Increased Petrous Bone Uptake on 18F-PSMA-1007 PET/CT Due to Otospongiosis

Article Surgery

False Positive Findings of [18F]PSMA-1007 PET/CT in Patients After Radical Prostatectomy with Undetectable Serum PSA Levels

Marina Orevi et al.

Summary: This prospective study investigated the frequency and pattern of false-positive findings of [F-18]PSMA-1007 PET/CT in patients after radical prostatectomy with undetectable serum PSA levels. The study found that about 80% of patients in this population had false-positive results.

FRONTIERS IN SURGERY (2022)

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Review Medicine, General & Internal

Diagnostic Role of 18F-PSMA-1007 PET/CT in Prostate Cancer Staging: A Systematic Review

Salam Awenat et al.

Summary: F-18-PSMA-1007 PET/CT demonstrates good diagnostic accuracy for PCa staging, showing similar results compared to other PSMA-targeted radiopharmaceuticals. This method has the potential to replace traditional imaging techniques for PCa staging. Prospective multicentric studies are needed to confirm these findings.

DIAGNOSTICS (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Focal unspecific bone uptake on [18F]-PSMA-1007 PET: a multicenter retrospective evaluation of the distribution, frequency, and quantitative parameters of a potential pitfall in prostate cancer imaging

Hannes Gruenig et al.

Summary: Improved logistics and availability have led to a rapid increase in the use of [F-18]-PSMA-1007 for prostate cancer PET imaging. Initial data suggest increased uptake in benign lesions compared to [(68)Ga]-PSMA-11, and clinical observations found increased unspecific bone uptake (UBU). UBUs occur in two-thirds of patients imaged with [F-18]-PSMA-1007 PET/CT and are significantly more frequent on digital PET scanners than analog scanners, highlighting the need for careful interpretation to avoid over-staging.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Clinical insignificance of [18F]PSMA-1007 avid non-specific bone lesions: a retrospective evaluation

Evyn G. Arnfield et al.

Summary: The study found that [F-18]PSMA-1007 avid NSBLs rarely indicate prostate cancer bone metastases. NSBLs with SUVmax < 7.2 were classified as likely benign, while those with SUVmax 7.2-11.1 may be classified as equivocal or metastatic based on patient clinical risk factors, scan appearance, and potential management implications. An SUVmax threshold of >= 7.2 was found to maximize the Youden's index in distinguishing between NSBLs and definite prostate cancer bone metastases.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Review Otorhinolaryngology

Imaging Studies in Otosclerosis: An Up-to-date Comprehensive Review

Lucas Resende Lucinda Mangia et al.

Summary: Although the diagnosis of otosclerosis is usually clinical, computed tomography (CT) plays a crucial role in certain cases, particularly for differential diagnosis. While the routine use of CT remains controversial, there is increasing evidence supporting its role in surgical planning and prognostic prediction.

INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging