Secretory-IgA binding to intestinal microbiota attenuates inflammatory reactions as the intestinal barrier of preterm infants matures

Mahdally et al. demonstrated the impact of Secretory-IgA functional binding to intestinal microbiota in preterm infants with varying levels of intestinal permeability. The attenuation of inflammatory responses through Secretory-IgA binding to intestinal microbiota was found to be dependent on the changes in microbiota that occur as the intestinal barrier matures. Previous work has shown that Secretory-IgA (SIgA) binding to the intestinal microbiota is variable and may regulate host inflammatory bowel responses. Nevertheless, the impact of the SIgA functional binding to the microbiota remains largely unknown in preterm infants whose immature epithelial barriers make them particularly susceptible to inflammation. Here, we investigated SIgA binding to intestinal microbiota isolated from stools of preterm infants <33 weeks gestation with various levels of intestinal permeability. We found that SIgA binding to intestinal microbiota attenuates inflammatory reactions in preterm infants. We also observed a significant correlation between SIgA affinity to the microbiota and the infant's intestinal barrier maturation. Still, SIgA affinity was not associated with developing host defenses, such as the production of mucus and inflammatory calprotectin protein, but it depended on the microbiota shifts as the intestinal barrier matures. In conclusion, we reported an association between the SIgA functional binding to the microbiota and the maturity of the preterm infant's intestinal barrier, indicating that the pattern of SIgA coating is altered as the intestinal barrier matures.

Automated summary

Mahdally et al. demonstrated that Secretory-IgA binding to intestinal microbiota attenuates inflammatory reactions in preterm infants, and this attenuation is dependent on the changes in microbiota as the intestinal barrier matures. The study found a significant correlation between Secretory-IgA affinity to the microbiota and the maturity of the infant's intestinal barrier. However, Secretory-IgA affinity was not associated with the development of host defenses, but rather depended on microbiota shifts.