Highly Regioselective Synthesis of N-β-trifluoromethyl 2-pyridones via anti-Markovnikov Hydroamination of α-(trifluoromethyl)styrenes with 2-pyridones

A novel and facile method for the synthesis of N-beta-CF3-substituted 2-pyridones via hydroamination of alpha-(trifluoromethyl)styrenes with 2-pyridones was described. The reaction proceeded smoothly at room temperature, affording a variety of N-(beta-trifluoromethyl-beta-arylethyl)pyridin-2(1H)-ones in moderate to good yields with excellent N-regioselectivity.

Automated summary

A convenient method for the synthesis of N-beta-CF3-substituted 2-pyridones via hydroamination of alpha-(trifluoromethyl)styrenes with 2-pyridones was developed. The reaction proceeded smoothly at room temperature, yielding a variety of N-(beta-trifluoromethyl-beta-arylethyl)pyridin-2(1H)-ones in moderate to good yields with excellent N-regioselectivity.