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Review
Medical Laboratory Technology
Biological variation: recent development and future challenges
Sverre Sandberg et al.
Summary: Biological variation (BV) data has various applications in laboratory medicine, but their usefulness relies on the availability of relevant and reliable BV data. BV data can be obtained through different study designs, including experimental studies and analysis of routine results from laboratory databases. The applications of BV data include setting performance specifications, calculating reference change values, defining individuality index, and establishing personalized reference intervals. This review discusses the major achievements in BV research from the past decade, such as new models and approaches for deriving BV data, the high-quality data delivered by the European Biological Variation Study (EuBIVAS), the Biological Variation Data Critical Appraisal Checklist (BIVAC) and other standards for deriving and reporting BV data, the EFLM Biological Variation Database, and new applications of BV data like personalized reference intervals and measurement uncertainty.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2023)
Editorial Material
Medical Laboratory Technology
Biological variation - eight years after the 1st Strategic Conference of EFLM
Sverre Sandberg et al.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2022)
Letter
Medical Laboratory Technology
Terms and Symbols Used in Studies on Biological Variation: The Need for Harmonization
Ana-Maria Simundic et al.
CLINICAL CHEMISTRY (2015)