Analytical performance specifications for the measurement uncertainty of 24,25-dihydroxyvitamin D examinations

Review Medical Laboratory Technology

Biological variation: recent development and future challenges

Sverre Sandberg et al.

Summary: Biological variation (BV) data has various applications in laboratory medicine, but their usefulness relies on the availability of relevant and reliable BV data. BV data can be obtained through different study designs, including experimental studies and analysis of routine results from laboratory databases. The applications of BV data include setting performance specifications, calculating reference change values, defining individuality index, and establishing personalized reference intervals. This review discusses the major achievements in BV research from the past decade, such as new models and approaches for deriving BV data, the high-quality data delivered by the European Biological Variation Study (EuBIVAS), the Biological Variation Data Critical Appraisal Checklist (BIVAC) and other standards for deriving and reporting BV data, the EFLM Biological Variation Database, and new applications of BV data like personalized reference intervals and measurement uncertainty.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2023)

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Article Medical Laboratory Technology

Comparison of two LC-MS/MS methods for the quantification of 24,25-dihydroxyvitamin D3 in patients and external quality assurance samples

Sieglinde Zelzer et al.

Summary: This study assessed the agreement of 24,25-dihydroxyvitamin D3 (24,25(OH)(2)D-3) measurements by two in-house LC-MS/MS methods. The results showed high precision measurements of 24,25(OH)(2)D-3 with both methods, despite minor differences between them.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2022)

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Review Medical Laboratory Technology

The European Biological Variation Study (EuBIVAS): a summary report

Anna Carobene et al.

Summary: The EuBIVAS conducted a multicenter European Biological Variation Study with serum/plasma samples taken from 91 ostensibly healthy individuals at 6 European centres, delivering high-quality BV data for 80 different measurands. The BV estimates for many measurands were lower than those previously reported, impacting the derived analytical performance specifications and reference change values.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2022)

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Article Medical Laboratory Technology

The multicenter European Biological Variation Study (EuBIVAS): a new glance provided by the Principal Component Analysis (PCA), a machine learning unsupervised algorithms, based on the basic metabolic panel linked measurands

Anna Carobene et al.

Summary: The study analyzed EuBIVAS data and found significant differences between males and females in mean values, while countries, alcohol intake, smoking habits, BMI, and physical activity had no significant impact on the measured values. The results suggest that the EuBIVAS sample has a certain degree of homogeneity.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2022)

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Article Nutrition & Dietetics

Analytical Performance Specifications for 25-Hydroxyvitamin D Examinations

Etienne Cavalier et al.

Summary: The study evaluated the biological variation of 25(OH)D to set analytical performance specifications for measurement uncertainty. The findings showed that participants were not in a steady state, so APS based on measurement uncertainty appear to be more appropriate.

NUTRIENTS (2021)

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Article Medical Laboratory Technology