repair pathway choice: a new focus on 53BP1
Fan Zhang et al.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B (2021)
Chromatin Regulation throuch Ubiquitin and Ubiquitin-like Histone Modifications
Robert M. Vaughan et al.
TRENDS IN BIOCHEMICAL SCIENCES (2021)
Wee1 Kinase: A Potential Target to Overcome Tumor Resistance to Therapy
Francesca Esposito et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
H3K27M-mutant diffuse midline gliomas should be further molecularly stratified: an integrated analysis of 669 patients
Huy Gia Vuong et al.
JOURNAL OF NEURO-ONCOLOGY (2021)
Chinese Glioma Genome Atlas (CGGA) : A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients
Zheng Zhao et al.
GENOMICS PROTEOMICS & BIOINFORMATICS (2021)
A phase I/II study of bevacizumab, irinotecan and erlotinib in children with progressive diffuse intrinsic pontine glioma
Fatma E. El-Khouly et al.
JOURNAL OF NEURO-ONCOLOGY (2021)
Histone sumoylation and chromatin dynamics
Hong-Yeoul Ryu et al.
NUCLEIC ACIDS RESEARCH (2021)
Challenges in diagnosis and management of adult spinal cord gliomas
C. Campello et al.
REVUE NEUROLOGIQUE (2021)
Clinical and Genomic Characteristics of Adult Diffuse Midline Glioma
Changhee Park et al.
CANCER RESEARCH AND TREATMENT (2021)
A DNA Repair and Cell Cycle Gene Expression Signature in Pediatric High-Grade Gliomas: Prognostic and Therapeutic Value
Natacha Entz-Werle et al.
CANCERS (2021)
Chemosensitization of Temozolomide-Resistant Pediatric Diffuse Midline Glioma Using Potent Nanoencapsulated Forms of a N(3)-Propargyl Analogue
Vahid Heravi Shargh et al.
ACS APPLIED MATERIALS & INTERFACES (2021)
Tumor microenvironment and radioresistance
Tatsuya Suwa et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2021)
The PI3K/AKT/mTOR signaling pathway inhibitors enhance radiosensitivity in cancer cell lines
Alireza Mardanshahi et al.
MOLECULAR BIOLOGY REPORTS (2021)
Integrative cBioPortal Analysis Revealed Molecular Mechanisms That Regulate EGFR-PI3K-AKT-mTOR Pathway in Diffuse Gliomas of the Brain
Petar Brlek et al.
CANCERS (2021)
DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy
Ruixue Huang et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)
Identification of prognostic markers in diffuse midline gliomas H3K27M-mutant
Charlotte Dufour et al.
BRAIN PATHOLOGY (2020)
Hypofractionated radiotherapy with temozolomide in diffuse intrinsic pontine gliomas: a randomized controlled trial
Yousra Izzuddeen et al.
JOURNAL OF NEURO-ONCOLOGY (2020)
Combined Targeting of Mutant p53 and Jumonji Family Histone Demethylase Augments Therapeutic Efficacy of Radiation in H3K27M DIPG
Anatoly Nikolaev et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
WEE1 kinase limits CDK activities to safeguard DNA replication and mitotic entry
Camilla R. Elbaek et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2020)
A phase I/II study of veliparib (ABT-888) with radiation and temozolomide in newly diagnosed diffuse pontine glioma: a Pediatric Brain Tumor Consortium study
Patricia A. Baxter et al.
NEURO-ONCOLOGY (2020)
Epithelial to Mesenchymal Transition: A Mechanism that Fuels Cancer Radio/Chemoresistance
Jozsef Dudas et al.
CELLS (2020)
MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas
Hideaki Abe et al.
FRONTIERS IN ONCOLOGY (2020)
Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib
Zhaohui Wang et al.
MOLECULAR CANCER RESEARCH (2020)
A combined approach of convection-enhanced delivery of peptide nanofiber reservoir to prolong local DM1 retention for diffuse intrinsic pontine glioma treatment
Vanessa Bellat et al.
NEURO-ONCOLOGY (2020)
A phase 2 study of valproic acid and radiation, followed by maintenance valproic acid and bevacizumab in children with newly diagnosed diffuse intrinsic pontine glioma or high-grade glioma
Jack Meng-Fen Su et al.
