☆ 4.7 Review

Lessons of Vascular Specialization From Secondary Lymphoid Organ Lymphatic Endothelial Cells

CIRCULATION RESEARCH (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Immunology

Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation

Milena Petkova et al.

Summary: Researchers have identified a new subtype of lymphatic endothelial cells called iLECs, which are positive for Ptx3 and are involved in PI3K-driven lymphatic malformations. These cells recruit pro-lymphangiogenic macrophages and promote pathological lymphatic vessel growth. Understanding the specific disease pathogenesis of different vessel types could lead to the development of more efficient therapies.

JOURNAL OF EXPERIMENTAL MEDICINE (2023)

添加到收藏夹

Article Oncology

Stromal transdifferentiation drives lipomatosis and induces extensive vascular remodeling in the aging human lymph node

Tove Bekkhus et al.

Summary: LN lipomatosis is a common phenomenon associated with aging, characterized by the gradual replacement of LN parenchyma with adipose tissue. The mechanisms behind these changes and their effects on LN are still unknown. However, our study suggests that the initiation of lipomatosis is associated with transdifferentiation of LN fibroblasts into adipocytes.

JOURNAL OF PATHOLOGY (2023)

添加到收藏夹

Review Immunology

Lymph node lymphatic endothelial cells as multifaceted gatekeepers in the immune system

Akira Takeda et al.

Summary: Single-cell technologies have revealed multiple subsets of lymphatic endothelial cells (LECs) in the lymph node sinus systems of mice and humans. These LECs play important immunological roles in the lymph node stroma, including guiding immune cell trafficking, capturing microbes, and transporting lymph-borne antigens. However, our understanding of LEC functions in human disease is still limited, hindering clinical translation in inflammation and metastasis. Nonetheless, targeting LECs in the lymph nodes has potential for modulating immune reactivity in these conditions.

TRENDS IN IMMUNOLOGY (2023)

添加到收藏夹

Article Cell Biology

Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics

Mona C. Friess et al.

Summary: In this study, the researchers identified an ACKR4-mediated mechanism by which lymphatic collectors facilitate the detachment and migration of lymph-borne T cells in inflammation.

CELL REPORTS (2022)

添加到收藏夹

Article Immunology

Fate mapping and scRNA sequencing reveal origin and diversity of lymph node stromal precursors

Elisa Lenti et al.

Summary: This study identifies the origin and composition of lymph node stromal and endothelial cells through lineage tracing and single-cell transcriptome analysis. The results show that stromal and endothelial cells originate from different cell populations in the embryo. Single-cell RNA sequencing reveals different subsets of stromal cells and suggests the presence of proliferating progenitors in embryonic lymph nodes.

IMMUNITY (2022)

添加到收藏夹

Article Cell Biology

A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling

Yoshiaki Abe et al.

Summary: This study constructed a single-cell transcriptome atlas of non-haematopoietic cells (NHCs), including mesenchymal stromal cells and endothelial cells, collected from human samples. The atlas revealed 30 distinct subclusters of NHCs, including previously unrecognized ones. Comparative analyses with lymphoma NHCs showed subcluster-specific changes in gene expression and interaction with malignant cells in follicular lymphoma NHCs, providing insights into stromal remodelling in lymphoma and potential clinical biomarkers. The study updates NHC taxonomy in human lymph nodes and provides a rich resource for advancing lymphoma management and therapy.

NATURE CELL BIOLOGY (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging

Sandip Ashok Sonar et al.

Summary: Secondary lymphoid organs (SLOs) age asynchronously, with a reduction in the capacity of older SLOs to maintain naive T cell numbers. Older SLOs exhibit an emigration phenotype and decreased participation in de novo immune responses in mice.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Recycling of memory B cells between germinal center and lymph node subcapsular sinus supports affinity maturation to antigenic drift

Yang Zhang et al.

Summary: This study demonstrates that memory B cells can recycle back to germinal centers via CCL-21 mediated chemotaxis to transport antigens, potentially contributing to affinity maturation and antigenic drift.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Dendritic cells direct circadian anti-tumour immune responses

Chen Wang et al.

NATURE (2022)

添加到收藏夹

Article Immunology

Lymph node homeostasis and adaptation to immune challenge resolved by fibroblast network mechanics

Harry L. Horsnell et al.

Summary: The study examines the mechanics of lymph node swelling during immune response, revealing the role of tissue tension and podoplanin-CLEC-2 signaling in regulating fibroblastic reticular cell proliferation and T cell activation. Molecular signals control the cellular, physical, and structural properties of lymph nodes, which maintain robust tissue architecture in homeostasis but can expand extensively during immune challenge.

NATURE IMMUNOLOGY (2022)

添加到收藏夹

Article Immunology

Multitier mechanics control stromal adaptations in the swelling lymph node

Frank P. Assen et al.

