期刊
CHINESE CHEMICAL LETTERS
卷 35, 期 2, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2023.108648
关键词
Photodynamic therapy; Biomaterials; Dental implant; Reactive oxygen species; Carbon monoxide; Hybrid nanoplatform
Antimicrobial photodynamic therapy (aPDT) is a noninvasive and effective treatment for bacterial infection in peri-implantitis. Researchers have designed a multi-functional gas generator that combines aPDT with oxygen and carbon monoxide release to address the challenges of hypoxia and inflammation regulation. The composite nanoplatform on the surface of titanium implants allows controlled release of reactive oxygen species, carbon monoxide, and oxygen, achieving antibacterial effectiveness.
Antimicrobial photodynamic therapy (aPDT) has been considered a noninvasive and effective modality against the bacterial infection of peri-implantitis, especially the aPDT triggered by near-infrared (NIR) light due to the large penetration depth in tissue. However, the complexity of hypoxia microenvironments and the distance of aPDT sterilization still pose challenges before realizing the aPDT clinical application. Due to the long lifespan and transmission distance of therapeutic gas molecules, we design a multi-functional gas generator that combines aPDT as well as O 2 and CO gas release function, which can solve the problem of hypoxia (O 2 ) in PDT and the problem of inflammation regulation (CO) in the distal part of peri-implant inflammation under near-infrared (NIR) irradiation. In the composite nanoplatform that spin-coated on the surface of titanium implants, up-conversion nanoparticles (UCNPs) were involved in converting the NIR to visible, which further excites the partially oxidized stannic sulfide (SnS2), realizing the therapeutic gas release. Indocyanine green (ICG) was further integrated to enhance the aPDT performance (Ti-U@SnS2/I). Therefore, reactive oxygen species (ROS), CO, and O 2 can be controllably administered via a composite nano-platform mediated by a single NIR light (808 nm). This implant surface modification strategy could achieve great self-enhancement antibacterial effectiveness and regulate the lingering questions, such as relieving the anoxic microenvironment and reaching deep infection sites, providing a viable antibiotic-free technique to combat peri-implantitis.(c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据