PEDIATRIC BLOOD & CANCER (2020)
Molecular and Cellular Complexity of Glioma. Focus on Tumour Microenvironment and the Use of Molecular and Imaging Biomarkers to Overcome Treatment Resistance
Silvia Valtorta et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Global activation of oncogenic pathways underlies therapy resistance in diffuse midline glioma
M-M Georgescu et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2020)
Inhibition of Sonic Hedgehog Signaling Suppresses Glioma Stem-Like Cells Likely Through Inducing Autophagic Cell Death
Hui-Chi Hung et al.
FRONTIERS IN ONCOLOGY (2020)
EZH2: a novel target for cancer treatment
Ran Duan et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)
Children with DIPG and high-grade glioma treated with temozolomide, irinotecan, and bevacizumab: the Seattle Children's Hospital experience
Erin E. Crotty et al.
JOURNAL OF NEURO-ONCOLOGY (2020)
Anti-tumor Effect of Hedgehog Signaling Inhibitor, Vismodegib, on Castration-resistant Prostate Cancer
Aya Ishii et al.
ANTICANCER RESEARCH (2020)
Roles for 53BP1 in the repair of radiation-induced DNA double strand breaks
Atsushi Shibata et al.
DNA REPAIR (2020)
STAT3 is a key molecule in the oncogenic behavior of diffuse intrinsic pontine glioma
Jinju Park et al.
ONCOLOGY LETTERS (2020)
CDK4/6 inhibitors: a novel strategy for tumor radiosensitization
Yilan Yang et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)
Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas
Faiqa Mudassar et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)
Diffuse midline glioma: review of epigenetics
Tabitha M. Cooney et al.
JOURNAL OF NEURO-ONCOLOGY (2020)
A phase I/II study of ribociclib following radiation therapy in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG)
Mariko DeWire et al.
JOURNAL OF NEURO-ONCOLOGY (2020)
Radio-Resistance and DNA Repair in Pediatric Diffuse Midline Gliomas
Henriette Pedersen et al.
CANCERS (2020)
Epigenetic alterations in cancer
Suganya Ilango et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2020)
DNA damage checkpoint kinases in cancer
Hannah L. Smith et al.
EXPERT REVIEWS IN MOLECULAR MEDICINE (2020)
DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer
Rui-Xue Huang et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)
Safety and Feasibility of Repeated and Transient Blood-Brain Barrier Disruption by Pulsed Ultrasound in Patients with Recurrent Glioblastoma
Ahmed Idbaih et al.
CLINICAL CANCER RESEARCH (2019)
Nimotuzumab and radiotherapy for treatment of newly diagnosed diffuse intrinsic pontine glioma (DIPG): a phase III clinical study
G. Fleischhack et al.
JOURNAL OF NEURO-ONCOLOGY (2019)
The expanding landscape of 'oncohistone' mutations in human cancers
Benjamin A. Nacev et al.
NATURE (2019)
Inhibition of mutant PPM1D enhances DNA damage response and growth suppressive effects of ionizing radiation in diffuse intrinsic pontine glioma
Mwangala Precious Akamandisa et al.
NEURO-ONCOLOGY (2019)
Evidence-Based Practice: Temozolomide Beyond Glioblastoma
Jason Chua et al.
CURRENT ONCOLOGY REPORTS (2019)
ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis
Christine M. Hoeman et al.
NATURE COMMUNICATIONS (2019)
Potent anti-tumor efficacy of palbociclib in treatment-naive H3.3K27M-mutant diffuse intrinsic pontine glioma
Yu Sun et al.
EBIOMEDICINE (2019)
Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models
Naiara Martinez-Velez et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)
Radiosensitization by Histone H3 Demethylase Inhibition in Diffuse Intrinsic Pontine Glioma
Hiroaki Katagi et al.
CLINICAL CANCER RESEARCH (2019)
Preclinical therapeutic targets in diffuse midline glioma
Michael Hananja Meel et al.
DRUG RESISTANCE UPDATES (2019)
Signal Transduction in Diffuse Intrinsic Pontine Glioma
Ryan J. Duchatel et al.
PROTEOMICS (2019)
The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models
Naiara Martinez-Velez et al.