Summary: Researchers have characterized the biomechanics of lymph node swelling and found that different fibroblast populations mechanically control its expansion in a multitier fashion.

NATURE IMMUNOLOGY (2022)

添加到收藏夹

Article Oncology

Immunomodulatory Responses of Subcapsular Sinus Floor Lymphatic Endothelial Cells in Tumor-Draining Lymph Nodes

Eliane Sibler et al.

Summary: Lymphatic endothelial cells (LECs) in tumor-draining lymph nodes (LNs) play a role in tumor immune response, particularly a specific subset of LECs with upregulated genes, including podoplanin, which mediate macrophage adhesion. Deletion of podoplanin in tumor-draining LNs leads to a decrease in macrophage numbers.

CANCERS (2022)

添加到收藏夹

Review Immunology

A guide to antigen processing and presentation

Novalia Pishesha et al.

Summary: This article provides an overview of antigen processing and presentation pathways, explaining how antigenic peptides are loaded onto MHC molecules for detection by T cells. These pathways are essential for adaptive immunity and involve several steps for acquiring and presenting antigens for T cell recognition.

NATURE REVIEWS IMMUNOLOGY (2022)

添加到收藏夹

Article Geriatrics & Gerontology

Age-Associated Changes to Lymph Node Fibroblastic Reticular Cells

Tina Kwok et al.

Summary: Aging leads to increased fibrosis in lymph nodes, impairing naive T-cell motility and turnover, which may be related to the reduced homeostatic factors and interactions necessary for T cell maintenance.

FRONTIERS IN AGING (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential

Siyi Huang et al.

Summary: The study found that peptidergic nociceptors, a subset of sensory neurons, innervate LNs, distinct from other sensory neurons surrounding the skin. Optogenetic stimulation of LN-innervating sensory fibers triggers rapid transcriptional changes in interacting cell types, particularly endothelium, stromal cells, and innate leukocytes.

CELL (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

MARCO+ lymphatic endothelial cells sequester arthritogenic alphaviruses to limit viremia and viral dissemination

Kathryn S. Carpentier et al.

Summary: The scavenger receptor MARCO plays critical roles in controlling viremia during arthritogenic alphavirus infections in mice, limiting viral spread to the bloodstream and clearing alphavirus particles from the circulation. This defense mechanism reduces viral tissue burdens and severity of disease, highlighting the importance of MARCO in viremia control.

EMBO JOURNAL (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Sialoglycans on lymphatic endothelial cells augment interactions with Siglec-1 (CD169) of lymph node macrophages

Marco D'Addio et al.

Summary: The interactions between sialoglycans on lymphatic endothelial cells (LEC) and macrophage-expressed Siglec-1 play a critical role in regulating macrophage localization and phenotype. The densely clustered, sialylated glycans on the SCS floor LEC were identified as a key component in the macrophage niche, providing anchorage for Siglec-1(+) LN-SCS macrophages. Defective binding of sialoglycans by Siglec-1 results in reduced numbers of Siglec-1(+) macrophages with a less proliferative and more anti-inflammatory phenotype.

FASEB JOURNAL (2021)

添加到收藏夹

Review Physiology

Aging, Immunity, and COVID-19: How Age Influences the Host Immune Response to Coronavirus Infections?

Varnica Bajaj et al.

Summary: The novel coronavirus has greatly impacted the world with over 72 million cases and 1.6 million deaths, mostly affecting the elderly population. Aging leads to changes in the immune system, making elderly individuals more susceptible to infections and less responsive to vaccines. Understanding age-related immune system changes is crucial for managing infectious diseases like COVID-19.

FRONTIERS IN PHYSIOLOGY (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

Development and aging of the lymphatic vascular system

Alejandra Gonzalez-Loyola et al.

Summary: The lymphatic vasculature plays a crucial role in maintaining body fluid balance, immune surveillance, and dietary fat absorption. Recent studies have shed light on the mechanisms of lymphatic vascular development and function.

ADVANCED DRUG DELIVERY REVIEWS (2021)

添加到收藏夹

Article Immunology

Circadian clocks guide dendritic cells into skin lymphatics

Stephan J. Holtkamp et al.

Summary: The study demonstrates that circadian clocks regulate the infiltration of dendritic cells into skin lymphatics, which is crucial for adaptive immune responses. The migration pattern of dendritic cells is influenced by rhythmic gradients in the expression of chemokines and adhesion molecules in both mice and humans. Targeting the circadian oscillations in skin lymphatic endothelial cells and dendritic cells disrupts the circadian trafficking of dendritic cells.

NATURE IMMUNOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

An aged immune system drives senescence and ageing of solid organs

Matthew J. Yousefzadeh et al.

