期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 29, 期 34, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202300828
关键词
2-aminoindole; anticancer; domino reaction; one-pot reaction; SET oxidative cyclization; synthetic methods
An efficient domino approach for the synthesis of biologically important 2-aminoindole derivatives has been developed using CuBr2-mediated SET oxidative cyclization as a key step. This one-pot multicomponent strategy utilizes readily available starting materials and demonstrates generality and scope with a wide variety of substrates, producing functionalized 2-aminoindoles in good yields. The synthetic power of this strategy is further exemplified in the concise synthesis of biologically important alkaloids, Phaitanthrin E and Tryptanthrin.
An efficient domino approach for the synthesis of biologically important 2-aminoindole derivatives has been developed using CuBr2-mediated SET oxidative cyclization as a key step. This one-pot multicomponent strategy utilizes readily available ethyl propiolate, tosyl azide, and substituted aryl amines as starting materials. The generality and scope of this mild method are demonstrated with a wide variety of substrates to furnish functionalized 2-aminoindoles in good yields. The synthetic power of this strategy is further exemplified in the concise synthesis of biologically important alkaloids, Phaitanthrin E and Tryptanthrin.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据