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Review
Cell Biology
Sohei Kitazawa et al.
Summary: This article discusses the importance of tumor-related genes and epigenetics in disease development and treatment, and introduces the progress in tumor gene testing and epigenetic alterations.
ACTA HISTOCHEMICA ET CYTOCHEMICA
(2022)
Review
Oncology
Shanshan Wang et al.
Summary: N-6-Methyladenosine (m6A) is the most abundant internal modification associated with eukaryotic mRNAs, and it plays a dynamic regulatory role in gene expression by affecting various steps of mRNA metabolism. This review discusses the general role of m6A, focusing on the three major types of enzymes that determine the level of m6A modification and the regulatory mechanism by which m6A influences RNA metabolism. Understanding the role of m6A in physiological and pathophysiological processes, especially in tumorigenesis, is of great importance.
CANCER CELL INTERNATIONAL
(2022)
Review
Environmental Sciences
Pooria Ebrahimi et al.
Summary: Microplastics, a contaminant of emerging concern, can enter the human food chain through seafood and honey. The control of MP pollution and its impact on human health remains unclear, indicating the need for further research and regulation.
Review
Cardiac & Cardiovascular Systems
Rajesh Kumari et al.
Summary: m(6)A methylation is a highly studied RNA modification that plays a crucial role in cellular functions during development, differentiation, and disease. It is found in different RNA species and is regulated by various enzymes and proteins. In cardiovascular diseases, m(6)A methylation is associated with cardiac hypertrophy, myocardial infarction, and atherosclerosis.
CARDIOVASCULAR RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Min Zhang et al.
Summary: This study identified the toxicity of microplastics on endothelial cell function and found that smaller particles can cause endothelial cell injury and atherosclerotic plaque development. Transcriptomic and metabolomic analyses provided evidence of abnormal gene expression and metabolic pathway changes. These findings are crucial for developing effective preventive strategies against microplastic damage.
ENVIRONMENTAL SCIENCE-NANO
(2022)
Review
Environmental Sciences
Ping Fan et al.
Summary: This paper reviews the degradation characteristics and ecological effects of biodegradable plastics (BPs) and biodegradable microplastics (BMPs) in soil ecosystems. It reveals that BMPs have different or more severe impacts on soil environment compared to conventional microplastics (MPs), and BPs are not a perfect substitute for solving plastic pollution. Further research should focus on the generation, environmental behavior, ecological impact of BPs, and whether BMPs cause greater harm.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Jianping Tang et al.
Summary: In this study, the role of m(6)A modification and FTO in cobalt-induced neurotoxicity was investigated using human neuroglioma H4 cells as an in vitro model. The findings suggest that cobalt exposure affects m(6)A modification of apoptosis-related genes by decreasing FTO expression, leading to the activation of apoptosis.
ENVIRONMENTAL POLLUTION
(2022)
Review
Environmental Sciences
Pavani Dulanja Dissanayake et al.
Summary: This review provides a comprehensive overview of the current knowledge regarding microplastic contamination in terrestrial environments. It discusses the sources, occurrences, fates, and risks associated with microplastics, and highlights the need for further research on the impacts of microplastics on soil properties and ecosystems.
ENVIRONMENTAL RESEARCH
(2022)
Review
Environmental Sciences
Gayathri Chellasamy et al.
Summary: This article reviews the presence of microplastics in the environment and the use of bionanomaterials for their removal. It emphasizes the importance of understanding the adverse consequences of microplastic pollution and developing eco-friendly strategies to control and eradicate them.
ENVIRONMENTAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Yazhen You et al.
Summary: This review focuses on the oncogenic role of m6A demethylases FTO and ALKBH5 in cancer and their potential as therapeutic targets. Studies have shown that FTO-specific inhibitors exhibit anti-tumor effects. The review also summarizes the biological functions of these two m6A demethylases in various cancers and other human diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Engineering, Environmental
Hongwei Luo et al.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Rui Zhang et al.
Summary: METTL3 plays a significant role in Ang-II-induced myocardial hypertrophy by modulating miR-221/222 and activating Wnt/β-catenin signaling.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Environmental Sciences
Juan Song et al.
Summary: This study used MeRIP-seq to reveal the m(6)A methylation profiles in the lung tissues of mice exposed to PM, and identified potential pathways related to PM-induced lung damage. The m(6)A-modified IL-1a was found to promote PM-induced inflammation through regulating the MAPK signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Environmental Sciences
Yanlu Feng et al.
Summary: The health risks caused by environmental pollution have long been a concern. Recent studies have shown that m6A modification plays a key role in regulating important life activities associated with various diseases, potentially contributing to health damage caused by environmental exposure. Moreover, m6A methylation modifications are involved in various health damages, such as oxidative stress imbalance, apoptosis, epithelial-mesenchymal transition (EMT), and inflammatory processes. Additionally, methyltransferase-like protein 3 (METTL3) and fat mass- and obesity-associated protein (FTO) are potential biomarkers for health damage induced by particulate matter exposure and heavy metal exposure, respectively.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Xu Wang et al.
Summary: This study found that polystyrene microplastics can induce apoptosis and necrosis in swine testis cells, and further elucidated the signaling pathway involved.
ENVIRONMENTAL TOXICOLOGY
(2022)
Review
Environmental Sciences
Sarawut Sangkham et al.
Summary: Microplastics and nanoplastics are emerging environmental pollutants that pose significant ecotoxicological concerns to humans and aquatic animals. However, there is still limited knowledge about the exposure routes and toxic effects of these particles on animal and human health. This review focuses on the potential exposure routes, human health impacts, and toxicity responses of microplastics/nanoplastics, based on studies conducted in vitro and in vivo experiments. It highlights ingestion, inhalation, and dermal contacts as major exposure routes, and identifies oxidative stress, cytotoxicity, DNA damage, inflammation, immune response, neurotoxicity, and metabolic disruption as serious health consequences.
