Clonal Hematopoiesis in Young Women Treated for Breast Cancer

Article Hematology

Association of clonal hematopoiesis with chronic obstructive pulmonary disease

Peter G. Miller et al.

Summary: Somatic mutations in blood cells are associated with the development and severity of chronic obstructive pulmonary disease (COPD), independent of age and smoking.

BLOOD (2022)

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Article Oncology

Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation

Christopher J. Gibson et al.

Summary: Donor clonal hematopoiesis (CH) has a significant impact on clinical outcomes and graft alloimmune function in transplant recipients. DNMT3A-CH is associated with improved recipient survival and an augmented network of inflammatory cytokines in recipients. Different mutations may contribute to donor cell leukemia (DCL) in allogeneic hematopoietic cell transplantation.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Article Multidisciplinary Sciences

Life histories of myeloproliferative neoplasms inferred from phylogenies

Nicholas Williams et al.

Summary: By sequencing the clones of 12 patients with myeloproliferative neoplasms, we identified that early driver mutations are the foundation for tumor development and are linked to lifelong growth and evolution. This discovery provides opportunities for early intervention and a new model for cancer development.

NATURE (2022)

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Article Hematology

Clonal hematopoiesis is associated with increased risk of progression of asymptomatic Waldenstrom macroglobulinemia

Sabrin Tahri et al.

Summary: Clonal hematopoiesis (CH) is associated with adverse outcomes in nonHodgkin lymphoma (NHL) and multiple myeloma patients undergoing autologous stem cell transplantation. However, its implications for patients with indolent NHL have not been well studied. This study reports the prevalence of CH in Waldenström macroglobulinemia (WM) patients and its association with clinical outcomes.

BLOOD ADVANCES (2022)

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Article Oncology

Clonal Hematopoiesis and Mosaicism Revealed by a Multi-Tissue Analysis of Constitutional TP53 Status

Danielle Castillo et al.

Summary: This study presents an effective approach and tools for discerning germline TP53 variants and postzygotic mosaicism, which can increase diagnostic accuracy and enable risk-appropriate care.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2022)

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Article Hematology

Patient perspectives on testing for clonal hematopoiesis of indeterminate potential

Tal Sella et al.

Summary: This study surveyed breast cancer survivors to understand their preferences for clonal hematopoiesis of indeterminate potential (CHIP) testing. The findings showed that most survivors favored CHIP testing, with preferences influenced by risk presentation and potential management strategies.

BLOOD ADVANCES (2022)

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Article Immunology

Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis

Peter Geon Kim et al.

Summary: The study revealed an association between clonal hematopoiesis and osteoporosis, with inflammation induced by Dnmt3a mutations driving bone loss. This inflammation-mediated osteoporosis can be ameliorated by specific drugs.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women

Michael C. Honigberg et al.

Summary: This study found that premature menopause, especially natural premature menopause, is independently associated with CHIP in postmenopausal women, serving as a risk signal for the development of CHIP and CHIP-related cardiovascular disease.

CIRCULATION (2021)

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Article Multidisciplinary Sciences

Association of premature menopause with incident pulmonary hypertension: A cohort study

Michael C. Honigberg et al.

Summary: Preliminary findings suggest that premature menopause may be an independent risk factor for pulmonary hypertension in women. Further research is needed to explore the role of sex hormones in pulmonary hypertension in order to understand the pathobiology and identify new therapeutic targets.

PLOS ONE (2021)

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Article Hematology

Clonal hematopoiesis in patients receiving chimeric antigen receptor T-cell therapy

Peter G. Miller et al.

Summary: CHIP, a state in which mutations in hematopoietic cells give rise to a clonal population of cells, is common in patients receiving CAR T-cell therapy but does not impact progression-free or overall survival, especially in patients younger than 60 years old. Although it can influence response rates and cytokine release syndrome severity, it should not be a factor in determining eligibility for this potentially life-prolonging treatment.

BLOOD ADVANCES (2021)

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Article Cardiac & Cardiovascular Systems