NATURE COMMUNICATIONS (2019)
TP53 Pathway Alterations Drive Radioresistance in Diffuse Intrinsic Pontine Gliomas (DIPG)
Coralie Werbrouck et al.
CLINICAL CANCER RESEARCH (2019)
Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma
Chul-Hwan Lee et al.
GENES & DEVELOPMENT (2019)
Regulation of histone methylation by automethylation of PRC2
Xueyin Wang et al.
GENES & DEVELOPMENT (2019)
Targets for improving tumor response to radiotherapy
Keywan Mortezaee et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2019)
Pediatric and adult H3 K27M-mutant diffuse midline glioma treated with the selective DRD2 antagonist ONC201
Andrew S. Chi et al.
JOURNAL OF NEURO-ONCOLOGY (2019)
Diagnostics and treatment of diffuse intrinsic pontine glioma: where do we stand?
Fatma E. El-Khouly et al.
JOURNAL OF NEURO-ONCOLOGY (2019)
PDTM-34. RADIOSENSITIZATION BY BRD4 INHIBITION IN DIFFUSE INTRINSIC PONTINE GLIOMA
Takahiro Sasaki et al.
NEURO-ONCOLOGY (2019)
Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression
Jon D. Larson et al.
CANCER CELL (2019)
NQO1-dependent, Tumor-selective Radiosensitization of Non-small Cell Lung Cancers
Edward A. Motea et al.
CLINICAL CANCER RESEARCH (2019)
Targeting DNA Double-Strand Break Repair Pathways to Improve Radiotherapy Response
Mahmoud Toulany
GENES (2019)
Antrocin Sensitizes Prostate Cancer Cells to Radiotherapy through Inhibiting PI3K/AKT and MAPK Signaling Pathways
Yu-An Chen et al.
CANCERS (2019)
Current Progress in CAR-T Cell Therapy for Solid Tumors
Shuo Ma et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)
Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location
Michael Karremann et al.
NEURO-ONCOLOGY (2018)
Dual HDAC and PI3K Inhibition Abrogates NF kappa B- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas
Sharmistha Pal et al.
CANCER RESEARCH (2018)
Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries
Lindsey M. Hoffman et al.
JOURNAL OF CLINICAL ONCOLOGY (2018)
Mechanism of cancer: Oncohistones in action
Lei Qiu et al.
JOURNAL OF GENETICS AND GENOMICS (2018)
Mechanisms of receptor tyrosine kinase activation in cancer
Zhenfang Du et al.
MOLECULAR CANCER (2018)
The mTOR-S6K pathway links growth signalling to DNA damage response by targeting RNF168
Xiaoduo Xie et al.
NATURE CELL BIOLOGY (2018)
MGMT Expression Contributes to Temozolomide Resistance in H3K27M-Mutant Diffuse Midline Gliomas and MGMT Silencing to Temozolomide Sensitivity in IDH-Mutant Gliomas
Hideaki Abe et al.
NEUROLOGIA MEDICO-CHIRURGICA (2018)
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq
Mariella G. Filbin et al.
SCIENCE (2018)
TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition
Anassuya Ramachandran et al.
ELIFE (2018)
H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers
Dong Fang et al.
ELIFE (2018)
Beyond the Blood: Brain Barrier: The Importance of Central Nervous System (CNS) Pharmacokinetics for the Treatment of CNS Tumors, Including Diffuse Intrinsic Pontine Glioma
Katherine Elizabeth Warren
FRONTIERS IN ONCOLOGY (2018)
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011-2015
Quinn T. Ostrom et al.
NEURO-ONCOLOGY (2018)
MELK Inhibition in Diffuse Intrinsic Pontine Glioma
Michael H. Meel et al.
CLINICAL CANCER RESEARCH (2018)
Diffuse Intrinsic Pontine Glioma : Clinical Features, Molecular Genetics, and Novel Targeted Therapeutics
Ryan K. Mathew et al.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY (2018)
Signaling pathways and mesenchymal transition in pediatric high-grade glioma
Michael H. Meel et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2018)
How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?
Brandon J. Aubrey et al.
CELL DEATH AND DIFFERENTIATION (2018)
Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas
Andrea Piunti et al.