MARINE POLLUTION BULLETIN
(2022)
Review
Biochemistry & Molecular Biology
Shino Murakami et al.
Summary: Information in mRNA is not only confined to its nucleotide sequence but also includes chemical modifications, such as N-6-methylade-nosine (m(6)A). m(6)A modifies mRNA and can affect nuclear processes and promote degradation of mRNA in the cytoplasm. It marks a specific group of mRNAs associated with certain biological processes and is enriched in other groups as well.
Article
Oncology
Aolin Li et al.
Summary: ZNF677 functions as a tumor suppressor in RCC and its low expression is associated with unfavorable prognosis and decreased m(6)A modification level. Furthermore, m(6)A modification regulates the translation and mRNA stability of ZNF677.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Environmental Sciences
Jun Shi et al.
Summary: Investigating the long-term effects of microplastics on wild type mice, this study found that microplastics aggravate vascular lesions, organ injuries, and oxidative injuries. RNA sequencing revealed abnormal expression of genes and RNA, and pathway enrichment analysis identified pathways linked to the toxicity of microplastics. These findings provide new insights into the biological toxicity of microplastics.
Review
Environmental Sciences
Xiang Gu et al.
Summary: The Bohai Sea, the largest semi-enclosed sea of China, serves as a significant sink for microplastics (MPs) from both terrestrial and marine sources. This study summarizes the sources and migration pathways of MPs in the Bohai Sea, as well as the abundance and characteristics of MPs in water, sediments, and organisms. The study finds that coastal anthropogenic activities and marine origins contribute to the enrichment of MPs in the Bohai Sea, with a medium ecological risk observed in the Liaodong Bay. The study recommends future research priorities to focus on field surveys, sampling standardization, and establishment of toxicity database for common polymer types of MPs in the Bohai Sea.
Article
Environmental Sciences
Xiang He et al.
Summary: This study reveals the significant role of m6A modification in lung injury caused by PM2.5 exposure. The findings suggest that PM2.5 exposure increases the total level of m6A modification and the expression of METTL3. This upregulation of METTL3 leads to increased expression and m6A modification of IL24, enhancing the stability of IL24 mRNA. Additionally, PM2.5 exposure also upregulates the expression of YTHDF1, which augments the translation efficiency of IL24 mRNA. Downregulation of Mettl3 reduces IL24 expression and improves pulmonary inflammation and mucus secretion in PM2.5-exposed mice.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Yue Zhang et al.
Summary: The study found that microplastics caused severe pathological damage to the hearts of chickens, leading to myocardial pyroptosis, inflammation, and mitochondrial damage. PS-MPs triggered alterations in NF-kappa B-NLRP3-GSDMD and AMPK-PGC-1 alpha pathways via ROS overload, resulting in oxidative stress, myocardial pyroptosis, inflammation, mitochondrial dysfunction, and energy metabolism disorders.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Tianxin Zhao et al.
Summary: DEHP, a common environmental endocrine disrupting chemical, induces testicular injury through modulating m6A modification. The study reveals that FTO-mediated m6A modification plays a critical role in Leydig cell injury induced by DEHP.
ENVIRONMENTAL POLLUTION
(2021)
Review
Environmental Sciences
Yanxiao Cao et al.
Summary: Limited knowledge is available on the interactions between heavy metals and microplastics (MPs), as well as potential biological impacts from their combinations. Factors influencing the adsorption of heavy metals on MPs, such as polymer properties and chemical properties of heavy metals, are important to consider. Potential combined toxic effects from MPs and heavy metals on organisms and human health are a key focus for further research.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Limei Sun et al.
Summary: Chronic exposure to triclosan in zebrafish leads to fatty liver and hepatitis, with miR-30b identified as a sensitive biomarker reflecting metabolic toxicity and lipid-metabolism disorder. The regulation of fto-mediated m(6)A methylation level by decreasing miR-30b expression is crucial in causing lipid-metabolism disorder in zebrafish.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Sathisaran Umamaheswari et al.
Summary: The study elucidates the molecular events underlying apoptosis in the gills of zebrafish exposed to polystyrene microplastics, demonstrating that the exposure induces dose-and time-dependent ROS mediated apoptotic responses. The physiological responses observed in the gills correlate with the molecular mechanisms underpinning the toxicity of PS-MPs in zebrafish.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Review
Biochemistry & Molecular Biology
Stephanie Oerum et al.
Summary: Gene expression is regulated through various levels, including chemical modifications on RNA during or after transcription. One such modification is N6-methylation, which affects the structure, stability, degradation, and cellular interactions of the modified RNA, with dysregulation linked to multiple human cancers.RNA methyltransferases are the enzymes responsible for these modifications, and structural characterization of these enzymes is critical for understanding their functions.
NUCLEIC ACIDS RESEARCH
(2021)
Review
Toxicology
Md Nur Alam et al.
Summary: Environmental epigenetic findings highlight the importance of epigenetic regulations in environmental exposure-induced toxicities or disease susceptibilities. Current research emphasizes on the potential adverse effects of emerging contaminants on health through epigenetic mechanisms, but further studies are needed to explore the broad spectrum of health effects, synergistic/antagonistic effects, transgenerational epigenetic effects, and epidemiologic and demographic data related to these contaminants.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Environmental Sciences
Tian-Xin Zhao et al.
ENVIRONMENTAL POLLUTION
(2020)
Review
Oncology
Yanchun Zhao et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Hailing Shi et al.
Review
Environmental Sciences
Stella Tommasi et al.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2019)
Review
Genetics & Heredity
Guifang Jia et al.
TRENDS IN GENETICS
(2013)
