☆ 4.5 Review

Challenges for the maintaining the microbiological safety of the UK blood supply

CLINICAL MEDICINE (2023)

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Article Ethics

Facing difficult but unavoidable choices: Donor blood safety and the deferral of men who have sex with men

Roland Pierik et al.

Summary: Blood service organizations employ various ways to ensure transfusion blood safety but the current exclusion of MSM based on sexual orientation is seen as discriminatory. The U.K. and the Netherlands have recently changed their policies, but we argue that there is a more reasonable option.

BIOETHICS (2022)

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Review Microbiology

Efficacy and Safety of Pathogen-Reduced Platelets Compared with Standard Apheresis Platelets: A Systematic Review of RCTs

Ilaria Pati et al.

Summary: This systematic review evaluated the efficacy and safety of blood components treated with pathogen reduction technologies (PRTs). The review included 19 randomized controlled trials (RCTs) involving 4332 patients and found that pathogen-reduced platelets (PR-PLTs) did not increase bleeding events compared to standard platelets (St-PLTs), although there was a slight increase in severe bleeding events. There were no differences in serious adverse events between the two groups. PR-PLT recipients had lower 1 and 24 hour CI and CCI. However, PR-PLT recipients had a higher occurrence of platelet refractoriness and alloimmunization compared to St-PLT recipients, and also required more platelet and RBC transfusions with shorter time intervals.

PATHOGENS (2022)

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Review Hematology

A Systematic Review of Interventions Used to Increase Blood Donor Compliance with Deferral Criteria

Julia C. Cutts et al.

Summary: This systematic review identified several interventions to improve donor compliance in blood donation settings, with evidence supporting the effectiveness of computerized interviews in improving detection of risk factors. Direct questioning also showed a moderate effect in increasing donor deferral, although the quality of evidence was low.

TRANSFUSION MEDICINE AND HEMOTHERAPY (2021)

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Article Hematology

Validation of a standardized donor health questionnaire across substances of human origin

Sabrina Sandner et al.

Summary: The study found that participants had a good understanding of the standardized DHQ questions and answered them truthfully, though there were differences in mood and response behavior under different characteristics.

VOX SANGUINIS (2021)

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Article Hematology

Hepatitis B infections among blood donors in England between 2009 and 2018: Is an occult hepatitis B infection a risk for blood safety?

Heli Harvala et al.

Summary: HBV is a significant infection in blood donors in England, with a high proportion of chronic and occult infections in donors born in Eastern Europe, Africa, or Asia. The majority of occult HBV infections were found in repeat donors, contributing to the residual transmission risk. Further cost-benefit analysis is needed to evaluate changes to the current screening strategy for HBV in blood donors.

TRANSFUSION (2021)

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Review Hematology

Prevention of transfusion-transmitted infections

Michael P. Busch et al.

BLOOD (2019)

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Review Hematology

Safe supplies: few infections in UK blood and tissue donors

C. Reynolds et al.

TRANSFUSION MEDICINE (2019)

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Review Gastroenterology & Hepatology

AGA Clinical Practice Update: Coagulation in Cirrhosis

Jacqueline G. O'Leary et al.

GASTROENTEROLOGY (2019)

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Review Hematology

Microbiological Screening of Platelet Concentrates in Europe

Marcel Prax et al.

TRANSFUSION MEDICINE AND HEMOTHERAPY (2019)

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Review Hematology

Emerging Infectious Diseases and Blood Safety: Modeling the Transfusion-Transmission Risk

Philip Kiely et al.

TRANSFUSION MEDICINE REVIEWS (2017)

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Article Hematology

Two decades of risk factors and transfusion-transmissible infections in Dutch blood donors

Ed Slot et al.

TRANSFUSION (2016)

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Article Hematology

HIV-positive blood donors unaware of their sexual at-risk behaviours before donation in Italy

M. Raimondo et al.

VOX SANGUINIS (2016)

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Article Hematology

Getting personal with blood donors - the rationale for, methodology of and an overview of participants in the UK blood donor survey

K. L. Davison et al.

TRANSFUSION MEDICINE (2015)

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Article Hematology

Understanding noncompliance with selective donor deferral criteria for high-risk behaviors in Australian blood donors

Tarana T. A. Lucky et al.

TRANSFUSION (2014)

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Editorial Material Microbiology

An Increasing Danger of Zoonotic Orthopoxvirus Infections

Sergei N. Shchelkunov

PLOS PATHOGENS (2013)

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Letter Hematology

Guideline on the investigation and management of acute transfusion reactions Prepared by the BCSH Blood Transfusion Task Force

Hazel Tinegate et al.

BRITISH JOURNAL OF HAEMATOLOGY (2012)

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