NATURE MEDICINE (2017)
Diffuse intrinsic pontine gliomas-current management and new biologic insights. Is there a glimmer of hope?
Kenneth J. Cohen et al.
NEURO-ONCOLOGY (2017)
Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma
Mitsuteru Natsuizaka et al.
NATURE COMMUNICATIONS (2017)
BMI-1 is a potential therapeutic target in diffuse intrinsic pontine glioma
Shiva Senthil Kumar et al.
ONCOTARGET (2017)
Potential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma
Wenyong Long et al.
FRONTIERS IN PHARMACOLOGY (2017)
Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma
Alan Mackay et al.
CANCER CELL (2017)
The dual mTOR kinase inhibitor TAK228 inhibits tumorigenicity and enhances radiosensitization in diffuse intrinsic pontine glioma
Hiroaki Miyahara et al.
CANCER LETTERS (2017)
A pilot study of bevacizumab-based therapy in patients with newly diagnosed high-grade gliomas and diffuse intrinsic pontine gliomas
Trent R. Hummel et al.
JOURNAL OF NEURO-ONCOLOGY (2016)
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
David N. Louis et al.
ACTA NEUROPATHOLOGICA (2016)
Polo-like Kinase 1 as a potential therapeutic target in Diffuse Intrinsic Pontine Glioma
Vladimir Amani et al.
BMC CANCER (2016)
Multiple functions of p21 in cell cycle, apoptosis and transcriptional regulation after DNA damage
Ansar Karimian et al.
DNA REPAIR (2016)
Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population
Carmela Ciccarelli et al.
MOLECULAR CANCER (2016)
Epithelial-mesenchymal transition in glioblastoma progression
Yasuo Iwadate
ONCOLOGY LETTERS (2016)
Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma
Hamid Nikbakht et al.
NATURE COMMUNICATIONS (2016)
Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
Neil Justin et al.
NATURE COMMUNICATIONS (2016)
The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression
Jiandong Chen
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)
p53 in the DNA-Damage-Repair Process
Ashley B. Williams et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)
Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes
David Castel et al.
ACTA NEUROPATHOLOGICA (2015)
The role of DNA damage responses in p53 biology
Daniel Speidel
ARCHIVES OF TOXICOLOGY (2015)
Tripartite motif 16 inhibits epithelial-mesenchymal transition and metastasis by down-regulating sonic hedgehog pathway in non-small cell lung cancer cells
Xiongwei Huo et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
Effect of Notch expression in glioma stem cells on therapeutic response to chemo-radiotherapy in recurrent glioblastoma
Norihiko Saito et al.
BRAIN TUMOR PATHOLOGY (2015)
Contribution of the immune system to bystander and non-targeted effects of ionizing radiation
Franz Roedel et al.
CANCER LETTERS (2015)
Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection
Balaji Parameswaran et al.
CELL CYCLE (2015)
Disrupting NOTCH Slows Diffuse Intrinsic Pontine Glioma Growth, Enhances Radiation Sensitivity, and Shows Combinatorial Efficacy With Bromodomain Inhibition
Isabella C. Taylor et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2015)
Poly-ADP-Ribose Polymerase as a Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma and Pediatric High-Grade Astrocytoma
Yevgen Chornenkyy et al.
MOLECULAR CANCER THERAPEUTICS (2015)
Functionally defined therapeutic targets in diffuse intrinsic pontine glioma
Catherine S. Grasso et al.
NATURE MEDICINE (2015)
Clinicopathology of diffuse intrinsic pontine glioma and its redefined genomic and epigenomic landscape
Eshini Panditharatna et al.
CANCER GENETICS (2015)
The network of epithelial-mesenchymal transition: potential new targets for tumor resistance
Danupon Nantajit et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2015)
Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria
Marc H. Jansen et al.
NEURO-ONCOLOGY (2015)
Ionizing Radiation-Induced DNA Damage, Response, and Repair
Wil L. Santivasi et al.
ANTIOXIDANTS & REDOX SIGNALING (2014)
FOXM1: An emerging master regulator of DNA damage response and genotoxic agent resistance
Stefania Zona et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2014)
Radiation-enhanced cell migration/invasion process: A review
Coralie Moncharmont et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2014)
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
Liufu Deng et al.
IMMUNITY (2014)
The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma
Gang Wu et al.
NATURE GENETICS (2014)
Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations
Pawel Buczkowicz et al.
NATURE GENETICS (2014)
Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma
Kathryn R. Taylor et al.
NATURE GENETICS (2014)
Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas
Liwei Zhang et al.
NATURE GENETICS (2014)
Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma
Adam M. Fontebasso et al.
NATURE GENETICS (2014)
Double-strand break repair: 53BP1 comes into focus
Stephanie Panier et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
Molecular mechanisms of epithelial-mesenchymal transition
Samy Lamouille et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
Targeting Wee1 for the treatment of pediatric high-grade gliomas
Sabine Mueller et al.
NEURO-ONCOLOGY (2014)
EGF receptor trafficking: consequences for signaling and cancer
Alejandra Tomas et al.
TRENDS IN CELL BIOLOGY (2014)
Targeting PI3K/Akt/mTOR signaling in cancer
Camillo Porta et al.
FRONTIERS IN ONCOLOGY (2014)
Molecularly targeting the PI3K-Akt-mTOR pathway can sensitize cancer cells to radiotherapy and chemotherapy
Ziwen Wang et al.
CELLULAR & MOLECULAR BIOLOGY LETTERS (2014)
Aurora Kinase B Is a Potential Therapeutic Target in Pediatric Diffuse Intrinsic Pontine Glioma
Pawel Buczkowicz et al.
BRAIN PATHOLOGY (2013)
Regulation of FANCD2 by the mTOR Pathway Contributes to the Resistance of Cancer Cells to DNA Double-Strand Breaks
Changxian Shen et al.
CANCER RESEARCH (2013)
Diffuse intrinsic pontine glioma treated with prolonged temozolomide and radiotherapy - Results of a United Kingdom phase II trial (CNS 2007 04)
S. Bailey et al.
EUROPEAN JOURNAL OF CANCER (2013)
WEE1 Kinase Inhibition Enhances the Radiation Response of Diffuse Intrinsic Pontine Gliomas
Viola Caretti et al.
MOLECULAR CANCER THERAPEUTICS (2013)
mTOR regulates DNA damage response through NF-κB-mediated FANCD2 pathway in hematopoietic cells
F. Guo et al.
LEUKEMIA (2013)
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
Yosef Shiloh et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
PD-0332991, a CDK4/6 Inhibitor, Significantly Prolongs Survival in a Genetically Engineered Mouse Model of Brainstem Glioma
Kelly L. Barton et al.
PLOS ONE (2013)
Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma
Peter W. Lewis et al.
SCIENCE (2013)
DNA Damage Sensing by the ATM and ATR Kinases
Alexandre Marechal et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
Management of Diffuse Pontine Gliomas in Children: Recent Developments
Rejin Kebudi et al.
PEDIATRIC DRUGS (2013)
K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
Dong-Anh Khuong-Quang et al.
ACTA NEUROPATHOLOGICA (2012)
Resistance of Glioblastoma-Initiating Cells to Radiation Mediated by the Tumor Microenvironment Can Be Abolished by Inhibiting Transforming Growth Factor-β
Matthew E. Hardee et al.
CANCER RESEARCH (2012)
Regulation of the Wip1 phosphatase and its effects on the stress response
Julie Lowe et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2012)
Radiotherapy with concurrent and adjuvant temozolomide in children with newly diagnosed diffuse intrinsic pontine glioma
Andrea Chassot et al.
JOURNAL OF NEURO-ONCOLOGY (2012)
Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact
Joshua C. Black et al.
MOLECULAR CELL (2012)
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: The molecular choreography
Larry H. Thompson
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2012)
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
Jeremy Schwartzentruber et al.
NATURE (2012)
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
Gang Wu et al.
NATURE GENETICS (2012)
Mesenchymal Transition and PDGFRA Amplification/Mutation Are Key Distinct Oncogenic Events in Pediatric Diffuse Intrinsic Pontine Gliomas
Stephanie Puget et al.
PLOS ONE (2012)
Establishment of animal model for the analysis of cancer cell metastasis during radiotherapy
Jong Kuk Park et al.
RADIATION ONCOLOGY (2012)
The Brain Microenvironment Preferentially Enhances the Radioresistance of CD133+ Glioblastoma Stem-like Cells
Muhammad Jamal et al.
NEOPLASIA (2012)
PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma
Erika F. Rodriguez et al.
ACTA NEUROPATHOLOGICA (2011)
Signals and Combinatorial Functions of Histone Modifications
Tamaki Suganuma et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80 (2011)
Low doses ionizing radiation enhances the invasiveness of breast cancer cells by inducing epithelial-mesenchymal transition
Xin Zhang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc- and Thereby Promotes Tumor Growth
Takatsugu Ishimoto et al.
CANCER CELL (2011)
Genome-Wide Analyses Identify Recurrent Amplifications of Receptor Tyrosine Kinases and Cell-Cycle Regulatory Genes in Diffuse Intrinsic Pontine Glioma
Barbara S. Paugh et al.
JOURNAL OF CLINICAL ONCOLOGY (2011)
Overexpression of ZNF217 in glioblastoma contributes to the maintenance of glioma stem cells regulated by hypoxia-inducible factors
Xing-gang Mao et al.
LABORATORY INVESTIGATION (2011)
Innovative Therapies for Children with Cancer pediatric phase I study of erlotinib in brainstem glioma and relapsing/refractory brain tumors
Birgit Geoerger et al.
NEURO-ONCOLOGY (2011)
A phase II study of gefitinib and irradiation in children with newly diagnosed brainstem gliomas: A report from the Pediatric Brain Tumor Consortium
Ian F. Pollack et al.
NEURO-ONCOLOGY (2011)
Temozolomide in the treatment of children with newly diagnosed diffuse intrinsic pontine gliomas: a report from the Children's Oncology Group
Kenneth J. Cohen et al.
NEURO-ONCOLOGY (2011)
The Phenotypic Radiation Resistance of CD44+/CD24-or low Breast Cancer Cells Is Mediated through the Enhanced Activation of ATM Signaling
Hong Yin et al.
PLOS ONE (2011)
PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation
Dannis G. van Vuurden et al.
ONCOTARGET (2011)
Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation
Fengxiang Wei et al.
CELLULAR SIGNALLING (2010)
S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response
Keng Po Lai et al.
EMBO JOURNAL (2010)
Focus on histone variant H2AX: To be or not to be
Jingsong Yuan et al.
FEBS LETTERS (2010)
Phase I Study of Vandetanib During and After Radiotherapy in Children With Diffuse Intrinsic Pontine Glioma
Alberto Broniscer et al.
JOURNAL OF CLINICAL ONCOLOGY (2010)
Whole-Genome Profiling of Pediatric Diffuse Intrinsic Pontine Gliomas Highlights Platelet-Derived Growth Factor Receptor α and Poly (ADP-ribose) Polymerase As Potential Therapeutic Targets
Maryam Zarghooni et al.
JOURNAL OF CLINICAL ONCOLOGY (2010)
The DNA Damage Response: Making It Safe to Play with Knives
Alberto Ciccia et al.
MOLECULAR CELL (2010)
The transcriptional network for mesenchymal transformation of brain tumours
Maria Stella Carro et al.
NATURE (2010)
Selective targeting of radiation-resistant tumor-initiating cells
Mei Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex
Joao D. Pereira et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Notch Promotes Radioresistance of Glioma Stem Cells
Jialiang Wang et al.
STEM CELLS (2010)
Interaction of Hypoxia-Inducible Factor-1α and Notch Signaling Regulates Medulloblastoma Precursor Proliferation and Fate
Francesca Pistollato et al.
STEM CELLS (2010)
Intratumoral Hypoxic Gradient Drives Stem Cells Distribution and MGMT Expression in Glioblastoma
Francesca Pistollato et al.
STEM CELLS (2010)
RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins
Carsten Doil et al.
CELL (2009)
Treatment of diffuse intrinsic brainstem gliomas: failed approaches and future strategies
James L. Frazier et al.
JOURNAL OF NEUROSURGERY-PEDIATRICS (2009)
Comparative Analysis of DNA Repair in Stem and Nonstem Glioma Cell Cultures
Monica Ropolo et al.
