Worsened Outcome in Patients with Membranous Nephropathy Carrying Apolipoprotein L1 High-Risk Genotype

Article Urology & Nephrology

Kidney Disease Progression in Membranous Nephropathy among Black Participants with High-Risk APOL1 Genotype

Dhruti P. Chen et al.

Summary: The prevalence of high-risk APOL1 variant among Black membranous nephropathy participants is comparable with the general Black population (10%-15%), yet the high-risk genotype was associated with worse eGFR decline and faster time to kidney failure compared with low-risk genotype and participants that were not Black.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2023)

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Article Immunology

APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis

Junnan Wu et al.

Summary: The incidence and severity of sepsis is higher among individuals of African versus European ancestry, with genetic risk variants in APOL1 associated with increased sepsis incidence and severity. APOL1 levels correlated with sepsis and COVID-19 severity, and targeting the inflammasome and STING pathways may help reduce APOL1-associated endothelial changes in sepsis.

IMMUNITY (2021)

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Review Medicine, General & Internal

Membranous nephropathy

Pierre Ronco et al.

Summary: Membranous nephropathy (MN) is a glomerular disease that can occur at any age, with about 80% of adult patients having no apparent cause. It is an autoimmune disease with unpredictable disease outcome, with some patients experiencing spontaneous remission. Various treatment options are available, but relapses and suboptimal treatment responses remain a challenge.

NATURE REVIEWS DISEASE PRIMERS (2021)

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Article Urology & Nephrology

Protocadherin 7?Associated Membranous Nephropathy

Sanjeev Sethi et al.

Summary: Membranous nephropathy (MN) can be caused by antibodies targeting different antigens in the glomerular basement membrane (GBM), such as PLA2R, THSD7A, NELL1, SEMA3B, and now, the novel protein PCHD7. PCHD7 appears to define a distinct type of MN with specific characteristics in terms of staining pattern and antibody reactivity.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

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Article Medicine, Research & Experimental

The key role of NLRP3 and STING in APOL1-associated podocytopathy

Junnan Wu et al.

Summary: Coding variants in APOL1, especially G1 and G2, are key factors contributing to excess kidney disease risk in African Americans. The study reveals that expression of G2 APOL1 induces activation of STING and NLRP3 inflammasome in podocytes, leading to kidney dysfunction. Inhibition of NLRP3, GSDMD, and STING shows promising therapeutic potential for APOL1-associated kidney disease.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Multidisciplinary Sciences