Summary: Researchers found that aged immune system could lead to attrition and senescence of specific immune cell populations, driving systemic ageing.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Scavenging of soluble and immobilized CCL21 by ACKR4 regulates peripheral dendritic cell emigration

Cameron R. Bastow et al.

Summary: This study reveals the mechanism by which ACKR4 controls DC migration in barrier tissues, identifying the existence of two forms of CCL21 in steady-state conditions and their regulation by ACKR4. It enhances understanding of functional chemokine gradient formation by showing how ACKR4 affects CCL21 gradients in barrier tissues and downstream lymph nodes.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Article Oncology

Lymphatic PD-L1 Expression Restricts Tumor-Specific CD8+ T-cell Responses

Nikola Cousin et al.

Summary: A new study using a lymphatic-specific PD-L1 knockout mouse model reveals that lymphatic endothelial PD-L1 expression reduces tumor immunity by inducing apoptosis in tumor-specific CD8(+) central memory cells in tumor-draining lymph nodes.

CANCER RESEARCH (2021)

添加到收藏夹

Article Developmental Biology

An inducible Cldn11-CreERT2 mouse line for selective targeting of lymphatic valves

Henrik Ortsater et al.

Summary: The generation of a transgenic mouse expressing tamoxifen inducible CreER(T2) under the control of Cldn11 promoter allows for selective and temporally controlled targeting of lymphatic valve endothelial cells. The study shows that CLDN11 is specifically expressed in lymphatic valves and not required for their development, with efficient labeling of valve endothelial cells observed. This mouse model provides a valuable tool for functional studies of valves.

GENESIS (2021)

添加到收藏夹

Review Immunology

Lymph node stromal cells: subsets and functions in health and disease

C. Grasso et al.

Summary: Lymph nodes stromal cells are crucial for guiding adaptive immune responses, with recent advancements in single-cell technologies revealing significant heterogeneity among subsets. While most knowledge comes from mouse studies, some similarities with human counterparts suggest their importance.

TRENDS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Visceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells

Vincenza Cifarelli et al.

Summary: Genetic variants in CD36 impact lymphatic lipid transport, while deficiency of CD36 in lymphatic endothelial cells leads to risks associated with metabolic syndrome and diabetes. The loss of CD36 in mice causes lymph leakage, visceral adiposity and glucose intolerance, increasing the risk of type 2 diabetes (T2D).

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure

Alejandra Gonzalez-Loyola et al.

Summary: Inactivation of Foxc2 in adult lymphatic endothelium leads to a stepwise intestine-to-lung systemic failure, compromising gut epithelial barrier and promoting dysbiosis. The loss of Foxc2 skewed the specialization of lymphatic endothelial subsets, resulting in populations with mixed identities and emergence of lymph node-like endothelial cells.

SCIENCE ADVANCES (2021)

添加到收藏夹

Article Cell Biology

Single-Cell Transcriptional Heterogeneity of Lymphatic Endothelial Cells in Normal and Inflamed Murine Lymph Nodes

Eliane Sibler et al.

Summary: The study used single-cell RNA sequencing to investigate transcriptional changes in lymphatic endothelial cells in lymph nodes draining naive and inflamed skin. It was found that subsets of these cells responded individually to skin inflammation, suggesting distinct functions under pathological conditions. Dysregulated genes during inflammation were identified, including an up-regulation of CD200, potentially involved in immune regulation. Additionally, in silico analysis predicted interactions of these cells with diverse immune cells in the lymph nodes, showing similarities in transcriptional changes in different skin inflammation settings.

CELLS (2021)

添加到收藏夹

Article Cell Biology

Lymph-Derived Neutrophils Primarily Locate to the Subcapsular and Medullary Sinuses in Resting and Inflamed Lymph Nodes

Jenny de Castro Pinho et al.

Summary: Neutrophils primarily localize in the subcapsular and medullary sinuses of lymph nodes, with resting and in vitro-activated neutrophils showing random migration within the medulla. Co-injected dendritic cells facilitate the entry of resting neutrophils into the lymph node parenchyma via the subcapsular sinus, while in vivo-activated adoptively transferred neutrophils migrate into the interfollicular areas of the lymph node.

CELLS (2021)

添加到收藏夹

Article Immunology

Robo4 contributes to the turnover of Peyer's patch B cells

Ruth Fair-Makela et al.

MUCOSAL IMMUNOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells

Sung Yong Choi et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance

Rieke Martens et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Structural and Functional Changes in the Mesenteric Lymph Nodes in Humans during Aging

L. M. Erofeeva et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes

Noriki Fujimoto et al.

PLOS BIOLOGY (2020)

添加到收藏夹

Review Immunology

Lymph node stromal cells: cartographers of the immune system

Akshay T. Krishnamurty et al.

NATURE IMMUNOLOGY (2020)

添加到收藏夹

Article Immunology

Lymph node stromal CCL2 limits antibody responses

Dragos C. Dasoveanu et al.

SCIENCE IMMUNOLOGY (2020)

添加到收藏夹

Review Immunology

Stromal cells and immune cells involved in formation of lymph nodes and their niches

Jasper J. Koning et al.

CURRENT OPINION IN IMMUNOLOGY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease

Guillermo Oliver et al.

CELL (2020)

添加到收藏夹

Article Medicine, Research & Experimental

S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling

Xin Geng et al.

JCI INSIGHT (2020)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature

Menglan Xiang et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2020)

添加到收藏夹

Review Multidisciplinary Sciences

Biological functions of lymphatic vessels

Tatiana V. Petrova et al.

SCIENCE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

T-cells produce acidic niches in lymph nodes to suppress their own effector functions

Hao Wu et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Lymph Node Subcapsular Sinus Microenvironment-On-A-Chip Modeling Shear Flow Relevant to Lymphatic Metastasis and Immune Cell Homing

Katherine G. Birmingham et al.

ISCIENCE (2020)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Circadian rhythms and the molecular clock in cardiovascular biology and disease

Sandra Crnko et al.

NATURE REVIEWS CARDIOLOGY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation

Choong-kun Lee et al.

SCIENCE (2019)

添加到收藏夹

Article Immunology

Lymphatic Endothelial Cells Are Essential Components of the Subcapsular Sinus Macrophage Niche

Isabelle Mondor et al.

IMMUNITY (2019)

添加到收藏夹

Article Immunology

Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche

Abdouramane Camara et al.

IMMUNITY (2019)

添加到收藏夹

Article Medicine, Research & Experimental

Transcytosis route mediates rapid delivery of intact antibodies to draining lymph nodes

Laura Kahari et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

添加到收藏夹

Review Immunology

The Antigen Processing and Presentation Machinery in Lymphatic Endothelial Cells

Laura Santambrogio et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Article Immunology

Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils

Akira Takeda et al.

IMMUNITY (2019)

添加到收藏夹

Article Cell Biology

Lymph nodes as barriers to T-cell rejuvenation in aging mice and nonhuman primates

Heather L. Thompson et al.

AGING CELL (2019)

添加到收藏夹

Review Immunology

Structure and function of the immune system in the spleen

Steven M. Lewis et al.

SCIENCE IMMUNOLOGY (2019)

添加到收藏夹

Review Cell Biology

Lymph node macrophages: Scavengers, immune sentinels and trophic effectors

Alicia Bellomo et al.

CELLULAR IMMUNOLOGY (2018)

添加到收藏夹

Article Immunology

Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity

Lauren B. Rodda et al.

IMMUNITY (2018)

添加到收藏夹

Review Physiology

PTX3, A HUMORAL PATTERN RECOGNITION MOLECULE, IN INNATE IMMUNITY, TISSUE REPAIR, AND CANCER

Cecilia Garlanda et al.

PHYSIOLOGICAL REVIEWS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis

Hsin-Ying Huang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

添加到收藏夹

Article Multidisciplinary Sciences

A molecular atlas of cell types and zonation in the brain vasculature

Michael Vanlandewijck et al.

NATURE (2018)

添加到收藏夹

Review Immunology

A Fresh View on Lymph Node Organogenesis

Lucas Onder et al.

TRENDS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

Moshe Biton et al.

CELL (2018)

添加到收藏夹

Article Immunology

Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues

Wenyan He et al.

IMMUNITY (2018)

添加到收藏夹

Article Immunology

IFN gamma-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin

Ryan S. Lane et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

添加到收藏夹

Article Immunology

The conduit system exports locally secreted IgM from lymph nodes

Guilhem R. Thierry et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

添加到收藏夹

Letter Immunology

Complexity of Lymphoid Tissue Organizers: A Response to Onder and Ludewig

Jasper J. Koning et al.

TRENDS IN IMMUNOLOGY (2018)

添加到收藏夹

Article Cell Biology

Mechanisms of Tumor-Induced Lymphovascular Niche Formation in Draining Lymph Nodes

Catharina D. Commerford et al.

CELL REPORTS (2018)

添加到收藏夹

Review Immunology

Clocking in to immunity

Christoph Scheiermann et al.

NATURE REVIEWS IMMUNOLOGY (2018)

添加到收藏夹

Article Biology

Absence of MHC-II expression by lymph node stromal cells results in autoimmunity

Juan Dubrot et al.

LIFE SCIENCE ALLIANCE (2018)

添加到收藏夹

Article Immunology

Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response

Victoria Fang et al.

NATURE IMMUNOLOGY (2017)

添加到收藏夹

Article Immunology

Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis

Lucas Onder et al.

IMMUNITY (2017)

添加到收藏夹

Article Immunology

Structural and functional changes to lymph nodes in ageing mice

Vivian M. Turner et al.

IMMUNOLOGY (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells

Alejandra Mendoza et al.

NATURE (2017)

添加到收藏夹

Review Multidisciplinary Sciences

Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology

Hellmut G. Augustin et al.

SCIENCE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Migratory dendritic cells acquire and present lymphatic endothelial cell-archived antigens during lymph node contraction

Ross M. Kedl et al.

NATURE COMMUNICATIONS (2017)

添加到收藏夹

Article Cell Biology

Infection Programs Sustained Lymphoid Stromal Cell Responses and Shapes Lymph Node Remodeling upon Secondary Challenge

Julia L. Gregory et al.

CELL REPORTS (2017)

添加到收藏夹

Article Immunology

Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1

Louise A. Johnson et al.

NATURE IMMUNOLOGY (2017)

添加到收藏夹

Article Biology

Differential DARC/ACKR1 expression distinguishes venular from non-venular endothelial cells in murine tissues

Aude Thiriot et al.

BMC BIOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation

Niwa Ali et al.

CELL (2017)

添加到收藏夹

Review Immunology

Tissue Tregs

Marisella Panduro et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 34 (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

Endothelial Cell Responses to Biomechanical Forces in Lymphatic Vessels

Amelie Sabine et al.

ANTIOXIDANTS & REDOX SIGNALING (2016)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Heterogeneity in the lymphatic vascular system and its origin

Maria H. Ulvmar et al.

CARDIOVASCULAR RESEARCH (2016)

添加到收藏夹

Article Anatomy & Morphology

Coordinated lymphangiogenesis is critical in lymph node development and maturation

Yulia Ga-eun Lee et al.

DEVELOPMENTAL DYNAMICS (2016)

添加到收藏夹

Article Immunology

Clonal Proliferation and Stochastic Pruning Orchestrate Lymph Node Vasculature Remodeling

Isabelle Mondor et al.

IMMUNITY (2016)

添加到收藏夹

Review Immunology

Peyer's patches: organizing B-cell responses at the intestinal frontier

Andrea Reboldi et al.

IMMUNOLOGICAL REVIEWS (2016)

添加到收藏夹

Article Immunology

Disorganization of the splenic microanatomy in ageing mice

Danielle Aw et al.

IMMUNOLOGY (2016)

添加到收藏夹

Review Multidisciplinary Sciences

Angiocrine functions of organ-specific endothelial cells

Shahin Rafii et al.

NATURE (2016)

添加到收藏夹

Article Endocrinology & Metabolism

Omentum and bone marrow: how adipocyte-rich organs create tumour microenvironments conducive for metastatic progression

H. Chkourko Gusky et al.

OBESITY REVIEWS (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Gene-expression profiling of different arms of lymphatic vasculature identifies candidates for manipulation of cell traffic

Imtiaz Iftakhar-E-Khuda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

添加到收藏夹

Article Cell Biology

Intralymphatic CCL21 Promotes Tissue Egress of Dendritic Cells through Afferent Lymphatic Vessels

Erica Russo et al.

CELL REPORTS (2016)

添加到收藏夹

Article Biology

Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node

Yang Zhang et al.

ELIFE (2016)

添加到收藏夹

Article Multidisciplinary Sciences

The aged lymphoid tissue environment fails to support naive T cell homeostasis

Bryan R. Becklund et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Review Medical Laboratory Technology

Splenic Lymphangioma

Ioannis Ioannidis et al.

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity

Denise Morais da Fonseca et al.

CELL (2015)

添加到收藏夹

Review Immunology

Antigen archiving by lymph node stroma: A novel function for the lymphatic endothelium

Ross M. Kedl et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2015)

添加到收藏夹

Review Immunology

Lymph formation, composition and circulation: a proteomics perspective

Kirk C. Hansen et al.

INTERNATIONAL IMMUNOLOGY (2015)

添加到收藏夹

Article Medicine, Research & Experimental

FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature

Amelie Sabine et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

添加到收藏夹

Article Immunology

The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes

Pia Rantakari et al.

NATURE IMMUNOLOGY (2015)

添加到收藏夹

Review Immunology

Stromal infrastructure of the lymph node and coordination of immunity

Jonathan E. Chang et al.

TRENDS IN IMMUNOLOGY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction

Sherin J. Rouhani et al.

NATURE COMMUNICATIONS (2015)

添加到收藏夹

Article Biology

Class 3 semaphorins negatively regulate dermal lymphatic network formation

Yutaka Uchida et al.

BIOLOGY OPEN (2015)

添加到收藏夹

Review Immunology

Modes of antigen presentation by lymph node stromal cells and their immunological implications

Sachiko Hirosue et al.

FRONTIERS IN IMMUNOLOGY (2015)

添加到收藏夹

Review Oncology

Understanding high endothelial venules: Lessons for cancer immunology

Ann Ager et al.

ONCOIMMUNOLOGY (2015)

添加到收藏夹

Article Cell Biology

Sinusoidal Immunity: Macrophages at the Lymphohematopoietic Interface

Siamon Gordon et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

添加到收藏夹

Review Immunology

How leukocytes cross the vascular endothelium

Dietmar Vestweber

NATURE REVIEWS IMMUNOLOGY (2015)

添加到收藏夹

Article Geriatrics & Gerontology

Thymus and aging: morphological, radiological, and functional overview

Rita Rezzani et al.

AGE (2014)

添加到收藏夹

Review Immunology

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

Jason W. Griffith et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

添加到收藏夹

Article Hematology

Perivascular Adipose Tissue in Vascular Function and Disease A Review of Current Research and Animal Models

Nicholas K. Brown et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)

添加到收藏夹

Article Hematology

CLEC-2 is required for development and maintenance of lymph nodes

Cecile Benezech et al.

BLOOD (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Transcription Factor Titration Effect Dictates Level of Gene Expression

Robert C. Brewster et al.

CELL (2014)

添加到收藏夹

Review Immunology

Leukocyte Migration into Inflamed Tissues

Sussan Nourshargh et al.

IMMUNITY (2014)

添加到收藏夹

Article Immunology

Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4+ T cell tolerance

Juan Dubrot et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2014)

添加到收藏夹

Article Immunology

Steady-State Antigen Scavenging, Cross-Presentation, and CD8+ T Cell Priming: A New Role for Lymphatic Endothelial Cells

Sachiko Hirosue et al.

JOURNAL OF IMMUNOLOGY (2014)

添加到收藏夹

Article Immunology

The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes

Maria H. Ulvmar et al.

NATURE IMMUNOLOGY (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Tolerogenic Properties of Lymphatic Endothelial Cells Are Controlled by the Lymph Node Microenvironment

Jarish N. Cohen et al.

PLOS ONE (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Mapping the Distinctive Populations of Lymphatic Endothelial Cells in Different Zones of Human Lymph Nodes

Saem Mul Park et al.

PLOS ONE (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress

Koyu Ito et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

添加到收藏夹

Article Multidisciplinary Sciences

Antigen capture and archiving by lymphatic endothelial cells following vaccination or viral infection

Beth A. Tamburini et al.

NATURE COMMUNICATIONS (2014)

添加到收藏夹

Review Immunology

Follicular dendritic cells: dynamic antigen libraries

Balthasar A. Heesters et al.

NATURE REVIEWS IMMUNOLOGY (2014)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

CD44 Binds to Macrophage Mannose Receptor on Lymphatic Endothelium and Supports Lymphocyte Migration via Afferent Lymphatics

Marko Salmi et al.

CIRCULATION RESEARCH (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network

Masayuki Nagahashi et al.

FASEB JOURNAL (2013)

添加到收藏夹

Review Immunology

The Spleen in Local and Systemic Regulation of Immunity

Vincenzo Bronte et al.

IMMUNITY (2013)

添加到收藏夹

Review Medicine, Research & Experimental

Causes, consequences, and reversal of immune system aging

Encarnacion Montecino-Rodriguez et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

添加到收藏夹

Article Immunology

CXCR4 promotes B cell egress from Peyer's patches

Timothy H. Schmidt et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

添加到收藏夹

Article Immunology

Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses

Suvendu Das et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients

Michele Weber et al.

SCIENCE (2013)

添加到收藏夹

Article Hematology

Annexin A2 System in Human Biology: Cell Surface and Beyond

Min Luo et al.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Aldara activates TLR7-independent immune defence

Anne Walter et al.

NATURE COMMUNICATIONS (2013)

添加到收藏夹

Article Hematology

Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells

Eric F. Tewalt et al.

BLOOD (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Mechanoinduction of lymph vessel expansion

Lara Planas-Paz et al.

EMBO JOURNAL (2012)

添加到收藏夹

Article Immunology

Lymphotoxin-β Receptor Signaling through NF-κB2-RelB Pathway Reprograms Adipocyte Precursors as Lymph Node Stromal Cells

Cecile Benezech et al.

IMMUNITY (2012)

添加到收藏夹

Review Immunology

Lymph Node Macrophages

Elizabeth E. Gray et al.

JOURNAL OF INNATE IMMUNITY (2012)

添加到收藏夹

Article Immunology

Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

Deepali Malhotra et al.

NATURE IMMUNOLOGY (2012)

添加到收藏夹

Review Immunology

Changes in primary lymphoid organs with aging

Ivan K. Chinn et al.

SEMINARS IN IMMUNOLOGY (2012)

添加到收藏夹

Article Cell Biology

The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate

Alejandra Mendoza et al.

CELL REPORTS (2012)

添加到收藏夹

Article Cell Biology

VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics

Amanda W. Lund et al.

CELL REPORTS (2012)

添加到收藏夹

Article Cell Biology

Infection-Induced Regulation of Natural Killer Cells by Macrophages and Collagen at the Lymph Node Subcapsular Sinus

Janine L. Coombes et al.

CELL REPORTS (2012)

添加到收藏夹

Review Immunology

HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes

Jean-Philippe Girard et al.

NATURE REVIEWS IMMUNOLOGY (2012)

添加到收藏夹

Article Hematology

D6 facilitates cellular migration and fluid flow to lymph nodes by suppressing lymphatic congestion

Kit Ming Lee et al.

BLOOD (2011)

添加到收藏夹

Article Immunology

T Lymphocytes Negatively Regulate Lymph Node Lymphatic Vessel Formation

Raghu P. Kataru et al.

IMMUNITY (2011)

添加到收藏夹

Article Immunology

Coordinated Regulation of Lymph Node Vascular-Stromal Growth First by CD11c+ Cells and Then by T and B Cells

Susan Chyou et al.

JOURNAL OF IMMUNOLOGY (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules

Christine Moussion et al.

NATURE (2011)

添加到收藏夹

Article Immunology

Afferent lymph-derived T cells and DCs use different chemokine receptor CCR7-dependent routes for entry into the lymph node and intranodal migration

Asolina Braun et al.

NATURE IMMUNOLOGY (2011)

添加到收藏夹

Review Biochemistry & Molecular Biology

The lymphatic vasculature in disease

Kari Alitalo

NATURE MEDICINE (2011)

添加到收藏夹

Review Immunology

Staying alive: regulation of plasma cell survival

Stuart G. Tangye

TRENDS IN IMMUNOLOGY (2011)

添加到收藏夹

Article Immunology

Reproducible isolation of lymph node stromal cells reveals site-dependent differences in fibroblastic reticular cells

Anne L. Fletcher et al.

FRONTIERS IN IMMUNOLOGY (2011)

添加到收藏夹

Review Immunology

Thymic fatness and approaches to enhance thymopoietic fitness in aging

Vishwa Deep Dixit

CURRENT OPINION IN IMMUNOLOGY (2010)

添加到收藏夹

Article Immunology

Immobilized Chemokine Fields and Soluble Chemokine Gradients Cooperatively Shape Migration Patterns of Dendritic Cells

Kathrin Schumann et al.

IMMUNITY (2010)

添加到收藏夹

Article Immunology

Development and Migration of Plasma Cells in the Mouse Lymph Node

David R. Fooksman et al.

IMMUNITY (2010)

添加到收藏夹

Article Anatomy & Morphology

Age-dependent histoarchitectural changes in human lymph nodes: an underestimated process with clinical relevance?

Catarina Hadamitzky et al.

JOURNAL OF ANATOMY (2010)

添加到收藏夹

Article Cell Biology

Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3

Yunling Xu et al.

JOURNAL OF CELL BIOLOGY (2010)

添加到收藏夹

Article Immunology

Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning

Trung H. M. Pham et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

添加到收藏夹

Article Immunology

Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation

Jarish N. Cohen et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

添加到收藏夹

Article Immunology

Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions

Anne L. Fletcher et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

添加到收藏夹

Review Immunology

New insights into the development of lymphoid tissues

Serge A. van de Pavert et al.

NATURE REVIEWS IMMUNOLOGY (2010)

添加到收藏夹

Article Cell Biology

Local lymphogenic migration pathway in normal mouse spleen

Kazuhiko Shimizu et al.

CELL AND TISSUE RESEARCH (2009)

添加到收藏夹

Article Developmental Biology

Lymph sacs are not required for the initiation of lymph node formation

Mark F. Vondenhoff et al.

DEVELOPMENT (2009)

添加到收藏夹

Article Immunology

Conduits Mediate Transport of Low-Molecular-Weight Antigen to Lymph Node Follicles

Ramon Roozendaal et al.

IMMUNITY (2009)

添加到收藏夹

Article Immunology

B Lymphocytes Exit Lymph Nodes through Cortical Lymphatic Sinusoids by a Mechanism Independent of Sphingosine-1-Phosphate-Mediated Chemotaxis

Rajesh K. Sinha et al.

IMMUNITY (2009)

添加到收藏夹

Article Immunology

LTβR Signaling Induces Cytokine Expression and Up-Regulates Lymphangiogenic Factors in Lymph Node Anlagen

Mark F. Vondenhoff et al.

