期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 -, 期 -, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202300094
关键词
DFT; imines; oxidation reactions; radical mechanisms; transition metal free
The synthesis of imines is a foundational aspect of organic chemistry. Alcohols can be used as renewable substitutes for carbonyl-functionality, allowing for the in situ generation of carbonyl moieties from alcohols using transition-metal catalysis under inert atmosphere or bases under aerobic conditions. In this study, we report the synthesis of imines from benzyl alcohols and anilines using (KOBu)-Bu-t as a catalyst under aerobic conditions at room temperature, without the need for a transition-metal catalyst. We also present a detailed investigation of the underlying radical mechanism, revealing a complex reaction network that supports the experimental findings.
The synthesis of imines denotes a cornerstone in organic chemistry. The use of alcohols as renewable substituents for carbonyl-functionality represents an attractive opportunity. Consequently, carbonyl moieties can be in situ generated from alcohols upon transition-metal catalysis under inert atmosphere. Alternatively, bases can be utilized under aerobic conditions. In this context, we report the synthesis of imines from benzyl alcohols and anilines, promoted by (KOBu)-Bu-t under aerobic conditions at room temperature, in the absence of any transition-metal catalyst. A detailed investigation of the radical mechanism of the underlying reaction is presented. This reveals a complex reaction network fully supporting the experimental findings.
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