Thrombocytopenia and hyperinflammation are induced by extracellular histones circulating in blood

Review Medicine, General & Internal

Coagulation Disorders in Sepsis and COVID-19-Two Sides of the Same Coin? A Review of Inflammation-Coagulation Crosstalk in Bacterial Sepsis and COVID-19

Georgeana Tuculeanu et al.

Summary: Sepsis is a leading cause of illness and death worldwide, and its associated coagulation disorders significantly worsen the prognosis. During the COVID-19 pandemic, research has focused on the pathogenesis and treatment of SARS-CoV-2. Coagulation disturbances have been found to contribute to severe outcomes of SARS-CoV-2 infection. Similarities between COVID-19-associated coagulopathy and sepsis-induced coagulopathy have been observed, but their relationship is yet to be established. Understanding the pathogenesis of COVID-19-associated coagulopathy is crucial for accurate definitions and classification criteria.

JOURNAL OF CLINICAL MEDICINE (2023)

添加到收藏夹

Article Medical Laboratory Technology

Monocyte distribution width alterations and cytokine storm are modulated by circulating histones

Daniela Ligi et al.

Summary: The study investigated the role of extracellular histones on monocyte distribution width (MDW) and their effect on the release of cytokines by blood cells. The results showed that extracellular histones can induce changes in MDW and promote heterogeneity in monocytes. They also lead to the release of cytokines, especially G-CSF, IL-1 beta, IL-6, MIP-1 beta, and IL-8. These findings may have significant implications for predicting the risk of severe outcomes.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2023)

添加到收藏夹

Review Medical Laboratory Technology

What is the impact of circulating histones in COVID-19: a systematic review

Daniela Ligi et al.

Summary: A literature review found an association between increased circulating histone levels in COVID-19 patients and disease severity/mortality. Monitoring blood histone concentration may be useful for early identification of unfavorable COVID-19 progression.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2022)

添加到收藏夹

Article Critical Care Medicine

Circulating histones contribute to monocyte and MDW alterations as common mediators in classical and COVID-19 sepsis

Daniela Ligi et al.

Summary: This study found that histones can significantly increase the monocyte distribution width (MDW) index in whole blood samples from healthy individuals when treated in vitro, similar to the changes found in patients with classic and viral sepsis. These changes are associated with histone-induced modifications of monocyte volume, cytoplasmic granularity, vacuolization, and nuclear structure. Therefore, histones may play a crucial role in the observed alterations of monocytes in acute classical and viral sepsis.

CRITICAL CARE (2022)

添加到收藏夹

Letter Hematology

Circulating histones play a central role in COVID-19-associated coagulopathy and mortality

Rebecca J. Shaw et al.

HAEMATOLOGICA (2021)

添加到收藏夹

Article Cell Biology

Analysis of Inflammatory Mediator Profiles in Sepsis Patients Reveals That Extracellular Histones Are Strongly Elevated in Nonsurvivors

Tanja Eichhorn et al.

Summary: The study found that there is a wide range of mediator concentrations among sepsis patients, indicating their heterogeneity. Elevated levels and correlations of damage-associated molecular patterns and markers of endothelial activation suggest severe tissue damage, with extracellular histones being significantly higher in nonsurvivors, indicating diagnostic and prognostic potential.

MEDIATORS OF INFLAMMATION (2021)

添加到收藏夹

Review Medicine, General & Internal