JOURNAL OF IMMUNOLOGY (2009)

添加到收藏夹

Article Immunology

Cortical sinus probing, S1P(1)-dependent entry and flow-based capture of egressing T cells

Irina L. Grigorova et al.

NATURE IMMUNOLOGY (2009)

添加到收藏夹

Article Immunology

The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity

Monika Pruenster et al.

NATURE IMMUNOLOGY (2009)

添加到收藏夹

Article Biochemical Research Methods

Lymph node mapping in the mouse

Maria I. Harrell et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2008)

添加到收藏夹

Article Medicine, Research & Experimental

Senile Changes in Human Lymph Nodes

Wei-Ren Pan et al.

Lymphatic Research and Biology (2008)

添加到收藏夹

Article Multidisciplinary Sciences

Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells

Tobias Junt et al.

NATURE (2007)

添加到收藏夹

Article Immunology

Functionally specialized junctions between endothelial cells of lymphatic vessels

Peter Baluk et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2007)

添加到收藏夹

Article Immunology

Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells

Tri Giang Phan et al.

NATURE IMMUNOLOGY (2007)

添加到收藏夹

Article Immunology

Deletional self-tolerance to a melanocyte/melanoma antigen derived from tyrosinase is mediated by a radio-resistant cell in peripheral and mesenteric lymph nodes

Lisa A. Nichols et al.

JOURNAL OF IMMUNOLOGY (2007)

添加到收藏夹

Article Immunology

Distinct activities of stromal cells involved in the organogenesis of lymph nodes and Peyer's patches

Masato Okuda et al.

JOURNAL OF IMMUNOLOGY (2007)

添加到收藏夹

Article Immunology

B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node

Yolanda R. Carrasco et al.

IMMUNITY (2007)

添加到收藏夹

Article Multidisciplinary Sciences

A silent chemokine receptor regulates steady-state leukocyte homing in vivo

Kornelia Heinzel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

添加到收藏夹

Article Immunology

Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self

Je-Wook Lee et al.

NATURE IMMUNOLOGY (2007)

添加到收藏夹

Article Hematology

VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites

Satoshi Hirakawa et al.

BLOOD (2007)

添加到收藏夹

Review Cell Biology

Matrix metalloproteinases and the regulation of tissue remodelling

Andrea Page-McCaw et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

添加到收藏夹

Article Immunology

Synchrony of high endothelial venules and lymphatic vessels revealed by immunization

Shan Liao et al.

JOURNAL OF IMMUNOLOGY (2006)

添加到收藏夹

Article Immunology

Regulation of lymph node vascular growth by dendritic cells

Brian Webster et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

T-cell tolerance or function is determined by combinatorial costimulatory signals

Roza Nurieva et al.

EMBO JOURNAL (2006)

添加到收藏夹

Article Oncology

Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis

JH Martens et al.

JOURNAL OF PATHOLOGY (2006)

添加到收藏夹

Article Immunology

B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization

V Angeli et al.

IMMUNITY (2006)

添加到收藏夹

Article Pathology

Normal structure, function, and histology of lymph nodes

Cynthia L. Willard-Mack

TOXICOLOGIC PATHOLOGY (2006)

添加到收藏夹

Article Multidisciplinary Sciences

Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients

SR Schwab et al.

SCIENCE (2005)

添加到收藏夹

Article Hematology

Disparate lymphoid chemokine expression in mice and men: no evidence of CCL21 synthesis by human high endothelial venules

HS Carlsen et al.

BLOOD (2005)

添加到收藏夹

Article Immunology

The conduit system transports soluble antigens from the afferent lymph to resident dendritic cells in the T cell area of the lymph node

M Sixt et al.

IMMUNITY (2005)

添加到收藏夹

Article Multidisciplinary Sciences

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

M Matloubian et al.

NATURE (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis

TV Petrova et al.

NATURE MEDICINE (2004)

添加到收藏夹

Article Immunology

CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions

L Ohl et al.

IMMUNITY (2004)

添加到收藏夹

Article Immunology

Lack of oral tolerance in aging is due to sequential loss of Peyer's patch cell interactions

H Kato et al.

INTERNATIONAL IMMUNOLOGY (2003)

添加到收藏夹

Article Immunology

Tumor necrosis factor-dependent segmental control of MIG expression by high endothelial venules in inflamed lymph nodes regulates monocyte recruitment

MJ Janatpour et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2001)

添加到收藏夹

Article Immunology

Inflammatory chemokine transport and presentation in HEV: A remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues

RT Palframan et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2001)

添加到收藏夹

Article Immunology

Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex

JE Gretz et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2000)

添加到收藏夹

Article Biochemistry & Molecular Biology

Molecular characterization of a human scavenger receptor, human MARCO

MA Elshourbagy et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.