MOLECULAR CANCER RESEARCH (2009)
Association of reactive oxygen species levels and radioresistance in cancer stem cells
Maximilian Diehn et al.
NATURE (2009)
Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells
Nawneet K. Kurrey et al.
STEM CELLS (2009)
p21 in cancer: intricate networks and multiple activities
Tarek Abbas et al.
NATURE REVIEWS CANCER (2009)
Cell Cycle Control by the CDC25 Phosphatases
Bernadette Aressy et al.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2008)
The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways
Xiongbin Lu et al.
CANCER AND METASTASIS REVIEWS (2008)
Preradiation chemotherapy may improve survival in pediatric diffuse intrinsic brainstem gliomas: Final results of BSG 98 prospective trial
Didier Frappaz et al.
NEURO-ONCOLOGY (2008)
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
Niels Mailand et al.
CELL (2007)
Irradiation-induced G2/M checkpoint response requires ERK1/2 activation
Y. Yan et al.
ONCOGENE (2007)
DNA damage checkpoints: from initiation to recovery or adaptation
Jiri Bartek et al.
CURRENT OPINION IN CELL BIOLOGY (2007)
Chromatin modifications and their function
Tony Kouzarides
CELL (2007)
Phase I trial of imatinib in children with newly diagnosed brainstem and recurrent malignant gliomas: A Pediatric Brain Tumor Consortium report
Ian F. Pollack et al.
NEURO-ONCOLOGY (2007)
Mammalian single-strand break repair: Mechanisms and links with chromatin
Keith W. Caldecott
DNA REPAIR (2007)
The response of CD24-/low/CD44+ breast cancer-initiating cells to radiation
Tiffany M. Phillips et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2006)
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
Shideng Bao et al.
NATURE (2006)
Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: Correlation with EGFR status, tumor grade, and survival
Masahiro Mizoguchi et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2006)
Wip1 phosphatase modulates ATM-dependent signaling pathways
Sathyavageeswaran Shreeram et al.
MOLECULAR CELL (2006)
Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase
H. Fujimoto et al.
CELL DEATH AND DIFFERENTIATION (2006)
Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy
Eric A. Reits et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
Diffuse brainstem glioma in children: critical review of clinical trials
D Hargrove et al.
LANCET ONCOLOGY (2006)
ERK activity facilitates activation of the S-phase DNA damage checkpoint by modulating ATR function
D Wu et al.
ONCOGENE (2006)
DNA polymerase η, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation
G Liu et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
P53 modulates homologous recombination by transcriptional regulation of the RAD51 gene
C Arias-Lopez et al.
EMBO REPORTS (2006)
Regulation of the p53-MDM2 pathway by 14-3-3 sigma and other proteins
Mong-Hong Lee et al.
SEMINARS IN CANCER BIOLOGY (2006)
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
M Stucki et al.
CELL (2005)
Dual roles for DNA polymerase η in homologous DNA recombination and translesion DNA synthesis
T Kawamoto et al.
MOLECULAR CELL (2005)
Human DNA polymerase η promotes DNA synthesis from strand invasion intermediates of homologous recombination
MJ McIlwraith et al.
MOLECULAR CELL (2005)
Poly(ADP-ribosylation) and genomic stability
SL Oei et al.
BIOCHEMISTRY AND CELL BIOLOGY (2005)
PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints
XB Lu et al.
GENES & DEVELOPMENT (2005)
P53C-terminal phosphorylation by CHM and CHK2 participates in the regulation of DNA-Damage-induced C-terminal acetylation
YH Ou et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Tumor suppressor p53 represses transcription of RECQ4 helicase
S Sengupta et al.
ONCOGENE (2005)
Role of cell cycle in mediating sensitivity to radiotherapy
TM Pawlik et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2004)
The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas
A Chakravarti et al.
JOURNAL OF CLINICAL ONCOLOGY (2004)
Radiosensitization by inhibition of IκB-α phosphorylation in human glioma cells
GR Ding et al.
RADIATION RESEARCH (2003)
Surgical approach to thalamic tumors
MM Özek et al.
CHILDS NERVOUS SYSTEM (2002)
Signaling to chromatin through histone modifications
P Cheung et al.
CELL (2000)
Cyclin-dependent kinase inhibitors: novel anticancer agents
S Mani et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2000)